Author results

5TPX
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BROMODOMAIN FROM PLASMODIUM FACIPARUM GCN5, COMPLEXED WITH COMPOUND
Descriptor:Histone acetyltransferase GCN5, CHLORIDE ION, SULFATE ION, ...
Authors:Lin, Y.H., Hou, C.F.D., MOUSTAKIM, M., DIXON, D.J., Loppnau, P., Tempel, W., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Hui, R., BRENNAN, P.E., Walker, J.R., Structural Genomics Consortium (SGC)
Deposit date:2016-10-21
Release date:2017-01-04
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of a PCAF Bromodomain Chemical Probe.
Angew. Chem. Int. Ed. Engl., 56, 2017
6HT0
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CRYSTAL STRUCTURE OF MLLT1 (ENL) YEATS DOMAIN IN COMPLEXED WITH COMPOUND 94
Descriptor:Protein ENL, SULFATE ION, 1,2-ETHANEDIOL, ...
Authors:Heidenreich, D., Chaikuad, A., Moustakim, M., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Fedorov, O., Brennan, P.E., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2018-10-02
Release date:2018-10-17
Last modified:2018-12-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of an MLLT1/3 YEATS Domain Chemical Probe.
Angew. Chem. Int. Ed. Engl., 57, 2018
6HT1
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CRYSTAL STRUCTURE OF MLLT1 (ENL) YEATS DOMAIN IN COMPLEXED WITH SGC-IMLLT (COMPOUND 92)
Descriptor:Protein ENL, SULFATE ION, 1,2-ETHANEDIOL, ...
Authors:Heidenreich, D., Chaikuad, A., Moustakim, M., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Fedorov, O., Brennan, P.E., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2018-10-02
Release date:2018-10-17
Last modified:2018-12-12
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of an MLLT1/3 YEATS Domain Chemical Probe.
Angew. Chem. Int. Ed. Engl., 57, 2018
6HPW
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CRYSTAL STRUCTURE OF ENL (MLLT1) IN COMPLEX WITH COMPOUND 20
Descriptor:Protein ENL, 1,2-ETHANEDIOL, 3-iodanyl-4-methyl-~{N}-[2-(piperidin-1-ylmethyl)-3~{H}-benzimidazol-5-yl]benzamide
Authors:Heidenreich, D., Chaikuad, A., Moustakim, M., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brennan, P.E., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2018-09-22
Release date:2018-11-28
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL).
J.Med.Chem., 61, 2018
6HPX
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CRYSTAL STRUCTURE OF ENL (MLLT1) IN COMPLEX WITH COMPOUND 19
Descriptor:Protein ENL, 1,2-ETHANEDIOL, ~{N}-[(3-chlorophenyl)methyl]-1-(2-pyrrolidin-1-ylethyl)benzimidazole-5-carboxamide
Authors:Heidenreich, D., Chaikuad, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2018-09-22
Release date:2018-11-28
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL).
J.Med.Chem., 61, 2018
6HPY
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CRYSTAL STRUCTURE OF ENL (MLLT1) IN COMPLEX WITH COMPOUND 12
Descriptor:Protein ENL, 1,2-ETHANEDIOL, SULFATE ION, ...
Authors:Heidenreich, D., Chaikuad, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2018-09-22
Release date:2018-11-28
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL).
J.Med.Chem., 61, 2018
6HPZ
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CRYSTAL STRUCTURE OF ENL (MLLT1) IN COMPLEX WITH ACETYLLYSINE
Descriptor:Protein ENL, 1,2-ETHANEDIOL, N(6)-ACETYLLYSINE
Authors:Heidenreich, D., Chaikuad, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2018-09-22
Release date:2018-11-28
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL).
J.Med.Chem., 61, 2018
6HQ0
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CRYSTAL STRUCTURE OF ENL (MLLT1), APO FORM
Descriptor:Protein ENL, 1,2-ETHANEDIOL
Authors:Heidenreich, D., Chaikuad, A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2018-09-22
Release date:2018-11-28
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL).
J.Med.Chem., 61, 2018