PDB: 2396 resultsInfo pagesStatus searchChemie searchBIRD

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8EVL	Crystal structure of alpha-COPI N-terminal WD40 domain Descriptor: Putative coatomer subunit alpha Authors: Dey, D, Hasan, S.S. Deposit date: 2022-10-20 Release date: 2023-08-30 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Strategies for rapid production of crystallization quality coatomer WD40 domains. Protein Expr.Purif., 212, 2023
8F0E	N-terminal WD40 domain of beta'-COPI subunit with four chains in the asymmetric unit Descriptor: Coatomer subunit beta' Authors: Dey, D, Hasan, S.S. Deposit date: 2022-11-02 Release date: 2023-08-30 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.31 Å) Cite: Strategies for rapid production of crystallization quality coatomer WD40 domains. Protein Expr.Purif., 212, 2023
8EWX	N-terminal WD40 domain of beta'-COPI subunit with two chains in the asymmetric unit Descriptor: Coatomer subunit beta' Authors: Dey, D, Hasan, S.S. Deposit date: 2022-10-24 Release date: 2023-08-30 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.24 Å) Cite: Strategies for rapid production of crystallization quality coatomer WD40 domains. Protein Expr.Purif., 212, 2023
8ENW	Crystal structure of beta'-COPI-WD40 domain in complex with SARS-CoV-2 clientized spike tail heptapeptide. Descriptor: 1,2-ETHANEDIOL, Clientized spike tail peptide, Coatomer subunit beta' Authors: Dey, D, Hasan, S.S. Deposit date: 2022-09-30 Release date: 2024-01-31 Method: X-RAY DIFFRACTION (1.45 Å) Cite: A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8ENY	Crystal structure of alpha-COPI-WD40 domain R13A mutant. Descriptor: ACETYL GROUP, Putative coatomer subunit alpha Authors: Dey, D, Hasan, S.S. Deposit date: 2022-09-30 Release date: 2024-01-31 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8ENS	Crystal structure of beta'-COPI-WD40 domain in complex with SARS-CoV-2 spike tail hepta-peptide Descriptor: Coatomer subunit beta', spike tail hepta-peptide Authors: Dey, D, Hasan, S.S. Deposit date: 2022-09-30 Release date: 2024-01-31 Method: X-RAY DIFFRACTION (1.45 Å) Cite: A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8ENZ	Crystal structure of alpha-COPI-WD40 domain K15A mutant. Descriptor: ACETYL GROUP, Putative coatomer subunit alpha Authors: Dey, D, Hasan, S.S. Deposit date: 2022-09-30 Release date: 2024-01-31 Method: X-RAY DIFFRACTION (1.65 Å) Cite: A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8EO0	Crystal structure of alpha-COPI WD40 domain R300A mutant. Descriptor: ACETYL GROUP, Putative coatomer subunit alpha Authors: Dey, D, Hasan, S.S. Deposit date: 2022-10-01 Release date: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8ENX	Crystal structure of beta'-COPI-WD40 domain Y33A mutant in complex with SARS-CoV-2 clientized spike tail heptapeptide. Descriptor: Clientized spike tail heptapeptide, Coatomer subunit beta' Authors: Dey, D, Hasan, S.S. Deposit date: 2022-09-30 Release date: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8G3C	Crystal structure of human WDR5 in complex with N-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxamide (compound 1, WDR5-MYC PPI inhibitor) Descriptor: N-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxamide, WD repeat-containing protein 5 Authors: Zhao, M. Deposit date: 2023-02-07 Release date: 2023-06-28 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction. J.Med.Chem., 66, 2023
8G3E	Crystal structure of human WDR5 in complex with (1M)-N-[(3,5-difluoro[1,1'-biphenyl]-4-yl)methyl]-6-methyl-4-oxo-1-(pyridin-3-yl)-1,4-dihydropyridazine-3-carboxamide (compound 2, WDR5-MYC inhibitor) Descriptor: (1M)-N-[(3,5-difluoro[1,1'-biphenyl]-4-yl)methyl]-6-methyl-4-oxo-1-(pyridin-3-yl)-1,4-dihydropyridazine-3-carboxamide, WD repeat-containing protein 5 Authors: Zhao, M. Deposit date: 2023-02-07 Release date: 2023-06-28 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.33 Å) Cite: Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction. J.Med.Chem., 66, 2023
8Q1N	Cyclic peptide binder of the WBM-site of WDR5 Descriptor: Cyclic peptide inhibitor, WD repeat-containing protein 5 Authors: Schmeing, S, Chang, J.Y, t Hart, P, Gasper, R. Deposit date: 2023-08-01 Release date: 2023-09-06 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.843 Å) Cite: Macrocyclic peptides as inhibitors of WDR5-lncRNA interactions. Chem.Commun.(Camb.), 59, 2023
8SIU	Origin Recognition Complex Associated (ORCA) protein bound to Orc2 Descriptor: Leucine-rich repeat and WD repeat-containing protein 1, Origin recognition complex subunit 2, SULFATE ION Authors: Bleichert, F, Ekundayo, B.E. Deposit date: 2023-04-17 Release date: 2023-08-02 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A dual role for the chromatin reader ORCA/LRWD1 in targeting the origin recognition complex to chromatin. Embo J., 42, 2023
8SZX	Crystal structure of b'-WD40 Lys17Ala mutant Descriptor: Coatomer subunit beta' Authors: Dey, D, Hasan, S.S. Deposit date: 2023-05-30 Release date: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8T5I	Crystal structure of human WDR5 in complex with MR4397 Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, N-[(2S)-1-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-oxopentan-2-yl]-3-[(1H-imidazol-1-yl)methyl]benzamide, ... Authors: Kimani, S, Dong, A, Li, F, Loppnau, P, Ackloo, S, Vedadi, M, Brown, P.J, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) Deposit date: 2023-06-13 Release date: 2023-08-09 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of human WDR5 in complex with MR4397 To be published
8UJY	Crystal structure of human WD repeat-containing protein 5 in complex with 4-(3,5-dimethoxybenzyl)-9-(4-fluoro-2-methylphenyl)-7-((2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl)methyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one (compound 8) Descriptor: (9P)-4-[(3,5-dimethoxyphenyl)methyl]-9-(4-fluoro-2-methylphenyl)-7-{[(2E)-2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl]methyl}-3,4-dihydro-1,4-benzoxazepin-5(2H)-one, WD repeat-containing protein 5 Authors: Zhao, B, Amporndanai, K, Fesik, S.W. Deposit date: 2023-10-11 Release date: 2023-12-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Structure-Based Discovery of Potent, Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 Inhibitors. J.Med.Chem., 66, 2023
7WVK	Crystal structure of human WDR5 in complex with compound 19 Descriptor: 1,2-ETHANEDIOL, 1-[2,5-bis(chloranyl)phenyl]sulfonylbenzimidazole, GLYCEROL, ... Authors: Han, Q.L, Zhang, X.L, Wang, L, Ren, P.X, Cao, Y, Li, K, Bai, F. Deposit date: 2022-02-10 Release date: 2022-10-19 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.42 Å) Cite: Discovery, evaluation and mechanism study of WDR5-targeted small molecular inhibitors for neuroblastoma. Acta Pharmacol.Sin., 44, 2023
8HMX	WDR5 in complex with histone H3Q5his peptide Descriptor: WD repeat-containing protein 5, histone H3Q5his peptide Authors: Li, H.T, Zhao, S, Wang, H.F. Deposit date: 2022-12-06 Release date: 2023-12-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: WDR5 in complex with histone H3Q5his peptide To Be Published
8HQX	The complex structure of COPI cargo sorting module with TAT-WDM peptide Descriptor: Coatomer subunit beta', TAT-WDM KxKxx motif Authors: Ma, W.F, Nan, Y.N, Yang, M.R, Li, Y.Q. Deposit date: 2022-12-14 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (1.538 Å) Cite: The complex structure of COPI cargo sorting module with TAT-WDM peptide To Be Published
8HQW	The complex structure of COPI cargo sorting module with MHV Spike Hxx sorting motif Descriptor: Coatomer subunit beta',MHV Spike Hxx sorting motif Authors: Ma, W.F, Nan, Y.N, Yang, M.R, Li, Y.Q. Deposit date: 2022-12-14 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (1.405 Å) Cite: Tighter ER retention of SARS-CoV-2 Omicron spike caused by a constellation of folding disruptive mutations To Be Published
8HQV	The complex structure of COPI cargo sorting module with HCoV-OC43 Spike KTSHxx sorting motif Descriptor: Coatomer subunit beta', HCoV-OC43 Spike KTSHxx sorting motif Authors: Ma, W.F, Nan, Y.N, Yang, M.R, Li, Y.Q. Deposit date: 2022-12-14 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (1.398 Å) Cite: Tighter ER retention of SARS-CoV-2 Omicron spike caused by a constellation of folding disruptive mutations To Be Published
8HQT	The complex structure of COPI cargo sorting module with SARS-CoV-2 Spike KxHxx sorting motif Descriptor: Coatomer subunit beta', SARS-CoV-2 Spike KxHxx motif Authors: Ma, W.F, Nan, Y.N, Yang, M.R, Li, Y.Q. Deposit date: 2022-12-14 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Tighter ER retention of SARS-CoV-2 Omicron spike caused by a constellation of folding disruptive mutations To Be Published
1A0R	HETEROTRIMERIC COMPLEX OF PHOSDUCIN/TRANSDUCIN BETA-GAMMA Descriptor: FARNESYL, PHOSDUCIN, TRANSDUCIN (BETA SUBUNIT), ... Authors: Loew, A, Ho, Y.-K, Blundell, T.L, Bax, B. Deposit date: 1997-12-05 Release date: 1998-12-30 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Phosducin induces a structural change in transducin beta gamma. Structure, 6, 1998
2I3S	Bub3 complex with Bub1 GLEBS motif Descriptor: Cell cycle arrest protein, Checkpoint serine/threonine-protein kinase Authors: Larsen, N.A, Harrison, S.C. Deposit date: 2006-08-20 Release date: 2007-01-09 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural analysis of Bub3 interactions in the mitotic spindle checkpoint. Proc.Natl.Acad.Sci.Usa, 104, 2007
2I3T	Bub3 complex with Mad3 (BubR1) GLEBS motif Descriptor: Cell cycle arrest protein, Spindle assembly checkpoint component Authors: Larsen, N.A, Harrison, S.C. Deposit date: 2006-08-20 Release date: 2007-01-09 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural analysis of Bub3 interactions in the mitotic spindle checkpoint. Proc.Natl.Acad.Sci.Usa, 104, 2007

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