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3B3O
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STRUCTURE OF NEURONAL NOS HEME DOMAIN IN COMPLEX WITH A INHIBITOR (+-)-N1-{CIS-4'-[(6"-AMINO-4"-METHYLPYRIDIN-2"-YL)METHYL]PYRROLIDIN-3'-YL}-N2-(4'-CHLOROBENZYL)ETHANE-1,2-DIAMINE
Descriptor:Nitric-oxide synthase, ACETATE ION, ZINC ION, ...
Authors:Igarashi, J., Li, H., Poulos, T.L.
Deposit date:2007-10-22
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors.
J.Med.Chem., 52, 2009
3B3P
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STRUCTURE OF NEURONAL NOS HEME DOMAIN IN COMPLEX WITH A INHIBITOR (+-)-N1-{CIS-4'-[(6"-AMINO-4"-METHYLPYRIDIN-2"-YL)METHYL]PYRROLIDIN-3'-YL}-N2-(4'-CHLOROBENZYL)ETHANE-1,2-DIAMINE
Descriptor:Nitric-oxide synthase, ACETATE ION, ZINC ION, ...
Authors:Igarashi, J., Li, H., Poulos, T.L.
Deposit date:2007-10-22
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors.
J.Med.Chem., 52, 2009
3DQR
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STRUCTURE OF NEURONAL NOS D597N/M336V MUTANT HEME DOMAIN IN COMPLEX WITH A INHIBITOR (+-)-N1-{CIS-4'-[(6"-AMINOPYRIDIN-2"-YL)METHYL]PYRROLIDIN-3'-YL}ETHANE-1,2-DIAMINE
Descriptor:Nitric oxide synthase, brain, ACETATE ION, ...
Authors:Igarashi, J., Li, H., Poulos, T.L.
Deposit date:2008-07-09
Release date:2009-03-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors.
J.Med.Chem., 52, 2009
3DQS
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STRUCTURE OF ENDOTHELIAL NOS HEME DOMAIN IN COMPLEX WITH A INHIBITOR (+-)-N1-{CIS-4'-[(6"-AMINO-4"-METHYLPYRIDIN-2"-YL)METHYL]PYRROLIDIN-3'-YL}-N2-(4'-CHLOROBENZYL)ETHANE-1,2-DIAMINE
Descriptor:Nitric oxide synthase, endothelial, CACODYLATE ION, ...
Authors:Igarashi, J., Li, H., Poulos, T.L.
Deposit date:2008-07-09
Release date:2009-03-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors.
J.Med.Chem., 52, 2009
3DQT
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STRUCTURE OF ENDOTHELIAL NOS HEME DOMAIN IN COMPLEX WITH A INHIBITOR (+-)-N1-{TRANS-4'-[(6"-AMINO-4"-METHYLPYRIDIN-2"-YL)METHYL]PYRROLIDIN-3'-YL}-N2-(3'-CHLOROBENZYL)ETHANE-1,2-DIAMINE
Descriptor:Nitric oxide synthase, endothelial, CACODYLATE ION, ...
Authors:Igarashi, J., Li, H., Poulos, T.L.
Deposit date:2008-07-09
Release date:2009-03-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors.
J.Med.Chem., 52, 2009
3AQ5
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CRYSTAL STRUCTURE OF TRUNCATED HEMOGLOBIN FROM TETRAHYMENA PYRIFORMIS, FE(II)-O2 FORM
Descriptor:Group 1 truncated hemoglobin, PROTOPORPHYRIN IX CONTAINING FE, OXYGEN MOLECULE
Authors:Igarashi, J., Kobayashi, K., Matsuoka, A.
Deposit date:2010-10-25
Release date:2011-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:A hydrogen-bonding network formed by the B10-E7-E11 residues of a truncated hemoglobin from Tetrahymena pyriformis is critical for stability of bound oxygen and nitric oxide detoxification.
J.Biol.Inorg.Chem., 16, 2011
3AQ6
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CRYSTAL STRUCTURE OF TRUNCATED HEMOGLOBIN FROM TETRAHYMENA PYRIFORMIS, FE(III) FORM
Descriptor:Group 1 truncated hemoglobin, PROTOPORPHYRIN IX CONTAINING FE
Authors:Igarashi, J., Kobayashi, K., Matsuoka, A.
Deposit date:2010-10-25
Release date:2011-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:A hydrogen-bonding network formed by the B10-E7-E11 residues of a truncated hemoglobin from Tetrahymena pyriformis is critical for stability of bound oxygen and nitric oxide detoxification.
J.Biol.Inorg.Chem., 16, 2011
3AQ7
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CRYSTAL STRUCTURE OF TRUNCATED HEMOGLOBIN FROM TETRAHYMENA PYRIFORMIS, Y25F MUTANT, FE(III) FORM
Descriptor:Group 1 truncated hemoglobin, PROTOPORPHYRIN IX CONTAINING FE
Authors:Igarashi, J., Kobayashi, K., Matsuoka, A.
Deposit date:2010-10-25
Release date:2011-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:A hydrogen-bonding network formed by the B10-E7-E11 residues of a truncated hemoglobin from Tetrahymena pyriformis is critical for stability of bound oxygen and nitric oxide detoxification.
J.Biol.Inorg.Chem., 16, 2011
3AQ8
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CRYSTAL STRUCTURE OF TRUNCATED HEMOGLOBIN FROM TETRAHYMENA PYRIFORMIS, Q46E MUTANT, FE(III) FORM
Descriptor:Group 1 truncated hemoglobin, PROTOPORPHYRIN IX CONTAINING FE
Authors:Igarashi, J., Kobayashi, K., Matsuoka, A.
Deposit date:2010-10-25
Release date:2011-04-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:A hydrogen-bonding network formed by the B10-E7-E11 residues of a truncated hemoglobin from Tetrahymena pyriformis is critical for stability of bound oxygen and nitric oxide detoxification.
J.Biol.Inorg.Chem., 16, 2011
3AQ9
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CRYSTAL STRUCTURE OF TRUNCATED HEMOGLOBIN FROM TETRAHYMENA PYRIFORMIS, Q50E MUTANT, FE(III) FORM
Descriptor:Group 1 truncated hemoglobin, PROTOPORPHYRIN IX CONTAINING FE
Authors:Igarashi, J., Kobayashi, K., Matsuoka, A.
Deposit date:2010-10-25
Release date:2011-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:A hydrogen-bonding network formed by the B10-E7-E11 residues of a truncated hemoglobin from Tetrahymena pyriformis is critical for stability of bound oxygen and nitric oxide detoxification.
J.Biol.Inorg.Chem., 16, 2011
3B3M
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STRUCTURE OF NEURONAL NOS HEME DOMAIN IN COMPLEX WITH A INHIBITOR (+-)-3-{CIS-4'-[(6"-AMINOPYRIDIN-2"-YL)METHYL]PYRROLIDIN-3'-YLAMINO}PROPAN-1-OL
Descriptor:Nitric-oxide synthase, ACETATE ION, ZINC ION, ...
Authors:Igarashi, J., Li, H., Poulos, T.L.
Deposit date:2007-10-22
Release date:2008-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors.
J.Am.Chem.Soc., 130, 2008
3B3N
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STRUCTURE OF NEURONAL NOS HEME DOMAIN IN COMPLEX WITH A INHIBITOR (+-)-N1-{CIS-4'-[(6"-AMINOPYRIDIN-2"-YL)METHYL]PYRROLIDIN-3'-YL}ETHANE-1,2-DIAMINE
Descriptor:Nitric-oxide synthase, ACETATE ION, ZINC ION, ...
Authors:Igarashi, J., Li, H., Poulos, T.L.
Deposit date:2007-10-22
Release date:2008-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors.
J.Am.Chem.Soc., 130, 2008
2HX2
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BOVINE ENOS HEME DOMAIN COMPLEXED WITH (4S)-N-{4-AMINO-5-[(2-AMINOETHYL)-HYDROXYAMINO]-PENTYL}-N'-NITROGUANIDINE
Descriptor:Nitric-oxide synthase, CACODYLATE ION, ACETATE ION, ...
Authors:Igarashi, J., Li, H., Poulos, T.L.
Deposit date:2006-08-02
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure-Based Design and Synthesis of N(omega)-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water.
J.Med.Chem., 50, 2007
2HX3
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RAT NNOS HEME DOMAIN COMPLEXED WITH (4S)-N-{4-AMINO-5-[(2-AMINOETHYL)-HYDROXYAMINO]-PENTYL}-N'-NITROGUANIDINE
Descriptor:Nitric-oxide synthase, ACETATE ION, ZINC ION, ...
Authors:Igarashi, J., Li, H., Poulos, T.L.
Deposit date:2006-08-02
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Based Design and Synthesis of N(omega)-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water.
J.Med.Chem., 50, 2007
2HX4
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RAT NNOS HEME DOMAIN COMPLEXED WITH 4-N-(NW-NITRO-L-ARGININYL)-TRANS-4-HYDROXYAMINO-L-PROLINE AMIDE
Descriptor:Nitric-oxide synthase, ACETATE ION, ZINC ION, ...
Authors:Igarashi, J., Li, H., Poulos, T.L.
Deposit date:2006-08-02
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure-Based Design and Synthesis of N(omega)-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water.
J.Med.Chem., 50, 2007
1ZZQ
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RAT NNOS D597N MUTANT WITH L-N(OMEGA)-NITROARGININE-(4R)-AMINO-L-PROLINE AMIDE BOUND
Descriptor:Nitric-oxide synthase, brain, ACETATE ION, ...
Authors:Li, H., Flinspach, M.L., Igarashi, J., Jamal, J., Yang, W., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2005-06-14
Release date:2005-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases.
Biochemistry, 44, 2005
1ZZR
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RAT NNOS D597N/M336V DOUBLE MUTANT WITH L-N(OMEGA)-NITROARGININE-(4R)-AMINO-L-PROLINE AMIDE BOUND
Descriptor:Nitric-oxide synthase, brain, ZINC ION, ...
Authors:Li, H., Flinspach, M.L., Igarashi, J., Jamal, J., Yang, W., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2005-06-14
Release date:2005-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases.
Biochemistry, 44, 2005
1ZZS
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BOVINE ENOS N368D SINGLE MUTANT WITH L-N(OMEGA)-NITROARGININE-(4R)-AMINO-L-PROLINE AMIDE BOUND
Descriptor:Nitric-oxide synthase, endothelial, ACETATE ION, ...
Authors:Li, H., Flinspach, M.L., Igarashi, J., Jamal, J., Yang, W., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2005-06-14
Release date:2005-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases.
Biochemistry, 44, 2005
1ZZT
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BOVINE ENOS N368D/V106M DOUBLE MUTANT WITH L-N(OMEGA)-NITROARGININE-(4R)-AMINO-L-PROLINE AMIDE BOUND
Descriptor:Nitric-oxide synthase, endothelial, ACETATE ION, ...
Authors:Li, H., Flinspach, M.L., Igarashi, J., Jamal, J., Yang, W., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2005-06-14
Release date:2005-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases.
Biochemistry, 44, 2005
1ZZU
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RAT NNOS D597N/M336V DOUBLE MUTANT WITH L-N(OMEGA)-NITROARGININE-2,4-L-DIAMINOBUTYRIC AMIDE BOUND
Descriptor:Nitric-oxide synthase, brain, ACETATE ION, ...
Authors:Li, H., Flinspach, M.L., Igarashi, J., Jamal, J., Yang, W., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L.
Deposit date:2005-06-14
Release date:2005-12-06
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases.
Biochemistry, 44, 2005
2G6H
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STRUCTURE OF RAT NNOS HEME DOMAIN (BH4 BOUND) IN THE REDUCED FORM
Descriptor:Nitric-oxide synthase, brain, ACETATE ION, ...
Authors:Li, H., Igarashi, J., Jamal, J., Yang, W., Poulos, T.L.
Deposit date:2006-02-24
Release date:2006-08-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural studies of constitutive nitric oxide synthases with diatomic ligands bound.
J.Biol.Inorg.Chem., 11, 2006
2G6I
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STRUCTURE OF RAT NNOS HEME DOMAIN (BH2-BOUND) IN THE REDUCED FORM
Descriptor:Nitric-oxide synthase, brain, ACETATE ION, ...
Authors:Li, H., Igarashi, J., Jamal, J., Yang, W., Poulos, T.L.
Deposit date:2006-02-24
Release date:2006-08-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural studies of constitutive nitric oxide synthases with diatomic ligands bound.
J.Biol.Inorg.Chem., 11, 2006
2G6J
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STRUCTURE OF RAT NNOS (L337N) HEME DOMAIN (4-AMINOBIOPTERIN BOUND) COMPLEXED WITH NO
Descriptor:Nitric-oxide synthase, brain, ACETATE ION, ...
Authors:Li, H., Igarashi, J., Jamal, J., Yang, W., Poulos, T.L.
Deposit date:2006-02-24
Release date:2006-08-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural studies of constitutive nitric oxide synthases with diatomic ligands bound.
J.Biol.Inorg.Chem., 11, 2006
2G6K
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STRUCTURE OF RAT NNOS HEME DOMAIN (BH4 BOUND) COMPLEXED WITH NO
Descriptor:Nitric-oxide synthase, brain, ACETATE ION, ...
Authors:Li, H., Igarashi, J., Jamal, J., Yang, W., Poulos, T.L.
Deposit date:2006-02-24
Release date:2006-08-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural studies of constitutive nitric oxide synthases with diatomic ligands bound.
J.Biol.Inorg.Chem., 11, 2006
2G6L
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STRUCTURE OF RAT NNOS HEME DOMAIN (BH2 BOUND) COMPLEXED WITH NO
Descriptor:Nitric-oxide synthase, brain, ACETATE ION, ...
Authors:Li, H., Igarashi, J., Jamal, J., Yang, W., Poulos, T.L.
Deposit date:2006-02-24
Release date:2006-08-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural studies of constitutive nitric oxide synthases with diatomic ligands bound.
J.Biol.Inorg.Chem., 11, 2006
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