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4D3I
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 6,6'-((5-(AMINOMETHYL)-1,3-PHENYLENE)BIS(ETHANE-2,1-DIYL))BIS(4- METHYLPYRIDIN-2-AMINE)
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, 6,6'-{[5-(aminomethyl)benzene-1,3-diyl]diethane-2,1-diyl}bis(4-methylpyridin-2-amine), ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-10-22
Release date:2015-01-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors.
J.Med.Chem., 58, 2015
4D3J
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 6,6'-(2,2'-(5-AMINO-1,3-PHENYLENE)BIS(ETHANE-2,1-DIYL))BIS(4- METHYLPYRIDIN-2-AMINE)
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-10-22
Release date:2015-01-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors.
J.Med.Chem., 58, 2015
4D3K
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 6,6'-((5-(3-AMINOPROPYL)-1,3-PHENYLENE)BIS(ETHANE-2,1-DIYL))BIS(4- METHYLPYRIDIN-2-AMINE)
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-10-22
Release date:2015-01-14
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.017 Å)
Cite:Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors.
J.Med.Chem., 58, 2015
4D3M
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 3-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)-5-(2-(4-METHYL-6-(METHYLAMINO)PYRIDIN-2-YL)ETHYL)BENZONITRILE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-10-23
Release date:2015-01-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.741 Å)
Cite:Structure-based design of bacterial nitric oxide synthase inhibitors.
J. Med. Chem., 58, 2015
4D3N
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 3-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)-5-((2-(PYRIDIN-2-YL)ETHYL)AMINO)BENZONITRILE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, 3-[2-(6-amino-4-methylpyridin-2-yl)ethyl]-5-{[2-(pyridin-2-yl)ethyl]amino}benzonitrile, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-10-23
Release date:2015-01-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structure-based design of bacterial nitric oxide synthase inhibitors.
J. Med. Chem., 58, 2015
4D3O
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 6-(3-(2-(1H-PYRROLO(2,3-B)PYRIDIN-6-YL)ETHYL)-5-(AMINOMETHYL) PHENETHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-10-23
Release date:2015-01-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors.
J.Med.Chem., 58, 2015
4D3T
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH N-{3-[(1S)-2-(3-{(Z)-[AMINO(THIOPHEN-2-YL)METHYLIDENE]AMINO}PHENOXY)-1-HYDROXYETHYL]PHENYL}THIOPHENE-2-CARBOXIMIDAMIDE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-10-23
Release date:2015-01-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors.
J.Med.Chem., 58, 2015
4D3U
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE H128S IN COMPLEX WITH N-{3-[(1S)-2-(3-{(Z)-[AMINO(THIOPHEN-2-YL)METHYLIDENE]AMINO}PHENOXY)-1-HYDROXYETHYL]PHENYL}THIOPHENE-2-CARBOXIMIDAMIDE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-10-23
Release date:2015-01-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.981 Å)
Cite:Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors.
J.Med.Chem., 58, 2015
4D3V
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE I218V IN COMPLEX WITH N-{3-[(1S)-2-(3-{(Z)-[AMINO(THIOPHEN-2-YL)METHYLIDENE]AMINO}PHENOXY)-1-HYDROXYETHYL]PHENYL}THIOPHENE-2-CARBOXIMIDAMIDE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-10-23
Release date:2015-01-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors.
J.Med.Chem., 58, 2015
4D7H
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 7-(2-(3-(3-FLUOROPHENYL(PROPYLAMINO)ETHYL))QUINOLIN-2- AMINE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-11-25
Release date:2015-07-01
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus Aureus
Chem.Biol., 22, 2015
4D7I
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE I218V IN COMPLEX WITH 6-(4-(((3-FLUOROPHENETHYL)AMINO)METHYL)PHENYL)-4-METHYLPYRIDIN-2- AMINE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-11-25
Release date:2015-07-01
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus Aureus
Chem.Biol., 22, 2015
4D7J
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 6-(4-(((3-FLUOROPHENETHYL)AMINO)METHYL)PHENYL)-4-METHYLPYRIDIN-2- AMINE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2014-11-25
Release date:2015-07-01
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus Aureus.
Chem.Biol., 22, 2015
4LWA
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH ((2S, 3S)-1,3-BIS((6-(2,5-DIMETHYL-1H-PYRROL-1-YL)-4-METHYLPYRIDIN-2-YL)METHOXY)-2-AMINOBUTANE
Descriptor:Nitric oxide synthase oxygenase, PROTOPORPHYRIN IX CONTAINING FE, 6,6'-{[(2S,3S)-2-aminobutane-1,3-diyl]bis(oxymethanediyl)}bis(4-methylpyridin-2-amine), ...
Authors:Holden, J.K., Li, H., Poulos, T.P.
Deposit date:2013-07-26
Release date:2013-10-23
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural and biological studies on bacterial nitric oxide synthase inhibitors.
Proc.Natl.Acad.Sci.USA, 110, 2013
4LWB
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 6-((((3R,5S)-5-(((6-AMINO-4-METHYLPYRIDIN-2-YL)METHOXY)METHYL)PYRROLIDIN-3-YL)OXY)METHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase oxygenase, PROTOPORPHYRIN IX CONTAINING FE, 6-({[(3R,5S)-5-{[(6-amino-4-methylpyridin-2-yl)methoxy]methyl}pyrrolidin-3-yl]oxy}methyl)-4-methylpyridin-2-amine, ...
Authors:Holden, J.K., Li, H., Poulos, T.L.
Deposit date:2013-07-26
Release date:2013-10-23
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural and biological studies on bacterial nitric oxide synthase inhibitors.
Proc.Natl.Acad.Sci.USA, 110, 2013
4UG5
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 6-(2-(5-(2-(2-AMINO-6-METHYLPYRIDIN-4-YL)ETHYL)PYRIDIN-3-YL)ETHYL)-4- METHYLPYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2015-03-22
Release date:2015-06-24
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.352 Å)
Cite:Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase.
Biochemistry, 54, 2015
4UG6
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 6,6'-(PYRIDINE-3,5-DIYLDIETHANE-2,1-DIYL)BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2015-03-22
Release date:2015-06-24
Last modified:2015-07-22
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase.
Biochemistry, 54, 2015
4UG7
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 3,5-BIS(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)BENZONITRILE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2015-03-22
Release date:2015-06-24
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase.
Biochemistry, 54, 2015
4UG8
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 6-(5-((3R,4R)-4-((6-AZANYL-4-METHYL-PYRIDIN-2-YL)METHYL)PYRROLIDIN-3- YL)OXYPENTYL)-4-METHYL-PYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2015-03-22
Release date:2015-06-24
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.888 Å)
Cite:Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase.
Biochemistry, 54, 2015
4UG9
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 6,6'-((4-(3-AMINOPROPYL)BENZENE-1,3-DIYL)DIETHANE-2,1-DIYL)BIS(4- METHYLPYRIDIN-2-AMINE)
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, CHLORIDE ION, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2015-03-22
Release date:2015-06-24
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.841 Å)
Cite:Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase.
Biochemistry, 54, 2015
4UGA
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 6-((3-(((2-(3-FLUOROPHENYL)ETHYL)AMINO)METHYL)PHENOXY)METHYL)-4- METHYLPYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2015-03-22
Release date:2015-06-24
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase.
Biochemistry, 54, 2015
4UGB
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 6-(((5-(((2-(3-FLUOROPHENYL)ETHYL)AMINO)METHYL)PYRIDIN-3-YL)OXY) METHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2015-03-22
Release date:2015-06-24
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.912 Å)
Cite:Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase.
Biochemistry, 54, 2015
4UGC
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 6,6'-(((2S)-3-AMINOPROPANE-1,2-DIYL)BIS(OXYMETHANEDIYL))BIS(4- METHYLPYRIDIN-2-AMINE)
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2015-03-22
Release date:2015-06-24
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase.
Biochemistry, 54, 2015
4UGD
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 6-((((2S)-1-AMINO-4-((6-AMINO-4-METHYLPYRIDIN-2-YL)METHOXY)BUTAN-2-YL) OXY)METHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2015-03-22
Release date:2015-06-24
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase.
Biochemistry, 54, 2015
4UGE
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 4-METHYL-6-((3-(PIPERIDIN-4-YLMETHOXY)PHENOXY)METHYL)PYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2015-03-22
Release date:2015-06-24
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase.
Biochemistry, 54, 2015
4UGF
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STRUCTURE OF BACILLUS SUBTILIS NITRIC OXIDE SYNTHASE IN COMPLEX WITH 6-((((3S, 5R)-5-(((6-AMINO-4-METHYLPYRIDIN-2-YL)METHOXY)METHYL) PYRROLIDIN-3-YL)OXY)METHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Holden, J.K., Poulos, T.L.
Deposit date:2015-03-22
Release date:2015-06-24
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase.
Biochemistry, 54, 2015
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