Author results

1GHE
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CRYSTAL STRUCTURE OF TABTOXIN RESISTANCE PROTEIN COMPLEXED WITH AN ACYL COENZYME A
Descriptor:ACETYLTRANSFERASE, ACETYL COENZYME *A
Authors:He, H., Ding, Y., Bartlam, M., Sun, F., Le, Y., Qin, X., Tang, H., Zhang, R., Joachimiak, A., Liu, Y., Zhao, N., Rao, Z.
Deposit date:2000-12-13
Release date:2003-01-14
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal Structure of Tabtoxin Resistance Protein Complexed with Acetyl Coenzyme A Reveals the Mechanism for beta-Lactam Acetylation
J.Mol.Biol., 325, 2003
1J4J
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CRYSTAL STRUCTURE OF TABTOXIN RESISTANCE PROTEIN (FORM II) COMPLEXED WITH AN ACYL COENZYME A
Descriptor:TABTOXIN RESISTANCE PROTEIN, ACETYL COENZYME *A
Authors:He, H., Ding, Y., Bartlam, M., Zhang, R., Duke, N., Joachimiak, A., Shao, Y., Cao, Z., Tang, H., Liu, Y., Jiang, F., Liu, J., Zhao, N., Rao, Z.
Deposit date:2001-10-02
Release date:2003-06-03
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of tabtoxin resistance protein complexed with acetyl coenzyme A reveals the mechanism for beta-lactam acetylation.
J.Mol.Biol., 325, 2003
3IG3
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CRYSTAL STRUCTURE OF MOUSE PLEXIN A3 INTRACELLULAR DOMAIN
Descriptor:Plxna3 protein, GLYCEROL
Authors:He, H., Zhang, X.
Deposit date:2009-07-27
Release date:2009-08-25
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration.
Proc.Natl.Acad.Sci.USA, 106, 2009
4OTM
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN FROM YEAST GCN2
Descriptor:Serine/threonine-protein kinase GCN2
Authors:He, H., Georgiadis, M.M.
Deposit date:2014-02-13
Release date:2014-04-16
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structures of GCN2 Protein Kinase C-terminal Domains Suggest Regulatory Differences in Yeast and Mammals.
J.Biol.Chem., 289, 2014
4OTN
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CRYSTAL STRUCTURE OF THE C-TERMINAL REGULATORY DOMAIN OF MURINE GCN2
Descriptor:Eukaryotic translation initiation factor 2-alpha kinase 4, SULFATE ION, 1,2-ETHANEDIOL
Authors:He, H., Georgiadis, M.M.
Deposit date:2014-02-13
Release date:2014-04-16
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structures of GCN2 Protein Kinase C-terminal Domains Suggest Regulatory Differences in Yeast and Mammals.
J.Biol.Chem., 289, 2014
4QHD
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CRYSTAL STRUCTURE OF APO HUMAN APE1
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, 1,2-ETHANEDIOL
Authors:He, H., Chen, Q., Georgiadis, M.M.
Deposit date:2014-05-28
Release date:2014-11-12
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.
Biochemistry, 53, 2014
4QHE
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CRYSTAL STRUCTURE OF MG2+ BOUND HUMAN APE1
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, MAGNESIUM ION, 1,2-ETHANEDIOL
Authors:He, H., Chen, Q., Georgiadis, M.M.
Deposit date:2014-05-28
Release date:2014-11-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.
Biochemistry, 53, 2014
4QH9
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CRYSTAL STRUCTURE OF MN2+ BOUND HUMAN APE1
Descriptor:DNA-(apurinic or apyrimidinic site) lyase, 1,2-ETHANEDIOL, MANGANESE (II) ION
Authors:Chen, Q., He, H., Georgiadis, M.M.
Deposit date:2014-05-27
Release date:2014-11-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.175 Å)
Cite:High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.
Biochemistry, 53, 2014
3NWN
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CRYSTAL STRUCTURE OF THE HUMAN KIF9 MOTOR DOMAIN IN COMPLEX WITH ADP
Descriptor:Kinesin-like protein KIF9, MAGNESIUM ION, CHLORIDE ION, ...
Authors:Zhu, H., Tempel, W., He, H., Shen, Y., Wang, J., Brothers, G., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2010-07-09
Release date:2010-07-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the human KIF9 motor domain in complex with ADP
To be Published
4HC4
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HUMAN HMT1 HNRNP METHYLTRANSFERASE-LIKE PROTEIN 6 (S. CEREVISIAE)
Descriptor:Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, 1,2-ETHANEDIOL, ...
Authors:Dong, A., Zeng, H., He, H., El Bakkouri, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2012-09-28
Release date:2012-10-17
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structural basis of arginine asymmetrical dimethylation by PRMT6.
Biochem. J., 473, 2016
4MI0
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HUMAN ENHANCER OF ZESTE (DROSOPHILA) HOMOLOG 2(EZH2)
Descriptor:Histone-lysine N-methyltransferase EZH2, ZINC ION, UNKNOWN ATOM OR ION
Authors:Dong, A., Zeng, H., He, H., Wernimont, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2013-08-30
Release date:2013-09-25
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations.
Plos One, 8, 2013
4QPP
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THE CRYSTAL STRUCTURE OF HUMAN HMT1 HNRNP METHYLTRANSFERASE-LIKE PROTEIN 6 IN COMPLEX WITH COMPOUND DS-421 (2-{4-[3-CHLORO-2-(2-METHOXYPHENYL)-1H-INDOL-5-YL]PIPERIDIN-1-YL}-N-METHYLETHANAMINE
Descriptor:Protein arginine N-methyltransferase 6, POLY-UNK, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Dong, A., Zeng, H., Smil, D., Walker, J.R., He, H., Eram, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Vedadi, M., Brown, P.J., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2014-06-24
Release date:2014-08-20
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:The Crystal Structure of Human HMT1 hnRNP methyltransferase-like protein 6 in complex with compound DS-421
To be Published
4QQK
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HUMAN HMT1 HNRNP METHYLTRANSFERASE-LIKE PROTEIN 6 (S. CEREVISIAE) WITH GMS
Descriptor:Protein arginine N-methyltransferase 6, (5S)-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}-N~6~-carbamimidoyl-L-lysine, GLYCEROL, ...
Authors:Dong, A., Zeng, H., He, H., Wernimont, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Min, J., Luo, M., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2014-06-27
Release date:2014-07-16
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural basis of arginine asymmetrical dimethylation by PRMT6.
Biochem. J., 473, 2016
4YVD
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CRYTSAL STRUCTURE OF HUMAN PLEIOTROPIC REGULATOR 1 (PRL1)
Descriptor:Pleiotropic regulator 1, SODIUM ION, CHLORIDE ION, ...
Authors:Dong, A., Zeng, H., Xu, C., Tempel, W., Li, Y., He, H., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Min, J., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2015-03-19
Release date:2015-04-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crytsal structure of human Pleiotropic Regulator 1 (PRL1).
to be published
4IKP
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CRYSTAL STRUCTURE OF COACTIVATOR-ASSOCIATED ARGININE METHYLTRANSFERASE 1 WITH METHYLENESINEFUNGIN
Descriptor:Histone-arginine methyltransferase CARM1, (2S,5S)-2,6-diamino-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}hexanoic acid, GLYCEROL, ...
Authors:Dong, A., Dombrovski, L., He, H., Ibanez, G., Wernimont, A., Zheng, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Min, J., Luo, M., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2012-12-27
Release date:2013-02-13
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of coactivator-associated arginine methyltransferase 1 with methylenesinefungin
TO BE PUBLISHED
3HM6
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CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF HUMAN PLEXIN B1
Descriptor:Plexin-B1, Unknown peptide, UNKNOWN ATOM OR ION
Authors:Tong, Y., He, H., Shen, L., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-05-28
Release date:2009-06-09
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:Structure and function of the intracellular region of the plexin-b1 transmembrane receptor.
J.Biol.Chem., 284, 2009
4LG8
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CRYSTAL STRUCTURE OF PRPF19 WD40 REPEATS
Descriptor:Pre-mRNA-processing factor 19, SODIUM ION, UNKNOWN ATOM OR ION
Authors:Xu, C., Tempel, W., He, H., Dobrovetsky, E., Seitova, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2013-06-27
Release date:2013-08-07
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Crystal structure of the WD40 domain of human PRPF19.
Biochem. Biophys. Res. Commun., 493, 2017
4OA7
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CRYSTAL STRUCTURE OF TANKYRASE1 IN COMPLEX WITH IWR1
Descriptor:Tankyrase-1, ZINC ION, 4-[(3aR,4R,7S,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl]-N-(quinolin-8-yl)benzamide
Authors:Zhang, X., He, H.
Deposit date:2014-01-03
Release date:2015-01-07
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Disruption of Wnt/ beta-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells.
Mol.Cell.Biol., 35, 2015
5GXH
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THE STRUCTURE OF THE GEMIN5 WD40 DOMAIN WITH AAUUUUUG
Descriptor:Gem-associated protein 5, RNA (5'-R(*A*AP*UP*UP*UP*UP*UP*G)-3'), UNKNOWN ATOM OR ION, ...
Authors:Xu, C., He, H., Li, Y., Dong, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2016-09-17
Release date:2016-10-26
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly
Genes Dev., 30, 2016
5GXI
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STRUCUTRE OF THE GEMIN5 WD40 DOMAIN IN COMPLEX WITH AAUUUUUGAG
Descriptor:Gem-associated protein 5, RNA (5'-R(*A*AP*UP*UP*UP*UP*UP*GP*AP*G)-3'), UNKNOWN ATOM OR ION
Authors:Xu, C., He, H., Li, Y., Dong, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2016-09-18
Release date:2016-10-26
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly
Genes Dev., 30, 2016
5TEE
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CRYSTAL STRUCTURE OF GEMIN5 WD40 REPEATS IN APO FORM
Descriptor:Gem-associated protein 5, GLYCEROL, UNKNOWN ATOM OR ION, ...
Authors:Chao, X., Tempel, W., Bian, C., Cerovina, T., He, H., Walker, J.R., Seitova, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2016-09-21
Release date:2016-10-19
Last modified:2017-05-10
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly.
Genes Dev., 30, 2016
5TEF
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CRYSTAL STRUCTURE OF GEMIN5 WD40 REPEATS IN COMPLEX WITH M7GPPPG
Descriptor:Gem-associated protein 5, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, GLYCEROL, ...
Authors:Chao, X., Tempel, W., Bian, C., He, H., Cerovina, T., Seitova, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2016-09-21
Release date:2016-10-19
Last modified:2017-05-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly.
Genes Dev., 30, 2016
5THA
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GEMIN5 WD40 REPEATS IN COMPLEX WITH A GUANOSYL MOIETY
Descriptor:Gem-associated protein 5, UNKNOWN ATOM OR ION, DIGUANOSINE-5'-TRIPHOSPHATE
Authors:Chao, X., Tempel, W., Bian, C., Cerovina, T., He, H., Seitova, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2016-09-29
Release date:2016-10-19
Last modified:2017-05-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly.
Genes Dev., 30, 2016
1X70
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HUMAN DIPEPTIDYL PEPTIDASE IV IN COMPLEX WITH A BETA AMINO ACID INHIBITOR
Descriptor:Dipeptidyl peptidase IV, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Kim, D., Wang, L., Beconi, M., Eiermann, G.J., Fisher, M.H., He, H., Hickey, G.J., Leiting, B., Lyons, K.
Deposit date:2004-08-12
Release date:2005-01-18
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:(2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
J.Med.Chem., 48, 2005
3DLJ
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CRYSTAL STRUCTURE OF HUMAN CARNOSINE DIPEPTIDASE 1
Descriptor:Beta-Ala-His dipeptidase, ZINC ION, UNKNOWN ATOM OR ION, ...
Authors:Dong, A., Dobrovetsky, E., Seitova, A., He, H., Tempel, W., Kozieradzki, I., Arrowsmith, C.H., Weigelt, J., Bountra, C., Edwards, A.M., Bochkarev, A., Cossar, D., Structural Genomics Consortium (SGC)
Deposit date:2008-06-27
Release date:2008-08-19
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystal structure of human carnosine dipeptidase 1.
To be Published