Author results

2W4O
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CRYSTAL STRUCTURE OF HUMAN CAMK4 IN COMPLEX WITH 4-AMINO(SULFAMOYL- PHENYLAMINO)-TRIAZOLE-CARBOTHIOIC ACID (2,6-DIFLUORO-PHENYL)-AMIDE)
Descriptor:CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE IV, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Authors:Muniz, J.R.C., Rellos, P., Gileadi, O., Fedorov, O., Filippakopoulos, P., Salah, E., Pike, A., Phillips, C., Niesen, F., Shrestha, L., Burgess-Brown, N., Bullock, A., Berridge, G., von Delft, F., Edwards, A.M., Bountra, C., Arrowsmith, C.H., Weigelt, J., Knapp, S.
Deposit date:2008-11-28
Release date:2009-01-20
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Crystal Structure of Human Camk4 in Complex with 4-Amino(Sulfamoyl-Phenylamino)-Triazole- Carbothioic Acid (2,6-Difluoro-Phenyl)-Amide)
To be Published
2WBI
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CRYSTAL STRUCTURE OF HUMAN ACYL-COA DEHYDROGENASE 11
Descriptor:ACYL-COA DEHYDROGENASE FAMILY MEMBER 11, FLAVIN-ADENINE DINUCLEOTIDE, PHOSPHATE ION, ...
Authors:Muniz, J.R.C., Guo, K., Savitsky, P., Roos, A., Yue, W., Pilka, E., von Delft, F., Edwards, A.M., Bountra, C., Arrowsmith, C.H., Weigelt, J., Oppermann, U.
Deposit date:2009-02-28
Release date:2009-05-12
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Human Acyl-Coa Dehydrogenase 11
To be Published
2WNT
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CRYSTAL STRUCTURE OF THE HUMAN RIBOSOMAL PROTEIN S6 KINASE
Descriptor:RIBOSOMAL PROTEIN S6 KINASE, SODIUM ION, CHLORIDE ION, ...
Authors:Muniz, J.R.C., Elkins, J.M., Wang, J., Ugochukwu, E., Salah, E., King, O., Picaud, S., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S.
Deposit date:2009-07-20
Release date:2009-08-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the Human Ribosomal Protein S6 Kinase
To be Published
2WZK
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STRUCTURE OF THE CUL5 N-TERMINAL DOMAIN AT 2.05A RESOLUTION.
Descriptor:CULLIN-5, 1,2-ETHANEDIOL
Authors:Muniz, J.R.C., Ayinampudi, V., Zhang, Y., Babon, J.J., Chaikuad, A., Krojer, T., Pike, A.C.W., Vollmar, M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Bullock, A.N.
Deposit date:2009-11-30
Release date:2009-12-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Molecular Architecture of the Ankyrin Socs Box Family of Cul5-Dependent E3 Ubiquitin Ligases
J.Mol.Biol., 425, 2013
2X4F
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THE CRYSTAL STRUCTURE OF THE HUMAN MYOSIN LIGHT CHAIN KINASE LOC340156.
Descriptor:MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4, 4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-dioxaziridin-3-ylphenyl)pyrimidin-2-amine, SULFATE ION, ...
Authors:Muniz, J.R.C., Mahajan, P., Rellos, P., Fedorov, O., Shrestha, B., Wang, J., Elkins, J.M., Daga, N., Cocking, R., Chaikuad, A., Krojer, T., Ugochukwu, E., Yue, W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Gileadi, O., Knapp, S.
Deposit date:2010-01-29
Release date:2010-02-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156
To be Published
2XIK
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STRUCTURE OF HUMAN YSK1 (YEAST SPS1-STE20-RELATED KINASE 1)
Descriptor:SERINE/THREONINE PROTEIN KINASE 25, 1,2-ETHANEDIOL, 5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE
Authors:Muniz, J.R.C., Rellos, P., Ugochukwu, E., Vollmar, M., Allerston, C., Chaikuad, A., Savitsky, P., Berridge, G., Brenner, B., Elkins, J.M., Daga, N., Gileadi, O., Mahajan, P., Shrestha, B., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S.
Deposit date:2010-06-30
Release date:2010-07-14
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structure of Human Ysk1 (Yeast Sps1-Ste20-Related Kinase 1)
To be Published
2XIO
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STRUCTURE OF PUTATIVE DEOXYRIBONUCLEASE TATDN1 ISOFORM A
Descriptor:PUTATIVE DEOXYRIBONUCLEASE TATDN1, SODIUM ION, NICKEL (II) ION, ...
Authors:Muniz, J.R.C., Cocking, R., Puranik, S., Krojer, T., Raynor, J., Vollmar, M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Yue, W.W., Kavanagh, K.L., Oppermann, U.
Deposit date:2010-06-30
Release date:2010-07-14
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:Structure of Putative Deoxyribonuclease Tatdn1 Isoform A
To be Published
2XSN
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CRYSTAL STRUCTURE OF HUMAN TYROSINE HYDROXYLASE CATALYTIC DOMAIN
Descriptor:TYROSINE 3-MONOOXYGENASE, ZINC ION
Authors:Muniz, J.R.C., Cooper, C.D.O., Yue, W.W., Krysztofinska, E., von Delft, F., Knapp, S., Gileadi, O., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Kavanagh, K.L., Oppermann, U.
Deposit date:2010-10-29
Release date:2010-11-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Crystal Structure of Human Tyrosine Hydroxylase Catalytic Domain
To be Published
2XST
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CRYSTAL STRUCTURE OF THE HUMAN LIPOCALIN 15
Descriptor:LIPOCALIN 15, 1,2-ETHANEDIOL
Authors:Muniz, J.R.C., Gileadi, C., Yue, W.W., Krojer, T., Ugochukwu, E., Phillips, C., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Kavanagh, K.L., Oppermann, U.
Deposit date:2010-09-30
Release date:2010-10-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Crystal Structure of the Human Lipocalin 15
To be Published
2Y1H
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CRYSTAL STRUCTURE OF THE HUMAN TATD-DOMAIN PROTEIN 3 (TATDN3)
Descriptor:PUTATIVE DEOXYRIBONUCLEASE TATDN3, ZINC ION, PHOSPHATE ION, ...
Authors:Muniz, J.R.C., Puranik, S., Krojer, T., Yue, W.W., Ugochukwu, E., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Kavanagh, K.L., Oppermann, U.
Deposit date:2010-12-08
Release date:2010-12-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the Human Tatd-Domain Protein 3 (Tatdn3)
To be Published
2Y7J
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STRUCTURE OF HUMAN PHOSPHORYLASE KINASE, GAMMA 2
Descriptor:PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
Authors:Muniz, J.R.C., Shrestha, A., Savitsky, P., Wang, J., Rellos, P., Fedorov, O., Burgess-Brown, N., Brenner, B., Berridge, G., Elkins, J.M., Krojer, T., Vollmar, M., Che, K.H., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S.
Deposit date:2011-01-31
Release date:2011-02-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Human Phosphorylase Kinase, Gamma 2
To be Published
2YL2
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CRYSTAL STRUCTURE OF HUMAN ACETYL-COA CARBOXYLASE 1, BIOTIN CARBOXYLASE (BC) DOMAIN
Descriptor:ACETYL-COA CARBOXYLASE 1
Authors:Muniz, J.R.C., Froese, D.S., Krysztofinska, E., Vollmar, M., Beltrami, A., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Yue, W.W., Oppermann, U.
Deposit date:2011-05-31
Release date:2011-06-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Human Acetyl-Coa Carboxylase 1, Biotin Carboxylase (Bc) Domain
To be Published
3Q2F
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BAZ2B IN COMPLEX WITH A TRIAZOLO LIGAND
Descriptor:Bromodomain adjacent to zinc finger domain protein 2B, 4-{4-[3-(1H-imidazol-1-yl)propyl]-5-methyl-4H-1,2,4-triazol-3-yl}-1-methyl-1H-pyrazol-5-amine, 1,2-ETHANEDIOL
Authors:Muniz, J.R.C., Filippakopoulos, P., Picaud, S., Felletar, I., Keates, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2010-12-20
Release date:2011-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Crystal Structure of the bromodomain of human BAZ2B in complex with a triazolo ligand
TO BE PUBLISHED
3ZKJ
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CRYSTAL STRUCTURE OF ANKYRIN REPEAT AND SOCS BOX-CONTAINING PROTEIN 9 (ASB9) IN COMPLEX WITH ELONGINB AND ELONGINC
Descriptor:ANKYRIN REPEAT AND SOCS BOX PROTEIN 9, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2, ...
Authors:Muniz, J.R.C., Guo, K., Zhang, Y., Ayinampudi, V., Savitsky, P., Keates, T., Filippakopoulos, P., Vollmar, M., Yue, W.W., Krojer, T., Ugochukwu, E., von Delft, F., Knapp, S., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N.
Deposit date:2013-01-23
Release date:2013-01-30
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Molecular Architecture of the Ankyrin Socs Box Family of Cul5-Dependent E3 Ubiquitin Ligases
J.Mol.Biol., 425, 2013
3ZW5
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CRYSTAL STRUCTURE OF THE HUMAN GLYOXALASE DOMAIN-CONTAINING PROTEIN 5
Descriptor:GLYOXALASE DOMAIN-CONTAINING PROTEIN 5, SULFATE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Muniz, J.R.C., Kiyani, W., Froese, S., Vollmar, M., von Delft, F., Burgess-Brown, N., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Yue, W.W.
Deposit date:2011-07-28
Release date:2011-08-10
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of the Human Glyoxalase Domain-Containing Protein 5
To be Published
3ZYQ
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CRYSTAL STRUCTURE OF THE TANDEM VHS AND FYVE DOMAINS OF HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE (HGS-HRS) AT 1.48 A RESOLUTION
Descriptor:HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE, ZINC ION, SULFATE ION, ...
Authors:Muniz, J.R.C., Ayinampudi, V., Shrestha, L., Krojer, T., Vollmar, M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Bullock, A.
Deposit date:2011-08-24
Release date:2011-09-07
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Crystal Structure of the Tandem Vhs and Fyve Domains of Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate (Hgs-Hrs) at 1.48 A Resolution
To be Published
4A60
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CRYSTAL STRUCTURE OF HUMAN TESTIS-SPECIFIC FATTY ACID BINDING PROTEIN 9 (FABP9)
Descriptor:FATTY ACID-BINDING PROTEIN 9 TESTIS LIPID-BINDING PROTEIN, TLBP, TESTIS-TYPE FATTY ACID-BINDING PROTEIN, ...
Authors:Muniz, J.R.C., Kiyani, W., Shrestha, L., Froese, D.S., Krojer, T., Vollmar, M., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., von Delft, F., Yue, W.W.
Deposit date:2011-10-31
Release date:2011-11-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:The Crystal Structure of the Human Fabp9A
To be Published
4A9Z
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CRYSTAL STRUCTURE OF HUMAN P63 TETRAMERIZATION DOMAIN
Descriptor:TUMOR PROTEIN 63, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL
Authors:Muniz, J.R.C., Coutandin, D., Salah, E., Chaikuad, A., Vollmar, M., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Dotsch, V., von Delft, F., Knapp, S.
Deposit date:2011-11-30
Release date:2011-12-07
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Crystal Structure of Human P63 Tetramerization Domain
To be Published
2W7R
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STRUCTURE OF THE PDZ DOMAIN OF HUMAN MICROTUBULE ASSOCIATED SERINE- THREONINE KINASE 4
Descriptor:MICROTUBULE-ASSOCIATED SERINE/THREONINE-PROTEIN KINASE 4, PHOSPHATE ION
Authors:Muniz, J.R.C., Elkins, J., Wang, J., Savitzky, P., Roos, A., Salah, E., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S.
Deposit date:2008-12-24
Release date:2009-05-12
Last modified:2015-01-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Unusual Binding Interactions in Pdz Domain Crystal Structures Help Explain Binding Mechanisms.
Protein Sci., 19, 2010
2WWW
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CRYSTAL STRUCTURE OF METHYLMALONIC ACIDEMIA TYPE A PROTEIN
Descriptor:METHYLMALONIC ACIDURIA TYPE A PROTEIN, MITOCHONDRIAL, NONAETHYLENE GLYCOL, ...
Authors:Muniz, J.R.C., Gileadi, C., Froese, D.S., Yue, W.W., Pike, A.C.W., von Delft, F., Kochan, G., Sethi, R., Chaikuad, A., Pilka, E., Picaud, S., Phillips, C., Guo, K., Krysztofinska, E., Bray, J., Burgess-Brown, N., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Gravel, R.A., Kavanagh, K.L., Oppermann, U.
Deposit date:2009-10-30
Release date:2009-11-17
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Structures of the Human Gtpase Mmaa and Vitamin B12-Dependent Methylmalonyl-Coa Mutase and Insight Into Their Complex Formation.
J.Biol.Chem., 285, 2010
2X64
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GLUTATHIONE-S-TRANSFERASE FROM XYLELLA FASTIDIOSA
Descriptor:GLUTATHIONE-S-TRANSFERASE, CHLORIDE ION, GLUTATHIONE
Authors:Muniz, J.R.C., Rodrigues, N.C., Bleicher, L., Travensolo, R.F., Garcia, W.
Deposit date:2010-02-14
Release date:2010-03-02
Last modified:2011-12-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and Biophysical Characterization of the Recombinant Glutathione-S-Transferase from Xylella
To be Published
2YDX
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CRYSTAL STRUCTURE OF HUMAN S-ADENOSYLMETHIONINE SYNTHETASE 2, BETA SUBUNIT
Descriptor:METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA, RESVERATROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Muniz, J.R.C., Shafqat, N., Pike, A.C.W., Yue, W.W., Vollmar, M., Papagriogriou, V., Roos, A., Gileadi, O., von Delft, F., Kavanagh, K.L., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Oppermann, U.
Deposit date:2011-03-25
Release date:2011-04-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insight Into S-Adenosylmethionine Biosynthesis from the Crystal Structures of the Human Methionine Adenosyltransferase Catalytic and Regulatory Subunits.
Biochem.J., 452, 2013
4UOJ
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STRUCTURE OF FUNGAL BETA-MANNOSIDASE (GH2) FROM TRICHODERMA HARZIANUM
Descriptor:BETA-MANNOSIDASE GH2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Muniz, J.R.C., Aparicio, R., Santos, J.C., Nascimento, A.S., Golubev, A.M., Polikarpov, I.
Deposit date:2014-06-04
Release date:2014-07-09
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insights Into the Structure and Function of Fungal Beta-Mannosidases from Glycoside Hydrolase Family 2 Based on Multiple Crystal Structures of the Trichoderma Harzianum Enzyme.
FEBS J., 281, 2014
2VNA
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STRUCTURE OF HUMAN ZINC-BINDING ALCOHOL DEHYDROGENASE 1 (ZADH1)
Descriptor:PROSTAGLANDIN REDUCTASE 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Shafqat, N., Kavanagh, K., Pike, A.C.W., Muniz, J.R.C., Pilka, E., Roos, A.K., Picaud, S., Johansson, C., Smee, C., Fedorov, O., Kochan, G., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., von Delft, F., Opperman, U.
Deposit date:2008-02-01
Release date:2009-02-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Structure of Human Zinc-Binding Alcohol Dehydrogenase 1 (Zadh1)
To be Published
2W2J
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CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE RELATED PROTEIN VIII
Descriptor:CARBONIC ANHYDRASE-RELATED PROTEIN, CHLORIDE ION, GLYCEROL, ...
Authors:Kramm, A., Muniz, J.R.C., Picaud, S.S., von Delft, F., Pilka, E.S., Yue, W.W., King, O.N.F., Kochan, G., Pike, A.C.W., Filippakopoulos, P., Arrowsmith, C., Wikstrom, M., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2008-10-31
Release date:2009-02-03
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of Human Carbonic Anhydrase-Related Protein Viii Reveals the Basis for Catalytic Silencing.
Proteins, 76, 2009