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3W9Z
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CRYSTAL STRUCTURE OF DUSC
Descriptor:tRNA-dihydrouridine synthase C, FLAVIN MONONUCLEOTIDE
Authors:Chen, M., Yu, J., Tanaka, Y., Tanaka, I., Yao, M.
Deposit date:2013-04-19
Release date:2013-07-31
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of dihydrouridine synthase C (DusC) from Escherichia coli
Acta Crystallogr.,Sect.F, 69, 2013
4KUX
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CRYSTAL STRUCTURE OF ASPERGILLUS TERREUS ARISTOLOCHENE SYNTHASE COMPLEXED WITH FARNESYL THIOLODIPHOSPHATE (FSPP)
Descriptor:Aristolochene synthase, MAGNESIUM ION, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, ...
Authors:Chen, M., Faraldos, J.A., Al-lami, N., Janvier, M., D'Antonio, E.L., Cane, D.E., Allemann, R.K., Christianson, D.W.
Deposit date:2013-05-22
Release date:2013-08-14
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase.
Biochemistry, 52, 2013
4KVD
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CRYSTAL STRUCTURE OF ASPERGILLUS TERREUS ARISTOLOCHENE SYNTHASE COMPLEXED WITH (4AS,7S)-1,4A-DIMETHYL-7-(PROP-1-EN-2-YL)DECAHYDROQUINOLIN-1-IUM
Descriptor:Aristolochene synthase, PYROPHOSPHATE 2-, MAGNESIUM ION, ...
Authors:Chen, M., Faraldos, J.A., Al-lami, N., Janvier, M., D'Antonio, E.L., Cane, D.E., Allemann, R.K., Christianson, D.W.
Deposit date:2013-05-22
Release date:2013-08-14
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase.
Biochemistry, 52, 2013
4KVI
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CRYSTAL STRUCTURE OF ASPERGILLUS TERREUS ARISTOLOCHENE SYNTHASE COMPLEXED WITH (4AS,7S)-4A-METHYL-7-(PROP-1-EN-2-YL)-2,3,4,4A,5,6,7,8-OCTAHYDROQUINOLIN-1-IUM
Descriptor:Aristolochene synthase, MAGNESIUM ION, PYROPHOSPHATE 2-, ...
Authors:Chen, M., Faraldos, J.A., Al-lami, N., Janvier, M., D'Antonio, E.L., Cane, D.E., Allemann, R.K., Christianson, D.W.
Deposit date:2013-05-22
Release date:2013-08-14
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase.
Biochemistry, 52, 2013
4KVW
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CRYSTAL STRUCTURE OF ASPERGILLUS TERREUS ARISTOLOCHENE SYNTHASE COMPLEXED WITH (3R,6R,9AR)-6,9A-DIMETHYL-3-(PROP-1-EN-2-YL)DECAHYDROQUINOLIZIN-5-IUM
Descriptor:Aristolochene synthase, PYROPHOSPHATE 2-, MAGNESIUM ION, ...
Authors:Chen, M., Al-lami, N., Janvier, M., D'Antonio, E.L., Faraldos, J.A., Cane, D.E., Allemann, R.K., Christianson, D.W.
Deposit date:2013-05-23
Release date:2013-08-14
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase.
Biochemistry, 52, 2013
4KVY
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CRYSTAL STRUCTURE OF ASPERGILLUS TERREUS ARISTOLOCHENE SYNTHASE COMPLEXED WITH (1S,8S,9AR)-1,9A-DIMETHYL-8-(PROP-1-EN-2-YL)DECAHYDROQUINOLIZIN-5-IUM
Descriptor:Aristolochene synthase, PYROPHOSPHATE 2-, MAGNESIUM ION, ...
Authors:Chen, M., Al-lami, N., Janvier, M., D'Antonio, E.L., Faraldos, J.A., Cane, D.E., Allemann, R.K., Christianson, D.W.
Deposit date:2013-05-23
Release date:2013-08-14
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase.
Biochemistry, 52, 2013
4KWD
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CRYSTAL STRUCTURE OF ASPERGILLUS TERREUS ARISTOLOCHENE SYNTHASE COMPLEXED WITH (1R,8R,9AS)-1,9A-DIMETHYL-8-(PROP-1-EN-2-YL)DECAHYDROQUINOLIZIN-5-IUM
Descriptor:Aristolochene synthase, PYROPHOSPHATE 2-, MAGNESIUM ION, ...
Authors:Chen, M., Al-lami, N., Janvier, M., D'Antonio, E.L., Faraldos, J.A., Cane, D.E., Allemann, R.K., Christianson, D.W.
Deposit date:2013-05-23
Release date:2013-08-14
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (1.857 Å)
Cite:Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase.
Biochemistry, 52, 2013
5B4E
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SULFUR TRANSFERASE TTUA IN COMPLEX WITH IRON SULFUR CLUSTER AND ATP DERIVATIVE
Descriptor:Sulfur Transferase TtuA, ZINC ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Chen, M., Narai, S., Tanaka, Y., Yao, M.
Deposit date:2016-04-03
Release date:2017-05-03
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2.698 Å)
Cite:Biochemical and structural characterization of oxygen-sensitive 2-thiouridine synthesis catalyzed by an iron-sulfur protein TtuA
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5B4F
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SULFUR TRANSFERASE TTUA IN COMPLEX WITH IRON SULFUR CLUSTER
Descriptor:Sulfur Transferase TtuA, SULFATE ION, ZINC ION, ...
Authors:Chen, M., Narai, S., Tanaka, Y., Yao, M.
Deposit date:2016-04-03
Release date:2017-05-10
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Biochemical and structural characterization of oxygen-sensitive 2-thiouridine synthesis catalyzed by an iron-sulfur protein TtuA
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5GHA
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SULFUR TRANSFERASE TTUA IN COMPLEX WITH SULFUR CARRIER TTUB
Descriptor:Sulfur Transferase TtuA, Sulfur Carrier TtuB, ZINC ION, ...
Authors:Chen, M., Narai, S., Tanaka, Y., Yao, M.
Deposit date:2016-06-19
Release date:2017-05-03
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2.502 Å)
Cite:Biochemical and structural characterization of oxygen-sensitive 2-thiouridine synthesis catalyzed by an iron-sulfur protein TtuA
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5X6B
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CRYSTAL STRUCTURE OF SEPCYSE-SEPCYSS IN COMPLEX WITH TRNACYS FROM METHANOCALDOCOCCUS JANNASCHII
Descriptor:O-phospho-L-seryl-tRNA:Cys-tRNA synthase, Uncharacterized protein MJ1481, tRNACys
Authors:Chen, M., Kato, K., Yao, M.
Deposit date:2017-02-21
Release date:2017-12-06
Method:X-RAY DIFFRACTION (2.596 Å)
Cite:Structural basis for tRNA-dependent cysteine biosynthesis
Nat Commun, 8, 2017
5X6C
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CRYSTAL STRUCTURE OF SEPRS-SEPCYSE FROM METHANOCALDOCOCCUS JANNASCHII
Descriptor:O-phosphoserine--tRNA(Cys) ligase, Uncharacterized protein MJ1481, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Chen, M., Kato, K., Yao, M.
Deposit date:2017-02-21
Release date:2017-12-06
Method:X-RAY DIFFRACTION (3.101 Å)
Cite:Structural basis for tRNA-dependent cysteine biosynthesis
Nat Commun, 8, 2017
3UZW
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CRYSTAL STRUCTURE OF 5BETA-REDUCTASE (AKR1D1) E120H MUTANT IN COMPLEX WITH NADP+
Descriptor:3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CHLORIDE ION
Authors:Chen, M., Christianson, D.W., Penning, T.M.
Deposit date:2011-12-07
Release date:2012-03-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.892 Å)
Cite:Conversion of Human Steroid 5beta-Reductase (AKR1D1) into 3β-Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERING.
J.Biol.Chem., 287, 2012
3UZX
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CRYSTAL STRUCTURE OF 5BETA-REDUCTASE (AKR1D1) E120H MUTANT IN COMPLEX WITH NADP+ AND EPIANDROSTERONE
Descriptor:3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-ALPHA-ANDROSTANE-3-BETA,17BETA-DIOL, ...
Authors:Chen, M., Christianson, D.W., Penning, T.M.
Deposit date:2011-12-07
Release date:2012-03-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.637 Å)
Cite:Conversion of Human Steroid 5beta-Reductase (AKR1D1) into 3β-Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERING.
J.Biol.Chem., 287, 2012
3UZY
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CRYSTAL STRUCTURE OF 5BETA-REDUCTASE (AKR1D1) E120H MUTANT IN COMPLEX WITH NADP+ AND 5BETA-DIHYDROTESTOSTERONE
Descriptor:3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-beta-DIHYDROTESTOSTERONE, ...
Authors:Chen, M., Christianson, D.W., Penning, T.M.
Deposit date:2011-12-07
Release date:2012-03-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.832 Å)
Cite:Conversion of Human Steroid 5beta-Reductase (AKR1D1) into 3β-Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERING.
J.Biol.Chem., 287, 2012
3UZZ
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CRYSTAL STRUCTURE OF 5BETA-REDUCTASE (AKR1D1) E120H MUTANT IN COMPLEX WITH NADP+ AND DELTA4-ANDROSTENEDIONE
Descriptor:3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TESTOSTERONE, ...
Authors:Chen, M., Christianson, D.W., Penning, T.M.
Deposit date:2011-12-07
Release date:2012-03-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Conversion of Human Steroid 5beta-Reductase (AKR1D1) into 3β-Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERING.
J.Biol.Chem., 287, 2012
4DBS
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CRYSTAL STRUCTURE OF HUMAN 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 5 (AKR1C3) IN COMPLEX WITH NADP+ AND 3'-[(4-NITRONAPHTHALEN-1-YL)AMINO]BENZOIC ACID
Descriptor:Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-[(4-nitronaphthalen-1-yl)amino]benzoic acid
Authors:Chen, M., Christianson, D.W., Winkler, J.D., Penning, T.M.
Deposit date:2012-01-16
Release date:2012-03-28
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.852 Å)
Cite:Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer.
Bioorg.Med.Chem.Lett., 22, 2012
4DBU
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CRYSTAL STRUCTURE OF HUMAN 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 5 (AKR1C3) IN COMPLEX WITH NADP+ AND 3-((4 -(TRIFLUOROMETHYL)PHENYL)AMINO)BENZOIC ACID
Descriptor:Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-{[4-(trifluoromethyl)phenyl]amino}benzoic acid
Authors:Chen, M., Christianson, D.W., Winkler, J.D., Penning, T.M.
Deposit date:2012-01-16
Release date:2012-03-28
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.528 Å)
Cite:Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer.
Bioorg.Med.Chem.Lett., 22, 2012
5ER8
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CRYSTAL STRUCTURE OF CYCLIZATION DOMAIN OF PHOMOPSIS AMYGDALI FUSICOCCADIENE SYNTHASE COMPLEXED WITH MANGANESE IONS AND NERIDRONATE
Descriptor:Fusicoccadiene synthase, MANGANESE (II) ION, (6-azanyl-1-oxidanyl-1-phosphono-hexyl)phosphonic acid, ...
Authors:Chen, M., Christianson, D.W.
Deposit date:2015-11-13
Release date:2016-01-20
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase.
Acs Chem.Biol., 11, 2016
5ERM
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CRYSTAL STRUCTURE OF CYCLIZATION DOMAIN OF PHOMOPSIS AMYGDALI FUSICOCCADIENE SYNTHASE COMPLEXED WITH MAGNESIUM IONS AND PAMIDRONATE
Descriptor:Fusicoccadiene synthase, PAMIDRONATE, CHLORIDE ION, ...
Authors:Chen, M., Christianson, D.W.
Deposit date:2015-11-14
Release date:2016-01-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.303 Å)
Cite:Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase.
Acs Chem.Biol., 11, 2016
5ERN
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CRYSTAL STRUCTURE OF ELONGATION DOMAIN OF PHOMOPSIS AMYGDALI FUSICOCCADIENE SYNTHASE
Descriptor:Fusicoccadiene synthase
Authors:Chen, M., Christianson, D.W.
Deposit date:2015-11-14
Release date:2016-01-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.434 Å)
Cite:Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase.
Acs Chem.Biol., 11, 2016
5ERO
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CRYSTAL STRUCTURE OF ELONGATION DOMAIN OF PHOMOPSIS AMYGDALI FUSICOCCADIENE SYNTHASE COMPLEXED WITH COBALT IONS AND PAMIDRONATE
Descriptor:Fusicoccadiene synthase, COBALT (II) ION, PAMIDRONATE
Authors:Chen, M., Christianson, D.W.
Deposit date:2015-11-14
Release date:2016-01-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase.
Acs Chem.Biol., 11, 2016
5IMI
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CRYSTAL STRUCTURE OF S303A ASPERGILLUS TERREUS ARISTOLOCHENE SYNTHASE COMPLEXED WITH (1S,8S,9AR)-1,9A-DIMETHYL-8-(PROP-1-EN-2-YL)DECAHYDROQUINOLIZIN-5-IUM
Descriptor:Aristolochene synthase, PYROPHOSPHATE 2-, MAGNESIUM ION, ...
Authors:Chen, M., Christianson, D.W.
Deposit date:2016-03-06
Release date:2016-05-25
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.462 Å)
Cite:Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase.
Biochemistry, 55, 2016
5IMN
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CRYSTAL STRUCTURE OF N299A/S303A ASPERGILLUS TERREUS ARISTOLOCHENE SYNTHASE COMPLEXED WITH (1S,8S,9AR)-1,9A-DIMETHYL-8-(PROP-1-EN-2-YL)DECAHYDROQUINOLIZIN-5-IUM
Descriptor:Aristolochene synthase, PYROPHOSPHATE 2-, MAGNESIUM ION, ...
Authors:Chen, M., Christianson, D.W.
Deposit date:2016-03-06
Release date:2016-05-25
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.527 Å)
Cite:Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase.
Biochemistry, 55, 2016
5IMP
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CRYSTAL STRUCTURE OF N299A ASPERGILLUS TERREUS ARISTOLOCHENE SYNTHASE COMPLEXED WITH (1S,8S,9AR)-1,9A-DIMETHYL-8-(PROP-1-EN-2-YL)DECAHYDROQUINOLIZIN-5-IUM
Descriptor:Aristolochene synthase, PYROPHOSPHATE 2-, MAGNESIUM ION, ...
Authors:Chen, M., Christianson, D.W.
Deposit date:2016-03-06
Release date:2016-05-25
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.038 Å)
Cite:Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase.
Biochemistry, 55, 2016