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3E1T
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BU of 3e1t by Molmil
Structure and action of the myxobacterial chondrochloren halogenase CndH, a new variant of FAD-dependent halogenases
Descriptor: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Halogenase
Authors:Buedenbender, S, Rachid, S, Mueller, R, Schulz, G.E.
Deposit date:2008-08-04
Release date:2009-02-24
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure and action of the myxobacterial chondrochloren halogenase CndH: a new variant of FAD-dependent halogenases.
J.Mol.Biol., 385, 2009
3EDJ
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BU of 3edj by Molmil
Structural base for cyclodextrin hydrolysis
Descriptor: CALCIUM ION, Cycloheptakis-(1-4)-(alpha-D-glucopyranose), Cyclomaltodextrinase, ...
Authors:Buedenbender, S, Schulz, G.E.
Deposit date:2008-09-03
Release date:2009-03-03
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural base for enzymatic cyclodextrin hydrolysis
J.Mol.Biol., 385, 2009
3EDK
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BU of 3edk by Molmil
Structural base for cyclodextrin hydrolysis
Descriptor: CALCIUM ION, Cyclomaltodextrinase, Cyclooctakis-(1-4)-(alpha-D-glucopyranose), ...
Authors:Buedenbender, S, Schulz, G.E.
Deposit date:2008-09-03
Release date:2009-03-03
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structural base for enzymatic cyclodextrin hydrolysis
J.Mol.Biol., 385, 2009
3EDD
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BU of 3edd by Molmil
Structural base for cyclodextrin hydrolysis
Descriptor: CALCIUM ION, Cyclohexakis-(1-4)-(alpha-D-glucopyranose), Cyclomaltodextrinase
Authors:Buedenbender, S, Schulz, G.E.
Deposit date:2008-09-03
Release date:2009-03-03
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural base for enzymatic cyclodextrin hydrolysis
J.Mol.Biol., 385, 2009
3EDE
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BU of 3ede by Molmil
Structural base for cyclodextrin hydrolysis
Descriptor: CALCIUM ION, Cyclomaltodextrinase, GLYCEROL
Authors:Buedenbender, S, Schulz, G.E.
Deposit date:2008-09-03
Release date:2009-03-03
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Structural base for enzymatic cyclodextrin hydrolysis
J.Mol.Biol., 385, 2009
3EDF
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BU of 3edf by Molmil
Structural base for cyclodextrin hydrolysis
Descriptor: CALCIUM ION, Cyclohexakis-(1-4)-(alpha-D-glucopyranose), Cyclomaltodextrinase, ...
Authors:Buedenbender, S, Schulz, G.E.
Deposit date:2008-09-03
Release date:2009-03-03
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural base for enzymatic cyclodextrin hydrolysis
J.Mol.Biol., 385, 2009
5FED
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BU of 5fed by Molmil
EGFR kinase domain in complex with a covalent aminobenzimidazole inhibitor.
Descriptor: Epidermal growth factor receptor, ~{N}-[7-methyl-1-[(3~{R})-1-propanoylazepan-3-yl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Authors:DiDonato, M, Spraggon, G.
Deposit date:2015-12-16
Release date:2016-07-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.651 Å)
Cite:Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers.
J.Med.Chem., 59, 2016
5FEE
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BU of 5fee by Molmil
EGFR kinase domain T790M mutant in complex with a covalent aminobenzimidazole inhibitor.
Descriptor: Epidermal growth factor receptor, ~{N}-[7-methyl-1-[(3~{R})-1-propanoylazepan-3-yl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Authors:DiDonato, M, Spraggon, G.
Deposit date:2015-12-16
Release date:2016-07-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers.
J.Med.Chem., 59, 2016
2XP2
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BU of 2xp2 by Molmil
Structure of the Human Anaplastic Lymphoma Kinase in Complex with Crizotinib (PF-02341066)
Descriptor: 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine, TYROSINE-PROTEIN KINASE RECEPTOR
Authors:McTigue, M, Deng, Y, Liu, W, Brooun, A, Timofeevski, S, Marrone, T, Cui, J.J.
Deposit date:2010-08-24
Release date:2010-09-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure Based Drug Design of Crizotinib (Pf-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal-Epithelial Transition Factor (C-met) Kinase and Anaplastic Lymphoma Kinase (Alk).
J.Med.Chem, 54, 2011
2WGJ
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BU of 2wgj by Molmil
X-ray Structure of PF-02341066 bound to the kinase domain of c-Met
Descriptor: 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine, HEPATOCYTE GROWTH FACTOR RECEPTOR
Authors:McTigue, M, Grodsky, N, Ryan, K, Tran-Dube, M, Cui, J.J, Mroczkowski, B.
Deposit date:2009-04-20
Release date:2009-06-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure Based Drug Design of Crizotinib (Pf-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal-Epithelial Transition Factor (C-met) Kinase and Anaplastic Lymphoma Kinase (Alk).
J.Med.Chem, 54, 2011
2WKM
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BU of 2wkm by Molmil
X-ray Structure of PHA-00665752 bound to the kinase domain of c-Met
Descriptor: (3Z)-5-[(2,6-DICHLOROBENZYL)SULFONYL]-3-[(3,5-DIMETHYL-4-{[(2S)-2-(PYRROLIDIN-1-YLMETHYL)PYRROLIDIN-1-YL]CARBONYL}-1H-PYRROL-2-YL)METHYLIDENE]-1,3-DIHYDRO-2H-INDOL-2-ONE, HEPATOCYTE GROWTH FACTOR RECEPTOR
Authors:McTigue, M, Grodsky, N, Ryan, K, Cui, J.J.
Deposit date:2009-06-15
Release date:2010-08-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure Based Drug Design of Crizotinib (Pf-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal-Epithelial Transition Factor (C-met) Kinase and Anaplastic Lymphoma Kinase (Alk).
J.Med.Chem, 54, 2011
6WYS
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BU of 6wys by Molmil
Lon protease proteolytic domain
Descriptor: Lon protease homolog, mitochondrial, SULFATE ION
Authors:Lee, C.C, Spraggon, G.
Deposit date:2020-05-13
Release date:2021-04-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.229 Å)
Cite:Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology.
J.Med.Chem., 64, 2021
6WZV
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BU of 6wzv by Molmil
Lon protease proteolytic domain
Descriptor: Lon protease homolog, mitochondrial, N-[(1R)-1-borono-3-methylbutyl]-Nalpha-(pyrazine-2-carbonyl)-D-phenylalaninamide, ...
Authors:Lee, C.C, Spraggon, G.
Deposit date:2020-05-14
Release date:2021-04-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology.
J.Med.Chem., 64, 2021
6X27
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BU of 6x27 by Molmil
Lon protease proteolytic domain complexed with bortezomib
Descriptor: GLYCEROL, Lon protease homolog, mitochondrial, ...
Authors:Lee, C.C, Spraggon, G.
Deposit date:2020-05-20
Release date:2021-04-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology.
J.Med.Chem., 64, 2021
6X1M
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BU of 6x1m by Molmil
Lon protease proteolytic domain complexed with covalent boronic acid inhibitor
Descriptor: Lon protease homolog, mitochondrial, [(1R)-4-phenyl-1-{[N-(pyrazine-2-carbonyl)-D-norvalyl]amino}butyl]boronic acid
Authors:Lee, C.C, Spraggon, G.
Deposit date:2020-05-19
Release date:2021-04-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.51 Å)
Cite:Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology.
J.Med.Chem., 64, 2021
5FEQ
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BU of 5feq by Molmil
EGFR KINASE DOMAIN IN COMPLEX WITH A COVALENT AMINOBENZIMIDAZOLE
Descriptor: Epidermal growth factor receptor, ~{N}-[1-[(3~{R})-1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-benzimidazol-2-yl]-2-methyl-pyridine-4-carboxamide
Authors:DiDonato, M, Spraggon, G.
Deposit date:2015-12-17
Release date:2016-07-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers.
J.Med.Chem., 59, 2016
5D41
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BU of 5d41 by Molmil
EGFR kinase domain in complex with mutant selective allosteric inhibitor
Descriptor: (2R)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2-phenyl-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ...
Authors:Yun, C.-H, Park, E, Eck, M.J.
Deposit date:2015-08-07
Release date:2016-06-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors.
Nature, 534, 2016
4AG8
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BU of 4ag8 by Molmil
CRYSTAL STRUCTURE OF THE VEGFR2 KINASE DOMAIN IN COMPLEX WITH AXITINIB (AG-013736) (N-Methyl-2-(3-((E)-2-pyridin-2-yl-vinyl)-1H- indazol-6-ylsulfanyl)-benzamide)
Descriptor: AXITINIB, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
Authors:McTigue, M, Wickersham, J, Pinko, C, Kania, R.S, Bender, S.
Deposit date:2012-01-24
Release date:2012-09-26
Last modified:2024-08-07
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Molecular Conformations, Interactions, and Properties Associated with Drug Efficiency and Clinical Performance Among Vegfr Tk Inhibitors.
Proc.Natl.Acad.Sci.USA, 109, 2012

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