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2E4U
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR REGION OF THE GROUP II METABOTROPIC GLUTAMATE RECEPTOR COMPLEXED WITH L-GLUTAMATE
Descriptor:Metabotropic glutamate receptor 3, N-ACETYL-D-GLUCOSAMINE, GLUTAMIC ACID
Authors:Muto, T., Tsuchiya, D., Morikawa, K., Jingami, H.
Deposit date:2006-12-17
Release date:2007-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E4V
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR REGION OF THE GROUP II METABOTROPIC GLUTAMATE RECEPTOR COMPLEXED WITH DCG-IV
Descriptor:Metabotropic glutamate receptor 3, N-ACETYL-D-GLUCOSAMINE, (1R,2R)-3-[(S)-amino(carboxy)methyl]cyclopropane-1,2-dicarboxylic acid
Authors:Muto, T., Tsuchiya, D., Morikawa, K., Jingami, H.
Deposit date:2006-12-17
Release date:2007-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E4W
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR REGION OF THE GROUP II METABOTROPIC GLUTAMATE RECEPTOR COMPLEXED WITH 1S,3S-ACPD
Descriptor:Metabotropic glutamate receptor 3, N-ACETYL-D-GLUCOSAMINE, (1S,3S)-1-aminocyclopentane-1,3-dicarboxylic acid
Authors:Muto, T., Tsuchiya, D., Morikawa, K., Jingami, H.
Deposit date:2006-12-17
Release date:2007-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E4X
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR REGION OF THE GROUP II METABOTROPIC GLUTAMATE RECEPTOR COMPLEXED WITH 1S,3R-ACPD
Descriptor:Metabotropic glutamate receptor 3, N-ACETYL-D-GLUCOSAMINE, (1S,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID
Authors:Muto, T., Tsuchiya, D., Morikawa, K., Jingami, H.
Deposit date:2006-12-17
Release date:2007-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E4Y
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR REGION OF THE GROUP II METABOTROPIC GLUTAMATE RECEPTOR COMPLEXED WITH 2R,4R-APDC
Descriptor:Metabotropic glutamate receptor 3, N-ACETYL-D-GLUCOSAMINE, (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid
Authors:Muto, T., Tsuchiya, D., Morikawa, K., Jingami, H.
Deposit date:2006-12-17
Release date:2007-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E4Z
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CRYSTAL STRUCTURE OF THE LIGAND-BINDING REGION OF THE GROUP III METABOTROPIC GLUTAMATE RECEPTOR
Descriptor:Metabotropic glutamate receptor 7, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Muto, T., Tsuchiya, D., Morikawa, K., Jingami, H.
Deposit date:2006-12-17
Release date:2007-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Proc.Natl.Acad.Sci.Usa, 104, 2007
2EGK
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CRYSTAL STRUCTURE OF TAMALIN PDZ-INTRINSIC LIGAND FUSION PROTEIN
Descriptor:General receptor for phosphoinositides 1-associated scaffold protein, PHOSPHATE ION
Authors:Sugi, T., Oyama, T., Muto, T., Nakanishi, S., Morikawa, K., Jingami, H.
Deposit date:2007-03-01
Release date:2007-05-08
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation
Embo J., 26, 2007
2EGN
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CRYSTAL STRUCTURE OF TAMALIN PDZ DOMAIN IN COMPLEX WITH MGLUR5 C-TERMINAL PEPTIDE
Descriptor:General receptor for phosphoinositides 1-associated scaffold protein, mGluR5 C-terminal peptide
Authors:Sugi, T., Oyama, T., Muto, T., Nakanishi, S., Morikawa, K., Jingami, H.
Deposit date:2007-03-01
Release date:2007-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation
Embo J., 26, 2007
2EGO
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CRYSTAL STRUCTURE OF TAMALIN PDZ DOMAIN
Descriptor:General receptor for phosphoinositides 1-associated scaffold protein
Authors:Sugi, T., Oyama, T., Muto, T., Nakanishi, S., Morikawa, K., Jingami, H.
Deposit date:2007-03-01
Release date:2007-05-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation
Embo J., 26, 2007
2ZVT
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CYS285SER MUTANT PPARGAMMA LIGAND-BINDING DOMAIN COMPLEXED WITH 15-DEOXY-DELTA12,14-PROSTAGLANDIN J2
Descriptor:Peroxisome proliferator-activated receptor gamma, (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid
Authors:Waku, T., Oyama, T., Shiraki, T., Morikawa, K.
Deposit date:2008-11-19
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Atomic structure of mutant PPARgamma LBD complexed with 15d-PGJ2: novel modulation mechanism of PPARgamma/RXRalpha function by covalently bound ligands
Febs Lett., 583, 2009
3AN3
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HUMAN PPAR GAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH A GAMMA SELECTIVE AGONIST MO3S
Descriptor:Peroxisome proliferator-activated receptor gamma, (2S)-2-benzyl-3-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}phenyl)propanoic acid
Authors:Oyama, T., Ohashi, M., Waku, T., Miyachi, H., Morikawa, K.
Deposit date:2010-08-30
Release date:2011-07-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design, Synthesis, and Structural Analysis of Phenylpropanoic Acid-Type PPAR gamma-Selective Agonists: Discovery of Reversed Stereochemistry-Activity Relationship
J.Med.Chem., 54, 2011
3AN4
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HUMAN PPAR GAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH A GAMMA SELECTIVE AGONIST MO4R
Descriptor:Peroxisome proliferator-activated receptor gamma, (2R)-2-benzyl-3-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}phenyl)propanoic acid
Authors:Oyama, T., Ohashi, M., Waku, T., Miyachi, H., Morikawa, K.
Deposit date:2010-08-30
Release date:2011-07-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design, Synthesis, and Structural Analysis of Phenylpropanoic Acid-Type PPAR gamma-Selective Agonists: Discovery of Reversed Stereochemistry-Activity Relationship
J.Med.Chem., 54, 2011
3VSP
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HUMAN PPAR GAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH A GAMMA SELECTIVE AGONIST MEKT28
Descriptor:Peroxisome proliferator-activated receptor gamma, (2R)-2-benzyl-3-[3-({[4-(piperidin-1-yl)benzoyl]amino}methyl)-4-propoxyphenyl]propanoic acid
Authors:Oyama, T., Waku, T., Ohashi, M., Morikawa, K., Miyachi, H.
Deposit date:2012-04-30
Release date:2013-05-01
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Human PPAR gamma ligand binding domain in complex with a gamma selective agonist mekt28
To be Published
3W0K
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CRYSTAL STRUCTURE OF A GLYCOSIDE HYDROLASE
Descriptor:Bifunctional endomannanase/endoglucanase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Oyama, T., Nakamura, H., Morikawa, K., Cann, I.K.O.
Deposit date:2012-10-31
Release date:2013-02-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of a glycoside hydrolase
To be Published
4Z2M
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CRYSTAL STRUCTURE OF HUMAN SPT16 MID-AID/H3-H4 TETRAMER FACT HISTONE COMPLEX
Descriptor:FACT complex subunit SPT16, Histone H3.1, Histone H4
Authors:Tsunaka, Y., Fujiwara, Y., Oyama, T., Hirose, S., Morikawa, K.
Deposit date:2015-03-30
Release date:2016-03-09
Last modified:2016-03-30
Method:X-RAY DIFFRACTION (2.981 Å)
Cite:Integrated molecular mechanism directing nucleosome reorganization by human FACT.
Genes Dev., 30, 2016
4Z2N
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CRYSTAL STRUCTURE OF HUMAN FACT SPT16 MIDDLE DOMAIN
Descriptor:FACT complex subunit SPT16
Authors:Tsunaka, Y., Fujiwara, Y., Oyama, T., Hirose, S., Morikawa, K.
Deposit date:2015-03-30
Release date:2016-03-09
Last modified:2016-03-30
Method:X-RAY DIFFRACTION (1.923 Å)
Cite:Integrated molecular mechanism directing nucleosome reorganization by human FACT.
Genes Dev., 30, 2016
2DQT
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HIGH RESOLUTION CRYSTAL STRUCTURE OF THE COMPLEX OF THE HYDROLYTIC ANTIBODY FAB 6D9 AND A TRANSITION-STATE ANALOG
Descriptor:IMMUNOGLOBULIN 6D9, [1-(3-DIMETHYLAMINO-PROPYL)-3-ETHYL-UREIDO]-[4-(2,2,2-TRIFLUORO-ACETYLAMINO)-BENZYL]PHOSPHINIC ACID-2-(2,2-DIHYDRO-ACETYLAMINO)-3-HYDROXY-1-(4-NITROPHENYL)-PROPYL ESTER
Authors:Kristensen, O., Vassylyev, D.G., Tanaka, F., Ito, N., Morikawa, K., Fujii, I.
Deposit date:2006-05-30
Release date:2006-06-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Thermodynamic and structural basis for transition-state stabilization in antibody-catalyzed hydrolysis
J.Mol.Biol., 369, 2007
2DQU
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CRYSTAL FORM II: HIGH RESOLUTION CRYSTAL STRUCTURE OF THE COMPLEX OF THE HYDROLYTIC ANTIBODY FAB 6D9 AND A TRANSITION-STATE ANALOG
Descriptor:IMMUNOGLOBULIN 6D9, [1-(3-DIMETHYLAMINO-PROPYL)-3-ETHYL-UREIDO]-[4-(2,2,2-TRIFLUORO-ACETYLAMINO)-BENZYL]PHOSPHINIC ACID-2-(2,2-DIHYDRO-ACETYLAMINO)-3-HYDROXY-1-(4-NITROPHENYL)-PROPYL ESTER
Authors:Kristensen, O., Vassylyev, D.G., Tanaka, F., Ito, N., Morikawa, K., Fujii, I.
Deposit date:2006-05-30
Release date:2006-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Thermodynamic and structural basis for transition-state stabilization in antibody-catalyzed hydrolysis
J.Mol.Biol., 369, 2007
1IO2
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CRYSTAL STRUCTURE OF TYPE 2 RIBONUCLEASE H FROM HYPERTHERMOPHILIC ARCHAEON, THERMOCOCCUS KODAKARAENSIS KOD1
Descriptor:RIBONUCLEASE HII
Authors:Muroya, A., Tsuchiya, D., Ishikawa, M., Haruki, M., Morikawa, M.
Deposit date:2000-12-28
Release date:2001-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Catalytic center of an archaeal type 2 ribonuclease H as revealed by X-ray crystallographic and mutational analyses.
Protein Sci., 10, 2001
1LHM
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THE CRYSTAL STRUCTURE OF A MUTANT LYSOZYME C77(SLASH)95A WITH INCREASED SECRETION EFFICIENCY IN YEAST
Descriptor:HUMAN LYSOZYME
Authors:Inaka, K., Matsushima, M.
Deposit date:1991-10-02
Release date:1992-04-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The crystal structure of a mutant human lysozyme C77/95A with increased secretion efficiency in yeast.
J.Biol.Chem., 266, 1991
2D5K
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CRYSTAL STRUCTURE OF DPS FROM STAPHYLOCOCCUS AUREUS
Descriptor:Dps family protein, GLYCEROL
Authors:Tanaka, Y., Yao, M., Watanabe, N., Tanaka, I.
Deposit date:2005-11-02
Release date:2006-10-17
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Nucleoid compaction by MrgA(Asp56Ala/Glu60Ala) does not contribute to staphylococcal cell survival against oxidative stress and phagocytic killing by macrophages
FEMS Microbiol. Lett., 360, 2014
3VI8
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HUMAN PPAR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH A SYNTHETIC AGONIST APHM13
Descriptor:Peroxisome proliferator-activated receptor alpha, (2S)-2-(4-methoxy-3-{[(pyren-1-ylcarbonyl)amino]methyl}benzyl)butanoic acid
Authors:Oyama, T., Miyachi, H., Morikawa, K.
Deposit date:2011-09-25
Release date:2012-08-29
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype
J.Med.Chem., 55, 2012
2BQA
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CONTRIBUTION OF HYDROPHOBIC EFFECT TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
Descriptor:LYSOZYME, SODIUM ION
Authors:Takano, K., Yamagata, Y., Yutani, K.
Deposit date:1998-05-21
Release date:1998-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A general rule for the relationship between hydrophobic effect and conformational stability of a protein: stability and structure of a series of hydrophobic mutants of human lysozyme.
J.Mol.Biol., 280, 1998
2BQB
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CONTRIBUTION OF HYDROPHOBIC EFFECT TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
Descriptor:LYSOZYME, SODIUM ION
Authors:Takano, K., Yamagata, Y., Yutani, K.
Deposit date:1998-05-21
Release date:1998-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A general rule for the relationship between hydrophobic effect and conformational stability of a protein: stability and structure of a series of hydrophobic mutants of human lysozyme.
J.Mol.Biol., 280, 1998
2BQC
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CONTRIBUTION OF HYDROPHOBIC EFFECT TO THE CONFORMATIONAL STABILITY OF HUMAN LYSOZYME
Descriptor:LYSOZYME, SODIUM ION
Authors:Takano, K., Yamagata, Y., Yutani, K.
Deposit date:1998-05-21
Release date:1998-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A general rule for the relationship between hydrophobic effect and conformational stability of a protein: stability and structure of a series of hydrophobic mutants of human lysozyme.
J.Mol.Biol., 280, 1998