5OBX
 
 | | Mycoplasma genitalium DnaK-NBD | | Descriptor: | Chaperone protein DnaK, GLYCEROL, SULFATE ION, ... | | Authors: | Adell, M, Calisto, B, Fita, I, Martinelli, L. | | Deposit date: | 2017-06-29 | | Release date: | 2018-05-09 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | The nucleotide-bound/substrate-bound conformation of the Mycoplasma genitalium DnaK chaperone.
Protein Sci., 27, 2018
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2QWQ
 | | Crystal structure of disulfide-bond-crosslinked complex of bovine hsc70 (1-394aa)R171C and bovine Auxilin (810-910aa)D876C in the AMPPNP hydrolyzed form | | Descriptor: | ACETIC ACID, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | | Authors: | Jiang, J, Maes, E.G, Wang, L, Taylor, A.B, Hinck, A.P, Lafer, E.M, Sousa, R. | | Deposit date: | 2007-08-10 | | Release date: | 2007-12-18 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | Structural basis of J cochaperone binding and regulation of Hsp70.
Mol.Cell, 28, 2007
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2QWL
 | | Crystal structure of bovine hsc70 (1-394aa)in the ADP state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Heat shock cognate 71 kDa protein, ... | | Authors: | Jiang, J, Maes, E.G, Wang, L, Taylor, A.B, Hinck, A.P, Lafer, E.M, Sousa, R. | | Deposit date: | 2007-08-10 | | Release date: | 2007-12-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural basis of J cochaperone binding and regulation of Hsp70.
Mol.Cell, 28, 2007
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2QXL
 | | Crystal Structure Analysis of Sse1, a yeast Hsp110 | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein homolog SSE1, MAGNESIUM ION, ... | | Authors: | Hendrickson, W.A, Liu, Q. | | Deposit date: | 2007-08-12 | | Release date: | 2007-10-23 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | Insights into hsp70 chaperone activity from a crystal structure of the yeast hsp110 Sse1.
Cell(Cambridge,Mass.), 131, 2007
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2QWN
 | | Crystal structure of disulfide-bond-crosslinked complex of bovine hsc70 (1-386aa)R171C and bovine Auxilin (810-910aa)D876C in the ADP*Pi state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Heat shock cognate 71 kDa protein, MAGNESIUM ION, ... | | Authors: | Jiang, J, Maes, E.G, Wang, L, Taylor, A.B, Hinck, A.P, Lafer, E.M, Sousa, R. | | Deposit date: | 2007-08-10 | | Release date: | 2007-12-18 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis of J cochaperone binding and regulation of Hsp70.
Mol.Cell, 28, 2007
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2QW9
 | | Crystal structure of bovine hsc70 (1-394aa)in the apo state | | Descriptor: | GLYCEROL, Heat shock cognate 71 kDa protein | | Authors: | Jiang, J, Maes, E.G, Wang, L, Taylor, A.B, Hinck, A.P, Lafer, E.M, Sousa, R. | | Deposit date: | 2007-08-10 | | Release date: | 2007-12-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural basis of J cochaperone binding and regulation of Hsp70.
Mol.Cell, 28, 2007
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2QWR
 | | Crystal structure of disulfide-bond-crosslinked complex of bovine hsc70 (1-394aa)R171C and bovine Auxilin (810-910aa)D876C in the AMPPNP intact form | | Descriptor: | ACETIC ACID, GLYCEROL, Heat shock cognate 71 kDa protein, ... | | Authors: | Jiang, J, Maes, E.G, Wang, L, Taylor, A.B, Hinck, A.P, Lafer, E.M, Sousa, R. | | Deposit date: | 2007-08-10 | | Release date: | 2007-12-18 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | Structural basis of J cochaperone binding and regulation of Hsp70.
Mol.Cell, 28, 2007
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2QWO
 | | Crystal structure of disulfide-bond-crosslinked complex of bovine hsc70 (1-394aa)R171C and bovine Auxilin (810-910aa)D876C in the ADP*Pi form #1 | | Descriptor: | ACETIC ACID, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | | Authors: | Jiang, J, Maes, E.G, Wang, L, Taylor, A.B, Hinck, A.P, Lafer, E.M, Sousa, R. | | Deposit date: | 2007-08-10 | | Release date: | 2007-12-18 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural basis of J cochaperone binding and regulation of Hsp70.
Mol.Cell, 28, 2007
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2QWP
 | | Crystal structure of disulfide-bond-crosslinked complex of bovine hsc70 (1-394aa)R171C and bovine Auxilin (810-910aa)D876C in the ADP*Pi form #2 | | Descriptor: | ACETIC ACID, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | | Authors: | Jiang, J, Maes, E.G, Wang, L, Taylor, A.B, Hinck, A.P, Lafer, E.M, Sousa, R. | | Deposit date: | 2007-08-10 | | Release date: | 2007-12-18 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural basis of J cochaperone binding and regulation of Hsp70.
Mol.Cell, 28, 2007
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2QWM
 | | Crystal structure of bovine hsc70 (1-394aa)in the ADP*Vi state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Heat shock cognate 71 kDa protein, ... | | Authors: | Jiang, J, Maes, E.G, Wang, L, Taylor, A.B, Hinck, A.P, Lafer, E.M, Sousa, R. | | Deposit date: | 2007-08-10 | | Release date: | 2007-12-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Structural basis of J cochaperone binding and regulation of Hsp70.
Mol.Cell, 28, 2007
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2V7Z
 | | Crystal structure of the 70-kDa heat shock cognate protein from Rattus norvegicus in post-ATP hydrolysis state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, HEAT SHOCK COGNATE 71 KDA PROTEIN, PHOSPHATE ION | | Authors: | Chang, Y.-W, Sun, Y.-J, Wang, C, Hsiao, C.-D. | | Deposit date: | 2007-08-02 | | Release date: | 2008-04-08 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Crystal Structures of the 70-kDa Heat Shock Proteins in Domain Disjoining Conformation.
J.Biol.Chem., 283, 2008
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2V7Y
 | | Crystal structure of the molecular chaperone DnaK from Geobacillus kaustophilus HTA426 in post-ATP hydrolysis state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHAPERONE PROTEIN DNAK, MAGNESIUM ION, ... | | Authors: | Chang, Y.-W, Sun, Y.-J, Wang, C, Hsiao, C.-D. | | Deposit date: | 2007-08-02 | | Release date: | 2008-04-08 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Crystal Structures of the 70-kDa Heat Shock Proteins in Domain Disjoining Conformation.
J.Biol.Chem., 283, 2008
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6DO2
 | | Crystal structure of human GRP78 in complex with 7-deaza-2'-C-methyladenosine | | Descriptor: | 7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Endoplasmic reticulum chaperone BiP | | Authors: | Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W. | | Deposit date: | 2018-06-08 | | Release date: | 2019-06-12 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structure of human GRP78 in complex with 7-deaza-2'-C-methyladenosine
To Be Published
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6DFM
 | | Crystal structure of human GRP78 in complex with 8-aminoadenosine | | Descriptor: | (2R,3R,4S,5R)-2-(6,8-diaminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol, Endoplasmic reticulum chaperone BiP | | Authors: | Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W. | | Deposit date: | 2018-05-15 | | Release date: | 2019-05-15 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Crystal structure of human GRP78 in complex with 8-aminoadenosine
To be Published
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6DWS
 | | Crystal structure of human GRP78 in complex with (2R,3R,4S,5R)-2-(6-amino-8-((2-chlorobenzyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol | | Descriptor: | 8-{[(2-chlorophenyl)methyl]amino}adenosine, Endoplasmic reticulum chaperone BiP, MAGNESIUM ION | | Authors: | Chen, Y, Antoshchenko, T, Smil, D, Zepeda, C, Huang, Y, Park, H.W. | | Deposit date: | 2018-06-27 | | Release date: | 2019-07-03 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of human GRP78 in complex with (2R,3R,4S,5R)-2-(6-amino-8-((2-chlorobenzyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
To Be Published
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6EOE
 | | Crystal structure of AMPylated GRP78 with nucleotide | | Descriptor: | 78 kDa glucose-regulated protein, ADENOSINE-5'-DIPHOSPHATE, CITRATE ANION, ... | | Authors: | Yan, Y, Preissler, S, Ron, D, Read, R.J. | | Deposit date: | 2017-10-09 | | Release date: | 2017-11-01 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.
Elife, 6, 2017
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6EOB
 | | Crystal structure of AMPylated GRP78 in apo form (Crystal form 1) | | Descriptor: | 78 kDa glucose-regulated protein, PHOSPHATE ION | | Authors: | Yan, Y, Preissler, S, Ron, D, Read, R.J. | | Deposit date: | 2017-10-09 | | Release date: | 2017-11-01 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.
Elife, 6, 2017
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6EOC
 | | Crystal structure of AMPylated GRP78 in apo form (Crystal form 2) | | Descriptor: | 78 kDa glucose-regulated protein, CITRATE ANION, SULFATE ION | | Authors: | Yan, Y, Preissler, S, Ron, D, Read, R.J. | | Deposit date: | 2017-10-09 | | Release date: | 2017-11-01 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.
Elife, 6, 2017
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6EOF
 | | Crystal structure of AMPylated GRP78 in ADP state | | Descriptor: | 78 kDa glucose-regulated protein, ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Yan, Y, Preissler, S, Read, R.J, Ron, D. | | Deposit date: | 2017-10-09 | | Release date: | 2017-11-01 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.59 Å) | | Cite: | AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.
Elife, 6, 2017
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6FHK
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6G3S
 | | Structure of tellurium-centred Anderson-Evans polyoxotungstate (TEW) bound to the nucleotide binding domain of HSP70. Second structure of two TEW-HSP70 structures deposited. | | Descriptor: | 6-tungstotellurate(VI), ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1A, ... | | Authors: | Mac Sweeney, A, Chambovey, A, Wicki, M, Mueller, M, Artico, N, Lange, R, Bijelic, A, Breibeck, J, Rompel, A. | | Deposit date: | 2018-03-26 | | Release date: | 2018-10-17 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The crystallization additive hexatungstotellurate promotes the crystallization of the HSP70 nucleotide binding domain into two different crystal forms.
PLoS ONE, 13, 2018
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6G3R
 | | Structure of tellurium-centred Anderson-Evans polyoxotungstate (TEW) bound to the nucleotide binding domain of HSP70. Structure one of two TEW-HSP70 structures deposited. | | Descriptor: | 6-tungstotellurate(VI), ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1A, ... | | Authors: | Mac Sweeney, A, Chambovey, A, Wicki, M, Mueller, M, Artico, N, Lange, R, Bijelic, A, Breibeck, J, Rompel, A. | | Deposit date: | 2018-03-26 | | Release date: | 2018-10-17 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | The crystallization additive hexatungstotellurate promotes the crystallization of the HSP70 nucleotide binding domain into two different crystal forms.
PLoS ONE, 13, 2018
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6GFA
 | | Structure of Nucleotide binding domain of HSP110, ATP and Mg2+ complexed | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein 105 kDa, MAGNESIUM ION | | Authors: | Gonzalez, D, Gotthard, G, Gozzi, G.J, Seigneuric, R, Neiers, F, Briand, L, Garrido, C. | | Deposit date: | 2018-04-29 | | Release date: | 2019-05-08 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Selecting the first chemical molecule inhibitor of HSP110 for colorectal cancer therapy.
Cell Death Differ., 27, 2020
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6H54
 | | CRYSTAL STRUCTURE OF BOVINE HSC70(AA1-554)E213A/D214A IN COMPLEX WITH INHIBITOR VER155008 | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile, GLYCEROL, ... | | Authors: | Plank, C, Zehe, M, Grimm, C, Sotriffer, C. | | Deposit date: | 2018-07-23 | | Release date: | 2019-08-14 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct.
Acs Chem.Biol., 2024
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3GL1
 | | Crystal structure of ATPase domain of Ssb1 chaperone, a member of the HSP70 family, from Saccharomyces cerevisiae | | Descriptor: | CHLORIDE ION, GLYCEROL, Heat shock protein SSB1, ... | | Authors: | Osipiuk, J, Li, H, Bargassa, M, Sahi, C, Craig, E.A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2009-03-11 | | Release date: | 2009-03-24 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Crystal structure of ATPase domain of Ssb1 chaperone, member of the HSP70 family from Saccharomyces cerevisiae.
To be Published
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