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6PGB	WDR5delta32 bound to N-(4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)-2-phenylacetamide Descriptor: N-{4-[5-(hydroxymethyl)-1H-imidazol-2-yl]butyl}-2-phenylacetamide, SULFATE ION, WD repeat-containing protein 5 Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG4	WDR5delta32 bound to (2-methyl-1H-imidazol-4-yl)methanol Descriptor: (2-methyl-1H-imidazol-4-yl)methanol, SULFATE ION, WD repeat-containing protein 5 Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG9	WDR5delta23 bound to N-(4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)benzamide Descriptor: N-{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]butyl}benzamide, WD repeat-containing protein 5 Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG8	WDR5delta23 bound to (2-(3-phenylpropyl)-1H-imidazol-4-yl)methanol Descriptor: CHLORIDE ION, SULFATE ION, WD repeat-containing protein 5, ... Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6E1Z	Displacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity Descriptor: 5-[(1H-imidazol-1-yl)methyl]furan-2-carboxylic acid, WD repeat-containing protein 5 Authors: Phan, J, Fesik, S.W. Deposit date: 2018-07-10 Release date: 2019-03-13 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep, 26, 2019
6PGA	WDR5delta32 bound to methyl (4-(4-(hydroxymethyl)-1H-imidazol-2-yl)butyl)carbamate Descriptor: SULFATE ION, WD repeat-containing protein 5, methyl {4-[5-(hydroxymethyl)-1H-imidazol-2-yl]butyl}carbamate Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6E23	Displacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, N-[(3,4-dichlorophenyl)methyl]-3-(6-fluoro-2-methylpyridin-3-yl)-5-{[(2E)-2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl]methyl}benzamide, WD repeat-containing protein 5 Authors: Phan, J, Fesik, S.W. Deposit date: 2018-07-10 Release date: 2019-03-13 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.66 Å) Cite: Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep, 26, 2019
6E22	Displacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity Descriptor: 3-{[(4,5-dihydro-1H-imidazol-2-yl)amino]methyl}-N-[(3,5-dimethoxyphenyl)methyl]-4-fluorobenzamide, SULFATE ION, WD repeat-containing protein 5 Authors: Phan, J, Fesik, S.W. Deposit date: 2018-07-10 Release date: 2019-03-13 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep, 26, 2019
6KM7	The structural basis for the internal interaction in RBBP5 Descriptor: HEXAETHYLENE GLYCOL, NONAETHYLENE GLYCOL, Retinoblastoma-binding protein 5, ... Authors: Han, J, Li, T, Chen, Y. Deposit date: 2019-07-31 Release date: 2019-10-02 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (1.801 Å) Cite: The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex. Nucleic Acids Res., 47, 2019
6N31	WD repeats of human WDR12 Descriptor: Ribosome biogenesis protein WDR12, UNKNOWN ATOM OR ION Authors: Halabelian, L, Zeng, H, Tempel, W, Li, Y, Seitova, A, Hutchinson, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC) Deposit date: 2018-11-14 Release date: 2018-12-12 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.6 Å) Cite: WD repeats of human WDR12 To Be Published
7KXT	Crystal structure of human EED Descriptor: 1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine, Polycomb protein EED, UNKNOWN ATOM OR ION Authors: Zhu, L, Dong, A, Du, D, Liu, Y, Luo, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) Deposit date: 2020-12-04 Release date: 2021-02-24 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction. J.Med.Chem., 64, 2021
7KLJ	Crystal structure of the WD-repeat domain of human KIF21A Descriptor: 1,2-ETHANEDIOL, Isoform 2 of Kinesin-like protein KIF21A, UNKNOWN ATOM OR ION Authors: Zeng, H, Dong, A, Loppnau, P, Hutchinson, A, Seitova, A, Edwards, A.M, Arrowsmith, C.H, Halabelian, L, Structural Genomics Consortium (SGC) Deposit date: 2020-10-30 Release date: 2020-12-16 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.52 Å) Cite: Crystal structure of the WD-repeat domain of human KIF21A To be Published
7MT1	Crystal structure of Human Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1) Descriptor: GLYCEROL, Platelet-activating factor acetylhydrolase IB subunit beta, UNKNOWN ATOM OR ION Authors: Hutchinson, A, Seitova, A, Dong, A, Loppnau, P, Edwards, A.M, Arrowsmith, C.H, Halabelian, L, Structural Genomics Consortium (SGC) Deposit date: 2021-05-12 Release date: 2021-06-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Crystal structure of Human Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1) To Be Published
6QTS	Crystal structure of a mutant Arabidopsis WD40 domain in complex with a photoreceptor Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ... Authors: Hothorn, M, Lau, K. Deposit date: 2019-02-25 Release date: 2019-07-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.11 Å) Cite: Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
7MSD	Structure of EED bound to EEDi-6068 Descriptor: (9aP,12aR)-4-(2,2-difluoropropyl)-12-{[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]amino}-7-(trifluoromethyl)-4,5-dihydro-3H-2,4,8,11,12a-pentaazabenzo[4,5]cycloocta[1,2,3-cd]inden-3-one, FORMIC ACID, Polycomb protein EED Authors: Petrunak, E, Stuckey, J. Deposit date: 2021-05-11 Release date: 2021-10-20 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression. J.Med.Chem., 64, 2021
7MSB	Structure of EED bound to EEDi-4259 Descriptor: (9aM,12aS)-12-{[(5-fluoro-1-benzofuran-4-yl)methyl]amino}-7-(trifluoromethyl)-4,5-dihydro-3H-2,4,11,12a-tetraazabenzo[4,5]cycloocta[1,2,3-cd]inden-3-one, Polycomb protein EED Authors: Petrunak, E, Stuckey, J. Deposit date: 2021-05-11 Release date: 2021-10-20 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression. J.Med.Chem., 64, 2021
6R60	asymmetric antiparallel assembly of two 5-bladed beta-propeller fragments Descriptor: WD-40 repeat protein Authors: Afanasieva, E, Lupas, A.N, Hartmann, M.D. Deposit date: 2019-03-26 Release date: 2019-11-13 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural diversity of oligomeric beta-propellers with different numbers of identical blades. Elife, 8, 2019
6R5X	8-bladed beta-propeller formed by four 2-bladed fragments Descriptor: WD-40 repeat protein Authors: Martin, J, Lupas, A.N, Hartmann, M.D. Deposit date: 2019-03-25 Release date: 2019-11-13 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural diversity of oligomeric beta-propellers with different numbers of identical blades. Elife, 8, 2019
6SFC	EED in complex with a methyl-thiazole Descriptor: CALCIUM ION, N-(1,3-benzodioxol-4-ylmethyl)-4-methyl-5-(1-methylpyrazol-3-yl)-1,3-thiazol-2-amine, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... Authors: Read, J.A. Deposit date: 2019-08-01 Release date: 2019-09-25 Last modified: 2021-07-14 Method: X-RAY DIFFRACTION (2 Å) Cite: Rapid Identification of Novel Allosteric PRC2 Inhibitors. Acs Chem.Biol., 14, 2019
6R5Y	8-bladed beta-propeller formed by two 4-bladed fragments Descriptor: WD-40 repeat protein, ZINC ION Authors: Martin, J, Lupas, A.N, Hartmann, M.D. Deposit date: 2019-03-25 Release date: 2019-11-13 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structural diversity of oligomeric beta-propellers with different numbers of identical blades. Elife, 8, 2019
6QTR	Crystal structure of a mutant Arabidopsis WD40 domain in complex with a transcription factor Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ... Authors: Hothorn, M, Lau, K. Deposit date: 2019-02-25 Release date: 2019-07-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.37 Å) Cite: Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTT	Crystal structure of an Arabidopsis WD40 domain in complex with a transcription factor homolog Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, MALONATE ION, ... Authors: Hothorn, M, Lau, K. Deposit date: 2019-02-25 Release date: 2019-07-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.51 Å) Cite: Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6SFB	EED in complex with a triazolopyrimidine Descriptor: GLYCEROL, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, Polycomb protein EED Authors: Read, J.A. Deposit date: 2019-08-01 Release date: 2019-09-25 Last modified: 2021-07-14 Method: X-RAY DIFFRACTION (1.52 Å) Cite: Rapid Identification of Novel Allosteric PRC2 Inhibitors. Acs Chem.Biol., 14, 2019
6R5Z	9-bladed beta-propeller formed by three 3-bladed fragments Descriptor: 9-bladed beta-propeller formed by three 3-bladed fragments Authors: Martin, J, Lupas, A.N, Hartmann, M.D. Deposit date: 2019-03-26 Release date: 2019-11-13 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural diversity of oligomeric beta-propellers with different numbers of identical blades. Elife, 8, 2019
6QTO	Crystal structure of an Arabidopsis WD40 domain in complex with a transcription factor Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ... Authors: Hothorn, M, Lau, K. Deposit date: 2019-02-25 Release date: 2019-07-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.27 Å) Cite: Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019

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