7E5E

Crystal structure of GDP-bound GNAS in complex with the cyclic peptide inhibitor GD20

Summary for 7E5E

• Entry DOI: 10.2210/pdb7e5e/pdb
• Related: 7BPH
• Descriptor: Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, GD20, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: g protein, gnas, adenylyl cyclase, inactive state, inhibitor, mrna display, rapid, cyclic peptide, gd20, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 171382.83

Authors

Hu, Q.,Dai, S.,Shokat, K.M. (deposition date: 2021-02-18, release date: 2022-03-02, Last modification date: 2023-11-29)

• Primary citation: Dai, S.A.,Hu, Q.,Gao, R.,Blythe, E.E.,Touhara, K.K.,Peacock, H.,Zhang, Z.,von Zastrow, M.,Suga, H.,Shokat, K.M.; State-selective modulation of heterotrimeric G alpha s signaling with macrocyclic peptides.; Cell, 185:3950-, 2022; PubMed: 36170854; DOI: 10.1016/j.cell.2022.09.019

Experimental method

X-RAY DIFFRACTION (1.95 Å)