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1L36
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TOWARD A SIMPLIFICATION OF THE PROTEIN FOLDING PROBLEM: A STABILIZING POLYALANINE ALPHA-HELIX ENGINEERED IN T4 LYSOZYME
Descriptor:LYSOZYME, CHLORIDE ION, BETA-MERCAPTOETHANOL
Authors:Zhang, X.-J., Baase, W.A., Matthews, B.W.
Deposit date:1990-12-26
Release date:1991-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Toward a simplification of the protein folding problem: a stabilizing polyalanine alpha-helix engineered in T4 lysozyme.
Biochemistry, 30, 1991
1CVK
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T4 LYSOZYME MUTANT L118A
Descriptor:LYSOZYME, CHLORIDE ION, 2-HYDROXYETHYL DISULFIDE
Authors:Gassner, N.C., Baase, W.A., Lindstrom, J., Lu, J., Matthews, B.W.
Deposit date:1999-08-23
Release date:1999-11-10
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.
Biochemistry, 38, 1999
261L
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STRUCTURAL CHARACTERISATION OF AN ENGINEERED TANDEM REPEAT CONTRASTS THE IMPORTANCE OF CONTEXT AND SEQUENCE IN PROTEIN FOLDING
Descriptor:LYSOZYME
Authors:Sagermann, M., Baase, W.A., Matthews, B.W.
Deposit date:1999-05-11
Release date:1999-05-24
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural characterization of an engineered tandem repeat contrasts the importance of context and sequence in protein folding.
Proc.Natl.Acad.Sci.USA, 96, 1999
262L
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STRUCTURAL CHARACTERISATION OF AN ENGINEERED TANDEM REPEAT CONTRASTS THE IMPORTANCE OF CONTEXT AND SEQUENCE IN PROTEIN FOLDING
Descriptor:LYSOZYME
Authors:Sagermann, M., Baase, W.A., Matthews, B.W.
Deposit date:1999-05-11
Release date:1999-05-24
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural characterization of an engineered tandem repeat contrasts the importance of context and sequence in protein folding.
Proc.Natl.Acad.Sci.USA, 96, 1999
2F2Q
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HIGH RESOLUTION CRYSTAL STRCUTURE OF T4 LYSOZYME MUTANT L20R63/A LIGANDED TO GUANIDINIUM ION
Descriptor:Lysozyme, CHLORIDE ION, GUANIDINE, ...
Authors:Yousef, M.S., Bischoff, N., Dyer, C.M., Baase, W.A., Matthews, B.W.
Deposit date:2005-11-17
Release date:2006-04-25
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Guanidinium derivatives bind preferentially and trigger long-distance conformational changes in an engineered T4 lysozyme.
Protein Sci., 15, 2006
2F32
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XRAY CRYSTAL STRUCTURE OF LYSOZYME MUTANT L20/R63A LIGANDED TO ETHYLGUANIDINIUM
Descriptor:Lysozyme, BETA-MERCAPTOETHANOL, N-ETHYLGUANIDINE
Authors:Yousef, M.S., Bischoff, N., Dyer, C.M., Baase, W.A., Matthews, B.W.
Deposit date:2005-11-18
Release date:2006-04-25
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Guanidinium derivatives bind preferentially and trigger long-distance conformational changes in an engineered T4 lysozyme.
Protein Sci., 15, 2006
2F47
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XRAY CRYSTAL STRUCTURE OF T4 LYSOZYME MUTANT L20/R63A LIGANDED TO METHYLGUANIDINIUM
Descriptor:Lysozyme, CHLORIDE ION, 1-METHYLGUANIDINE, ...
Authors:Yousef, M.S., Bischoff, N., Dyer, C.M., Baase, W.A., Matthews, B.W.
Deposit date:2005-11-22
Release date:2006-04-25
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Guanidinium derivatives bind preferentially and trigger long-distance conformational changes in an engineered T4 lysozyme.
Protein Sci., 15, 2006
1CTW
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T4 LYSOZYME MUTANT I78A
Descriptor:LYSOZYME, CHLORIDE ION, 2-HYDROXYETHYL DISULFIDE
Authors:Gassner, N.C., Baase, W.A., Lindstrom, J.D., Lu, J., Matthews, B.W.
Deposit date:1999-08-20
Release date:1999-11-10
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.
Biochemistry, 38, 1999
1CU0
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T4 LYSOZYME MUTANT I78M
Descriptor:LYSOZYME, CHLORIDE ION, 2-HYDROXYETHYL DISULFIDE
Authors:Gassner, N.C., Baase, W.A., Lindstrom, J.D., Lu, J., Matthews, B.W.
Deposit date:1999-08-20
Release date:1999-11-10
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.
Biochemistry, 38, 1999
1CU2
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T4 LYSOZYME MUTANT L84M
Descriptor:LYSOZYME, CHLORIDE ION, 2-HYDROXYETHYL DISULFIDE
Authors:Gassner, N.C., Baase, W.A., Lindstrom, J.D., Lu, J., Matthews, B.W.
Deposit date:1999-08-20
Release date:1999-11-10
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.
Biochemistry, 38, 1999
1CU3
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T4 LYSOZYME MUTANT V87M
Descriptor:LYSOZYME, CHLORIDE ION, 2-HYDROXYETHYL DISULFIDE
Authors:Gassner, N.C., Baase, W.A., Lindstrom, J.D., Lu, J., Matthews, B.W.
Deposit date:1999-08-20
Release date:1999-11-10
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.
Biochemistry, 38, 1999
1CU5
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T4 LYSOZYME MUTANT L91M
Descriptor:LYSOZYME, CHLORIDE ION, 2-HYDROXYETHYL DISULFIDE
Authors:Gassner, N.C., Baase, W.A., Lindstrom, J.D., Lu, J., Matthews, B.W.
Deposit date:1999-08-20
Release date:1999-11-10
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.
Biochemistry, 38, 1999
1CU6
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T4 LYSOZYME MUTANT L91A
Descriptor:LYSOZYME, CHLORIDE ION, 2-HYDROXYETHYL DISULFIDE
Authors:Gassner, N.C., Baase, W.A., Lindstrom, J.D., Lu, J., Matthews, B.W.
Deposit date:1999-08-20
Release date:1999-11-17
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.
Biochemistry, 38, 1999
1CUP
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METHIONINE CORE MUTANT OF T4 LYSOZYME
Descriptor:LYSOZYME, CHLORIDE ION, 2-HYDROXYETHYL DISULFIDE
Authors:Gassner, N.C., Baase, W.A., Lindstrom, J.D., Lu, J., Matthews, B.W.
Deposit date:1999-08-20
Release date:1999-11-10
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.
Biochemistry, 38, 1999
1CUQ
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T4 LYSOZYME MUTANT V103M
Descriptor:LYSOZYME, CHLORIDE ION, 2-HYDROXYETHYL DISULFIDE
Authors:Gassner, N.C., Baase, W.A., Lindstrom, J.D., Lu, J., Matthews, B.W.
Deposit date:1999-08-20
Release date:1999-11-10
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.
Biochemistry, 38, 1999
1CV0
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T4 LYSOZYME MUTANT F104M
Descriptor:LYSOZYME, CHLORIDE ION, 2-HYDROXYETHYL DISULFIDE
Authors:Gassner, N.C., Baase, W.A., Lindstrom, J.D., Lu, J., Matthews, B.W.
Deposit date:1999-08-20
Release date:1999-11-10
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.
Biochemistry, 38, 1999
1CV1
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T4 LYSOZYME MUTANT V111M
Descriptor:LYSOZYME, CHLORIDE ION, 2-HYDROXYETHYL DISULFIDE
Authors:Gassner, N.C., Baase, W.A., Lindstrom, J.D., Lu, J., Matthews, B.W.
Deposit date:1999-08-20
Release date:1999-11-10
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.
Biochemistry, 38, 1999
1CV3
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T4 LYSOZYME MUTANT L121M
Descriptor:LYSOZYME, CHLORIDE ION, 2-HYDROXYETHYL DISULFIDE
Authors:Gassner, N.C., Baase, W.A., Lindstrom, J., Lu, J., Matthews, B.W.
Deposit date:1999-08-22
Release date:1999-08-24
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.
Biochemistry, 38, 1999
1CV4
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T4 LYSOZYME MUTANT L118M
Descriptor:LYSOZYME, CHLORIDE ION, 2-HYDROXYETHYL DISULFIDE
Authors:Gassner, N.C., Baase, W.A., Lindstrom, J., Lu, J., Matthews, B.W.
Deposit date:1999-08-22
Release date:1999-11-10
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.
Biochemistry, 38, 1999
1CV5
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T4 LYSOZYME MUTANT L133M
Descriptor:LYSOZYME, CHLORIDE ION, 2-HYDROXYETHYL DISULFIDE
Authors:Gassner, N.C., Baase, W.A., Lindstrom, J., Lu, J., Matthews, B.W.
Deposit date:1999-08-22
Release date:1999-11-10
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.
Biochemistry, 38, 1999
1CV6
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T4 LYSOZYME MUTANT V149M
Descriptor:LYSOZYME, CHLORIDE ION, 2-HYDROXYETHYL DISULFIDE
Authors:Gassner, N.C., Baase, W.A., Lindstrom, J., Lu, J., Matthews, B.W.
Deposit date:1999-08-22
Release date:1999-11-10
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.
Biochemistry, 38, 1999
1CX6
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T4 LYSOZYME SUBSTITUTED WITH SELENOMETHIONINE
Descriptor:LYSOZYME, CHLORIDE ION, 2-HYDROXYETHYL DISULFIDE
Authors:Gassner, N.C., Baase, W.A., Matthews, B.W.
Deposit date:1999-08-28
Release date:1999-12-15
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Substitution with selenomethionine can enhance the stability of methionine-rich proteins.
J.Mol.Biol., 294, 1999
1KS3
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METHIONINE CORE MUTANT OF T4 LYSOZYME
Descriptor:LYSOZYME, CHLORIDE ION, 2-HYDROXYETHYL DISULFIDE
Authors:Gassner, N.C., Baase, W.A., Mooers, B.H., Busam, R.D., Weaver, L.H., Lindstrom, J.D., Quillin, M.L., Matthews, B.W.
Deposit date:2002-01-10
Release date:2003-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability
BIOPHYS.CHEM., 100, 2003
1KW5
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METHIONINE CORE MUTANT OF T4 LYSOZYME
Descriptor:LYSOZYME, CHLORIDE ION, 2-HYDROXYETHYL DISULFIDE
Authors:Gassner, N.C., Baase, W.A., Mooers, B.H., Busam, R.D., Weaver, L.H., Lindstrom, J.D., Quillin, M.L., Matthews, B.W.
Deposit date:2002-01-28
Release date:2003-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability
BIOPHYS.CHEM., 100, 2003
1KW7
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METHIONINE CORE MUTANT OF T4 LYSOZYME
Descriptor:LYSOZYME, CHLORIDE ION, 2-HYDROXYETHYL DISULFIDE
Authors:Gassner, N.C., Baase, W.A., Mooers, B.H., Busam, R.D., Weaver, L.H., Lindstrom, J.D., Quillin, M.L., Matthews, B.W.
Deposit date:2002-01-28
Release date:2003-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability
BIOPHYS.CHEM., 100, 2003