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8EST
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REACTION OF PORCINE PANCREATIC ELASTASE WITH 7-SUBSTITUTED 3-ALKOXY-4-CHLOROISOCOUMARINS: DESIGN OF POTENT INHIBITORS USING THE CRYSTAL STRUCTURE OF THE COMPLEX FORMED WITH 4-CHLORO-3-ETHOXY-7-GUANIDINO-ISOCOUMARIN
Descriptor:PORCINE PANCREATIC ELASTASE, SULFATE ION, CALCIUM ION, ...
Authors:Radhakrishnan, R., Powers, J.C., Meyerjunior, E.F.
Deposit date:1990-02-21
Release date:1992-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin.
Biochemistry, 29, 1990
4EST
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CRYSTAL STRUCTURE OF THE COVALENT COMPLEX FORMED BY A PEPTIDYL ALPHA,ALPHA-DIFLUORO-BETA-KETO AMIDE WITH PORCINE PANCREATIC ELASTASE AT 1.78-ANGSTROMS RESOLUTION
Descriptor:ELASTASE, INHIBITOR ACE-ALA-PRO-VAI-DIFLUORO-N-PHENYLETHYLACETAMIDE, SULFATE ION, ...
Authors:Takahashi, L.H., Radhakrishnan, R., Rosenfieldjunior, R.E., Meyerjunior, E.F., Trainor, D.A.
Deposit date:1989-05-15
Release date:1992-04-15
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Crystal Structure of the Covalent Complex Formed by a Peptidyl Alpha,Alpha-Difluoro-Beta-Keto Amide with Porcine Pancreatic Elastase at 1.78-Angstroms Resolution
J.Am.Chem.Soc., 111, 1989
9EST
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STRUCTURAL STUDY OF PORCINE PANCREATIC ELASTASE COMPLEXED WITH 7-AMINO-3-(2-BROMOETHOXY)-4-CHLOROISOCOUMARIN AS A NONREACTIVATABLE DOUBLY COVALENT ENZYME-INHIBITOR COMPLEX
Descriptor:PORCINE PANCREATIC ELASTASE, SULFATE ION, CALCIUM ION, ...
Authors:Radhakrishnan, R., Powers, J.C., Meyer Jr., E.F.
Deposit date:1991-01-14
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural study of porcine pancreatic elastase complexed with 7-amino-3-(2-bromoethoxy)-4-chloroisocoumarin as a nonreactivatable doubly covalent enzyme-inhibitor complex.
Biochemistry, 30, 1991
3EST
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STRUCTURE OF NATIVE PORCINE PANCREATIC ELASTASE AT 1.65 ANGSTROMS RESOLUTION
Descriptor:PORCINE PANCREATIC ELASTASE, CALCIUM ION, SULFATE ION
Authors:Meyer, E.F., Cole, G., Radhakrishnan, R., Epp, O.
Deposit date:1987-09-17
Release date:1988-01-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of native porcine pancreatic elastase at 1.65 A resolutions.
Acta Crystallogr.,Sect.B, 44, 1988
5EST
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CRYSTALLOGRAPHIC ANALYSIS OF THE INHIBITION OF PORCINE PANCREATIC ELASTASE BY A PEPTIDYL BORONIC ACID: STRUCTURE OF A REACTION INTERMEDIATE
Descriptor:ELASTASE, N~2~-[(benzyloxy)carbonyl]-N-[(1R,2S)-1-(dihydroxyboranyl)-2-methylbutyl]-L-alaninamide, SULFATE ION, ...
Authors:Takahashi, L.H., Radhakrishnan, R., Rosenfieldjunior, R.E., Meyerjunior, E.F.
Deposit date:1989-05-15
Release date:1992-04-15
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Crystallographic analysis of the inhibition of porcine pancreatic elastase by a peptidyl boronic acid: structure of a reaction intermediate.
Biochemistry, 28, 1989