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4L2Z
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CRYSTAL STRUCTURE OF S-ADENOSYLMETHIONINE SYNTHETASE FROM SULFOLOBUS SOLFATARICUS COMPLEXED WITH SAE AND PPI
Descriptor:S-adenosylmethionine synthase, MAGNESIUM ION, [(3S)-3-amino-3-carboxypropyl]{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}ethylsulfonium, ...
Authors:Wang, F., Hurley, K.A., Helmich, K.E., Singh, S., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2013-06-05
Release date:2013-06-19
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.494 Å)
Cite:Understanding molecular recognition of promiscuity of thermophilic methionine adenosyltransferase sMAT from Sulfolobus solfataricus.
Febs J., 281, 2014
4L7I
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CRYSTAL STRUCTURE OF S-ADENOSYLMETHIONINE SYNTHASE FROM SULFOLOBUS SOLFATARICUS COMPLEXED WITH SAM AND PPI
Descriptor:S-adenosylmethionine synthase, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Wang, F., Hurley, K.A., Helmich, K.E., Singh, S., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2013-06-13
Release date:2013-07-03
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.189 Å)
Cite:Understanding molecular recognition of promiscuity of thermophilic methionine adenosyltransferase sMAT from Sulfolobus solfataricus.
Febs J., 281, 2014
4MV2
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CRYSTAL STRUCTURE OF PLU4264 PROTEIN FROM PHOTORHABDUS LUMINESCENS
Descriptor:plu4264, NICKEL (II) ION, SODIUM ION
Authors:Michalska, K., Li, H., Jedrzejczak, R., Babnigg, G., Bingman, C.A., Yennamalli, R., Weerth, S., Thomas, M.G., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2013-09-23
Release date:2013-10-02
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (1.349 Å)
Cite:Structure of a cupin protein Plu4264 from Photorhabdus luminescens subsp. laumondii TTO1 at 1.35 angstrom resolution.
Proteins, 83, 2015
4NEO
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STRUCTURE OF BLMI, A TYPE-II ACYL-CARRIER-PROTEIN FROM STREPTOMYCES VERTICILLUS INVOLVED IN BLEOMYCIN BIOSYNTHESIS
Descriptor:Peptide synthetase NRPS type II-PCP, 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL
Authors:Cuff, M.E., Bigelow, L., Bearden, J., Babnigg, G., Bruno, C.J.P., Bingman, C., Yennamalli, R., Lohman, J., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG)
Deposit date:2013-10-29
Release date:2014-01-29
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins.
Proteins, 82, 2014
4NI3
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CRYSTAL STRUCTURE OF GH29 FAMILY ALPHA-L-FUCOSIDASE FROM FUSARIUM GRAMINEARUM IN THE CLOSED FORM
Descriptor:Alpha-fucosidase GH29, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Cao, H., Walton, J.D., Brumm, P., Phillips Jr., G.N.
Deposit date:2013-11-05
Release date:2013-12-25
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (1.3993 Å)
Cite:Structure and Substrate Specificity of a Eukaryotic Fucosidase from Fusarium graminearum.
J.Biol.Chem., 289, 2014
4OO2
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STREPTOMYCES GLOBISPORUS C-1027 FAD DEPENDENT (S)-3-CHLORO-β-TYROSINE-S-SGCC2 C-5 HYDROXYLASE SGCC APO FORM
Descriptor:Chlorophenol-4-monooxygenase, CALCIUM ION, GLYCEROL
Authors:Cao, H., Xu, W., Bingman, C., Lohman, J.R., Yennamalli, R., Shen, B., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2014-01-29
Release date:2014-02-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.
Biochemistry, 55, 2016
4OPE
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STREPTOMCYES ALBUS JA3453 OXAZOLOMYCIN KETOSYNTHASE DOMAIN OZMH KS7
Descriptor:NRPS/PKS, NITRATE ION
Authors:Osipiuk, J., Mack, J., Endres, M., Babnigg, G., Bingman, C.A., Yennamalli, R., Lohman, J.R., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2014-02-05
Release date:2014-02-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
4OPF
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STREPTOMCYES ALBUS JA3453 OXAZOLOMYCIN KETOSYNTHASE DOMAIN OZMH KS8
Descriptor:NRPS/PKS
Authors:Osipiuk, J., Bigelow, L., Endres, M., Babnigg, G., Bingman, C.A., Yennamalli, R., Lohman, J.R., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2014-02-05
Release date:2014-02-19
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
4OQJ
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STREPTOMCYES ALBUS JA3453 OXAZOLOMYCIN KETOSYNTHASE DOMAIN OZMQ KS1
Descriptor:PKS, POTASSIUM ION, PHOSPHATE ION, ...
Authors:Nocek, B., Mack, J., Endras, M., Babnigg, G., Bingman, C.A., Yennamalli, R., Lohman, J.R., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2014-02-09
Release date:2014-03-19
Last modified:2016-11-02
Method:X-RAY DIFFRACTION (1.904 Å)
Cite:Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
4OVM
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CRYSTAL STRUCTURE OF SGCJ PROTEIN FROM STREPTOMYCES CARZINOSTATICUS
Descriptor:uncharacterized protein SgcJ
Authors:Chang, C., Bigelow, L., Clancy, S., Bingman, C., Yennamalli, R., Lohman, J.R., Ma, M., Shen, B., Phillips Jr., G.N., Babnigg, G., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2013-11-20
Release date:2013-12-25
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.719 Å)
Cite:Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027.
J.Antibiot., 2016
4PSP
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CRYSTAL STRUCTURE OF GH29 FAMILY ALPHA-L-FUCOSIDASE FROM FUSARIUM GRAMINEARUM IN THE OPEN FORM
Descriptor:Alpha-fucosidase GH29, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Cao, H., Walton, J., Brumm, P., Phillips Jr., G.N.
Deposit date:2014-03-07
Release date:2014-03-19
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.561 Å)
Cite:Structure and Substrate Specificity of a Eukaryotic Fucosidase from Fusarium graminearum.
J.Biol.Chem., 289, 2014
4PSR
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CRYSTAL STRUCTURE OF ALPHA-L-FUCOSIDASE FROM FUSARIUM GRAMINEARUM IN THE OPEN FORM IN COMPLEX WITH L-FUCOSE
Descriptor:Alpha-fucosidase GH29, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Cao, H., Walton, J., Brumm, P., Phillips Jr., G.N.
Deposit date:2014-03-07
Release date:2014-03-19
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Structure and Substrate Specificity of a Eukaryotic Fucosidase from Fusarium graminearum.
J.Biol.Chem., 289, 2014
4PYT
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CRYSTAL STRUCTURE OF A MURB FAMILY EP-UDP-N-ACETYLGLUCOSAMINE REDUCTASE
Descriptor:UDP-N-acetylenolpyruvoylglucosamine reductase, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, ...
Authors:Cao, H., Franz, L., Sen, S., Bingman, C., Auldridge, M., Steinmetz, E., Mead, D., Phillips Jr., G.N.
Deposit date:2014-03-27
Release date:2014-05-21
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.853 Å)
Cite:LucY: A Versatile New Fluorescent Reporter Protein.
Plos One, 10, 2015
4Q29
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ENSEMBLE REFINEMENT OF PLU4264 PROTEIN FROM PHOTORHABDUS LUMINESCENS
Descriptor:plu4264 protein, NICKEL (II) ION, SODIUM ION
Authors:Wang, F., Michalska, K., Li, H., Jedrzejczak, R., Babnigg, G., Bingman, C.A., Yennamalli, R., Weerth, S., Miller, M.D., Thomas, M.G., Joachimiak, A., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG)
Deposit date:2014-04-07
Release date:2014-05-07
Last modified:2015-02-11
Method:X-RAY DIFFRACTION (1.349 Å)
Cite:Structure of a cupin protein Plu4264 from Photorhabdus luminescens subsp. laumondii TTO1 at 1.35 angstrom resolution.
Proteins, 83, 2015
4Q31
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THE CRYSTAL STRUCTURE OF CYSTATHIONE GAMMA LYASE (CALE6) FROM MICROMONOSPORA ECHINOSPORA
Descriptor:cystathione gamma lyase CalE6, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ...
Authors:Tan, K., Bigelow, L., Jedrzejczak, R., Babnigg, G., Bingman, C.A., Yennamalli, R.M., Singh, S., Kharel, M.K., Thorson, J.S., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2014-04-10
Release date:2014-05-07
Last modified:2017-03-08
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Structural dynamics of a methionine gamma-lyase for calicheamicin biosynthesis: Rotation of the conserved tyrosine stacking with pyridoxal phosphate.
Struct Dyn, 3, 2016
4QYR
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STREPTOMYCES PLATENSIS ISOMIGRASTATIN KETOSYNTHASE DOMAIN MGSE KS3
Descriptor:AT-less polyketide synthase, GLYCEROL, ACETIC ACID, ...
Authors:Kim, Y., Li, H., Endres, M., Babnigg, J., Bingman, C.A., Yennamalli, R., Lohman, J.R., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2014-07-25
Release date:2014-08-20
Last modified:2016-12-07
Method:X-RAY DIFFRACTION (2.902 Å)
Cite:Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
4R82
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STREPTOMYCES GLOBISPORUS C-1027 NADH:FAD OXIDOREDUCTASE SGCE6 IN COMPLEX WITH NAD AND FAD FRAGMENTS
Descriptor:Oxidoreductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, CALCIUM ION, ...
Authors:Tan, K., Bigelow, L., Clancy, S., Babnigg, G., Bingman, C.A., Yennamalli, R., Lohman, J.R., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2014-08-29
Release date:2014-10-01
Last modified:2016-11-02
Method:X-RAY DIFFRACTION (1.659 Å)
Cite:Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.
Biochemistry, 55, 2016
4TKT
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STREPTOMYCES PLATENSIS ISOMIGRASTATIN KETOSYNTHASE DOMAIN MGSF KS6
Descriptor:AT-less polyketide synthase, CHLORIDE ION, SULFATE ION, ...
Authors:Chang, C., Li, H., Endres, M., Bingman, C., Yennamalli, R., Lohman, J.R., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2014-05-27
Release date:2014-06-11
Last modified:2016-11-02
Method:X-RAY DIFFRACTION (2.4289 Å)
Cite:Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
4UC4
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CRYSTAL STRUCTURE OF HYBRID TUDOR DOMAIN OF HUMAN LYSINE DEMETHYLASE KDM4B
Descriptor:Lysine-specific demethylase 4B
Authors:Wang, F., Su, Z., Denu, J.M., Phillips Jr., G.N.
Deposit date:2014-08-13
Release date:2016-03-16
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.5612 Å)
Cite:Reader domain specificity and lysine demethylase-4 family function.
Nat Commun, 7, 2016
4W79
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CRYSTAL STRUCTURE OF HUMAN PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE
Descriptor:Protein N-terminal glutamine amidohydrolase, 1,2-ETHANEDIOL, SULFATE ION, ...
Authors:Bitto, E., Bingman, C.A., McCoy, J.G., Wesenberg, G.E., Phillips Jr., G.N., Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2014-08-21
Release date:2014-09-17
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of human protein N-terminal glutamine amidohydrolase, an initial component of the N-end rule pathway.
Plos One, 9, 2014
4WKY
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STREPTOMCYES ALBUS JA3453 OXAZOLOMYCIN KETOSYNTHASE DOMAIN OZMN KS2
Descriptor:Beta-ketoacyl synthase, SULFATE ION, GLYCEROL, ...
Authors:Cuff, M.E., Mack, J.C., Endres, M., Babnigg, G., Bingman, C.A., Yennamalli, R., Lohman, J.R., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2014-10-03
Release date:2014-10-29
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
4XAU
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CRYSTAL STRUCTURE OF ATS13 FROM ACTINOMADURA MELLIAURA
Descriptor:Putative aminotransferase, PYRIDOXAL-5'-PHOSPHATE
Authors:Wang, F., Singh, S., Xu, W., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2014-12-15
Release date:2014-12-24
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (3.0012 Å)
Cite:Structural characterization of AtmS13, a putative sugar aminotransferase involved in indolocarbazole AT2433 aminopentose biosynthesis.
Proteins, 83, 2015
4XRR
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CRYSTAL STRUCTURE OF CALS8 FROM MICROMONOSPORA ECHINOSPORA (P294S MUTANT)
Descriptor:CalS8, GLYCEROL
Authors:Michalska, K., Bigelow, L., Endres, M., Babnigg, G., Bingman, C.A., Yennamalli, R.M., Singh, S., Kharel, M.K., Thorson, J.S., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2015-01-21
Release date:2015-02-11
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural Characterization of CalS8, a TDP-alpha-D-Glucose Dehydrogenase Involved in Calicheamicin Aminodideoxypentose Biosynthesis.
J. Biol. Chem., 290, 2015
4XT0
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CRYSTAL STRUCTURE OF BETA-ETHERASE LIGF FROM SPHINGOBIUM SP. STRAIN SYK-6
Descriptor:Protein LigF, GLUTATHIONE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Helmich, K.E., Bingman, C.A., Donohue, T.J., Phillips Jr., G.N.
Deposit date:2015-01-22
Release date:2016-02-03
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structural Basis of Stereospecificity in the Bacterial Enzymatic Cleavage of beta-Aryl Ether Bonds in Lignin.
J.Biol.Chem., 291, 2016
4ZAH
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CRYSTAL STRUCTURE OF SUGAR AMINOTRANSFERASE WECE WITH EXTERNAL ALDIMINE VII FROM ESCHERICHIA COLI K-12
Descriptor:dTDP-4-amino-4,6-dideoxygalactose transaminase, [[(2R,3S,5R)-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3R,4S,5R,6R)-6-methyl-5-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]-3,4-bis(oxidanyl)oxan-2-yl] hydrogen phosphate
Authors:Wang, F., Singh, S., Cao, H., Xu, W., Miller, M.D., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2015-04-13
Release date:2015-04-29
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Structural Basis for the Stereochemical Control of Amine Installation in Nucleotide Sugar Aminotransferases.
Acs Chem.Biol., 10, 2015