Author results

1GL3
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ASPARTATE BETA-SEMIALDEHYDE DEHYDROGENASE IN COMPLEX WITH NADP AND SUBSTRATE ANALOGUE S-METHYL CYSTEINE SULFOXIDE
Descriptor:ASPARTATE-SEMIALDEHYDE DEHYDROGENASE, CYSTEINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Hadfield, A.T., Kryger, G., Ouyang, J., Ringe, D., Petsko, G.A., Viola, R.E.
Deposit date:2001-08-23
Release date:2001-11-01
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Active Site Analysis of the Potential Antimicrobial Target Aspartate Semialdehyde Dehydrogenase.
Biochemistry, 40, 2001
1QJU
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HUMAN RHINOVIRUS 16 COAT PROTEIN IN COMPLEX WITH ANTIVIRAL COMPOUND VP61209
Descriptor:PROTEIN VP1, PROTEIN VP2, PROTEIN VP3, ...
Authors:Hadfield, A.T., Minor, I., Diana, G.D., Rossmann, M.G.
Deposit date:1999-07-05
Release date:1999-07-20
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Analysis of Three Structurally Related Antiviral Compounds in Complex with Human Rhinovirus 16
Proc.Natl.Acad.Sci.USA, 96, 1999
1QJX
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HUMAN RHINOVIRUS 16 COAT PROTEIN IN COMPLEX WITH ANTIVIRAL COMPOUND WIN68934
Descriptor:PROTEIN VP1, PROTEIN VP2, PROTEIN VP3, ...
Authors:Hadfield, A.T., Diana, G.D., Rossmann, M.G.
Deposit date:1999-07-06
Release date:1999-07-20
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Analysis of Three Structurally Related Antiviral Compounds in Complex with Human Rhinovirus 16
Proc.Natl.Acad.Sci.USA, 96, 1999
1QJY
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HUMAN RHINOVIRUS 16 COAT PROTEIN IN COMPLEX WITH ANTIVIRAL COMPOUND VP65099
Descriptor:PROTEIN VP1, PROTEIN VP2, PROTEIN VP3, ...
Authors:Hadfield, A.T., Diana, G.D., Rossmann, M.G.
Deposit date:1999-07-06
Release date:1999-07-20
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Analysis of Three Structurally Related Antiviral Compounds in Complex with Human Rhinovirus 16
Proc.Natl.Acad.Sci.USA, 96, 1999
1AYM
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HUMAN RHINOVIRUS 16 COAT PROTEIN AT HIGH RESOLUTION
Descriptor:HUMAN RHINOVIRUS 16 COAT PROTEIN, ZINC ION, LAURIC ACID, ...
Authors:Hadfield, A.T., Rossmann, M.G.
Deposit date:1997-11-06
Release date:1998-01-21
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The refined structure of human rhinovirus 16 at 2.15 A resolution: implications for the viral life cycle.
Structure, 5, 1997
1W4Z
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STRUCTURE OF ACTINORHODIN POLYKETIDE (ACTIII) REDUCTASE
Descriptor:KETOACYL REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, FORMIC ACID
Authors:Hadfield, A.T., Limpkin, C., Teartasin, W., Simpson, T.J., Crosby, J., Crump, M.P.
Deposit date:2004-08-03
Release date:2004-12-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Crystal Structure of the Actiii Actinorhodin Polyketide Reductase; Proposed Mechanism for Acp and Polyketide Binding
Structure, 12, 2004
1LSY
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CRYSTAL STRUCTURE OF THE MUTANT D52S HEN EGG WHITE LYSOZYME WITH AN OLIGOSACCHARIDE PRODUCT
Descriptor:HEN EGG WHITE LYSOZYME
Authors:Johnson, L.N., Hadfield, A.T.
Deposit date:1994-09-27
Release date:1995-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the mutant D52S hen egg white lysozyme with an oligosaccharide product.
J.Mol.Biol., 243, 1994
1LSZ
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CRYSTAL STRUCTURE OF THE MUTANT D52S HEN EGG WHITE LYSOZYME WITH AN OLIGOSACCHARIDE PRODUCT
Descriptor:HEN EGG WHITE LYSOZYME, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, N-ACETYL-D-GLUCOSAMINE
Authors:Johnson, L.N., Hadfield, A.T.
Deposit date:1994-09-27
Release date:1995-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the mutant D52S hen egg white lysozyme with an oligosaccharide product.
J.Mol.Biol., 243, 1994
1AYN
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HUMAN RHINOVIRUS 16 COAT PROTEIN
Descriptor:HUMAN RHINOVIRUS 16 COAT PROTEIN, ZINC ION, LAURIC ACID, ...
Authors:Hadfield, A.T., Oliveira, M.A., Zhao, R., Rossmann, M.G.
Deposit date:1997-11-06
Release date:1998-01-21
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The structure of human rhinovirus 16.
Structure, 1, 1993
2FHX
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PSEUDOMONAS AERUGINOSA SPM-1 METALLO-BETA-LACTAMASE
Descriptor:SPM-1, ZINC ION, AZIDE ION, ...
Authors:Murphy, T.A., Catto, L.E., Halford, S.E., Hadfield, A.T., Minor, W., Walsh, T.R., Spencer, J.
Deposit date:2005-12-27
Release date:2006-01-17
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of Pseudomonas aeruginosa SPM-1 Provides Insights into Variable Zinc Affinity of Metallo-beta-lactamases.
J.Mol.Biol., 357, 2006
2JBZ
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CRYSTAL STRUCTURE OF THE STREPTOMYCES COELICOLOR HOLO-[ACYL-CARRIER-PROTEIN] SYNTHASE (ACPS) IN COMPLEX WITH COENZYME A AT 1.6 A
Descriptor:HOLO-[ACYL-CARRIER-PROTEIN] SYNTHASE, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Dall'Aglio, P., Arthur, C., Law, C.K.E., Crump, M.P., Crosby, J., Hadfield, A.T.
Deposit date:2006-12-15
Release date:2007-01-23
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Analysis of Streptomyces Coelicolor Phosphopantetheinyl Transferase, Acps, Reveals the Basis for Relaxed Substrate Specificity.
Biochemistry, 50, 2011
2JCA
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CRYSTAL STRUCTURE OF THE STREPTOMYCES COELICOLOR HOLO- [ACYL-CARRIER-PROTEIN] SYNTHASE (ACPS) AT 2 A.
Descriptor:HOLO-[ACYL-CARRIER-PROTEIN] SYNTHASE, SULFATE ION, SODIUM ION, ...
Authors:Dall'Aglio, P., Arthur, C., Crump, M.P., Crosby, J., Hadfield, A.T.
Deposit date:2006-12-21
Release date:2007-01-30
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Analysis of Streptomyces Coelicolor Phosphopantetheinyl Transferase, Acps, Reveals the Basis for Relaxed Substrate Specificity.
Biochemistry, 50, 2011
2JL4
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HOLO STRUCTURE OF MALEYL PYRUVATE ISOMERASE, A BACTERIAL GLUTATHIONE- S-TRANSFERASE IN ZETA CLASS
Descriptor:MALEYLPYRUVATE ISOMERASE, GLUTATHIONE
Authors:Shoemark, D.K., Y Zhou, N., Williams, P.A., Hadfield, A.T.
Deposit date:2008-09-04
Release date:2008-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of Bacterial Glutathione-S-Transferase Maleyl Pyruvate Isomerase and Implications for Mechanism of Isomerisation.
J.Mol.Biol., 384, 2008
2V6K
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STRUCTURE OF MALEYL PYRUVATE ISOMERASE, A BACTERIAL GLUTATHIONE-S- TRANSFERASE IN ZETA CLASS, IN COMPLEX WITH SUBSTRATE ANALOGUE DICARBOXYETHYL GLUTATHIONE
Descriptor:MALEYLPYRUVATE ISOMERASE, GAMMA-GLUTAMYL-S-(1,2-DICARBOXYETHYL)CYSTEINYLGLYCINE, SODIUM ION, ...
Authors:Shoemark, D.K., Zhou, N.-Y., Williams, P.A., Hadfield, A.T.
Deposit date:2007-07-19
Release date:2008-07-22
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure of Bacterial Glutathione-S-Transferase Maleyl Pyruvate Isomerase and Implications for Mechanism of Isomerisation.
J.Mol.Biol., 384, 2008
2WDO
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CRYSTAL STRUCTURE OF THE S. COELICOLOR ACPS IN COMPLEX WITH ACETYL- COA AT 1.5 A
Descriptor:HOLO-[ACYL-CARRIER-PROTEIN] SYNTHASE, MAGNESIUM ION, ACETYL COENZYME *A, ...
Authors:Dall'Aglio, P., Arthur, C., Crump, M.P., Crosby, J., Hadfield, A.T.
Deposit date:2009-03-25
Release date:2010-04-21
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Analysis of Streptomyces Coelicolor Phosphopantetheinyl Transferase, Acps, Reveals the Basis for Relaxed Substrate Specificity.
Biochemistry, 50, 2011
2WDS
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CRYSTAL STRUCTURE OF THE STREPTOMYCES COELICOLOR H110A ACPS MUTANT IN COMPLEX WITH COFACTOR COA AT 1.3 A
Descriptor:HOLO-[ACYL-CARRIER-PROTEIN] SYNTHASE, COENZYME A, MAGNESIUM ION
Authors:Dall'Aglio, P., Arthur, C., Crump, M.P., Crosby, J., Hadfield, A.T.
Deposit date:2009-03-26
Release date:2010-04-21
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Analysis of Streptomyces Coelicolor Phosphopantetheinyl Transferase, Acps, Reveals the Basis for Relaxed Substrate Specificity.
Biochemistry, 50, 2011
2WDY
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CRYSTAL STRUCTURE OF THE STREPTOMYCES COELICOLOR D111A ACPS MUTANT IN COMPLEX WITH COFACTOR COA AT 1.4 A
Descriptor:HOLO-[ACYL-CARRIER-PROTEIN] SYNTHASE, MAGNESIUM ION, SODIUM ION, ...
Authors:Dall'Aglio, P., Arthur, C., Crump, M.P., Crosby, J., Hadfield, A.T.
Deposit date:2009-03-27
Release date:2010-04-21
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Analysis of Streptomyces Coelicolor Phosphopantetheinyl Transferase, Acps, Reveals the Basis for Relaxed Substrate Specificity.
Biochemistry, 50, 2011
2WX5
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HEXA-COORDINATION OF A BACTERIOCHLOROPHYLL COFACTOR IN THE RHODOBACTER SPHAEROIDES REACTION CENTRE
Descriptor:REACTION CENTER PROTEIN H CHAIN, REACTION CENTRE PROTEIN L CHAIN, REACTION CENTRE PROTEIN M CHAIN, ...
Authors:Marsh, M., Frolov, D., Crouch, L.I., Fyfe, P.K., Robert, B., van Grondelle, R., Jones, M.R., Hadfield, A.T.
Deposit date:2009-11-02
Release date:2010-02-09
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Structural and Spectroscopic Consequences of Hexa-Coordination of a Bacteriochlorophyll Cofactor in the Rhodobacter Sphaeroides Reaction Centre
Biochemistry, 49, 2010
3FLU
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CRYSTAL STRUCTURE OF DIHYDRODIPICOLINATE SYNTHASE FROM THE PATHOGEN NEISSERIA MENINGITIDIS
Descriptor:Dihydrodipicolinate synthase, SULFATE ION, GLYCEROL
Authors:Devenish, S.R.A., Hadfield, A.T.
Deposit date:2008-12-19
Release date:2009-06-23
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Cloning and characterisation of dihydrodipicolinate synthase from the pathogen Neisseria meningitidis.
Biochim.Biophys.Acta, 2009
5CTW
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CRYSTAL STRUCTURE OF THE ATP BINDING DOMAIN OF S. AUREUS GYRB COMPLEXED WITH A FRAGMENT
Descriptor:DNA gyrase subunit B, 2-(butanoylamino)thiophene-3-carboxamide, MAGNESIUM ION, ...
Authors:Andersen, O.A., Barker, J., Hadfield, A.T., Cheng, R.K., Kahmann, J., Felicetti, B., Wood, M., Scheich, C., Mesleh, M., Cross, J.B., Zhang, J., Yang, Q., Lippa, B., Ryan, M.D.
Deposit date:2015-07-24
Release date:2016-02-03
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB.
Bioorg.Med.Chem.Lett., 26, 2016
1BRM
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ASPARTATE BETA-SEMIALDEHYDE DEHYDROGENASE FROM ESCHERICHIA COLI
Descriptor:ASPARTATE-SEMIALDEHYDE DEHYDROGENASE
Authors:Hadfield, A.T., Kryger, G., Ouyang, J., Ringe, D., Petsko, G.A., Viola, R.E.
Deposit date:1998-08-24
Release date:1999-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of aspartate-beta-semialdehyde dehydrogenase from Escherichia coli, a key enzyme in the aspartate family of amino acid biosynthesis.
J.Mol.Biol., 289, 1999
1RUC
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RHINOVIRUS 14 MUTANT N1105S COMPLEXED WITH ANTIVIRAL COMPOUND WIN 52035
Descriptor:RHINOVIRUS 14, 5-(5-(4-(4,5-DIHYDRO-2-OXAZOLY)PHENOXY)PENTYL)-3-METHYL ISOXAZOLE
Authors:Hadfield, A., Oliveira, M.A., Kim, K.H., Minor, I., Kremer, M.J., Heinz, B.A., Shepard, D., Pevear, D.C., Rueckert, R.R., Rossmann, M.G.
Deposit date:1995-06-09
Release date:1995-11-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural studies on human rhinovirus 14 drug-resistant compensation mutants.
J.Mol.Biol., 253, 1995
1RUD
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RHINOVIRUS 14 MUTANT N1105S COMPLEXED WITH ANTIVIRAL COMPOUND WIN 52084
Descriptor:RHINOVIRUS 14, 5-(7-(5-HYDRO-4-METHYL-2-OXAZOLYL)PHENOXY)HEPTYL)-3-METHYL ISOXAZOLE
Authors:Hadfield, A., Oliveira, M.A., Kim, K.H., Minor, I., Kremer, M.J., Heinz, B.A., Shepard, D., Pevear, D.C., Rueckert, R.R., Rossmann, M.G.
Deposit date:1995-06-09
Release date:1995-11-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural studies on human rhinovirus 14 drug-resistant compensation mutants.
J.Mol.Biol., 253, 1995
1RUE
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RHINOVIRUS 14 SITE DIRECTED MUTANT N1219A COMPLEXED WITH ANTIVIRAL COMPOUND WIN 52035
Descriptor:RHINOVIRUS 14, 5-(5-(4-(4,5-DIHYDRO-2-OXAZOLY)PHENOXY)PENTYL)-3-METHYL ISOXAZOLE
Authors:Hadfield, A., Oliveira, M.A., Kim, K.H., Minor, I., Kremer, M.J., Heinz, B.A., Shepard, D., Pevear, D.C., Rueckert, R.R., Rossmann, M.G.
Deposit date:1995-06-09
Release date:1995-11-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural studies on human rhinovirus 14 drug-resistant compensation mutants.
J.Mol.Biol., 253, 1995
1RUF
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RHINOVIRUS 14 (HRV14) (MUTANT WITH ASN 1 219 REPLACED BY ALA (N219A IN CHAIN 1)
Descriptor:RHINOVIRUS 14
Authors:Hadfield, A., Oliveira, M.A., Kim, K.H., Minor, I., Kremer, M.J., Heinz, B.A., Shepard, D., Pevear, D.C., Rueckert, R.R., Rossmann, M.G.
Deposit date:1995-06-09
Release date:1995-11-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural studies on human rhinovirus 14 drug-resistant compensation mutants.
J.Mol.Biol., 253, 1995
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