Author results

5EIQ
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HUMAN OSCAR LIGAND-BINDING DOMAIN
Descriptor:Osteoclast-associated immunoglobulin-like receptor
Authors:Hinerman, J.M., Conrady, D.G., Herr, A.B.
Deposit date:2015-10-30
Release date:2015-11-25
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structural basis for collagen recognition by the immune receptor OSCAR.
Blood, 127, 2016
3WSQ
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STRUCTURE OF HER2 WITH AN FAB
Descriptor:Receptor tyrosine-protein kinase erbB-2, Antibody Light Chain, Antibody Heavy Chain
Authors:Fu, W.Y., Wang, Y.X., Zhou, L.J.
Deposit date:2014-03-20
Release date:2015-03-25
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Insights into HER2 signaling from step-by-step optimization of anti-HER2 antibodies.
MAbs, 6, 2014
3WY7
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CRYSTAL STRUCTURE OF MYCOBACTERIUM SMEGMATIS 7-KETO-8-AMINOPELARGONIC ACID (KAPA) SYNTHASE BIOF
Descriptor:8-amino-7-oxononanoate synthase
Authors:Fan, S.H., Li, D.F., Wang, D.C., Chen, G.J., Zhang, X.E., Bi, L.J.
Deposit date:2014-08-20
Release date:2014-12-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and function of Mycobacterium smegmatis 7-keto-8-aminopelargonic acid (KAPA) synthase
Int.J.Biochem.Cell Biol., 58C, 2014
5HSM
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MARR FAMILY PROTEIN RV2887
Descriptor:Uncharacterized HTH-type transcriptional regulator Rv2887, SULFATE ION
Authors:Gao, Y.R., Li, D.F., Wang, D.C., Bi, L.J.
Deposit date:2016-01-26
Release date:2017-02-01
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis
Sci Rep, 7, 2017
5HSO
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MARR FAMILY PROTEIN RV2887 COMPLEX WITH DNA
Descriptor:Uncharacterized HTH-type transcriptional regulator Rv2887, DNA (30-MER), the upstream sequence of Rv0560c
Authors:Gao, Y.R., Li, D.F., Wang, D.C., Bi, L.J.
Deposit date:2016-01-26
Release date:2017-02-01
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis
Sci Rep, 7, 2017
5X7Z
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MARR FAMILY PROTEIN RV2887 COMPLEX WITH P-AMINOSALICYLIC ACID
Descriptor:Uncharacterized HTH-type transcriptional regulator Rv2887, 2-HYDROXY-4-AMINOBENZOIC ACID
Authors:Gao, Y.R., Li, D.F., Wang, D.C., Bi, L.J.
Deposit date:2017-02-28
Release date:2017-08-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis
Sci Rep, 7, 2017
5X80
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MARR FAMILY PROTEIN RV2887 COMPLEX WITH SALICYLIC ACID
Descriptor:Uncharacterized HTH-type transcriptional regulator Rv2887, 2-HYDROXYBENZOIC ACID, SULFATE ION
Authors:Gao, Y.R., Li, D.F., Wang, D.C., Bi, L.J.
Deposit date:2017-02-28
Release date:2017-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis
Sci Rep, 7, 2017
5YF4
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A KINASE COMPLEX MST4-MOB4
Descriptor:MOB-like protein phocein, Peptide from Serine/threonine-protein kinase 26, ZINC ION
Authors:Chen, M., Zhou, Z.C.
Deposit date:2017-09-20
Release date:2018-08-15
Last modified:2018-09-26
Method:X-RAY DIFFRACTION (1.897 Å)
Cite:The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer.
J. Biol. Chem., 293, 2018
6AKM
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CRYSTAL STRUCTURE OF SLMAP-SIKE1 COMPLEX
Descriptor:Suppressor of IKBKE 1, Sarcolemmal membrane-associated protein, GLYCEROL
Authors:Ma, J., Chen, M., Zhou, Z.C.
Deposit date:2018-09-02
Release date:2019-01-16
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling.
Cell Discov, 5, 2019
3QAE
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3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE OF STREPTOCOCCUS PNEUMONIAE
Descriptor:3-hydroxy-3-methylglutaryl-coenzyme a reductase, CITRIC ACID, GLYCEROL, ...
Authors:Zhang, L., Feng, L., Zhou, L., Gui, J., Wan, J.
Deposit date:2011-01-10
Release date:2011-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:3-hydroxy-3-methylglutaryl-coenzyme A reductase of Streptococcus pneumoniae
To be Published
3QAU
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3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:3-hydroxy-3-methylglutaryl-coenzyme a reductase, GLYCEROL, SULFATE ION, ...
Authors:Zhang, L., Feng, L., Zhou, L., Gui, J., Wan, J.
Deposit date:2011-01-11
Release date:2011-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:3-Hydroxy-3-MethylGlutaryl-Coenzyme A Reductase from Streptococcus pneumoniae
To be Published
3N9L
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CEKDM7A FROM C.ELEGANS, COMPLEX WITH H3K4ME3 PEPTIDE AND NOG
Descriptor:Putative uncharacterized protein, Histone H3 peptide, FE (II) ION, ...
Authors:Yang, Y., Hu, L., Wang, P., Hou, H., Chen, C.D., Xu, Y.
Deposit date:2010-05-31
Release date:2010-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.796 Å)
Cite:Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Cell Res., 20, 2010
3N9M
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CEKDM7A FROM C.ELEGANS, ALONE
Descriptor:Putative uncharacterized protein, FE (II) ION, ZINC ION
Authors:Yang, Y., Hu, L., Wang, P., Hou, H., Chen, C.D., Xu, Y.
Deposit date:2010-05-31
Release date:2010-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.493 Å)
Cite:Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Cell Res., 20, 2010
3N9N
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CEKDM7A FROM C.ELEGANS, COMPLEX WITH H3K4ME3K9ME2 PEPTIDE AND NOG
Descriptor:Putative uncharacterized protein, Histone H3 peptide, FE (II) ION, ...
Authors:Yang, Y., Hu, L., Wang, P., Hou, H., Chen, C.D., Xu, Y.
Deposit date:2010-05-31
Release date:2010-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.299 Å)
Cite:Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Cell Res., 20, 2010
3N9O
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CEKDM7A FROM C.ELEGANS, COMPLEX WITH H3K4ME3 PEPTIDE, H3K9ME2 PEPTIDE AND NOG
Descriptor:Putative uncharacterized protein, Histone H3 peptide, FE (II) ION, ...
Authors:Yang, Y., Hu, L., Wang, P., Hou, H., Chen, C.D., Xu, Y.
Deposit date:2010-05-31
Release date:2010-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.309 Å)
Cite:Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Cell Res., 20, 2010
3N9P
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CEKDM7A FROM C.ELEGANS, COMPLEX WITH H3K4ME3K27ME2 PEPTIDE AND NOG
Descriptor:Putative uncharacterized protein, Histone H3 peptide, FE (II) ION, ...
Authors:Yang, Y., Hu, L., Wang, P., Hou, H., Chen, C.D., Xu, Y.
Deposit date:2010-05-31
Release date:2010-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.388 Å)
Cite:Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Cell Res., 20, 2010
3N9Q
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CEKDM7A FROM C.ELEGANS, COMPLEX WITH H3K4ME3 PEPTIDE, H3K27ME2 PEPTIDE AND NOG
Descriptor:Putative uncharacterized protein, Histone H3 peptide, FE (II) ION, ...
Authors:Yang, Y., Hu, L., Wang, P., Hou, H., Chen, C.D., Xu, Y.
Deposit date:2010-05-31
Release date:2010-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Cell Res., 20, 2010
4HJK
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U7UB7 DISULFIDE VARIANT
Descriptor:Ubiquitin, PHOSPHATE ION
Authors:Murray, J.M., Rouge, L.
Deposit date:2012-10-12
Release date:2012-11-21
Method:X-RAY DIFFRACTION (1.784 Å)
Cite:Potent and selective inhibitors of USP7/HAUSP activity by protein conformational stabilization
to be published
4HK2
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U7UB25.2540
Descriptor:Ubiquitin, SULFATE ION
Authors:Murray, J.M., Rouge, L.
Deposit date:2012-10-14
Release date:2012-11-21
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Potent and selective inhibitors of USP7/HAUSP activity by protein conformational stabilization
to be published
4QBA
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CRYSTAL STRUCTURE OF THE EFFECTOR-BINDING DOMAIN OF S. AUREUS CCPE
Descriptor:LysR family regulatory protein, CHLORIDE ION
Authors:Liu, X., Lan, L., Yang, C.G.
Deposit date:2014-05-06
Release date:2014-11-19
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Metabolic sensor governing bacterial virulence in Staphylococcus aureus.
Proc.Natl.Acad.Sci.USA, 2014
5YP5
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CRYSTAL STRUCTURE OF RORGAMMA COMPLEXED WITH SRC2 AND COMPOUND 5D
Descriptor:Nuclear receptor ROR-gamma, SRC2-2 peptide, 2-[4-(ethylsulfonyl)phenyl]-N-{5-[2-(2-methylpropyl)benzoyl]-4-phenyl-1,3-thiazol-2-yl}acetamide
Authors:Gao, M., Cai, W., Chunwa, C.
Deposit date:2017-11-01
Release date:2018-04-04
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:From ROR gamma t Agonist to Two Types of ROR gamma t Inverse Agonists
ACS Med Chem Lett, 9, 2018
5YP6
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RORGAMMA (263-509) COMPLEXED WITH SRC2 AND COMPOUND 6
Descriptor:Nuclear receptor ROR-gamma, SRC2, N-[3'-cyano-4'-(2-methylpropyl)-2-(trifluoromethyl)biphenyl-4-yl]-2-[4-(ethylsulfonyl)phenyl]acetamide
Authors:Gao, M., Cai, W.
Deposit date:2017-11-01
Release date:2018-02-07
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:From ROR gamma t Agonist to Two Types of ROR gamma t Inverse Agonists
ACS Med Chem Lett, 9, 2018
4NIE
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CRYSTAL STRUCTURE OF THE ORPHAN NUCLEAR RECEPTOR ROR(GAMMA)T LIGAND-BINDING DOMAIN IN COMPLEX WITH SMALL MOLECULE LIGAND
Descriptor:Nuclear receptor ROR-gamma, Peptide from Nuclear receptor coactivator 2, N-(4-{[benzyl(propyl)amino]methyl}phenyl)-2-[4-(ethylsulfonyl)phenyl]acetamide, ...
Authors:Ma, Y.L., Yang, L.Q.
Deposit date:2013-11-06
Release date:2013-12-11
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Discovery of Tertiary Amine and Indole Derivatives as Potent ROR-gamma-t Inverse Agonists
ACS MED.CHEM.LETT., 2013
4O1V
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SPOP PROMOTES TUMORIGENESIS BY ACTING AS A KEY REGULATORY HUB IN KIDNEY CANCER
Descriptor:Speckle-type POZ protein, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Authors:Calabrese, M.F., Watson, E.R., Schulman, B.A.
Deposit date:2013-12-16
Release date:2014-04-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer.
Cancer Cell, 25, 2014
4XT9
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RORGAMMA (263-509) COMPLEXED WITH GSK2435341A AND SRC2
Descriptor:Nuclear receptor ROR-gamma, LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN, N-[4-(2,5-dichlorophenyl)-5-phenyl-1,3-thiazol-2-yl]-2-[4-(ethylsulfonyl)phenyl]acetamide, ...
Authors:Wang, Y., Ma, Y.
Deposit date:2015-01-23
Release date:2015-08-12
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent ROR gamma t inverse agonists
Bioorg.Med.Chem., 23, 2015