5TD5

Crystal Structure of Human APOBEC3B variant complexed with ssDNA

Summary for 5TD5

• Entry DOI: 10.2210/pdb5td5/pdb
• Descriptor: DNA dC->dU-editing enzyme APOBEC-3B, DNA (5'-D(P*TP*TP*CP*AP*T)-3'), ZINC ION, ... (7 entities in total)
• Functional Keywords: deaminase, dna substrate complex, hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : Q9UH17
• Total number of polymer chains: 2
• Total formula weight: 26122.60

Authors

Shi, K.,Banerjee, S.,Kurahashi, K.,Aihara, H. (deposition date: 2016-09-16, release date: 2016-12-28, Last modification date: 2024-03-06)

• Primary citation: Shi, K.,Carpenter, M.A.,Banerjee, S.,Shaban, N.M.,Kurahashi, K.,Salamango, D.J.,McCann, J.L.,Starrett, G.J.,Duffy, J.V.,Demir, O.,Amaro, R.E.,Harki, D.A.,Harris, R.S.,Aihara, H.; Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.; Nat. Struct. Mol. Biol., 24:131-139, 2017; PubMed: 27991903; DOI: 10.1038/nsmb.3344

Experimental method

X-RAY DIFFRACTION (1.718 Å)