Author results

3F1J
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CRYSTAL STRUCTURE OF THE BORNA DISEASE VIRUS MATRIX PROTEIN (BDV-M) REVEALS RNA BINDING PROPERTIES
Descriptor:Matrix protein, CYTIDINE-5'-MONOPHOSPHATE, SULFATE ION
Authors:Neumann, P., Lieber, D., Meyer, S., Dautel, P., Kerth, A., Kraus, I., Garten, W., Stubbs, M.T.
Deposit date:2008-10-28
Release date:2009-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal structure of the Borna disease virus matrix protein (BDV-M) reveals ssRNA binding properties
Proc.Natl.Acad.Sci.USA, 106, 2009
1Z7J
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HUMAN TRANSTHYRETIN (ALSO CALLED PREALBUMIN) COMPLEX WITH 3, 3',5,5'-TETRAIODOTHYROACETIC ACID (T4AC)
Descriptor:Transthyretin, 3,3',5,5'-TETRAIODOTHYROACETIC ACID
Authors:Neumann, P., Wojtczak, A., Cody, V.
Deposit date:2005-03-25
Release date:2005-06-07
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Ligand binding at the transthyretin dimer-dimer interface: structure of the transthyretin-T4Ac complex at 2.2 Angstrom resolution.
Acta Crystallogr.,Sect.D, 61, 2005
3EY9
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STRUCTURAL BASIS FOR MEMBRANE BINDING AND CATALYTIC ACTIVATION OF THE PERIPHERAL MEMBRANE ENZYME PYRUVATE OXIDASE FROM ESCHERICHIA COLI
Descriptor:Pyruvate dehydrogenase [cytochrome], THIAMIN DIPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Neumann, P., Weidner, A., Pech, A., Stubbs, M.T., Tittmann, K.
Deposit date:2008-10-20
Release date:2008-11-04
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for membrane binding and catalytic activation of the peripheral membrane enzyme pyruvate oxidase from Escherichia coli.
Proc.Natl.Acad.Sci.USA, 105, 2008
3EYA
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STRUCTURAL BASIS FOR MEMBRANE BINDING AND CATALYTIC ACTIVATION OF THE PERIPHERAL MEMBRANE ENZYME PYRUVATE OXIDASE FROM ESCHERICHIA COLI
Descriptor:Pyruvate dehydrogenase [cytochrome], THIAMIN DIPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Neumann, P., Weidner, A., Pech, A., Stubbs, M.T., Tittmann, K.
Deposit date:2008-10-20
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for membrane binding and catalytic activation of the peripheral membrane enzyme pyruvate oxidase from Escherichia coli.
Proc.Natl.Acad.Sci.USA, 105, 2008
4H69
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CRYSTAL STRUCTURE OF THE ALLENE OXIDE CYCLASE 2 FROM PHYSCOMITRELLA PATENS COMPLEXED WITH SUBSTRATE ANALOG
Descriptor:Allene oxide cyclase, PHOSPHATE ION, (9Z)-11-{(2R,3S)-3-[(2Z)-pent-2-en-1-yl]oxiran-2-yl}undec-9-enoic acid, ...
Authors:Neumann, P., Ficner, R.
Deposit date:2012-09-19
Release date:2012-10-17
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of Physcomitrella patens AOC1 and AOC2: Insights into the Enzyme Mechanism and Differences in Substrate Specificity.
Plant Physiol., 160, 2012
4H6A
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CRYSTAL STRUCTURE OF THE ALLENE OXIDE CYCLASE 2 FROM PHYSCOMITRELLA PATENS
Descriptor:Allene oxide cyclase, (4S)-2-METHYL-2,4-PENTANEDIOL, ISOPROPYL ALCOHOL, ...
Authors:Neumann, P., Ficner, R.
Deposit date:2012-09-19
Release date:2012-10-17
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structures of Physcomitrella patens AOC1 and AOC2: Insights into the Enzyme Mechanism and Differences in Substrate Specificity.
Plant Physiol., 160, 2012
4H6B
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STRUCTURAL BASIS FOR ALLENE OXIDE CYCLIZATION IN MOSS
Descriptor:Allene oxide cyclase, (9Z)-11-{(2S,3S)-3-[(2Z)-pent-2-en-1-yl]oxiran-2-yl}undec-9-enoic acid, (9Z)-11-{(2R,3S)-3-[(2Z)-pent-2-en-1-yl]oxiran-2-yl}undec-9-enoic acid, ...
Authors:Neumann, P., Ficner, R.
Deposit date:2012-09-19
Release date:2012-10-17
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystal Structures of Physcomitrella patens AOC1 and AOC2: Insights into the Enzyme Mechanism and Differences in Substrate Specificity.
Plant Physiol., 160, 2012
4H6C
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CRYSTAL STRUCTURE OF THE ALLENE OXIDE CYCLASE 1 FROM PHYSCOMITRELLA PATENS
Descriptor:Allene oxide cyclase, PHOSPHATE ION, HEXANE-1,6-DIOL
Authors:Neumann, P., Ficner, R.
Deposit date:2012-09-19
Release date:2012-10-17
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystal Structures of Physcomitrella patens AOC1 and AOC2: Insights into the Enzyme Mechanism and Differences in Substrate Specificity.
Plant Physiol., 160, 2012
4KR6
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CRYSTAL STRUCTURE OF A 4-THIOURIDINE SYNTHETASE - RNA COMPLEX
Descriptor:Probable tRNA sulfurtransferase, RNA (39-MER), MERCURY (II) ION
Authors:Neumann, P., Ficner, R., Lakomek, K.
Deposit date:2013-05-16
Release date:2014-04-23
Last modified:2014-07-16
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystal structure of a 4-thiouridine synthetase-RNA complex reveals specificity of tRNA U8 modification.
Nucleic Acids Res., 42, 2014
4KR7
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CRYSTAL STRUCTURE OF A 4-THIOURIDINE SYNTHETASE - RNA COMPLEX WITH BOUND ATP
Descriptor:Probable tRNA sulfurtransferase, RNA (39-MER), ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Neumann, P., Ficner, R., Lakomek, K.
Deposit date:2013-05-16
Release date:2014-04-23
Last modified:2014-07-16
Method:X-RAY DIFFRACTION (3.421 Å)
Cite:Crystal structure of a 4-thiouridine synthetase-RNA complex reveals specificity of tRNA U8 modification.
Nucleic Acids Res., 42, 2014
4KR9
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CRYSTAL STRUCTURE OF A 4-THIOURIDINE SYNTHETASE - RNA COMPLEX AT 3.5 ANGSTROM RESOLUTION
Descriptor:Probable tRNA sulfurtransferase, RNA (39-MER)
Authors:Neumann, P., Ficner, R., Lakomek, K.
Deposit date:2013-05-16
Release date:2014-04-23
Last modified:2014-07-16
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structure of a 4-thiouridine synthetase-RNA complex reveals specificity of tRNA U8 modification.
Nucleic Acids Res., 42, 2014
3CGN
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CRYSTAL STRUCTURE OF THERMOPHILIC SLYD
Descriptor:Peptidyl-prolyl cis-trans isomerase, SULFATE ION
Authors:Neumann, P., Loew, C., Stubbs, M.T., Balbach, J.
Deposit date:2008-03-06
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure Determination and Functional Characterization of the Metallochaperone SlyD from Thermus thermophilus
J.Mol.Biol., 398, 2010
3FD7
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CRYSTAL STRUCTURE OF ONCONASE C87A/C104A-ONC
Descriptor:Protein P-30, SULFATE ION, GLYCEROL, ...
Authors:Neumann, P., Schulenburg, C., Arnold, U., Ulbrich-Hofmann, R., Stubbs, M.T.
Deposit date:2008-11-25
Release date:2009-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.531 Å)
Cite:Impact of the C-terminal disulfide bond on the folding and stability of onconase.
Chembiochem, 11, 2010
3FT7
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CRYSTAL STRUCTURE OF AN EXTREMELY STABLE DIMERIC PROTEIN FROM SULFOLOBUS ISLANDICUS
Descriptor:Uncharacterized protein ORF56, GLYCEROL
Authors:Neumann, P., Loew, C., Weininger, U., Stubbs, M.T.
Deposit date:2009-01-12
Release date:2009-10-20
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Based Stability Analysis of an Extremely Stable Dimeric DNA Binding Protein from Sulfolobus islandicus
Biochemistry, 48, 2009
3MWQ
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CRYSTAL STRUCTURE OF RIBONUCLEASE A TANDEM ENZYMES AND THEIR INTERACTION WITH THE CYTOSOLIC RIBONUCLEASE INHIBITOR
Descriptor:Ribonuclease pancreatic, LINKER, SULFATE ION, ...
Authors:Neumann, P., Leich, F.
Deposit date:2010-05-06
Release date:2011-02-09
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Crystal structure of RNase A tandem enzymes and their interaction with the cytosolic ribonuclease inhibitor
Febs J., 278, 2011
3MWR
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CRYSTAL STRUCTURE OF RIBONUCLEASE A TANDEM ENZYMES AND THEIR INTERACTION WITH THE CYTOSOLIC RIBONUCLEASE INHIBITOR
Descriptor:Ribonuclease pancreatic, LINKER, SULFATE ION, ...
Authors:Neumann, P., Leich, F.
Deposit date:2010-05-06
Release date:2011-02-09
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of RNase A tandem enzymes and their interaction with the cytosolic ribonuclease inhibitor
Febs J., 278, 2011
4KGD
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HIGH-RESOLUTION CRYSTAL STRUCTURE OF PYRUVATE OXIDASE FROM L. PLANTARUM IN COMPLEX WITH PHOSPHATE
Descriptor:Pyruvate oxidase, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, ...
Authors:Neumann, P., Tittmann, K.
Deposit date:2013-04-29
Release date:2013-06-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:Observation of a stable carbene at the active site of a thiamin enzyme.
Nat.Chem.Biol., 9, 2013
4KXU
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HUMAN TRANSKETOLASE IN COVALENT COMPLEX WITH DONOR KETOSE D-FRUCTOSE-6-PHOSPHATE
Descriptor:Transketolase, 1,2-ETHANEDIOL, MAGNESIUM ION, ...
Authors:Neumann, P., Luedtke, S., Ficner, R., Tittmann, K.
Deposit date:2013-05-28
Release date:2013-08-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (0.98 Å)
Cite:Sub-angstrom-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate.
Nat Chem, 5, 2013
4KXV
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HUMAN TRANSKETOLASE IN COVALENT COMPLEX WITH DONOR KETOSE D-XYLULOSE-5-PHOSPHATE, CRYSTAL 1
Descriptor:Transketolase, CALCIUM ION, 1,2-ETHANEDIOL, ...
Authors:Neumann, P., Luedtke, S., Ficner, R., Tittmann, K.
Deposit date:2013-05-28
Release date:2013-08-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (0.97 Å)
Cite:Sub-angstrom-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate.
Nat Chem, 5, 2013
4KXW
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HUMAN TRANSKETOLASE IN COVALENT COMPLEX WITH DONOR KETOSE D-XYLULOSE-5-PHOSPHATE, CRYSTAL 2
Descriptor:Transketolase, MAGNESIUM ION, 1,2-ETHANEDIOL, ...
Authors:Neumann, P., Luedtke, S., Ficner, R., Tittmann, K.
Deposit date:2013-05-28
Release date:2013-08-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (0.97 Å)
Cite:Sub-angstrom-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate.
Nat Chem, 5, 2013
4KXX
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HUMAN TRANSKETOLASE IN COVALENT COMPLEX WITH DONOR KETOSE D-SEDOHEPTULOSE-7-PHOSPHATE
Descriptor:Transketolase, (2R,3R,4S,5R,6S)-2,3,4,5,6,7-hexahydroxyheptyl dihydrogen phosphate, THIAMIN DIPHOSPHATE, ...
Authors:Neumann, P., Luedtke, S., Ficner, R., Tittmann, K.
Deposit date:2013-05-28
Release date:2013-08-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.03 Å)
Cite:Sub-angstrom-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate.
Nat Chem, 5, 2013
4KXY
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HUMAN TRANSKETOLASE IN COMPLEX WITH THDP ANALOGUE (R)-2-(1,2-DIHYDROXYETHYL)-3-DEAZA-THDP
Descriptor:Transketolase, 1,2-ETHANEDIOL, CALCIUM ION, ...
Authors:Neumann, P., Luedtke, S., Erixon, K.M., Leeper, F., Kluger, R., Ficner, R., Tittmann, K.
Deposit date:2013-05-28
Release date:2013-08-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Sub-angstrom-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate.
Nat Chem, 5, 2013
5HSA
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ALCOHOL OXIDASE AOX1 FROM PICHIA PASTORIS
Descriptor:Alcohol oxidase 1, ARABINO-FLAVIN-ADENINE DINUCLEOTIDE, HEXAETHYLENE GLYCOL, ...
Authors:Neumann, P., Ficner, R., Feussner, I., Koch, C.
Deposit date:2016-01-25
Release date:2016-03-09
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structure of Alcohol Oxidase from Pichia pastoris.
Plos One, 11, 2016
3PLB
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BOVINE TRYPSIN VARIANT X(TRIPLEILE227) IN COMPLEX WITH SMALL MOLECULE INHIBITOR
Descriptor:Cationic trypsin, CALCIUM ION, BENZAMIDINE, ...
Authors:Tziridis, A., Neumann, P., Kolenko, P., Stubbs, M.T.
Deposit date:2010-11-15
Release date:2011-12-07
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues.
Biol.Chem., 395, 2014
3PLK
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BOVINE TRYPSIN VARIANT X(TRIPLEILE227) IN COMPLEX WITH SMALL MOLECULE INHIBITOR
Descriptor:Cationic trypsin, CALCIUM ION, METHYL N-[(4-METHYLPHENYL)SULFONYL]GLYCYL-3-[AMINO(IMINO)METHYL]-D-PHENYLALANINATE, ...
Authors:Tziridis, A., Neumann, P., Braeuer, U., Kolenko, P., Stubbs, M.T.
Deposit date:2010-11-15
Release date:2011-12-07
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues.
Biol.Chem., 395, 2014