PDB: 2374 resultsInfo pagesStatus searchChemie searchBIRD

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8ENY	Crystal structure of alpha-COPI-WD40 domain R13A mutant. Descriptor: ACETYL GROUP, Putative coatomer subunit alpha Authors: Dey, D, Hasan, S.S. Deposit date: 2022-09-30 Release date: 2024-01-31 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8ENZ	Crystal structure of alpha-COPI-WD40 domain K15A mutant. Descriptor: ACETYL GROUP, Putative coatomer subunit alpha Authors: Dey, D, Hasan, S.S. Deposit date: 2022-09-30 Release date: 2024-01-31 Method: X-RAY DIFFRACTION (1.65 Å) Cite: A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8EO0	Crystal structure of alpha-COPI WD40 domain R300A mutant. Descriptor: ACETYL GROUP, Putative coatomer subunit alpha Authors: Dey, D, Hasan, S.S. Deposit date: 2022-10-01 Release date: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8ENS	Crystal structure of beta'-COPI-WD40 domain in complex with SARS-CoV-2 spike tail hepta-peptide Descriptor: Coatomer subunit beta', spike tail hepta-peptide Authors: Dey, D, Hasan, S.S. Deposit date: 2022-09-30 Release date: 2024-01-31 Method: X-RAY DIFFRACTION (1.45 Å) Cite: A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8ENW	Crystal structure of beta'-COPI-WD40 domain in complex with SARS-CoV-2 clientized spike tail heptapeptide. Descriptor: 1,2-ETHANEDIOL, Clientized spike tail peptide, Coatomer subunit beta' Authors: Dey, D, Hasan, S.S. Deposit date: 2022-09-30 Release date: 2024-01-31 Method: X-RAY DIFFRACTION (1.45 Å) Cite: A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8F1G	Crystal structure of human WDR5 in complex with compound WM662 Descriptor: (2S)-2-({(2S)-3-(3'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-1-[(1H-tetrazol-5-yl)amino]propan-2-yl}oxy)propanoic acid, GLYCEROL, SULFATE ION, ... Authors: Liu, H. Deposit date: 2022-11-05 Release date: 2023-01-11 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction. Acs Chem.Biol., 18, 2023
8F93	WDR5 covalently modified at Y228 by (R)-2-SF Descriptor: 3-ethynyl-5-{[(3R)-4-{1-[(2-methoxyphenyl)methyl]-1H-benzimidazole-5-carbonyl}-3-methylpiperazin-1-yl]methyl}benzene-1-sulfonyl fluoride, CHLORIDE ION, GLYCEROL, ... Authors: Taunton, J, Craven, G.B, Chen, Y. Deposit date: 2022-11-23 Release date: 2023-05-31 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes. Nat.Chem., 15, 2023
8G3C	Crystal structure of human WDR5 in complex with N-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxamide (compound 1, WDR5-MYC PPI inhibitor) Descriptor: N-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxamide, WD repeat-containing protein 5 Authors: Zhao, M. Deposit date: 2023-02-07 Release date: 2023-06-28 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction. J.Med.Chem., 66, 2023
8G3E	Crystal structure of human WDR5 in complex with (1M)-N-[(3,5-difluoro[1,1'-biphenyl]-4-yl)methyl]-6-methyl-4-oxo-1-(pyridin-3-yl)-1,4-dihydropyridazine-3-carboxamide (compound 2, WDR5-MYC inhibitor) Descriptor: (1M)-N-[(3,5-difluoro[1,1'-biphenyl]-4-yl)methyl]-6-methyl-4-oxo-1-(pyridin-3-yl)-1,4-dihydropyridazine-3-carboxamide, WD repeat-containing protein 5 Authors: Zhao, M. Deposit date: 2023-02-07 Release date: 2023-06-28 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.33 Å) Cite: Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction. J.Med.Chem., 66, 2023
8EWX	N-terminal WD40 domain of beta'-COPI subunit with two chains in the asymmetric unit Descriptor: Coatomer subunit beta' Authors: Dey, D, Hasan, S.S. Deposit date: 2022-10-24 Release date: 2023-08-30 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.24 Å) Cite: Strategies for rapid production of crystallization quality coatomer WD40 domains. Protein Expr.Purif., 212, 2023
8F0E	N-terminal WD40 domain of beta'-COPI subunit with four chains in the asymmetric unit Descriptor: Coatomer subunit beta' Authors: Dey, D, Hasan, S.S. Deposit date: 2022-11-02 Release date: 2023-08-30 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.31 Å) Cite: Strategies for rapid production of crystallization quality coatomer WD40 domains. Protein Expr.Purif., 212, 2023
8EVL	Crystal structure of alpha-COPI N-terminal WD40 domain Descriptor: Putative coatomer subunit alpha Authors: Dey, D, Hasan, S.S. Deposit date: 2022-10-20 Release date: 2023-08-30 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Strategies for rapid production of crystallization quality coatomer WD40 domains. Protein Expr.Purif., 212, 2023
7CFP	Crystal structure of WDR5 in complex with a H3Q5ser peptide Descriptor: H3Q5ser peptide, SEROTONIN, WD repeat-containing protein 5 Authors: Zhao, J, Zhang, X, Zang, J. Deposit date: 2020-06-27 Release date: 2021-07-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural insights into the recognition of histone H3Q5 serotonylation by WDR5. Sci Adv, 7, 2021
7CFQ	Crystal structure of WDR5 in complex with H3K4me3Q5ser peptide Descriptor: 1,2-ETHANEDIOL, GLYCEROL, H3K4me3Q5ser peptide, ... Authors: Zhao, J, Zhang, X, Zang, J. Deposit date: 2020-06-27 Release date: 2021-07-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural insights into the recognition of histone H3Q5 serotonylation by WDR5. Sci Adv, 7, 2021
7DNO	Characterization of Peptide Ligands Against WDR5 Isolated Using Phage Display Technique Descriptor: CYS-ARG-THR-LEU-PRO-PHE, WD repeat-containing protein 5 Authors: Cao, J, Cao, D, Xiong, B, Li, Y, Fan, T. Deposit date: 2020-12-10 Release date: 2021-02-10 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Phage-Display Based Discovery and Characterization of Peptide Ligands against WDR5. Molecules, 26, 2021
7DH6	Crystal structure of PLRG1 Descriptor: CALCIUM ION, NICKEL (II) ION, Pleiotropic regulator 1, ... Authors: Wang, X, Xu, C. Deposit date: 2020-11-13 Release date: 2020-12-02 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.584 Å) Cite: Crystal structure of the WD40 domain of human PLRG1. Biochem.Biophys.Res.Commun., 534, 2021
7WVK	Crystal structure of human WDR5 in complex with compound 19 Descriptor: 1,2-ETHANEDIOL, 1-[2,5-bis(chloranyl)phenyl]sulfonylbenzimidazole, GLYCEROL, ... Authors: Han, Q.L, Zhang, X.L, Wang, L, Ren, P.X, Cao, Y, Li, K, Bai, F. Deposit date: 2022-02-10 Release date: 2022-10-19 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.42 Å) Cite: Discovery, evaluation and mechanism study of WDR5-targeted small molecular inhibitors for neuroblastoma. Acta Pharmacol.Sin., 44, 2023
8HMX	WDR5 in complex with histone H3Q5his peptide Descriptor: WD repeat-containing protein 5, histone H3Q5his peptide Authors: Li, H.T, Zhao, S, Wang, H.F. Deposit date: 2022-12-06 Release date: 2023-12-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: WDR5 in complex with histone H3Q5his peptide To Be Published
8HQT	The complex structure of COPI cargo sorting module with SARS-CoV-2 Spike KxHxx sorting motif Descriptor: Coatomer subunit beta', SARS-CoV-2 Spike KxHxx motif Authors: Ma, W.F, Nan, Y.N, Yang, M.R, Li, Y.Q. Deposit date: 2022-12-14 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Tighter ER retention of SARS-CoV-2 Omicron spike caused by a constellation of folding disruptive mutations To Be Published
8HQX	The complex structure of COPI cargo sorting module with TAT-WDM peptide Descriptor: Coatomer subunit beta', TAT-WDM KxKxx motif Authors: Ma, W.F, Nan, Y.N, Yang, M.R, Li, Y.Q. Deposit date: 2022-12-14 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (1.538 Å) Cite: The complex structure of COPI cargo sorting module with TAT-WDM peptide To Be Published
8HQV	The complex structure of COPI cargo sorting module with HCoV-OC43 Spike KTSHxx sorting motif Descriptor: Coatomer subunit beta', HCoV-OC43 Spike KTSHxx sorting motif Authors: Ma, W.F, Nan, Y.N, Yang, M.R, Li, Y.Q. Deposit date: 2022-12-14 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (1.398 Å) Cite: Tighter ER retention of SARS-CoV-2 Omicron spike caused by a constellation of folding disruptive mutations To Be Published
8HQW	The complex structure of COPI cargo sorting module with MHV Spike Hxx sorting motif Descriptor: Coatomer subunit beta',MHV Spike Hxx sorting motif Authors: Ma, W.F, Nan, Y.N, Yang, M.R, Li, Y.Q. Deposit date: 2022-12-14 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (1.405 Å) Cite: Tighter ER retention of SARS-CoV-2 Omicron spike caused by a constellation of folding disruptive mutations To Be Published
3C9C	Structural Basis of Histone H4 Recognition by p55 Descriptor: CADMIUM ION, Chromatin assembly factor 1 p55 subunit, Histone H4, ... Authors: Song, J.J, Garlick, J.D, Kingston, R.E. Deposit date: 2008-02-15 Release date: 2008-05-13 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structural basis of histone H4 recognition by p55. Genes Dev., 22, 2008
2QXV	Structural basis of EZH2 recognition by EED Descriptor: Embryonic ectoderm development, Enhancer of zeste homolog 2 Authors: Han, Z. Deposit date: 2007-08-13 Release date: 2007-08-28 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Structural basis of EZH2 recognition by EED Structure, 15, 2007
2TRC	PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX Descriptor: GADOLINIUM ATOM, PHOSDUCIN, TRANSDUCIN Authors: Gaudet, R, Bohm, A, Sigler, P.B. Deposit date: 1997-01-06 Release date: 1997-06-05 Last modified: 2019-08-14 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure at 2.4 angstroms resolution of the complex of transducin betagamma and its regulator, phosducin. Cell(Cambridge,Mass.), 87, 1996

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