1EBL | | THE 1.8 A CRYSTAL STRUCTURE AND ACTIVE SITE ARCHITECTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE III (FABH) FROM ESCHERICHIA COLI | | Descriptor: | BETA-KETOACYL-ACP SYNTHASE III, COENZYME A | | Authors: | Davies, C., Heath, R.J., White, S.W., Rock, C.O. | | Deposit date: | 2000-01-24 | | Release date: | 2000-02-11 | | Last modified: | 2018-01-31 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The 1.8 A crystal structure and active-site architecture of beta-ketoacyl-acyl carrier protein synthase III (FabH) from escherichia coli.
Structure Fold.Des., 8, 2000
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1FJ4 | | THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH THIOLACTOMYCIN, IMPLICATIONS FOR DRUG DESIGN | | Descriptor: | BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I, THIOLACTOMYCIN | | Authors: | Price, A.C., Choi, K., Heath, R.J., Li, Z., White, S.W., Rock, C.O. | | Deposit date: | 2000-08-07 | | Release date: | 2000-08-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism.
J.Biol.Chem., 276, 2001
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1FJ8 | | THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH CERULENIN, IMPLICATIONS FOR DRUG DESIGN | | Descriptor: | BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I, (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE | | Authors: | Price, A.C., Choi, K., Heath, R.J., Li, Z., White, S.W., Rock, C.O. | | Deposit date: | 2000-08-07 | | Release date: | 2000-08-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism.
J.Biol.Chem., 276, 2001
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1ESM | | STRUCTURAL BASIS FOR THE FEEDBACK REGULATION OF ESCHERICHIA COLI PANTOTHENATE KINASE BY COENZYME A | | Descriptor: | PANTOTHENATE KINASE, COENZYME A | | Authors: | Yun, M., Park, C.G., Kim, J.Y., Rock, C.O., Jackowski, S., Park, H.W. | | Deposit date: | 2000-04-10 | | Release date: | 2000-09-20 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for the feedback regulation of Escherichia coli pantothenate kinase by coenzyme A.
J.Biol.Chem., 275, 2000
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1G5X | | THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I | | Descriptor: | BETA-KETOACYL ACYL CARRIER PROTEIN SYNTHASE I | | Authors: | Zhang, Y.M., Rao, M.S., Heath, R.J., Price, A.C., Olson, A.J., Rock, C.O., White, S.W. | | Deposit date: | 2000-11-02 | | Release date: | 2000-11-15 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Identification and analysis of the acyl carrier protein (ACP) docking site on beta-ketoacyl-ACP synthase III.
J.Biol.Chem., 276, 2001
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1ESN | | STRUCTURAL BASIS FOR THE FEEDBACK REGULATION OF ESCHERICHIA COLI PANTOTHENATE KINASE BY COENZYME A | | Descriptor: | PANTOTHENATE KINASE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Yun, M., Park, C.G., Kim, J.Y., Rock, C.O., Jackowski, S., Park, H.W. | | Deposit date: | 2000-04-10 | | Release date: | 2000-11-17 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis for the feedback regulation of Escherichia coli pantothenate kinase by coenzyme A.
J.Biol.Chem., 275, 2000
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1HW2 | | FADR-DNA COMPLEX: TRANSCRIPTIONAL CONTROL OF FATTY ACID METABOLISM IN ECHERICHIA COLI | | Descriptor: | 5'-D(*CP*GP*AP*TP*CP*TP*GP*GP*TP*CP*CP*GP*AP*CP*CP*AP*GP*AP*TP*GP*CP*T)-3', 5'-D(*G*CP*AP*TP*CP*TP*GP*GP*TP*CP*GP*GP*AP*CP*CP*AP*GP*AP*TP*CP*GP*A)-3', FATTY ACID METABOLISM REGULATOR PROTEIN, ... | | Authors: | Xu, Y., Heath, R.J., Li, Z., Rock, C.O., White, S.W. | | Deposit date: | 2001-01-09 | | Release date: | 2001-01-22 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.25 Å) | | Cite: | The FadR.DNA complex. Transcriptional control of fatty acid metabolism in Escherichia coli.
J.Biol.Chem., 276, 2001
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1HW1 | | THE FADR-DNA COMPLEX: TRANSCRIPTIONAL CONTROL OF FATTY ACID METABOLISM IN ESCHERICHIA COLI | | Descriptor: | FATTY ACID METABOLISM REGULATOR PROTEIN, SULFATE ION, ZINC ION | | Authors: | Xu, Y., Heath, R.J., Li, Z., Rock, C.O., White, S.W. | | Deposit date: | 2001-01-09 | | Release date: | 2001-01-24 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | The FadR.DNA complex. Transcriptional control of fatty acid metabolism in Escherichia coli.
J.Biol.Chem., 276, 2001
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1I01 | |
1JYK | |
1JYL | |
1KLP | | THE SOLUTION STRUCTURE OF ACYL CARRIER PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS | | Descriptor: | MEROMYCOLATE EXTENSION ACYL CARRIER PROTEIN | | Authors: | Wong, H.C., Liu, G., Zhang, Y.-M., Rock, C.O., Zheng, J. | | Deposit date: | 2001-12-12 | | Release date: | 2002-06-07 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | The solution structure of acyl carrier protein from Mycobacterium tuberculosis.
J.Biol.Chem., 277, 2002
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1OX0 | |
1OXH | |
1M7E | | CRYSTAL STRUCTURE OF THE PHOSPHOTYROSINE BINDING DOMAIN(PTB) OF MOUSE DISABLED 2(DAB2):IMPLICATIONS FOR REELING SIGNALING | | Descriptor: | Disabled homolog 2, NGYENPTYK peptide | | Authors: | Yun, M., Keshvara, L., Park, C.-G., Zhang, Y.-M., Dickerson, J.B., Zheng, J., Rock, C.O., Curran, T., Park, H.-W. | | Deposit date: | 2002-07-19 | | Release date: | 2003-08-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Crystal structures of the Dab homology domains of mouse disabled 1 and 2
J.Biol.Chem., 278, 2003
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1OQN | | CRYSTAL STRUCTURE OF THE PHOSPHOTYROSINE BINDING DOMAIN (PTB) OF MOUSE DISABLED 1 (DAB1) | | Descriptor: | Disabled homolog 1, Alzheimer's disease amyloid A4 protein homolog, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE | | Authors: | Yun, M., Keshvara, L., Park, C.-G., Zhang, Y.-M., Dickerson, J.B., Zheng, J., Rock, C.O., Curran, T., Park, H.-W. | | Deposit date: | 2003-03-10 | | Release date: | 2003-08-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structures of the Dab homology domains of mouse disabled 1 and 2
J.Biol.Chem., 278, 2003
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1P3R | | CRYSTAL STRUCTURE OF THE PHOSPHOTYROSIN BINDING DOMAIN(PTB) OF MOUSE DISABLED 1(DAB1) | | Descriptor: | Disabled homolog 2 | | Authors: | Yun, M., Keshvara, L., Park, C.G., Zhang, Y.M., Dickerson, J.B., Zheng, J., Rock, C.O., Curran, T., Park, H.W. | | Deposit date: | 2003-04-18 | | Release date: | 2003-08-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structures of the Dab homology domains of mouse disabled 1 and 2.
J.Biol.Chem., 278, 2003
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1Q7B | | THE STRUCTURE OF BETAKETOACYL-[ACP] REDUCTASE FROM E. COLI IN COMPLEX WITH NADP+ | | Descriptor: | 3-oxoacyl-[acyl-carrier protein] reductase, CALCIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Price, A.C., Zhang, Y.-M., Rock, C.O., White, S.M. | | Deposit date: | 2003-08-17 | | Release date: | 2004-02-17 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Cofactor-Induced Conformational Rearrangements Establish a Catalytically Competent Active Site and a Proton Relay Conduit in FabG
Structure, 12, 2004
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1Q7C | | THE STRUCTURE OF BETAKETOACYL-[ACP] REDUCTASE Y151F MUTANT IN COMPLEX WITH NADPH FRAGMENT | | Descriptor: | 3-oxoacyl-[acyl-carrier protein] reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Price, A.C., Zhang, Y.-M., Rock, C.O., White, S.M. | | Deposit date: | 2003-08-17 | | Release date: | 2004-02-17 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Cofactor-Induced Conformational Rearrangements Establish a Catalytically Competent Active Site and a
Proton Relay Conduit in FabG
Structure, 12, 2004
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1SQ5 | | CRYSTAL STRUCTURE OF E. COLI PANTOTHENATE KINASE | | Descriptor: | Pantothenate kinase, PANTOTHENOIC ACID, ADENOSINE-5'-DIPHOSPHATE | | Authors: | Ivey, R.A., Zhang, Y.-M., Virga, K.G., Hevener, K., Lee, R.E., Rock, C.O., Jackowski, S., Park, H.-W. | | Deposit date: | 2004-03-17 | | Release date: | 2004-09-28 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites.
J.Biol.Chem., 279, 2004
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1U1Z | | THE STRUCTURE OF (3R)-HYDROXYACYL-ACP DEHYDRATASE (FABZ) | | Descriptor: | (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase, SULFATE ION | | Authors: | Kimber, M.S., Martin, F., Lu, Y., Houston, S., Vedadi, M., Dharamsi, A., Fiebig, K.M., Schmid, M., Rock, C.O. | | Deposit date: | 2004-07-16 | | Release date: | 2004-09-28 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The Structure of (3R)-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Pseudomonas aeruginosa
J.Biol.Chem., 279, 2004
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2ALM | | CRYSTAL STRUCTURE ANALYSIS OF A MUTANT BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE II FROM STREPTOCOCCUS PNEUMONIAE | | Descriptor: | 3-oxoacyl-(acyl-carrier-protein) synthase II, MAGNESIUM ION | | Authors: | Zhang, Y.M., Hurlbert, J., White, S.W., Rock, C.O. | | Deposit date: | 2005-08-07 | | Release date: | 2005-08-30 | | Last modified: | 2011-11-16 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Roles of the active site water, histidine 303, and phenylalanine 396 in the catalytic mechanism of the elongation condensing enzyme of Streptococcus pneumoniae.
J.Biol.Chem., 281, 2006
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2AQ7 | | STRUCTURE-ACTIVITY RELATIONSHIPS AT THE 5-POSIITON OF THIOLACTOMYCIN: AN INTACT 5(R)-ISOPRENE UNIT IS REQUIRED FOR ACTIVITY AGAINST THE CONDENSING ENZYMES FROM MYCOBACTERIUM TUBERCULOSIS AND ESCHERICHIA COLI | | Descriptor: | 3-oxoacyl-[acyl-carrier-protein] synthase I, (5R)-4-HYDROXY-3,5-DIMETHYL-5-[(1E,3E)-2-METHYLPENTA-1,3-DIENYL]THIOPHEN-2(5H)-ONE | | Authors: | Kim, P., Zhang, Y.M., Shenoy, G., Nguyen, Q.A., Boshoff, H.I., Manjunatha, U.H., Goodwin, M.B., Lonsdale, J., Price, A.C., Miller, D.J. | | Deposit date: | 2005-08-17 | | Release date: | 2006-01-17 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli
J.Med.Chem., 49, 2006
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2AQB | | STRUCTURE-ACTIVITY RELATIONSHIPS AT THE 5-POSITION OF THIOLACTOMYCIN: AN INTACT 5(R)-ISOPRENE UNIT IS REQUIRED FOR ACTIVITY AGAINST THE CONDENSING ENZYMES FROM MYCOBACTERIUM TUBERCULOSIS AND ESCHERCHIA COLI | | Descriptor: | 3-oxoacyl-[acyl-carrier-protein] synthase I, (5R)-5-[(1E)-BUTA-1,3-DIENYL]-4-HYDROXY-3,5-DIMETHYLTHIOPHEN-2(5H)-ONE | | Authors: | Kim, P., Zhang, Y.M., Shenoy, G., Nguyen, Q.A., Boshoff, H.I., Manjunatha, U.H., Goodwin, M.B., Lonsdale, J., Price, A.C., Miller, D.J. | | Deposit date: | 2005-08-17 | | Release date: | 2006-01-17 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli
J.Med.Chem., 49, 2006
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2B4Q | | PSEUDOMONAS AERUGINOSA RHLG/NADP ACTIVE-SITE COMPLEX | | Descriptor: | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Miller, D.J., White, S.W. | | Deposit date: | 2005-09-26 | | Release date: | 2006-05-02 | | Last modified: | 2019-07-24 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of RhlG, an Essential beta-Ketoacyl Reductase in the Rhamnolipid Biosynthetic Pathway of Pseudomonas aeruginosa.
J.Biol.Chem., 281, 2006
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