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5X2X
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Crystal structure of Pseudomonas putida methionine gamma-lyase wild type with L-homocysteine intermediates
Descriptor: (2E)-2-{[(1E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}but-2-enoic acid, HYDROSULFURIC ACID, L-methionine gamma-lyase
Authors:Shiba, T, Sato, D, Harada, S.
Deposit date:2017-02-02
Release date:2017-04-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and mechanistic insights into homocysteine degradation by a mutant of methionine gamma-lyase based on substrate-assisted catalysis
Protein Sci., 26, 2017
5X2W
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BU of 5x2w by Molmil
Crystal structure of Pseudomonas putida methionine gamma-lyase wild type with L-methionine intermediates
Descriptor: (2E)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-4-(methylsulfanyl)but-2-enoic acid, L-methionine gamma-lyase
Authors:Shiba, T, Sato, D, Harada, S.
Deposit date:2017-02-02
Release date:2017-04-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and mechanistic insights into homocysteine degradation by a mutant of methionine gamma-lyase based on substrate-assisted catalysis
Protein Sci., 26, 2017
5X2V
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BU of 5x2v by Molmil
Crystal structure of Pseudomonas putida methionine gamma-lyase wild type without sulfate ion
Descriptor: L-methionine gamma-lyase
Authors:Shiba, T, Sato, D, Harada, S.
Deposit date:2017-02-02
Release date:2017-04-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and mechanistic insights into homocysteine degradation by a mutant of methionine gamma-lyase based on substrate-assisted catalysis
Protein Sci., 26, 2017
5TT2
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BU of 5tt2 by Molmil
Inactive conformation of engineered human cystathionine gamma lyase (E59N, R119L, E339V) to depleting methionine
Descriptor: Cystathionine gamma-lyase, SULFATE ION
Authors:Yan, W, Zhang, Y.
Deposit date:2016-10-31
Release date:2017-10-11
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (2.949 Å)
Cite:Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.
Biochemistry, 56, 2017
5TSU
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BU of 5tsu by Molmil
Active conformation for Engineered human cystathionine gamma lyase (E59N, R119L, E339V) to depleting methionine
Descriptor: CYSTEINE, Cystathionine gamma-lyase, METHIONINE, ...
Authors:Yan, W, Zhang, Y.
Deposit date:2016-10-31
Release date:2017-10-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.
Biochemistry, 56, 2017
5M3Z
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BU of 5m3z by Molmil
Crystal structure of Citrobacter freundii methionine gamma-lyase with C115H replacement in the complex with L-norleucine
Descriptor: 2-[O-PHOSPHONOPYRIDOXYL]-AMINO-HEXANOIC ACID, Methionine gamma-lyase, NORLEUCINE, ...
Authors:Revtovich, S.V, Nikulin, A.D, Anufrieva, N.V, Morozova, E.A, Demidkina, T.V.
Deposit date:2016-10-17
Release date:2017-06-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of mutant form Cys115His of Citrobacter freundii methionine gamma-lyase complexed with l-norleucine.
Biochim. Biophys. Acta, 1865, 2017
5K30
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BU of 5k30 by Molmil
Crystal structure of methionine gamma-lyase from Citrobacter freundii modified by S-Ethyl-L-cysteine sulfoxide
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, Methionine gamma-lyase, ...
Authors:Revtovich, S.V, Nikulin, A.D, Morozova, E.A, Demidkina, T.V.
Deposit date:2016-05-19
Release date:2017-07-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Sulfoxides of sulfur-containing amino acids are suicide substrates of Citrobacter freundii methionine gamma-lyase. Structural bases of the enzyme inactivation.
Biochimie, 168, 2020
5IJG
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BU of 5ijg by Molmil
Crystal structure of O-acetylhomoserine sulfhydrolase from Brucella melitensis at 2.0 A resolution
Descriptor: Cys/Met metabolism pyridoxal-phosphate-dependent enzyme, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE
Authors:Boyko, K.M, Nikolaeva, A.Y, Koolikova, V.V, Kotlov, M.I, Demidkina, T.V, Popov, V.O.
Deposit date:2016-03-02
Release date:2017-04-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of O-acetylhomoserine sulfhydrolase from Brucella melitensis at 2.0 A resolution
To Be Published
5EIG
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BU of 5eig by Molmil
Engineered human cystathionine gamma lyase (E59T, E339V) to deplet cysteine
Descriptor: CYSTEINE, Cystathionine gamma-lyase, SULFATE ION
Authors:Yan, W, Zhang, J.
Deposit date:2015-10-29
Release date:2016-11-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Systemic Depletion of Serum L-Cyst(e)ine with an Engineered Human Enzyme Mediates Potent Induction of ROS and Cancer Ablation
To Be Published
5E4Z
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BU of 5e4z by Molmil
Crystal structure of methionine gamma-lyase from Citrobacter freundii with C115A substitution
Descriptor: DI(HYDROXYETHYL)ETHER, Methionine gamma-lyase, PENTAETHYLENE GLYCOL, ...
Authors:Revtovich, S.V, Nikulin, A.D, Anufrieva, N.V, Morozova, E.A, Demidkina, T.V.
Deposit date:2015-10-07
Release date:2016-10-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Crystal structure of C115A mutant L-methionine gamma-lyase from Citrobacter freundii
To Be Published
5DX5
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BU of 5dx5 by Molmil
Crystal structure of methionine gamma-lyase from Clostridium sporogenes
Descriptor: CHLORIDE ION, Methionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Revtovich, S.V, Nikulin, A.D, Morozova, E.A, Anufrieva, N.V, Demidkina, T.V.
Deposit date:2015-09-23
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structure of methionine gamma-lyase from Clostridium sporogenes.
Acta Crystallogr.,Sect.F, 72, 2016
5D5S
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BU of 5d5s by Molmil
Crystal structure of methionine gamma-lyase from Citrobacter freundii, S339A mutant
Descriptor: DI(HYDROXYETHYL)ETHER, Methionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Revtovich, S.V, Nikulin, A.D, Anufrieva, N.V, Morozova, E.A, Demidkina, T.V.
Deposit date:2015-08-11
Release date:2016-08-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The crystal structure of methionine gamma-lyase from Citrobacter freundii, S339A mutant
To Be Published
4XQ2
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BU of 4xq2 by Molmil
Ensemble refinement of cystathione gamma lyase (CalE6) D7G from Micromonospora echinospora
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, CalE6, ...
Authors:Wang, F, Yennamalli, R.M, Singh, S, Tan, K, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2015-01-18
Release date:2015-04-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structure of cystathione gamma lyase (CalE6) from Micromonospora echinospora
To Be Published
4U2H
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BU of 4u2h by Molmil
The crystal structure of apo CalE6, a methionine gamma lyase from Micromonospora echinospora
Descriptor: CalE6, SULFATE ION
Authors:Song, H.G, Xu, R.
Deposit date:2014-07-17
Release date:2015-01-07
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Identification and Characterization of a Methionine gamma-Lyase in the Calicheamicin Biosynthetic Cluster of Micromonospora echinospora
Chembiochem, 16, 2015
4U1T
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BU of 4u1t by Molmil
The crystal structure of holo CalE6, a methionine gamma lyase from Micromonospora echinospora
Descriptor: CalE6, SULFATE ION
Authors:Song, H.G, Guo, Z.H.
Deposit date:2014-07-16
Release date:2015-01-07
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification and Characterization of a Methionine gamma-Lyase in the Calicheamicin Biosynthetic Cluster of Micromonospora echinospora
Chembiochem, 16, 2015
4Q31
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BU of 4q31 by Molmil
The crystal structure of cystathione gamma lyase (CalE6) from Micromonospora echinospora
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, FORMIC ACID, ...
Authors:Tan, K, Bigelow, L, Jedrzejczak, R, Babnigg, G, Bingman, C.A, Yennamalli, R.M, Singh, S, Kharel, M.K, Thorson, J.S, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2014-04-10
Release date:2014-05-07
Last modified:2017-03-08
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Structural dynamics of a methionine gamma-lyase for calicheamicin biosynthesis: Rotation of the conserved tyrosine stacking with pyridoxal phosphate.
Struct Dyn, 3, 2016
4OMA
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BU of 4oma by Molmil
The crystal structure of methionine gamma-lyase from Citrobacter freundii in complex with L-cycloserine pyridoxal-5'-phosphate
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, TRIETHYLENE GLYCOL, ...
Authors:Revtovich, S.V, Nikulin, A.D, Morozova, E.A, Demidkina, T.V.
Deposit date:2014-01-27
Release date:2014-11-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Pre-steady-state Kinetic and Structural Analysis of Interaction of Methionine gamma-Lyase from Citrobacter freundii with Inhibitors.
J.Biol.Chem., 290, 2015
4OC9
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BU of 4oc9 by Molmil
2.35 Angstrom resolution crystal structure of putative O-acetylhomoserine (thiol)-lyase (metY) from Campylobacter jejuni subsp. jejuni NCTC 11168 with N'-Pyridoxyl-Lysine-5'-Monophosphate at position 205
Descriptor: GLYCEROL, IMIDAZOLE, PHOSPHATE ION, ...
Authors:Halavaty, A.S, Brunzelle, J.S, Wawrzak, Z, Onopriyenko, O, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2014-01-08
Release date:2014-03-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:2.35 Angstrom resolution crystal structure of putative O-acetylhomoserine (thiol)-lyase (metY) from Campylobacter jejuni subsp. jejuni NCTC 11168 with N'-Pyridoxyl-Lysine-5'-Monophosphate at position 205
To be Published
4MKK
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BU of 4mkk by Molmil
Crystal structure of C115A mutant L-methionine gamma-lyase from Citrobacter freundii modified by allicine
Descriptor: CHLORIDE ION, Methionine gamma-lyase, POTASSIUM ION, ...
Authors:Revtovich, S.V, Nikulin, A.D, Morozova, E.A, Zakomirdina, L.N, Demidkina, T.V.
Deposit date:2013-09-05
Release date:2014-11-12
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Alliin is a suicide substrate of Citrobacter freundii methionine gamma-lyase: structural bases of inactivation of the enzyme.
Acta Crystallogr.,Sect.D, 70, 2014
4MKJ
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BU of 4mkj by Molmil
Crystal structure of L-methionine gamma-lyase from Citrobacter freundii modified by allicine
Descriptor: Methionine gamma-lyase, PENTAETHYLENE GLYCOL, SODIUM ION, ...
Authors:Revtovich, S.V, Nikulin, A.D, Morozova, E.A, Zakomirdina, L.N, Demidkina, T.V.
Deposit date:2013-09-05
Release date:2014-11-12
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:Alliin is a suicide substrate of Citrobacter freundii methionine gamma-lyase: structural bases of inactivation of the enzyme.
Acta Crystallogr.,Sect.D, 70, 2014
4L0O
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BU of 4l0o by Molmil
Structure determination of cystathionine gamma-synthase from Helicobacter pylori
Descriptor: Cystathionine gamma-synthase, PHOSPHATE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Tarique, K.F, Rehman, S.A.A, Gourinath, S.
Deposit date:2013-05-31
Release date:2013-12-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structure determination of cystathionine gamma-synthase from Helicobacter pylori
To be Published
4KAM
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BU of 4kam by Molmil
X-ray crystal structure of O-acetylhomoserine sulfhydrylase MetC from Mycobacterium marinum ATCC BAA-535 / M
Descriptor: O-acetylhomoserine sulfhydrylase MetC, SULFATE ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2013-04-22
Release date:2013-05-01
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
4IYO
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BU of 4iyo by Molmil
Crystal structure of cystathionine gamma lyase from Xanthomonas oryzae pv. oryzae (XometC) in complex with E-site serine, A-site serine, A-site external aldimine structure with aminoacrylate and A-site iminopropionate intermediates
Descriptor: 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid, AMINO-ACRYLATE, Cystathionine gamma-lyase-like protein, ...
Authors:Ngo, H.P.T, Kim, J.K, Kang, L.W.
Deposit date:2013-01-29
Release date:2014-01-29
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:PLP undergoes conformational changes during the course of an enzymatic reaction.
Acta Crystallogr.,Sect.D, 70, 2014
4IY7
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BU of 4iy7 by Molmil
crystal structure of cystathionine gamma lyase (XometC) from Xanthomonas oryzae pv. oryzae in complex with E-site serine, A-site external aldimine structure with serine and A-site external aldimine structure with aminoacrylate intermediates
Descriptor: (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-serine, 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid, Cystathionine gamma-lyase-like protein, ...
Authors:Ngo, H.P.T, Kim, J.K, Kang, L.W.
Deposit date:2013-01-28
Release date:2014-01-29
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:PLP undergoes conformational changes during the course of an enzymatic reaction.
Acta Crystallogr.,Sect.D, 70, 2014
4IXZ
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BU of 4ixz by Molmil
Native structure of cystathionine gamma lyase (XometC) from xanthomonas oryzae pv. oryzae at pH 9.0
Descriptor: BETA-MERCAPTOETHANOL, BICARBONATE ION, Cystathionine gamma-lyase-like protein, ...
Authors:Ngo, H.P.T, Kim, J.K, Kang, L.W.
Deposit date:2013-01-28
Release date:2014-01-29
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:PLP undergoes conformational changes during the course of an enzymatic reaction.
Acta Crystallogr.,Sect.D, 70, 2014

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