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3UMR
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CRYSTAL STRUCTURE OF THE G202D MUTANT OF HUMAN G-ALPHA-I1
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ...
Authors:Johnston, C.A., Afshar, K., Snyder, J.T., Tall, G.G., Gonczy, P., Siderovski, D.P., Willard, F.S.
Deposit date:2011-11-14
Release date:2012-10-24
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural Determinants Underlying the Temperature-sensitive Nature of a G-alpha Mutant in Asymmetric Cell Division of Caenorhabditis elegans
To be Published
4TPZ
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N-TERMINAL DOMAIN OF C. REINHARDTII SAS-6 HOMOLOG BLD12P F145W (NN2)
Descriptor:Centriole protein
Authors:Hilbert, M., Kraatz, S.H.W.
Deposit date:2014-06-10
Release date:2015-06-24
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.
Nat.Cell Biol., 18, 2016
4TO7
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N-TERMINAL DOMAIN OF C. REINHARDTII SAS-6 HOMOLOG BLD12P Q93E F145W K146R (NN24)
Descriptor:Centriole protein
Authors:Hilbert, M., Kraatz, S.H.W.
Deposit date:2014-06-05
Release date:2015-06-17
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (1.252 Å)
Cite:SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.
Nat.Cell Biol., 18, 2016
4TQ7
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N-TERMINAL DOMAIN OF C. REINHARDTII SAS-6 HOMOLOG BLD12P Q93E (NN10)
Descriptor:Centriole protein
Authors:Hilbert, M., Kraatz, S.H.W.
Deposit date:2014-06-10
Release date:2015-06-24
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (2.643 Å)
Cite:SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.
Nat.Cell Biol., 18, 2016
4TTW
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N-TERMINAL DOMAIN OF C. REINHARDTII SAS-6 HOMOLOG BLD12P K105C F145C (NN18)
Descriptor:Centriole protein
Authors:Hilbert, M., Kraatz, S.H.W.
Deposit date:2014-06-23
Release date:2015-07-01
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.
Nat.Cell Biol., 18, 2016
4TTX
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N-TERMINAL DOMAIN OF C. REINHARDTII SAS-6 HOMOLOG BLD12P VARIANT G94C K146C (NN19)
Descriptor:Centriole protein
Authors:Hilbert, M., Kraatz, S.H.W.
Deposit date:2014-06-23
Release date:2015-07-01
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (2.498 Å)
Cite:SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.
Nat.Cell Biol., 18, 2016
4TTZ
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N-TERMINAL DOMAIN OF C. REINHARDTII SAS-6 HOMOLOG BLD12P VARIANT G94E F145W Q147K (NN26)
Descriptor:Centriole protein
Authors:Hilbert, M., Kraatz, S.H.W.
Deposit date:2014-06-23
Release date:2015-07-01
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.
Nat.Cell Biol., 18, 2016
4U2J
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N-TERMINAL DOMAIN OF C. REINHARDTII SAS-6 HOMOLOG BLD12P VARIANT Q93E F145W (NN27)
Descriptor:Centriole protein
Authors:Hilbert, M., Kraatz, S.H.W.
Deposit date:2014-07-17
Release date:2015-07-29
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.
Nat.Cell Biol., 18, 2016
3Q0X
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N-TERMINAL COILED-COIL DIMER DOMAIN OF C. REINHARDTII SAS-6 HOMOLOG BLD12P
Descriptor:Centriole protein
Authors:Kitagawa, D., Vakonakis, I., Olieric, N., Hilbert, M., Keller, D., Olieric, V., Bortfeld, M., Erat, M.C., Flueckiger, I., Goenczy, P., Steinmetz, M.O.
Deposit date:2010-12-16
Release date:2011-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Structural basis of the 9-fold symmetry of centrioles.
Cell(Cambridge,Mass.), 144, 2011
3Q0Y
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N-TERMINAL DOMAIN OF C. REINHARDTII SAS-6 HOMOLOG BLD12P
Descriptor:Centriole protein
Authors:Kitagawa, D., Vakonakis, I., Olieric, N., Hilbert, M., Keller, D., Olieric, V., Bortfeld, M., Erat, M.C., Flueckiger, I., Goenczy, P., Steinmetz, M.O.
Deposit date:2010-12-16
Release date:2011-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of the 9-fold symmetry of centrioles.
Cell(Cambridge,Mass.), 144, 2011
4G79
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STRUCTURE A C. ELEGANS SAS-6 VARIANT
Descriptor:Spindle assembly abnormal protein 6, GLYCEROL, TETRAETHYLENE GLYCOL
Authors:Erat, M.C., Vakonakis, I.
Deposit date:2012-07-20
Release date:2013-06-19
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry.
Proc.Natl.Acad.Sci.USA, 110, 2013
4GEU
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STRUCTURE OF A STABILISED CESAS-6 DIMER
Descriptor:Spindle assembly abnormal protein 6, GLYCEROL, TETRAETHYLENE GLYCOL
Authors:Erat, M.C., Vakonakis, I.
Deposit date:2012-08-02
Release date:2013-06-19
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry.
Proc.Natl.Acad.Sci.USA, 110, 2013
4GEX
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STRUCTURE OF A STABILISED CESAS-6 DIMER, SECOND CRYSTAL FORM
Descriptor:Spindle assembly abnormal protein 6, SULFATE ION
Authors:Erat, M.C., Vakonakis, I.
Deposit date:2012-08-02
Release date:2013-06-19
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry.
Proc.Natl.Acad.Sci.USA, 110, 2013
4GFA
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N-TERMINAL COILED-COIL DIMER OF C.ELEGANS SAS-6, CRYSTAL FORM A
Descriptor:Spindle assembly abnormal protein 6, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Erat, M.C., Vakonakis, I.
Deposit date:2012-08-03
Release date:2013-06-19
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (3.55 Å)
Cite:Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry.
Proc.Natl.Acad.Sci.USA, 110, 2013
4GFC
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N-TERMINAL COILED-COIL DIMER OF C.ELEGANS SAS-6, CRYSTAL FORM B
Descriptor:Spindle assembly abnormal protein 6, 1,2-ETHANEDIOL, IMIDAZOLE, ...
Authors:Erat, M.C., Vakonakis, I.
Deposit date:2012-08-03
Release date:2013-06-19
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry.
Proc.Natl.Acad.Sci.USA, 110, 2013
4TTY
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N-TERMINAL DOMAIN OF C. REINHARDTII SAS-6 HOMOLOG BLD12P G94D F145W Q147R (NN25)
Descriptor:Centriole protein
Authors:Hilbert, M., Kraatz, S.H.W.
Deposit date:2014-06-23
Release date:2015-07-01
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.
Nat.Cell Biol., 18, 2016
4U2I
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N-TERMINAL DOMAIN OF C. RHEINHARDTII SAS-6 HOMOLOG BLD12P Q93E G94D K146R Q147R (NN23)
Descriptor:Centriole protein
Authors:Hilbert, M., Kraatz, S.H.W.
Deposit date:2014-07-17
Release date:2015-07-29
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (2.281 Å)
Cite:SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.
Nat.Cell Biol., 18, 2016
5FCM
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CRBLD10-N 1-70
Descriptor:Basal body protein, ISOPROPYL ALCOHOL, SULFATE ION
Authors:Kraatz, S.H.W., Steinmetz, M.O.
Deposit date:2015-12-15
Release date:2016-07-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.229 Å)
Cite:The Human Centriolar Protein CEP135 Contains a Two-Stranded Coiled-Coil Domain Critical for Microtubule Binding.
Structure, 24, 2016
5FCN
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MICROTUBULE BINDING DOMAIN OF HUMAN CEP135
Descriptor:Centrosomal protein of 135 kDa
Authors:Kraatz, S.H.W.
Deposit date:2015-12-15
Release date:2016-07-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Human Centriolar Protein CEP135 Contains a Two-Stranded Coiled-Coil Domain Critical for Microtubule Binding.
Structure, 24, 2016
3PYI
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STRUCTURE OF THE N-TERMINAL DOMAIN OF C. ELEGANS SAS-6
Descriptor:Spindle assembly abnormal protein 6, TETRAETHYLENE GLYCOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Vakonakis, I., Steinmetz, M.O.
Deposit date:2010-12-13
Release date:2011-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.104 Å)
Cite:Structural basis of the 9-fold symmetry of centrioles.
Cell(Cambridge,Mass.), 144, 2011
4YNH
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STRUCTURE OF THE C. ELEGANS SAS-5 IMPLICO DIMERIZATION DOMAIN
Descriptor:Spindle assembly abnormal protein 5
Authors:Rogala, K.B., Vakonakis, I., Hatzopoulos, G.N.
Deposit date:2015-03-10
Release date:2015-06-10
Last modified:2015-08-26
Method:X-RAY DIFFRACTION (1 Å)
Cite:The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation.
Elife, 4, 2015
4YV4
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STRUCTURE OF THE C. ELEGANS SAS-5 COILED COIL DOMAIN
Descriptor:Spindle assembly abnormal protein 5, PHOSPHATE ION, SULFATE ION
Authors:Rogala, K.B., Hatzopoulos, G.N., Vakonakis, I.
Deposit date:2015-03-19
Release date:2015-06-10
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation.
Elife, 4, 2015
4ZS0
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HUMAN AURORA A CATALYTIC DOMAIN BOUND TO SB-6-OH
Descriptor:Aurora kinase A, 5-hydroxy-1'H-1,2'-bibenzimidazol-2(3H)-one
Authors:Marcaida, M.J., Kilchmann, F., Schick, T., Reymond, J.L.
Deposit date:2015-05-12
Release date:2016-07-20
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening.
J.Med.Chem., 59, 2016
4ZTQ
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HUMAN AURORA A CATALYTIC DOMAIN BOUND TO FK932
Descriptor:Aurora kinase A, (2Z,5Z)-2-[(4-ethylphenyl)imino]-3-(2-methoxyethyl)-5-(pyridin-4-ylmethylidene)-1,3-thiazolidin-4-one, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Marcaida, M.J., Kilchmann, F., Schick, T., Reymond, J.L.
Deposit date:2015-05-14
Release date:2016-07-20
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening.
J.Med.Chem., 59, 2016
4ZTR
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HUMAN AURORA A CATALYTIC DOMAIN BOUND TO FK1141
Descriptor:Aurora kinase A, 6-({4-[(Z)-{(2Z)-2-[(4-ethylphenyl)imino]-3-methyl-4-oxo-1,3-thiazolidin-5-ylidene}methyl]pyridin-2-yl}amino)pyridine-3-carboxylic acid
Authors:Marcaida, M.J., Kilchmann, F., Schick, T., Reymond, J.L.
Deposit date:2015-05-15
Release date:2016-07-20
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening.
J.Med.Chem., 59, 2016
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