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3VS9	Crystal structure of type III PKS ArsC mutant Descriptor: SODIUM ION, TETRAETHYLENE GLYCOL, Type III polyketide synthase Authors: Satou, R, Miyanaga, A, Ozawa, H, Funa, N, Miyazono, K, Tanokura, M, Ohnishi, Y, Horinouchi, S. Deposit date: 2012-04-23 Release date: 2013-04-24 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Structural basis for cyclization specificity of two Azotobacter type III polyketide synthases: a single amino acid substitution reverses their cyclization specificity J.Biol.Chem., 288, 2013
6L73	Quinolone synthase (AmQNS) from Aegle marmelos Correa Descriptor: Type III polyketide synthase Authors: Mallika, V, Abhinav, K.V, Soniya, E.V. Deposit date: 2019-10-30 Release date: 2020-11-04 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Quinolone synthase from Aegle marmelos Correa, Dimer To Be Published
3EUT	X-ray crystal structure of a type III pentaketide synthase from Neurospora crassa Descriptor: Putative uncharacterized protein, icosanoic acid Authors: Zhang, H, Brunzelle, J.S, Nair, S.K. Deposit date: 2008-10-10 Release date: 2008-11-11 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Distinct Structural Elements Dictate the Specificity of the Type III Pentaketide Synthase from Neurospora crassa. Chem.Biol., 15, 2008
1XET	Crystal structure of stilbene synthase from Pinus sylvestris, complexed with methylmalonyl CoA Descriptor: 3-(1H-INDOL-3-YL)-2-OXOPROPANOIC ACID, Dihydropinosylvin synthase, METHYLMALONYL-COENZYME A Authors: Ng, S.H, Chirgadze, D, Spiteller, D, Li, T.L, Spencer, J.B, Blundell, T.L. Deposit date: 2004-09-12 Release date: 2006-04-11 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of stilbene synthase from Pinus sylvestris, complexed with methylmalonyl CoA To be Published
8B35	Chalcone synthase from Hordeum vulgare complexed with CoA and naringenin Descriptor: COENZYME A, Chalcone synthase 2, NARINGENIN Authors: Zhang, L, Groves, M.R. Deposit date: 2022-09-15 Release date: 2023-09-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2 Å) Cite: Engineering a Plant Polyketide Synthase for the Biosynthesis of Methylated Flavonoids. J.Agric.Food Chem., 72, 2024
8B3C	Chalcone synthase from Hordeum vulgare complexed with CoA and eriodictyol Descriptor: (2S)-2-(3,4-DIHYDROXYPHENYL)-5,7-DIHYDROXY-2,3-DIHYDRO-4H-CHROMEN-4-ONE, COENZYME A, Chalcone synthase 2 Authors: Zhang, L, Groves, M.R. Deposit date: 2022-09-16 Release date: 2023-09-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2 Å) Cite: Engineering a Plant Polyketide Synthase for the Biosynthesis of Methylated Flavonoids. J.Agric.Food Chem., 72, 2024
1D6I	CHALCONE SYNTHASE (H303Q MUTANT) Descriptor: CHALCONE SYNTHASE, SULFATE ION Authors: Jez, J.M, Ferrer, J.L, Bowman, M.E, Dixon, R.A, Noel, J.P. Deposit date: 1999-10-13 Release date: 2000-02-03 Last modified: 2021-11-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase. Biochemistry, 39, 2000
3AWK	Crystal structure of the polyketide synthase 1 from huperzia serrata Descriptor: Chalcone synthase-like polyketide synthase, GLYCEROL, SULFATE ION Authors: Morita, H, Kondo, S, Kato, R, Sugio, S, Kohno, T, Abe, I. Deposit date: 2011-03-23 Release date: 2011-08-31 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Synthesis of unnatural alkaloid scaffolds by exploiting plant polyketide synthase. Proc.Natl.Acad.Sci.USA, 108, 2011
1U0W	An Aldol Switch Discovered in Stilbene Synthases Mediates Cyclization Specificity of Type III Polyketide Synthases: 18xCHS+resveratrol Structure Descriptor: Chalcone synthase 2, RESVERATROL Authors: Austin, M.B, Bowman, M.E, Ferrer, J.-L, Schroder, J, Noel, J.P. Deposit date: 2004-07-14 Release date: 2004-10-12 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2 Å) Cite: An Aldol Switch Discovered in Stilbene Synthases Mediates Cyclization Specificity of Type III Polyketide Synthases Chem.Biol., 11, 2004
3OIT	Crystal structure of curcuminoid synthase CUS from Oryza sativa Descriptor: Os07g0271500 protein Authors: Miyazono, K, Um, J, Imai, F.L, Katsuyama, Y, Ohnishi, Y, Horinouchi, S, Tanokura, M. Deposit date: 2010-08-19 Release date: 2010-10-20 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of curcuminoid synthase CUS from Oryza sativa Proteins, 79, 2011
3WY0	The I375W mutant of CsyB complexed with CoA-SH Descriptor: COENZYME A, Putative uncharacterized protein csyB Authors: Mori, T, Yang, D, Matsui, T, Morita, H, Fujii, I, Abe, I. Deposit date: 2014-08-13 Release date: 2015-01-14 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.001 Å) Cite: Structural basis for the formation of acylalkylpyrones from two beta-ketoacyl units by the fungal type III polyketide synthase CsyB. J.Biol.Chem., 290, 2015
6DXA	Crystal structure of chalcone synthase from Pinus sylvestris Descriptor: Chalcone synthase Authors: Liou, G, Chiang, Y.C, Wang, Y, Weng, J.K. Deposit date: 2018-06-28 Release date: 2018-10-17 Last modified: 2019-11-27 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Mechanistic basis for the evolution of chalcone synthase catalytic cysteine reactivity in land plants. J. Biol. Chem., 293, 2018
4JAO	Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones Descriptor: (2S)-2-methylheptadecan-1-ol, Alpha-pyrone synthesis polyketide synthase-like Pks11, PALMITIC ACID Authors: Gokulan, K, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) Deposit date: 2013-02-18 Release date: 2013-04-24 Last modified: 2013-11-27 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones. J.Biol.Chem., 288, 2013
1EE0	2-PYRONE SYNTHASE COMPLEXED WITH ACETOACETYL-COA Descriptor: 2-PYRONE SYNTHASE, ACETOACETYL-COENZYME A Authors: Jez, J.M, Austin, M.B, Ferrer, J, Bowmann, M.E, Schroeder, J, Noel, J.P. Deposit date: 2000-01-28 Release date: 2001-01-31 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structural control of polyketide formation in plant-specific polyketide synthases. Chem.Biol., 7, 2000
1QLV	Pyrone synthase (PYS) from Gerbera hybrida Descriptor: PYRONE SYNTHASE Authors: Ferrer, J.-L, Jez, J.M, Bowman, M.E, Schroder, J, Noel, J.P. Deposit date: 1999-09-16 Release date: 2000-09-24 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Pyrone Synthase (Pys) from Gerbera Hybrida To be Published
3EUQ	X-ray structural of a type III pentaketide synthase from Neurospora crassa Descriptor: HEXAETHYLENE GLYCOL, Putative uncharacterized protein Authors: Zhang, H, Brunzelle, J.S, Nair, S.K. Deposit date: 2008-10-10 Release date: 2008-11-11 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Distinct Structural Elements Dictate the Specificity of the Type III Pentaketide Synthase from Neurospora crassa. Chem.Biol., 15, 2008
7W6G	TKS-L190G mutant from Cannabis sativa in complex with lauroyl-CoA Descriptor: 3,5,7-trioxododecanoyl-CoA synthase, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... Authors: Nakashima, Y, Lee, Y.E, Morita, H. Deposit date: 2021-12-01 Release date: 2022-02-02 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Dual Engineering of Olivetolic Acid Cyclase and Tetraketide Synthase to Generate Longer Alkyl-Chain Olivetolic Acid Analogs. Org.Lett., 24, 2022
5UC5	Chalcone synthase from Malus domestica Descriptor: CHS2 chalcone synthase Authors: Stewart Jr, C.E, Noel, J.P. Deposit date: 2016-12-21 Release date: 2017-12-13 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.102 Å) Cite: Molecular architectures of benzoic acid-specific type III polyketide synthases. Acta Crystallogr D Struct Biol, 73, 2017
1U0U	An Aldol Switch Discovered in Stilbene Synthases Mediates Cyclization Specificity of Type III Polyketide Synthases: Pine stilbene synthase structure Descriptor: Dihydropinosylvin synthase Authors: Austin, M.B, Bowman, M.E, Ferrer, J.-L, Schroder, J, Noel, J.P. Deposit date: 2004-07-14 Release date: 2004-10-12 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.11 Å) Cite: An Aldol Switch Discovered in Stilbene Synthases Mediates Cyclization Specificity of Type III Polyketide Synthases Chem.Biol., 11, 2004
1D6H	CHALONE SYNTHASE (N336A MUTANT COMPLEXED WITH COA) Descriptor: CHALCONE SYNTHASE, COENZYME A, SULFATE ION Authors: Jez, J.M, Ferrer, J.L, Bowman, M.E, Dixon, R.A, Noel, J.P. Deposit date: 1999-10-13 Release date: 2000-02-03 Last modified: 2021-11-03 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase. Biochemistry, 39, 2000
3AWJ	Crystal structure of the Huperzia serrata polyketide synthase 1 complexed with CoA-SH Descriptor: COENZYME A, Chalcone synthase-like polyketide synthase, SULFATE ION Authors: Morita, H, Kondo, S, Kato, R, Sugio, S, Kohno, T, Abe, I. Deposit date: 2011-03-23 Release date: 2011-08-31 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Synthesis of unnatural alkaloid scaffolds by exploiting plant polyketide synthase. Proc.Natl.Acad.Sci.USA, 108, 2011
7FFH	Diarylpentanoid-producing polyketide synthase (N199L mutant) Descriptor: Type III polyketide synthase Authors: Morita, H, Wong, C.P, Liu, Q, Takeshi, K, Lee, Y, Nakashima, Y. Deposit date: 2021-07-23 Release date: 2022-01-19 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Identification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood. Nat Commun, 13, 2022
5WX4	Alkylquinolone synthase from Evodia rutaecarpa Descriptor: alkylquinolone synthase Authors: Matsui, T, Kodama, T, Tadakoshi, T, Morita, H. Deposit date: 2017-01-06 Release date: 2017-04-26 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.203 Å) Cite: 2-Alkylquinolone alkaloid biosynthesis in the medicinal plant Evodia rutaecarpa involves collaboration of two novel type III polyketide synthases J. Biol. Chem., 292, 2017
1U0M	Crystal Structure of 1,3,6,8-Tetrahydroxynaphthalene Synthase (THNS) from Streptomyces coelicolor A3(2): a Bacterial Type III Polyketide Synthase (PKS) Provides Insights into Enzymatic Control of Reactive Polyketide Intermediates Descriptor: GLYCEROL, POLYETHYLENE GLYCOL (N=34), putative polyketide synthase Authors: Austin, M.B, Izumikawa, M, Bowman, M.E, Udwary, D.W, Ferrer, J.L, Moore, B.S, Noel, J.P. Deposit date: 2004-07-13 Release date: 2004-09-14 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.22 Å) Cite: Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates J.Biol.Chem., 279, 2004
4JD3	Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones Descriptor: Alpha-pyrone synthesis polyketide synthase-like Pks11, COENZYME A, PALMITIC ACID Authors: Gokulan, K, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) Deposit date: 2013-02-22 Release date: 2013-04-24 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones. J.Biol.Chem., 288, 2013

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