4PAM
| A conserved phenylalanine as relay between the 5 helix and the GDP binding region of heterotrimeric G protein | Descriptor: | CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Kaya, A.I, Lokits, A.D, Gilbert, J, Iverson, T.M, Meiler, J, Hamm, H.E. | Deposit date: | 2014-04-09 | Release date: | 2014-07-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.101 Å) | Cite: | A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit. J.Biol.Chem., 289, 2014
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1AZT
| GS-ALPHA COMPLEXED WITH GTP-GAMMA-S | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GS-ALPHA, MAGNESIUM ION, ... | Authors: | Tesmer, J.J.G, Sprang, S.R. | Deposit date: | 1997-11-20 | Release date: | 1998-02-25 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the adenylyl cyclase activator Gsalpha Science, 278, 1997
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3FFB
| Gi-alpha-1 mutant in GDP bound form | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ... | Authors: | Chauhan, R, Kapoor, N. | Deposit date: | 2008-12-02 | Release date: | 2009-10-06 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Structural evidence for a sequential release mechanism for activation of heterotrimeric g proteins. J.Mol.Biol., 393, 2009
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2ZJZ
| Structure of the K349P mutant of Gi alpha 1 subunit bound to GDP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit | Authors: | Morikawa, T, Muroya, A, Sugio, S, Wakamatsu, K, Kohno, T. | Deposit date: | 2008-03-11 | Release date: | 2009-03-24 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | How GPCRs activate G proteins: Structural changes from C-terminal tail to GDP binding pocket To be Published
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2ZJY
| Structure of the K349P mutant of Gi alpha 1 subunit bound to ALF4 and GDP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ... | Authors: | Morikawa, T, Muroya, A, Sugio, S, Wakamatsu, K, Kohno, T. | Deposit date: | 2008-03-11 | Release date: | 2009-03-24 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | How GPCRs activate G proteins: Structural changes form C-terminal tail to GDP binding pocket To be Published
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4PAN
| A conserved phenylalanine as relay between the 5 helix and the GDP binding region of heterotrimeric G protein | Descriptor: | CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Kaya, A.I, Lokits, A.D, Gilbert, J, Iverson, T.M, Meiler, J, Hamm, H.E. | Deposit date: | 2014-04-09 | Release date: | 2014-07-30 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit. J.Biol.Chem., 289, 2014
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1SVK
| Structure of the K180P mutant of Gi alpha subunit bound to AlF4 and GDP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ... | Authors: | Thomas, C.J, Du, X, Li, P, Wang, Y, Ross, E.M, Sprang, S.R. | Deposit date: | 2004-03-29 | Release date: | 2004-06-01 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein {alpha}-subunit. Proc.Natl.Acad.Sci.USA, 101, 2004
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1SVS
| Structure of the K180P mutant of Gi alpha subunit bound to GppNHp. | Descriptor: | Guanine nucleotide-binding protein G(i), alpha-1 subunit, MAGNESIUM ION, ... | Authors: | Thomas, C.J, Du, X, Li, P, Wang, Y, Ross, E.M, Sprang, S.R. | Deposit date: | 2004-03-29 | Release date: | 2004-06-01 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein {alpha}-subunit. Proc.Natl.Acad.Sci.USA, 101, 2004
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1TND
| THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, CACODYLATE ION, MAGNESIUM ION, ... | Authors: | Noel, J.P, Hamm, H.E, Sigler, P.B. | Deposit date: | 1994-03-31 | Release date: | 1994-07-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S. Nature, 366, 1993
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1TAG
| STRUCTURAL DETERMINANTS FOR ACTIVATION OF THE ALPHA-SUBUNIT OF A HETEROTRIMERIC G PROTEIN | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, TRANSDUCIN-ALPHA | Authors: | Lambright, D.G, Noel, J.P, Hamm, H.E, Sigler, P.B. | Deposit date: | 1994-11-23 | Release date: | 1995-02-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein. Nature, 369, 1994
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1TAD
| GTPASE MECHANISM OF GPROTEINS FROM THE 1.7-ANGSTROM CRYSTAL STRUCTURE OF TRANSDUCIN ALPHA-GDP-ALF4- | Descriptor: | CACODYLATE ION, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Sondek, J, Lambright, D.G, Noel, J.P, Hamm, H.E, Sigler, P.B. | Deposit date: | 1995-01-05 | Release date: | 1995-05-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4. Nature, 372, 1994
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6MHE
| Galphai3 co-crystallized with KB752 | Descriptor: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(k) subunit alpha, ... | Authors: | Rees, S.D, Kalogriopoulos, N.A, Ngo, T, Kopcho, N, Ilatovskiy, A, Sun, N, Komives, E, Chang, G, Ghosh, P, Kufareva, I. | Deposit date: | 2018-09-17 | Release date: | 2019-07-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis for GPCR-independent activation of heterotrimeric Gi proteins. Proc.Natl.Acad.Sci.USA, 116, 2019
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6MHF
| Galphai3 co-crystallized with GIV/Girdin | Descriptor: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, Girdin, ... | Authors: | Rees, S.D, Kalogriopoulos, N.A, Ngo, T, Kopcho, N, Ilatovskiy, A, Sun, N, Komives, E, Chang, G, Ghosh, P, Kufareva, I. | Deposit date: | 2018-09-17 | Release date: | 2019-07-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for GPCR-independent activation of heterotrimeric Gi proteins. Proc.Natl.Acad.Sci.USA, 116, 2019
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6M8H
| Crystal Structure of the R208Q mutant of G(i) subunit alpha-1 | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, MAGNESIUM ION | Authors: | Mascarenhas, R, Goossens, J, Leverson, B, Kothawala, S, Ballicora, M, Olsen, K, de freitas, D, Liu, D. | Deposit date: | 2018-08-21 | Release date: | 2019-08-21 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | FUNCTIONAL CONSEQUENCES OF ONCOGENIC MUTATIONS IN THE SWITCH II REGION OF Galphai1 and Galphas PROTEINS To Be Published
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1CIP
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1GIT
| STRUCTURE OF GTP-BINDING PROTEIN | Descriptor: | G PROTEIN GI ALPHA 1, GUANOSINE-5'-DIPHOSPHATE, PHOSPHATE ION | Authors: | Berghuis, A.M, Lee, E, Sprang, S.R. | Deposit date: | 1996-10-16 | Release date: | 1997-02-12 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of the GDP-Pi complex of Gly203-->Ala gialpha1: a mimic of the ternary product complex of galpha-catalyzed GTP hydrolysis. Structure, 4, 1996
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1GDD
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1GIA
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1BOF
| GI-ALPHA-1 BOUND TO GDP AND MAGNESIUM | Descriptor: | GI ALPHA 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Coleman, D.E, Sprang, S.R. | Deposit date: | 1998-08-04 | Release date: | 1999-01-06 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of the G protein Gi alpha 1 complexed with GDP and Mg2+: a crystallographic titration experiment. Biochemistry, 37, 1998
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1GFI
| STRUCTURES OF ACTIVE CONFORMATIONS OF GI ALPHA 1 AND THE MECHANISM OF GTP HYDROLYSIS | Descriptor: | GUANINE NUCLEOTIDE-BINDING PROTEIN G, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Coleman, D.E, Berghuis, A.M, Sprang, S.R. | Deposit date: | 1994-11-11 | Release date: | 1995-03-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis. Science, 265, 1994
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1GIL
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7E5E
| Crystal structure of GDP-bound GNAS in complex with the cyclic peptide inhibitor GD20 | Descriptor: | CHLORIDE ION, GD20, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Hu, Q, Dai, S, Shokat, K.M. | Deposit date: | 2021-02-18 | Release date: | 2022-03-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | State-selective modulation of heterotrimeric G alpha s signaling with macrocyclic peptides. Cell, 185, 2022
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8HTG
| Crystal structure of Golf in complex with GTP-gamma S and Mg | Descriptor: | 1,2-ETHANEDIOL, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Guanine nucleotide-binding protein G(olf) subunit alpha, ... | Authors: | Kang, H, Choi, H.-J. | Deposit date: | 2022-12-21 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family. Nat Commun, 14, 2023
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8JPE
| Focused refinement structure of Galpha(q) in NTSR1-GRK2-Galpha(q) complexes | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ... | Authors: | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | Deposit date: | 2023-06-11 | Release date: | 2023-08-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (2.91 Å) | Cite: | GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
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1KJY
| Crystal Structure of Human G[alpha]i1 Bound to the GoLoco Motif of RGS14 | Descriptor: | CESIUM ION, GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT, ... | Authors: | Kimple, R.J, Kimple, M.E, Betts, L, Sondek, J, Siderovski, D.P. | Deposit date: | 2001-12-05 | Release date: | 2002-05-08 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits. Nature, 416, 2002
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