2DQ5
 
 | | solution structure of the Mid1 B Box2 Chc(D/C)C2H2 Zinc-Binding Domain: insights into an evolutionary conserved ring fold | | Descriptor: | Midline-1, ZINC ION | | Authors: | Massiah, M.A, Matts, J.A.B, Short, K.M, Simmons, B.N, Singireddy, S, Zou, J, Cox, T.C. | | Deposit date: | 2006-05-20 | | Release date: | 2007-04-03 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution Structure of the MID1 B-box2 CHC(D/C)C(2)H(2) Zinc-binding Domain: Insights into an Evolutionarily Conserved RING Fold
J.Mol.Biol., 369, 2007
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2FFW
 | | Solution structure of the RBCC/TRIM B-box1 domain of human MID1: B-box with a RING | | Descriptor: | Midline-1, ZINC ION | | Authors: | Massiah, M.A, Simmons, B.N, Short, K.M, Cox, T.C. | | Deposit date: | 2005-12-20 | | Release date: | 2006-05-09 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution Structure of the RBCC/TRIM B-box1 Domain of Human MID1: B-box with a RING.
J.Mol.Biol., 358, 2006
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2JUN
 | | Structure of the MID1 tandem B-boxes reveals an interaction reminiscent of intermolecular RING heterodimers | | Descriptor: | Midline-1, ZINC ION | | Authors: | Tao, H, Singireddy, S, Jakkidi, M, Simmons, B.N, Short, K.M, Cox, T.C, Massiah, M.A. | | Deposit date: | 2007-08-31 | | Release date: | 2008-03-04 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Structure of the MID1 Tandem B-Boxes Reveals an Interaction Reminiscent of Intermolecular Ring Heterodimers
Biochemistry, 47, 2008
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3DBS
 | | Structure of PI3K gamma in complex with GDC0941 | | Descriptor: | 2-(1H-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | | Authors: | Wiesmann, C, Ultsch, M. | | Deposit date: | 2008-06-02 | | Release date: | 2008-06-17 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer
J.Med.Chem., 51, 2008
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