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HUMAN DNA TOPOISOMERASE I (70 KDA) IN NON-COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX CONTAINING AN 8-OXOG LESION
Descriptor:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*(8OG)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I
Authors:Lesher, D.T., Pommier, Y., Stewart, L., Redinbo, M.R.
Deposit date:2002-05-08
Release date:2002-08-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:8-Oxoguanine rearranges the active site of human topoisomerase I
Proc.Natl.Acad.Sci.USA, 99, 2002