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1YWV
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CRYSTAL STRUCTURES OF PROTO-ONCOGENE KINASE PIM1: A TARGET OF ABERRANT SOMATIC HYPERMUTATIONS IN DIFFUSE LARGE CELL LYMPHOMA
Descriptor:Proto-oncogene serine/threonine-protein kinase Pim-1, IMIDAZOLE
Authors:Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R.
Deposit date:2005-02-18
Release date:2005-04-26
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
J.Mol.Biol., 348, 2005
1YXS
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CRYSTAL STRUCTURE OF KINASE PIM1 WITH P123M MUTATION
Descriptor:Proto-oncogene serine/threonine-protein kinase Pim-1, IMIDAZOLE
Authors:Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R.
Deposit date:2005-02-22
Release date:2005-04-26
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
J.Mol.Biol., 348, 2005
1YXT
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CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH AMPPNP
Descriptor:Proto-oncogene serine/threonine-protein kinase Pim-1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R.
Deposit date:2005-02-22
Release date:2005-04-26
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
J.Mol.Biol., 348, 2005
1YXU
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CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH AMP
Descriptor:Proto-oncogene serine/threonine-protein kinase Pim-1, IMIDAZOLE, ADENOSINE MONOPHOSPHATE
Authors:Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R.
Deposit date:2005-02-22
Release date:2005-04-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Crystal Structures of Proto-oncogene Kinase Pim1: A Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma.
J.Mol.Biol., 348, 2005
1YXV
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CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH 3,4-DIHYDROXY-1-METHYLQUINOLIN-2(1H)-ONE
Descriptor:Proto-oncogene serine/threonine-protein kinase Pim-1, IMIDAZOLE, 3,4-DIHYDROXY-1-METHYLQUINOLIN-2(1H)-ONE
Authors:Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R.
Deposit date:2005-02-22
Release date:2005-04-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of Proto-oncogene Kinase Pim1: A Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma.
J.Mol.Biol., 348, 2005
1YXX
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CRYSTAL STRUCTURE OF KINASE PIM1 IN COMPLEX WITH (3E)-3-[(4-HYDROXYPHENYL)IMINO]-1H-INDOL-2(3H)-ONE
Descriptor:Proto-oncogene serine/threonine-protein kinase Pim-1, IMIDAZOLE, (3E)-3-[(4-HYDROXYPHENYL)IMINO]-1H-INDOL-2(3H)-ONE
Authors:Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R.
Deposit date:2005-02-22
Release date:2005-04-26
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
J.Mol.Biol., 348, 2005
5WMA
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N-TERMINAL BROMODOMAIN OF BRD4 IN COMPLEX WITH PLX5981
Descriptor:Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 5-(3,5-dimethyl-1,2-oxazol-4-yl)-1H-pyrrolo[2,3-b]pyridine
Authors:Zhang, Y.
Deposit date:2017-07-28
Release date:2018-08-01
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.401 Å)
Cite:BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor.
Cancer Discov, 8, 2018
5WMD
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N-TERMINAL BROMODOMAIN OF BRD4 IN COMPLEX WITH OTX-015
Descriptor:Bromodomain-containing protein 4, 2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(4-hydroxyphenyl)acetamide
Authors:Zhang, Y.
Deposit date:2017-07-28
Release date:2018-08-01
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor.
Cancer Discov, 8, 2018
5WMG
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N-TERMINAL BROMODOMAIN OF BRD4 IN COMPLEX WITH OTX-015
Descriptor:Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 4-{6-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1S)-1-(pyridin-2-yl)ethyl]-1H-pyrrolo[3,2-b]pyridin-3-yl}benzoic acid
Authors:Zhang, Y.
Deposit date:2017-07-28
Release date:2018-08-01
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor.
Cancer Discov, 8, 2018
6N33
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CRYSTAL STRUCTURE OF FMS KINASE DOMAIN WITH A SMALL MOLECULAR INHIBITOR, PLX5622
Descriptor:Macrophage colony-stimulating factor 1 receptor, 6-fluoro-N-[(5-fluoro-2-methoxypyridin-3-yl)methyl]-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-amine
Authors:Zhang, Y.
Deposit date:2018-11-14
Release date:2019-09-18
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model.
Nat Commun, 10, 2019