Author results

4EPR
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DISCOVERY OF SMALL MOLECULES THAT BIND TO K-RAS AND INHIBIT SOS-MEDIATED ACTIVATION.
分子名称:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Sun, Q., Burke, J.P., Phan, J., Burns, M.C., Olejniczak, E.T., Waterson, A.G., Lee, T., Rossanese, O.W., Fesik, S.W.
登録日2012-04-17
公開日2012-05-23
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.
Angew.Chem.Int.Ed.Engl., 51, 2012
4EPT
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DISCOVERY OF SMALL MOLECULES THAT BIND TO K-RAS AND INHIBIT SOS-MEDIATED ACTIVATION
分子名称:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Sun, Q., Burke, J.P., Phan, J., Burns, M.C., Olejniczak, E.T., Waterson, A.G., Lee, T., Rossanese, O.W., Fesik, S.W.
登録日2012-04-17
公開日2012-05-23
最終更新日2012-07-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.
Angew.Chem.Int.Ed.Engl., 51, 2012
4EPV
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DISCOVERY OF SMALL MOLECULES THAT BIND TO K-RAS AND INHIBIT SOS-MEDIATED ACTIVATION
分子名称:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Sun, Q., Burke, J.P., Phan, J., Burns, M.C., Olejniczak, E.T., Waterson, A.G., Lee, T., Rossanese, O.W., Fesik, S.W.
登録日2012-04-17
公開日2012-05-23
最終更新日2012-07-25
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.
Angew.Chem.Int.Ed.Engl., 51, 2012
4EPW
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DISCOVERY OF SMALL MOLECULES THAT BIND TO K-RAS AND INHIBIT SOS-MEDIATED ACTIVATION
分子名称:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Sun, Q., Burke, J.P., Phan, J., Burns, M.C., Olejniczak, E.T., Waterson, A.G., Lee, T., Rossanese, O.W., Fesik, S.W.
登録日2012-04-17
公開日2012-05-23
最終更新日2012-07-25
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.
Angew.Chem.Int.Ed.Engl., 51, 2012
4EPX
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DISCOVERY OF SMALL MOLECULES THAT BIND TO K-RAS AND INHIBIT SOS-MEDIATED ACTIVATION
分子名称:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Sun, Q., Burke, J.P., Phan, J., Burns, M.C., Olejniczak, E.T., Waterson, A.G., Lee, T., Rossanese, O.W., Fesik, S.W.
登録日2012-04-17
公開日2012-05-23
最終更新日2012-07-25
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.
Angew.Chem.Int.Ed.Engl., 51, 2012
4EPY
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DISCOVERY OF SMALL MOLECULES THAT BIND TO K-RAS AND INHIBIT SOS-MEDIATED ACTIVATION
分子名称:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Sun, Q., Burke, J.P., Phan, J., Burns, M.C., Olejniczak, E.T., Waterson, A.G., Lee, T., Rossanese, O.W., Fesik, S.W.
登録日2012-04-17
公開日2012-05-23
最終更新日2012-07-25
実験手法X-RAY DIFFRACTION (1.801 Å)
主引用文献Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.
Angew.Chem.Int.Ed.Engl., 51, 2012
4ZBF
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MCL-1 COMPLEXED WITH SMALL MOLECULES
分子名称:Induced myeloid leukemia cell differentiation protein Mcl-1, (1R)-7-[3-(naphthalen-1-yloxy)propyl]-3,4-dihydro-2H-[1,4]thiazepino[2,3,4-hi]indole-6-carboxylic acid 1-oxide
著者Zhao, B.
登録日2015-04-14
公開日2015-04-29
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of tricyclic indoles that potently inhibit mcl-1 using fragment-based methods and structure-based design.
J.Med.Chem., 58, 2015
4ZBI
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MCL-1 COMPLEXED WITH SMALL MOLECULES
分子名称:Induced myeloid leukemia cell differentiation protein Mcl-1, 1-[3-(naphthalen-1-yloxy)propyl]-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid
著者Zhao, B.
登録日2015-04-14
公開日2015-04-29
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Discovery of tricyclic indoles that potently inhibit mcl-1 using fragment-based methods and structure-based design.
J.Med.Chem., 58, 2015
3L0H
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CRYSTAL STRUCTURE ANALYSIS OF W21A MUTANT OF HUMAN GSTA1-1 IN COMPLEX WITH S-HEXYLGLUTATHIONE
分子名称:Glutathione S-transferase A1, S-HEXYLGLUTATHIONE
著者Fanucchi, S., Achilonu, I.A., Adamson, R.J., Fernandes, M.A., Burke, J.P., Dirr, H.W.
登録日2009-12-10
公開日2010-01-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Stability of the domain interface contributes towards the catalytic function at the H-site of class alpha glutathione transferase A1-1.
Biochim.Biophys.Acta, 1804, 2010
4HW2
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DISCOVERY OF POTENT MCL-1 INHIBITORS USING FRAGMENT-BASED METHODS AND STRUCTURE-BASED DESIGN
分子名称:Induced myeloid leukemia cell differentiation protein Mcl-1, 6-chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1H-indole-2-carboxylic acid, TRIETHYLENE GLYCOL, ...
著者Zhao, B.
登録日2012-11-07
公開日2013-01-09
最終更新日2013-03-06
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
J.Med.Chem., 56, 2013
4HW3
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DISCOVERY OF POTENT MCL-1 INHIBITORS USING FRAGMENT-BASED METHODS AND STRUCTURE-BASED DESIGN
分子名称:Induced myeloid leukemia cell differentiation protein Mcl-1, 3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-benzothiophene-2-carboxylic acid
著者Zhao, B.
登録日2012-11-07
公開日2013-01-09
最終更新日2013-03-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
J.Med.Chem., 56, 2013
4HW4
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DISCOVERY OF POTENT MCL-1 INHIBITORS USING FRAGMENT-BASED METHODS AND STRUCTURE-BASED DESIGN
分子名称:Induced myeloid leukemia cell differentiation protein Mcl-1, Mcl-1 BH3 peptide
著者Friberg, A., Zhao, B.
登録日2012-11-07
公開日2013-01-09
最終更新日2013-03-06
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
J.Med.Chem., 56, 2013