5SWW
 
 | | Crystal Structure of Human APOBEC3A complexed with ssDNA | | Descriptor: | DNA 15-Mer, DNA dC->dU-editing enzyme APOBEC-3A, GLYCEROL, ... | | Authors: | Shi, K, Banerjee, S, Kurahashi, K, Aihara, H. | | Deposit date: | 2016-08-09 | | Release date: | 2016-12-28 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.151 Å) | | Cite: | Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.
Nat. Struct. Mol. Biol., 24, 2017
|
|
5TD5
 | | Crystal Structure of Human APOBEC3B variant complexed with ssDNA | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(P*TP*TP*CP*AP*T)-3'), ... | | Authors: | Shi, K, Banerjee, S, Kurahashi, K, Aihara, H. | | Deposit date: | 2016-09-16 | | Release date: | 2016-12-28 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.718 Å) | | Cite: | Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.
Nat. Struct. Mol. Biol., 24, 2017
|
|
6NFK
 | | Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B with loop 7 from APOBEC3G bound to iodide | | Descriptor: | 1,2-ETHANEDIOL, DNA dC->dU-editing enzyme APOBEC-3B, IODIDE ION | | Authors: | Shi, K, Orellana, K, Aihara, H. | | Deposit date: | 2018-12-20 | | Release date: | 2019-12-25 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B
Faseb Bioadv, 2, 2020
|
|
5CQK
 | | Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B | | Descriptor: | DNA dC->dU-editing enzyme APOBEC-3B, GLYCEROL, SODIUM ION, ... | | Authors: | Shi, K, Kurahashi, K, Aihara, H. | | Deposit date: | 2015-07-21 | | Release date: | 2015-10-07 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain.
J.Biol.Chem., 290, 2015
|
|
5CQH
 | | Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B | | Descriptor: | 1,2-ETHANEDIOL, 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, CHLORIDE ION, ... | | Authors: | Shi, K, Kurahashi, K, Aihara, H. | | Deposit date: | 2015-07-21 | | Release date: | 2015-10-07 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain.
J.Biol.Chem., 290, 2015
|
|
5CQI
 | |
6NFM
 | |
5CQD
 | |
8FII
 | | Wild type APOBEC3A in complex with TT(FdZ)-hairpin inhibitor (crystal form 1) | | Descriptor: | DNA (5'-D(P*GP*CP*GP*CP*TP*TP*(UFP)P*GP*CP*GP*C)-3'), DNA dC->dU-editing enzyme APOBEC-3A, PHOSPHATE ION, ... | | Authors: | Harjes, S, Jameson, G.B, Harjes, E, Filichev, V.V, Kurup, H.M. | | Deposit date: | 2022-12-16 | | Release date: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.94 Å) | | Cite: | DNA-based inhibitors restrict mutagenic activity of APOBEC3 in cells
To Be Published
|
|
8FIJ
 | | Wild type APOBEC3A in complex with TT(FdZ)-hairpin inhibitor (crystal form 2) | | Descriptor: | DNA (5'-D(*GP*CP*GP*CP*TP*TP*(UFP)P*GP*CP*GP*CP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3A, PHOSPHATE ION, ... | | Authors: | Harjes, S, Jameson, G.B, Harjes, E, Filichev, V.V, Kurup, H.M. | | Deposit date: | 2022-12-16 | | Release date: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.799 Å) | | Cite: | DNA-based inhibitors restrict mutagenic activity of APOBEC3 in cells
To Be Published
|
|
8FIM
 | | Structure of APOBEC3A (E72A inactive mutant) in complex with TTC-hairpin DNA substrate | | Descriptor: | CHLORIDE ION, DNA (5'-D(*TP*GP*CP*GP*CP*TP*TP*CP*GP*CP*GP*CP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3A, ... | | Authors: | Harjes, S, Jameson, G.B, Harjes, E, Filichev, V.V, Kurup, H.M. | | Deposit date: | 2022-12-16 | | Release date: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | DNA-based inhibitors restrict mutagenic activity of APOBEC3 in cells
To Be Published
|
|
8FIL
 | | Zinc-free APOBEC3A (inactive E72A mutant) in complex with TTC-hairpin DNA substrate | | Descriptor: | CHLORIDE ION, DNA (5'-D(*TP*GP*CP*GP*CP*TP*TP*CP*GP*CP*GP*CP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3A, ... | | Authors: | Harjes, S, Jameson, G.B, Harjes, E, Filichev, V.V, Kurup, H.M. | | Deposit date: | 2022-12-16 | | Release date: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | DNA-based inhibitors restrict mutagenic activity of APOBEC3 in cells
To Be Published
|
|
8FIK
 | | APOBEC3A E72A inactive mutant in complex with ATTC-hairpin DNA substrate | | Descriptor: | CHLORIDE ION, DNA (5'-D(P*CP*CP*CP*AP*TP*CP*AP*TP*TP*CP*GP*AP*TP*GP*GP*G)-3'), DNA dC->dU-editing enzyme APOBEC-3A, ... | | Authors: | Harjes, S, Jameson, G.B, Harjes, E, Filichev, V.V, Kurup, H.M. | | Deposit date: | 2022-12-16 | | Release date: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.912 Å) | | Cite: | DNA-based inhibitors restrict mutagenic activity of APOBEC3 in cells
To Be Published
|
|
7RW6
 | | BORF2-APOBEC3Bctd Complex | | Descriptor: | DNA dC->dU-editing enzyme APOBEC-3B, Maltose/maltodextrin-binding periplasmic protein,Ribonucleoside-diphosphate reductase large subunit, ZINC ION | | Authors: | Shaban, N.M, Yan, R, Shi, K, McLellan, J.S, Yu, Z, Harris, R.S. | | Deposit date: | 2021-08-19 | | Release date: | 2022-04-27 | | Last modified: | 2022-05-04 | | Method: | ELECTRON MICROSCOPY (2.55 Å) | | Cite: | Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition.
Sci Adv, 8, 2022
|
|
6X91
 | | Crystal structure of MBP-fused human APOBEC1 | | Descriptor: | CACODYLATE ION, Maltodextrin-binding protein, C->U-editing enzyme APOBEC-1 chimera, ... | | Authors: | Wolfe, A.D, Li, S.-X, Chen, X.S. | | Deposit date: | 2020-06-02 | | Release date: | 2020-12-09 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.51 Å) | | Cite: | The structure of APOBEC1 and insights into its RNA and DNA substrate selectivity.
NAR Cancer, 2, 2020
|
|
8H0I
 | | Cryo-EM structure of APOBEC3G-Vif complex | | Descriptor: | APOBEC3G, CHLORIDE ION, Core binding factor beta, ... | | Authors: | Kouno, T, Shibata, S, Hyun, J, Kim, T.G, Wolf, M. | | Deposit date: | 2022-09-29 | | Release date: | 2023-07-19 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G.
Nat Commun, 14, 2023
|
|
6BWY
 | | DNA substrate selection by APOBEC3G | | Descriptor: | DNA (30-MER), PHOSPHATE ION, Protection of telomeres protein 1, ... | | Authors: | Ziegler, S.J, Buzovetsky, O. | | Deposit date: | 2017-12-15 | | Release date: | 2018-04-18 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies.
PLoS ONE, 13, 2018
|
|
8J62
 | | Cryo-EM structure of APOBEC3G-Vif complex | | Descriptor: | APOBEC3G, Core binding factor beta, RNA (5'-R(*CP*GP*GP*UP*UP*GP*AP*UP*UP*GP*UP*UP*UP*UP*AP*AP*CP*AP*A)-3'), ... | | Authors: | Kouno, T, Shibata, S, Hyun, J, Kim, T.G, Wolf, M. | | Deposit date: | 2023-04-24 | | Release date: | 2023-07-19 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G.
Nat Commun, 14, 2023
|
|
8CX2
 | | Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 2 | | Descriptor: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | | Authors: | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | | Deposit date: | 2022-05-19 | | Release date: | 2023-02-15 | | Last modified: | 2023-04-05 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | The structural basis for HIV-1 Vif antagonism of human APOBEC3G.
Nature, 615, 2023
|
|
8CX0
 | | Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC monomeric complex | | Descriptor: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | | Authors: | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | | Deposit date: | 2022-05-19 | | Release date: | 2023-02-15 | | Last modified: | 2023-04-05 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | The structural basis for HIV-1 Vif antagonism of human APOBEC3G.
Nature, 615, 2023
|
|
8CX1
 | | Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 1 | | Descriptor: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | | Authors: | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | | Deposit date: | 2022-05-19 | | Release date: | 2023-02-15 | | Last modified: | 2023-04-05 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | The structural basis for HIV-1 Vif antagonism of human APOBEC3G.
Nature, 615, 2023
|
|
