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6V42
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BU of 6v42 by Molmil
Crystal structure of the flavin oxygenase with cofactor bound involved in folate catabolism
Descriptor: FAD/FMN-containing dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Begley, T.P, Adak, S, Zhao, B, Li, P.
Deposit date:2019-11-27
Release date:2020-12-02
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:A novel flavoenzyme catalyzed Baeyer-Villiger type rearrangement in bacterial folic acid catabolic pathway
To Be Published
6V43
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BU of 6v43 by Molmil
Crystal structure of the flavin oxygenase with cofactor and substrate bound involved in folate catabolism
Descriptor: FAD/FMN-containing dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, pteridine-2,4(1H,3H)-dione
Authors:Begley, T.P, Adak, S, Zhao, B, Li, P.
Deposit date:2019-11-27
Release date:2020-12-09
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:A novel flavoenzyme catalyzed Baeyer-Villiger type rearrangement in bacterial folic acid catabolic pathway
To Be Published
6O9A
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BU of 6o9a by Molmil
Crystal structure of MqnA complexed with 3-hydroxybenzoic acid
Descriptor: 3-HYDROXYBENZOIC ACID, ACETATE ION, Chorismate dehydratase
Authors:Hicks, K.A, Mahanta, N, Naseem, S, Fedoseyenko, D, Begley, T.P, Ealick, S.E.
Deposit date:2019-03-13
Release date:2019-04-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.326 Å)
Cite:Menaquinone Biosynthesis: Biochemical and Structural Studies of Chorismate Dehydratase.
Biochemistry, 58, 2019
1C3Q
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BU of 1c3q by Molmil
CRYSTAL STRUCTURE OF NATIVE THIAZOLE KINASE IN THE MONOCLINIC FORM
Descriptor: 2-(4-METHYL-THIAZOL-5-YL)-ETHANOL, CHLORIDE ION, Hydroxyethylthiazole kinase
Authors:Campobasso, N, Mathews, I.I, Begley, T.P, Ealick, S.E.
Deposit date:1999-07-28
Release date:1999-08-09
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of 4-methyl-5-beta-hydroxyethylthiazole kinase from Bacillus subtilis at 1.5 A resolution.
Biochemistry, 39, 2000
3KXP
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BU of 3kxp by Molmil
Crystal Structure of E-2-(Acetamidomethylene)succinate Hydrolase
Descriptor: Alpha-(N-acetylaminomethylene)succinic acid hydrolase, CHLORIDE ION
Authors:McCulloch, K.M, Mukherjee, T, Begley, T.P, Ealick, S.E.
Deposit date:2009-12-03
Release date:2010-02-09
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structure determination and characterization of the vitamin B(6) degradative enzyme (E)-2-(acetamidomethylene)succinate hydrolase.
Biochemistry, 49, 2010
3KU4
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BU of 3ku4 by Molmil
Trapping of an oxocarbenium ion intermediate in UP crystals
Descriptor: SULFATE ION, Uridine phosphorylase
Authors:Paul, D, O'Leary, S, Rajashankar, K, Bu, W, Toms, A, Settembre, E, Sanders, J, Begley, T.P, Ealick, S.E.
Deposit date:2009-11-26
Release date:2010-04-28
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Glycal formation in crystals of uridine phosphorylase.
Biochemistry, 49, 2010
3RP8
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BU of 3rp8 by Molmil
Crystal Structure of Klebsiella pneumoniae R204Q HpxO complexed with FAD
Descriptor: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, flavoprotein monooxygenase
Authors:Hicks, K.A, O'Leary, S.E, Begley, T.P, Ealick, S.E.
Deposit date:2011-04-26
Release date:2012-05-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.968 Å)
Cite:Structural and Mechanistic Studies of HpxO, a Novel Flavin Adenine Dinucleotide-Dependent Urate Oxidase from Klebsiella pneumoniae.
Biochemistry, 52, 2013
1G4P
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BU of 1g4p by Molmil
THIAMIN PHOSPHATE SYNTHASE
Descriptor: 4-AMINO-2-TRIFLUOROMETHYL-5-HYDROXYMETHYLPYRIMIDINE PYROPHOSPHATE, MAGNESIUM ION, THIAMIN PHOSPHATE SYNTHASE
Authors:Peapus, D.H, Chiu, H.-J, Campobasso, N, Reddick, J.J, Begley, T.P, Ealick, S.E.
Deposit date:2000-10-27
Release date:2001-09-26
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural characterization of the enzyme-substrate, enzyme-intermediate, and enzyme-product complexes of thiamin phosphate synthase.
Biochemistry, 40, 2001
1G6C
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BU of 1g6c by Molmil
THIAMIN PHOSPHATE SYNTHASE
Descriptor: 2-TRIFLUOROMETHYL-5-METHYLENE-5H-PYRIMIDIN-4-YLIDENEAMINE, 4-METHYL-5-HYDROXYETHYLTHIAZOLE PHOSPHATE, MAGNESIUM ION, ...
Authors:Peapus, D.H, Chiu, H.-J, Campobasso, N, Reddick, J.J, Begley, T.P, Ealick, S.E.
Deposit date:2000-11-03
Release date:2001-09-26
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural characterization of the enzyme-substrate, enzyme-intermediate, and enzyme-product complexes of thiamin phosphate synthase.
Biochemistry, 40, 2001
1G4T
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BU of 1g4t by Molmil
THIAMIN PHOSPHATE SYNTHASE
Descriptor: 3-(4-AMINO-2-TRIFLUOROMETHYL-PYRIMIDIN-5-YLMETHYL)-4-METHYL-5-(2-PHOSPHONATOOXY-ETHYL)-THIAZOL-3-IUM, MAGNESIUM ION, PYROPHOSPHATE 2-, ...
Authors:Peapus, D.H, Chiu, H.-J, Campobasso, N, Reddick, J.J, Begley, T.P, Ealick, S.E.
Deposit date:2000-10-28
Release date:2001-09-26
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural characterization of the enzyme-substrate, enzyme-intermediate, and enzyme-product complexes of thiamin phosphate synthase.
Biochemistry, 40, 2001
2THI
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BU of 2thi by Molmil
THIAMINASE I FROM BACILLUS THIAMINOLYTICUS
Descriptor: SULFATE ION, THIAMINASE I
Authors:Campobasso, N, Begley, T.P, Ealick, S.E.
Deposit date:1998-09-17
Release date:1999-10-07
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of thiaminase-I from Bacillus thiaminolyticus at 2.0 A resolution.
Biochemistry, 37, 1998
1G69
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BU of 1g69 by Molmil
THIAMIN PHOSPHATE SYNTHASE
Descriptor: 2-METHYL-5-METHYLENE-5H-PYRIMIDIN-4-YLIDENEAMINE, 4-METHYL-5-HYDROXYETHYLTHIAZOLE PHOSPHATE, MAGNESIUM ION, ...
Authors:Peapus, D.H, Chiu, H.-J, Campobasso, N, Reddick, J.J, Begley, T.P, Ealick, S.E.
Deposit date:2000-11-03
Release date:2001-09-26
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural characterization of the enzyme-substrate, enzyme-intermediate, and enzyme-product complexes of thiamin phosphate synthase.
Biochemistry, 40, 2001
1G4E
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BU of 1g4e by Molmil
THIAMIN PHOSPHATE SYNTHASE
Descriptor: THIAMIN PHOSPHATE SYNTHASE
Authors:Peapus, D.H, Chiu, H.-J, Campobasso, N, Reddick, J.J, Begley, T.P, Ealick, S.E.
Deposit date:2000-10-26
Release date:2001-09-26
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural characterization of the enzyme-substrate, enzyme-intermediate, and enzyme-product complexes of thiamin phosphate synthase.
Biochemistry, 40, 2001
1G4S
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BU of 1g4s by Molmil
THIAMIN PHOSPHATE SYNTHASE
Descriptor: MAGNESIUM ION, PYROPHOSPHATE 2-, THIAMIN PHOSPHATE, ...
Authors:Peapus, D.H, Chiu, H.-J, Campobasso, N, Reddick, J.J, Begley, T.P, Ealick, S.E.
Deposit date:2000-10-27
Release date:2001-09-26
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural characterization of the enzyme-substrate, enzyme-intermediate, and enzyme-product complexes of thiamin phosphate synthase.
Biochemistry, 40, 2001
1G67
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BU of 1g67 by Molmil
THIAMIN PHOSPHATE SYNTHASE
Descriptor: 2-METHYL-5-METHYLENE-5H-PYRIMIDIN-4-YLIDENEAMINE, 4-METHYL-5-HYDROXYETHYLTHIAZOLE PHOSPHATE, MAGNESIUM ION, ...
Authors:Peapus, D.H, Chiu, H.-J, Campobasso, N, Reddick, J.J, Begley, T.P, Ealick, S.E.
Deposit date:2000-11-03
Release date:2001-09-26
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural characterization of the enzyme-substrate, enzyme-intermediate, and enzyme-product complexes of thiamin phosphate synthase.
Biochemistry, 40, 2001
2ISS
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BU of 2iss by Molmil
Structure of the PLP synthase Holoenzyme from Thermotoga maritima
Descriptor: Glutamine amidotransferase subunit pdxT, PHOSPHATE ION, Pyridoxal biosynthesis lyase pdxS, ...
Authors:Zein, F, Zhang, Y, Kang, Y.N, Burns, K, Begley, T.P, Ealick, S.E.
Deposit date:2006-10-18
Release date:2007-01-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Insights into the Mechanism of the PLP Synthase Holoenzyme from Thermotoga maritima
Biochemistry, 45, 2006
4N7Q
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BU of 4n7q by Molmil
Crystal structure of eukaryotic THIC from A. thaliana
Descriptor: COBALT (II) ION, HEXANE-1,6-DIOL, Phosphomethylpyrimidine synthase, ...
Authors:Coquille, S.C, Roux, C, Mehta, A, Begley, T.P, Fitzpatrick, T.B, Thore, S.
Deposit date:2013-10-16
Release date:2013-11-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:High-resolution crystal structure of the eukaryotic HMP-P synthase (THIC) from Arabidopsis thaliana.
J.Struct.Biol., 184, 2013
2NOX
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BU of 2nox by Molmil
Crystal structure of tryptophan 2,3-dioxygenase from Ralstonia metallidurans
Descriptor: PROTOPORPHYRIN IX CONTAINING FE, Tryptophan 2,3-dioxygenase
Authors:Zhang, Y, Kang, S.A, Mukherjee, T, Bale, S, Crane, B.R, Begley, T.P, Ealick, S.E.
Deposit date:2006-10-26
Release date:2006-12-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis.
Biochemistry, 46, 2007
4THI
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BU of 4thi by Molmil
THIAMINASE I FROM BACILLUS THIAMINOLYTICUS WITH COVALENTLY BOUND 4-AMINO-2,5-DIMETHYLPYRIMIDINE
Descriptor: 2,5-DIMETHYL-PYRIMIDIN-4-YLAMINE, PROTEIN (THIAMINASE I), SULFATE ION
Authors:Campobasso, N, Begley, T.P, Ealick, S.E.
Deposit date:1998-10-05
Release date:1998-10-14
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of thiaminase-I from Bacillus thiaminolyticus at 2.0 A resolution.
Biochemistry, 37, 1998
1ESQ
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BU of 1esq by Molmil
CRYSTAL STRUCTURE OF THIAZOLE KINASE MUTANT (C198S) WITH ATP AND THIAZOLE PHOSPHATE.
Descriptor: 4-METHYL-5-HYDROXYETHYLTHIAZOLE PHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, HYDROXYETHYLTHIAZOLE KINASE, ...
Authors:Campobasso, N, Mathews, I.I, Begley, T.P, Ealick, S.E.
Deposit date:2000-04-10
Release date:2000-08-09
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of 4-methyl-5-beta-hydroxyethylthiazole kinase from Bacillus subtilis at 1.5 A resolution.
Biochemistry, 39, 2000
1ESJ
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BU of 1esj by Molmil
CRYSTAL STRUCTURE OF THIAZOLE KINASE MUTANT (C198S)
Descriptor: HYDROXYETHYLTHIAZOLE KINASE, SULFATE ION
Authors:Campobasso, N, Mathews, I.I, Begley, T.P, Ealick, S.E.
Deposit date:2000-04-10
Release date:2000-08-09
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of 4-methyl-5-beta-hydroxyethylthiazole kinase from Bacillus subtilis at 1.5 A resolution.
Biochemistry, 39, 2000
5UFM
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BU of 5ufm by Molmil
Crystal structure of Burkholderia thailandensis 1,6-didemethyltoxoflavin-N1-methyltransferase with bound 1,6-didemethyltoxoflavin and S-adenosylhomocysteine
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Methyltransferase domain protein, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Fenwick, M.K, Ealick, S.E, Almabruk, K.H, Begley, T.P, Philmus, B.
Deposit date:2017-01-05
Release date:2017-12-13
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Biochemical Characterization and Structural Basis of Reactivity and Regioselectivity Differences between Burkholderia thailandensis and Burkholderia glumae 1,6-Didesmethyltoxoflavin N-Methyltransferase.
Biochemistry, 56, 2017
5UFN
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BU of 5ufn by Molmil
Crystal structure of Burkholderia thailandensis 1,6-didemethyltoxoflavin-N1-methyltransferase with bound S-adenosylhomocysteine
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Methyltransferase domain protein, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Fenwick, M.K, Ealick, S.E, Almabruk, K.H, Begley, T.P, Philmus, B.
Deposit date:2017-01-05
Release date:2017-12-13
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Biochemical Characterization and Structural Basis of Reactivity and Regioselectivity Differences between Burkholderia thailandensis and Burkholderia glumae 1,6-Didesmethyltoxoflavin N-Methyltransferase.
Biochemistry, 56, 2017
5W4Y
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BU of 5w4y by Molmil
Crystal Structure of Riboflavin Lyase (RcaE) with cofactor FMN
Descriptor: FLAVIN MONONUCLEOTIDE, Riboflavin Lyase
Authors:Bhandari, D.M, Chakrabarty, Y, Zhao, B, Wood, J, Li, P, Begley, T.P.
Deposit date:2017-06-13
Release date:2018-06-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Cannibalism Among the Flavins: a Novel C-N Bond Cleavage in Riboflavin Catabolism Mediated by Flavin-Generated Superoxide Radical
To be Published
5W4Z
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BU of 5w4z by Molmil
Crystal Structure of Riboflavin Lyase (RcaE) with modified FMN and substrate Riboflavin
Descriptor: 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-3-O-phosphono-D-ribitol, RIBOFLAVIN, Riboflavin Lyase
Authors:Bhandari, D.M, Chakrabarty, Y, Zhao, B, Wood, J, Li, P, Begley, T.P.
Deposit date:2017-06-13
Release date:2018-06-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Cannibalism Among the Flavins: a Novel C-N Bond Cleavage in Riboflavin Catabolism Mediated by Flavin-Generated Superoxide Radical
To be Published

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