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4I5I
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CRYSTAL STRUCTURE OF THE SIRT1 CATALYTIC DOMAIN BOUND TO NAD AND AN EX527 ANALOG
Descriptor:NAD-dependent protein deacetylase sirtuin-1, (6S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Zhao, X., Allison, D., Condon, B., Zhang, F., Gheyi, T., Zhang, A., Ashok, S., Russell, M., Macewan, I., Qian, Y., Jamison, J.A., Luz, J.G.
Deposit date:2012-11-28
Release date:2013-01-23
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The 2.5 angstrom crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition.
J.Med.Chem., 56, 2013
4YK5
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CRYSTAL STRUCTURES OF MPGES-1 INHIBITOR COMPLEXES
Descriptor:Prostaglandin E synthase, 3-[1-(4-chlorobenzyl)-5-(2-fluoro-2'-methylbiphenyl-4-yl)-3-methyl-1H-indol-2-yl]-2,2-dimethylpropanoic acid, 2-(2-METHOXYETHOXY)ETHANOL, ...
Authors:Luz, J.G., Antonysamy, S., Kuklish, S.L., Fisher, M.J.
Deposit date:2015-03-04
Release date:2015-07-15
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics.
J.Med.Chem., 58, 2015
4YL0
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CRYSTAL STRUCTURES OF MPGES-1 INHIBITOR COMPLEXES
Descriptor:Prostaglandin E synthase, 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)benzene-1,3-dicarbonitrile, GLUTATHIONE, ...
Authors:Luz, J.G., Antonysamy, S., Kuklish, S.L., Fisher, M.J.
Deposit date:2015-03-04
Release date:2015-06-10
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics.
J.Med.Chem., 58, 2015
4YL1
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CRYSTAL STRUCTURES OF MPGES-1 INHIBITOR COMPLEXES
Descriptor:Prostaglandin E synthase, 5-(4-tert-butylphenyl)-1-[4-(propan-2-yloxy)phenyl]-1H-indole-2-carboxylic acid, DI(HYDROXYETHYL)ETHER, ...
Authors:Luz, J.G., Antonysamy, S., Kuklish, S.L., Fisher, M.J.
Deposit date:2015-03-04
Release date:2015-06-10
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics.
J.Med.Chem., 58, 2015
4YL3
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CRYSTAL STRUCTURES OF MPGES-1 INHIBITOR COMPLEXES
Descriptor:Prostaglandin E synthase, 5-[4-bromo-2-(2-chloro-6-fluorophenyl)-1H-imidazol-5-yl]-2-{[4-(trifluoromethyl)phenyl]ethynyl}pyridine, GLUTATHIONE, ...
Authors:Luz, J.G., Antonysamy, S., Kuklish, S.L., Fisher, M.J.
Deposit date:2015-03-04
Release date:2015-07-08
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics.
J.Med.Chem., 58, 2015