Author results

4FI6
  • Download 4fi6
  • View 4fi6
Molmil generated image of 4fi6
KINETIC STABILIZATION OF TRANSTHYRETIN THROUGH COVALENT MODIFICATION OF K15 BY 3-(5-(3,5-DICHLOROPHENYL)-1,3,4-OXADIAZOL-2-YL)-BENZENESULFONAMIDE
Descriptor:Transthyretin, 3-[5-(3,5-dichlorophenyl)-1,3,4-oxadiazol-2-yl]benzenesulfonyl fluoride
Authors:Connelly, S., Grimster, N., Wilson, I.A., Kelly, J.W.
Deposit date:2012-06-08
Release date:2013-02-20
Last modified:2014-01-29
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate.
J.Am.Chem.Soc., 135, 2013
4FI7
  • Download 4fi7
  • View 4fi7
Molmil generated image of 4fi7
KINETIC STABILIZATION OF TRANSTHYRETIN THROUGH COVALENT MODIFICATION OF K15 BY 3-(5-(3,5-DICHLORO-4-HYDROXYPHENYL)-1,3,4-OXADIAZOL-2-YL)-BENZENESULFONAMIDE
Descriptor:Transthyretin, 3-[5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]benzenesulfonyl fluoride
Authors:Connelly, S., Grimster, N., Wilson, I.A., Kelly, J.W.
Deposit date:2012-06-08
Release date:2013-02-20
Last modified:2014-01-29
Method:X-RAY DIFFRACTION (1.402 Å)
Cite:Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate.
J.Am.Chem.Soc., 135, 2013
4FI8
  • Download 4fi8
  • View 4fi8
Molmil generated image of 4fi8
KINETIC STABILIZATION OF TRANSTHYRETIN THROUGH COVALENT MODIFICATION OF K15 BY 4-BROMO-3-(5-(3,5-DICHLORO-4-HYDROXYPHENYL)-1,3,4-OXADIAZOL-2-YL)-BENZENESULFONAMIDE
Descriptor:Transthyretin, 4-bromo-3-[5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]benzenesulfonyl fluoride
Authors:Connelly, S., Grimster, N., Wilson, I.A., Kelly, J.W.
Deposit date:2012-06-08
Release date:2013-02-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate.
J.Am.Chem.Soc., 135, 2013
5O49
  • Download 5o49
  • View 5o49
Molmil generated image of 5o49
HUMAN FGF IN COMPLEX WITH A COVALENT INHIBITOR
Descriptor:Fibroblast growth factor receptor 1, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl 3-fluorosulfonylbenzoate, SULFATE ION
Authors:Debreczeni, J., Breed, J., Mukherjee, H., Aquila, B., Kaiser, C., Tentarelli, S., Whitty, A., Grimster, N.
Deposit date:2017-05-26
Release date:2018-02-07
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:A study of the reactivity of S(VI)-F containing warheads with nucleophilic amino-acid side chains under physiological conditions.
Org. Biomol. Chem., 15, 2017
5O4A
  • Download 5o4a
  • View 5o4a
Molmil generated image of 5o4a
HUMAN FGF IN COMPLEX WITH A COVALENT INHIBITOR
Descriptor:Fibroblast growth factor receptor 1, SULFATE ION, GLYCEROL, ...
Authors:Debreczeni, J., Breed, J., Mukherjee, H., Aquila, B., Kaiser, C., Tentarelli, S., Whitty, A., Grimster, N.
Deposit date:2017-05-26
Release date:2018-02-07
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:A study of the reactivity of S(VI)-F containing warheads with nucleophilic amino-acid side chains under physiological conditions.
Org. Biomol. Chem., 15, 2017