7ZMO
| Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G3-052 | Descriptor: | ATP-dependent DNA helicase Q5, Gluebody G3-052, SULFATE ION, ... | Authors: | Ye, M, Makola, M, Newman, J.A, Fairhead, M, MacLean, E, Krojer, T, Aitkenhead, H, Bountra, C, Gileadi, O, von Delft, F. | Deposit date: | 2022-04-19 | Release date: | 2022-06-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.75 Å) | Cite: | Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive crystal contacts To Be Published
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7ZMN
| Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G3-048 | Descriptor: | ATP-dependent DNA helicase Q5, Gluebody G3-048, SULFATE ION, ... | Authors: | Ye, M, Makola, M, Newman, J.A, Fairhead, M, MacLean, E, Krojer, T, Aitkenhead, H, Bountra, C, Gileadi, O, von Delft, F. | Deposit date: | 2022-04-19 | Release date: | 2022-06-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive crystal contacts To Be Published
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7ZMM
| Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G2-001 | Descriptor: | ATP-dependent DNA helicase Q5, Gluebody G2-001, ZINC ION | Authors: | Ye, M, Makola, M, Newman, J.A, Fairhead, M, MacLean, E, Krojer, T, Aitkenhead, H, Bountra, C, Gileadi, O, von Delft, F. | Deposit date: | 2022-04-19 | Release date: | 2022-06-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive crystal contacts To Be Published
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7ZML
| Crystal structure of human RECQL5 helicase APO form in complex with engineered nanobody (Gluebody) G1-001 | Descriptor: | ATP-dependent DNA helicase Q5, Gluebody G1-001, SULFATE ION, ... | Authors: | Ye, M, Makola, M, Newman, J.A, Fairhead, M, MacLean, E, Krojer, T, Aitkenhead, H, Bountra, C, Gileadi, O, von Delft, F. | Deposit date: | 2022-04-19 | Release date: | 2022-06-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive crystal contacts To Be Published
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7Z52
| Human NEXT dimer - focused reconstruction of the single MTR4 | Descriptor: | Exosome RNA helicase MTR4, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, RNA (5'-R(P*UP*UP*UP*UP*U)-3'), ... | Authors: | Gerlach, P, Lingaraju, M, Salerno-Kochan, A, Bonneau, F, Basquin, J, Conti, E. | Deposit date: | 2022-03-07 | Release date: | 2022-06-22 | Last modified: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome. Mol.Cell, 82, 2022
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7Z4Z
| Human NEXT dimer - focused reconstruction of the dimerization module | Descriptor: | Exosome RNA helicase MTR4, Zinc finger CCHC domain-containing protein 8 | Authors: | Gerlach, P, Lingaraju, M, Salerno-Kochan, A, Bonneau, F, Basquin, J, Conti, E. | Deposit date: | 2022-03-06 | Release date: | 2022-06-22 | Last modified: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome. Mol.Cell, 82, 2022
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7Z4Y
| Human NEXT dimer - overall reconstruction of the core complex | Descriptor: | Exosome RNA helicase MTR4, Zinc finger CCHC domain-containing protein 8 | Authors: | Gerlach, P, Lingaraju, M, Salerno-Kochan, A, Bonneau, F, Basquin, J, Conti, E. | Deposit date: | 2022-03-06 | Release date: | 2022-06-22 | Last modified: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome. Mol.Cell, 82, 2022
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7YMF
| Crystal Structure of DDX3X449_450ET>DP | Descriptor: | ATP-dependent RNA helicase DDX3X | Authors: | Xiong, J. | Deposit date: | 2022-07-28 | Release date: | 2024-01-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structure of DDX3X449_450ET>DP To Be Published
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7XW3
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7XW2
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7W5B
| The cryo-EM structure of human C* complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | Authors: | Zhan, X, Lu, Y, Shi, Y. | Deposit date: | 2021-11-29 | Release date: | 2022-06-22 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
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7W5A
| The cryo-EM structure of human pre-C*-II complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | Authors: | Zhan, X, Lu, Y, Shi, Y. | Deposit date: | 2021-11-29 | Release date: | 2022-06-22 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
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7W59
| The cryo-EM structure of human pre-C*-I complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | Authors: | Zhan, X, Lu, Y, Shi, Y. | Deposit date: | 2021-11-29 | Release date: | 2022-06-22 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
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7W0F
| dmDicer2-LoqsPD-dsRNA Post-dicing status | Descriptor: | Dicer-2, isoform A, Loquacious, ... | Authors: | Su, S, Wang, J, Wang, H.W, Ma, J. | Deposit date: | 2021-11-18 | Release date: | 2022-04-27 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (4.55 Å) | Cite: | Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
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7W0E
| dmDicer2-LoqsPD-dsRNA Active-dicing status | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Dicer-2, isoform A, ... | Authors: | Su, S, Wang, J, Wang, H.W, Ma, J. | Deposit date: | 2021-11-18 | Release date: | 2022-04-27 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (4.03 Å) | Cite: | Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
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7W0D
| Dicer2-LoqsPD-dsRNA complex at mid-translocation state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Dicer-2, isoform A, ... | Authors: | Su, S, Wang, J, Wang, H.W, Ma, J. | Deposit date: | 2021-11-18 | Release date: | 2022-04-27 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (4.18 Å) | Cite: | Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
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7W0C
| Dicer2-Loqs-PD-dsRNA complex at early-translocation state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Dicer-2, isoform A, ... | Authors: | Su, S, Wang, J, Wang, H.W, Ma, J. | Deposit date: | 2021-11-18 | Release date: | 2022-04-27 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3.93 Å) | Cite: | Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
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7W0B
| Dicer2-LoqsPD complex at apo status | Descriptor: | Dicer-2, isoform A, Loquacious, ... | Authors: | Su, S, Wang, J, Wang, H.W, Ma, J. | Deposit date: | 2021-11-18 | Release date: | 2022-04-27 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3.33 Å) | Cite: | Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
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7W0A
| dmDicer2-LoqsPD-dsRNA Dimer status | Descriptor: | Dicer-2, isoform A, Loquacious, ... | Authors: | Su, S, Wang, J, Wang, H.W, Ma, J. | Deposit date: | 2021-11-18 | Release date: | 2022-04-27 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
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7VPX
| The cryo-EM structure of the human pre-A complex | Descriptor: | 5SS, DnaJ homolog subfamily C member 8, PHD finger-like domain-containing protein 5A, ... | Authors: | Zhang, X, Zhan, X, Shi, Y. | Deposit date: | 2021-10-18 | Release date: | 2023-05-03 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural insights into branch site proofreading by human spliceosome. Nat.Struct.Mol.Biol., 2024
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7VG3
| Cryo-EM structure of Arabidopsis DCL3 in complex with a 30-bp RNA | Descriptor: | CALCIUM ION, Dicer-like 3, TAS1a RNA forward strand (5'-phosphorylated), ... | Authors: | Wang, Q, Du, J. | Deposit date: | 2021-09-14 | Release date: | 2021-10-27 | Last modified: | 2021-12-15 | Method: | ELECTRON MICROSCOPY (3.73 Å) | Cite: | Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation. Science, 374, 2021
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7VG2
| Cryo-EM structure of Arabidopsis DCL3 in complex with a 40-bp RNA | Descriptor: | CALCIUM ION, Dicer-like 3, TAS1a forward strand (5'-phosphorylation), ... | Authors: | Wang, Q, Du, J. | Deposit date: | 2021-09-14 | Release date: | 2021-10-27 | Last modified: | 2021-12-15 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation. Science, 374, 2021
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7V6C
| Structure of the Dicer-2-R2D2 heterodimer bound to small RNA duplex | Descriptor: | Dicer-2, isoform A, R2D2, ... | Authors: | Yamaguchi, S, Nishizawa, T, Kusakizako, T, Yamashita, K, Tomita, A, Hirano, H, Nishimasu, H, Nureki, O. | Deposit date: | 2021-08-20 | Release date: | 2022-03-23 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of the Dicer-2-R2D2 heterodimer bound to a small RNA duplex. Nature, 607, 2022
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7V6B
| Structure of the Dicer-2-R2D2 heterodimer | Descriptor: | Dicer-2, isoform A, R2D2 | Authors: | Yamaguchi, S, Nishizawa, T, Kusakizako, T, Yamashita, K, Tomita, A, Hirano, H, Nishimasu, H, Nureki, O. | Deposit date: | 2021-08-20 | Release date: | 2022-03-23 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of the Dicer-2-R2D2 heterodimer bound to a small RNA duplex. Nature, 607, 2022
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7V2Y
| cryo-EM structure of yeast THO complex with Sub2 | Descriptor: | ATP-dependent RNA helicase SUB2, Protein TEX1, THO complex subunit 2, ... | Authors: | Chen, C, Tan, M, Wu, Z, Wu, J, Lei, M. | Deposit date: | 2021-08-10 | Release date: | 2022-07-27 | Last modified: | 2023-02-01 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex. Sci Bull (Beijing), 66, 2021
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