7W3G
| Structure of USP14-bound human 26S proteasome in substrate-engaged state ED2.0_USP14 | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | Deposit date: | 2021-11-25 | Release date: | 2022-05-04 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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7W3J
| Structure of USP14-bound human 26S proteasome in substrate-inhibited state SC_USP14 | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | Deposit date: | 2021-11-25 | Release date: | 2022-05-04 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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7W38
| Structure of USP14-bound human 26S proteasome in state EA2.0_UBL | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | Deposit date: | 2021-11-25 | Release date: | 2022-05-04 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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7W3A
| Structure of USP14-bound human 26S proteasome in substrate-engaged state ED4_USP14 | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | Deposit date: | 2021-11-25 | Release date: | 2022-05-04 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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7W37
| Structure of USP14-bound human 26S proteasome in state EA1_UBL | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | Deposit date: | 2021-11-25 | Release date: | 2022-05-04 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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7W3B
| Structure of USP14-bound human 26S proteasome in substrate-engaged state ED5_USP14 | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | Deposit date: | 2021-11-25 | Release date: | 2022-05-04 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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7W3I
| Structure of USP14-bound human 26S proteasome in substrate-inhibited state SB_USP14 | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | Deposit date: | 2021-11-25 | Release date: | 2022-05-18 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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7W3H
| Structure of USP14-bound human 26S proteasome in substrate-engaged state ED2.1_USP14 | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | Deposit date: | 2021-11-25 | Release date: | 2022-05-04 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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7W3M
| Structure of USP14-bound human 26S proteasome in substrate-inhibited state SD5_USP14 | Descriptor: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | Authors: | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | Deposit date: | 2021-11-25 | Release date: | 2022-05-18 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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7W3U
| USP34 catalytic domain in complex with UbPA | Descriptor: | Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 34, ZINC ION, ... | Authors: | Xu, G.L, Ming, Z.H. | Deposit date: | 2021-11-26 | Release date: | 2022-06-01 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (3.13 Å) | Cite: | Structural Insights into the Catalytic Mechanism and Ubiquitin Recognition of USP34. J.Mol.Biol., 434, 2022
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7W3R
| USP34 catalytic domain | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 34, ZINC ION | Authors: | Xu, G.L, Ming, Z.H. | Deposit date: | 2021-11-26 | Release date: | 2022-06-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Structural Insights into the Catalytic Mechanism and Ubiquitin Recognition of USP34. J.Mol.Biol., 434, 2022
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3HGM
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5XVE
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8ITP
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6AQR
| SAGA DUB module Ubp8(C146A)/Sgf11/Sus1/Sgf73 bound to monoubiquitin | Descriptor: | Polyubiquitin-C, SAGA-associated factor 11, SAGA-associated factor 73, ... | Authors: | Morrow, M.E, Morgan, M.T, Wolberger, C. | Deposit date: | 2017-08-21 | Release date: | 2018-07-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins. EMBO Rep., 19, 2018
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7AY1
| Cryo-EM structure of USP1-UAF1 bound to mono-ubiquitinated FANCD2, and FANCI | Descriptor: | DNA (61-MER), Fanconi anemia group D2 protein, Fanconi anemia group I protein, ... | Authors: | Rennie, M.L, Arkinson, C, Walden, H. | Deposit date: | 2020-11-10 | Release date: | 2021-03-24 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural basis of FANCD2 deubiquitination by USP1-UAF1. Nat.Struct.Mol.Biol., 28, 2021
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4MEL
| Crystal Structure of the human USP11 DUSP-UBL domains | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 11 | Authors: | Harper, S, Gratton, H.E, Cornaciu, I, Oberer, M, Scott, D.J, Emsley, J, Dreveny, I. | Deposit date: | 2013-08-27 | Release date: | 2014-05-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.899 Å) | Cite: | Structure and Catalytic Regulatory Function of Ubiquitin Specific Protease 11 N-Terminal and Ubiquitin-like Domains. Biochemistry, 53, 2014
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4MEM
| Crystal Structure of the rat USP11 DUSP-UBL domains | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 11 | Authors: | Harper, S, Gratton, H.E, Cornaciu, I, Oberer, M, Scott, D.J, Emsley, J, Dreveny, I. | Deposit date: | 2013-08-27 | Release date: | 2014-05-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Structure and Catalytic Regulatory Function of Ubiquitin Specific Protease 11 N-Terminal and Ubiquitin-like Domains. Biochemistry, 53, 2014
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5K19
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6H4K
| Structure of the Usp25 C-terminal domain | Descriptor: | CHLORIDE ION, Ubiquitin carboxyl-terminal hydrolase 25 | Authors: | Klemm, T.A, Sauer, F, Kisker, C. | Deposit date: | 2018-07-21 | Release date: | 2019-03-27 | Last modified: | 2019-05-15 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Differential Oligomerization of the Deubiquitinases USP25 and USP28 Regulates Their Activities. Mol.Cell, 74, 2019
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7ZH3
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7ZH4
| USP1 bound to ML323 and ubiquitin conjugated to FANCD2 (focused refinement) | Descriptor: | 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine, Ubiquitin carboxyl-terminal hydrolase 1, Ubiquitin-60S ribosomal protein L40, ... | Authors: | Rennie, M.L, Walden, H. | Deposit date: | 2022-04-05 | Release date: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (2.49 Å) | Cite: | Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site. Sci Adv, 8, 2022
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8A9J
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8A9K
| Cryo-EM structure of USP1-UAF1 bound to FANCI and mono-ubiquitinated FANCD2 with ML323 (consensus reconstruction) | Descriptor: | 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine, DNA (61-MER), Fanconi anemia group D2 protein, ... | Authors: | Rennie, M.L, Walden, H. | Deposit date: | 2022-06-28 | Release date: | 2022-10-12 | Last modified: | 2023-03-01 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site. Sci Adv, 8, 2022
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5TXK
| CRYSTAL STRUCTURE OF USP35 C450S IN COMPLEX WITH UBIQUITIN | Descriptor: | 1,2-ETHANEDIOL, Polyubiquitin-B, SULFATE ION, ... | Authors: | Bader, G, Weiss-Puxbaum, A, Zoephel, A. | Deposit date: | 2016-11-17 | Release date: | 2018-05-09 | Last modified: | 2019-10-16 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Expansion of DUB functionality generated by alternative isoforms - USP35, a case study. J. Cell. Sci., 131, 2018
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