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5M8N	Crystal structure of human tyrosinase related protein 1 in complex with mimosine Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W. Deposit date: 2016-10-29 Release date: 2017-07-12 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Angew. Chem. Int. Ed. Engl., 56, 2017
5M8M	Crystal structure of human tyrosinase related protein 1 in complex with kojic acid Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W. Deposit date: 2016-10-29 Release date: 2017-07-12 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Angew. Chem. Int. Ed. Engl., 56, 2017
5OAE	Crystal Structure of tyrosinase from Bacillus megaterium with SVF inhibitor in the active site Descriptor: 1-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]ethanone, COPPER (II) ION, Tyrosinase Authors: Deri, B, Gitto, R, Pazy Benhar, Y, Fishman, A. Deposit date: 2017-06-21 Release date: 2018-04-25 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments. J. Med. Chem., 61, 2018
5OR4	Crystal structure of Aspergillus oryzae catechol oxidase in deoxy-form Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COPPER (II) ION, ... Authors: Hakulinen, N, Penttinen, L, Rutanen, C, Rouvinen, J. Deposit date: 2017-08-15 Release date: 2018-05-09 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.445 Å) Cite: A new crystal form of Aspergillus oryzae catechol oxidase and evaluation of copper site structures in coupled binuclear copper enzymes. PLoS ONE, 13, 2018
5OR3	Crystal structure of Aspergillus oryzae catechol oxidase in met/deoxy-form Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Hakulinen, N, Penttinen, L, Rutanen, C, Rouvinen, J. Deposit date: 2017-08-15 Release date: 2018-05-09 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (1.795 Å) Cite: A new crystal form of Aspergillus oryzae catechol oxidase and evaluation of copper site structures in coupled binuclear copper enzymes. PLoS ONE, 13, 2018
6EI4	Crystal Structure of tyrosinase from Bacillus megaterium with B5N inhibitor in the active site Descriptor: COPPER (II) ION, Tyrosinase, [4-[(4-fluorophenyl)methyl]piperazin-1-yl]-(2-methylphenyl)methanone Authors: Deri, B, Gitto, R, Pazy Benhar, Y, Fishman, A. Deposit date: 2017-09-17 Release date: 2018-04-25 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2 Å) Cite: Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments. J. Med. Chem., 61, 2018
6ELS	Structure of latent apple tyrosinase (MdPPO1) Descriptor: COPPER (II) ION, OXYGEN ATOM, Polyphenol oxidase, ... Authors: Kampatsikas, I, Bijelic, A, Pretzler, M, Rompel, A. Deposit date: 2017-09-29 Release date: 2019-03-20 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.346 Å) Cite: A Peptide-Induced Self-Cleavage Reaction Initiates the Activation of Tyrosinase. Angew.Chem.Int.Ed.Engl., 58, 2019
5Z0G	Crystal structure of copper-bound tyrosinase from Streptomyces castaneoglobisporus in complex with the caddie protein obtained by soaking in the hydroxylamine-containing solution for 20 min at 298 K Descriptor: COPPER (II) ION, MelC, NITRATE ION, ... Authors: Matoba, Y, Sugiyama, M. Deposit date: 2017-12-19 Release date: 2018-12-26 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.32 Å) Cite: Catalytic mechanism of tyrosinase implied from the quinone formation on the Tyr98 residue of the caddie protein To Be Published
5Z0E	Crystal structure of copper-bound tyrosinase from Streptomyces castaneoglobisporus in complex with the Y98F mutant of the caddie protein obtained by soaking in the hydroxylamine-containing solution for 2 h at 298 K Descriptor: COPPER (II) ION, MelC, NITRATE ION, ... Authors: Matoba, Y, Sugiyama, M. Deposit date: 2017-12-19 Release date: 2018-12-26 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.16 Å) Cite: Catalytic mechanism of tyrosinase implied from the quinone formation on the Tyr98 residue of the caddie protein To Be Published
5Z0L	Crystal structure of copper-bound tyrosinase from Streptomyces castaneoglobisporus in complex with the caddie protein obtained by soaking in the hydroxylamine-containing solution for 9 h at 277 K Descriptor: COPPER (II) ION, MelC, NITRATE ION, ... Authors: Matoba, Y, Sugiyama, M. Deposit date: 2017-12-19 Release date: 2018-12-26 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.17 Å) Cite: Catalytic mechanism of tyrosinase implied from the quinone formation on the Tyr98 residue of the caddie protein To Be Published
5Z0F	Crystal structure of copper-bound tyrosinase from Streptomyces castaneoglobisporus in complex with the caddie protein obtained by soaking in the hydroxylamine-containing solution for 10 min at 298 K Descriptor: COPPER (II) ION, MelC, NITRATE ION, ... Authors: Matoba, Y, Sugiyama, M. Deposit date: 2017-12-19 Release date: 2018-12-26 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.16 Å) Cite: Catalytic mechanism of tyrosinase implied from the quinone formation on the Tyr98 residue of the caddie protein To Be Published
5Z0M	Crystal structure of copper-bound H63F-mutated tyrosinase from Streptomyces castaneoglobisporus in complex with the caddie protein obtained by soaking in the hydroxylamine-containing solution for 12 h at 298 K Descriptor: COPPER (II) ION, MelC, NITRATE ION, ... Authors: Matoba, Y, Sugiyama, M. Deposit date: 2017-12-19 Release date: 2018-12-26 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Catalytic mechanism of tyrosinase implied from the quinone formation on the Tyr98 residue of the caddie protein To Be Published
5Z0K	Crystal structure of copper-bound tyrosinase from Streptomyces castaneoglobisporus in complex with the caddie protein obtained by soaking in the hydroxylamine-containing solution for 4 h at 277 K Descriptor: COPPER (II) ION, MelC, NITRATE ION, ... Authors: Matoba, Y, Sugiyama, M. Deposit date: 2017-12-19 Release date: 2018-12-26 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.28 Å) Cite: Catalytic mechanism of tyrosinase implied from the quinone formation on the Tyr98 residue of the caddie protein To Be Published
5Z0D	1.16 A-resolution crystal structure of the deoxy-form tyrosinase from Streptomyces castaneoglobisporus in complex with the caddie protein Descriptor: COPPER (II) ION, MelC, NITRATE ION, ... Authors: Matoba, Y, Sugiyama, M. Deposit date: 2017-12-19 Release date: 2018-12-26 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.16 Å) Cite: Catalytic mechanism of tyrosinase implied from the quinone formation on the Tyr98 residue of the caddie protein To Be Published
5Z0J	Crystal structure of copper-bound tyrosinase from Streptomyces castaneoglobisporus in complex with the caddie protein obtained by soaking in the hydroxylamine-containing solution for 2 h at 277 K Descriptor: COPPER (II) ION, MelC, NITRATE ION, ... Authors: Matoba, Y, Sugiyama, M. Deposit date: 2017-12-19 Release date: 2018-12-26 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Catalytic mechanism of tyrosinase implied from the quinone formation on the Tyr98 residue of the caddie protein To Be Published
5Z0H	Crystal structure of copper-bound tyrosinase from Streptomyces castaneoglobisporus in complex with the caddie protein obtained by soaking in the hydroxylamine-containing solution for 2 h at 298 K Descriptor: COPPER (II) ION, MelC, NITRATE ION, ... Authors: Matoba, Y, Sugiyama, M. Deposit date: 2017-12-19 Release date: 2018-12-26 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.18 Å) Cite: Catalytic mechanism of tyrosinase implied from the quinone formation on the Tyr98 residue of the caddie protein To Be Published
5Z0I	Crystal structure of copper-bound tyrosinase from Streptomyces castaneoglobisporus in complex with the caddie protein obtained by soaking in the hydroxylamine-containing solution for 1 h at 277 K Descriptor: COPPER (II) ION, MelC, NITRATE ION, ... Authors: Matoba, Y, Sugiyama, M. Deposit date: 2017-12-19 Release date: 2018-12-26 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.32 Å) Cite: Catalytic mechanism of tyrosinase implied from the quinone formation on the Tyr98 residue of the caddie protein To Be Published
5ZRD	Tyrosinase from Burkholderia thailandensis (BtTYR) at low pH condition Descriptor: CITRIC ACID, COPPER (II) ION, GLYCEROL, ... Authors: Lee, S, Son, H.-F, Kim, K.-J. Deposit date: 2018-04-24 Release date: 2018-10-31 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural Basis for Highly Efficient Production of Catechol Derivatives at Acidic pH by Tyrosinase from Burkholderia thailandensis Acs Catalysis, 8, 2018
5ZRE	Tyrosinase from Burkholderia thailandensis (BtTYR) at high pH condition Descriptor: COPPER (II) ION, GLYCEROL, OXYGEN ATOM, ... Authors: Lee, S, Son, H.-F, Kim, K.-J. Deposit date: 2018-04-24 Release date: 2018-10-31 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural Basis for Highly Efficient Production of Catechol Derivatives at Acidic pH by Tyrosinase from Burkholderia thailandensis Acs Catalysis, 8, 2018
6GSG	Crystal structure of Aspergillus oryzae catechol oxidase complexed with resorcinol Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, COPPER (II) ION, Catechol oxidase, ... Authors: Penttinen, L, Hakulinen, N, Rouvinen, J. Deposit date: 2018-06-14 Release date: 2018-09-19 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.192 Å) Cite: Unraveling Substrate Specificity and Catalytic Promiscuity of Aspergillus oryzae Catechol Oxidase. Chembiochem, 19, 2018
6HQJ	apo-form of polyphenol oxidase from Solanum lycopersicum Descriptor: Polyphenol oxidase A, chloroplastic Authors: Kampatsikas, I, Bijelic, A, Rompel, A. Deposit date: 2018-09-25 Release date: 2019-03-20 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.802 Å) Cite: Biochemical and structural characterization of tomato polyphenol oxidases provide novel insights into their substrate specificity. Sci Rep, 9, 2019
6HQI	holo-form of polyphenol oxidase from Solanum lycopersicum Descriptor: COPPER (II) ION, OXYGEN ATOM, Polyphenol oxidase A, ... Authors: Kampatsikas, I, Bijelic, A, Rompel, A. Deposit date: 2018-09-25 Release date: 2019-03-20 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Biochemical and structural characterization of tomato polyphenol oxidases provide novel insights into their substrate specificity. Sci Rep, 9, 2019
6J2U	Crystal structure of Tyrosinase caddy protein(MelC1)with Tyrosinase (MelC2)from Streptomyces avermitilis in complex with Zinc ion Descriptor: Tyrosinase, Tyrosinase co-factor protein, ZINC ION Authors: Lee, S.-H, Hong, H, Kim, K.-J. Deposit date: 2019-01-03 Release date: 2020-02-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Crystal structure of Tyrosinase caddy protein(MelC1)with tyrosinase (MelC2)from Streptomyces avermitilis in complex with Zinc ion To Be Published
6QXD	Crystal Structure of tyrosinase from Bacillus megaterium with JKB inhibitor in the active site. Descriptor: (2,4-dinitrophenyl)-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]methanone, COPPER (II) ION, Tyrosinase Authors: Deri Zenaty, B, Gitto, R, Pazy, Y, Fishman, A. Deposit date: 2019-03-07 Release date: 2019-06-19 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.317 Å) Cite: Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile. Eur.J.Med.Chem., 178, 2019
6R83	CryoEM structure and molecular model of squid hemocyanin (Todarodes pacificus , TpH) Descriptor: Hemocyanin subunit 1 Authors: Tanaka, Y, Kato, S, Stabrin, M, Raunser, S, Matsui, T, Gatsogiannis, C. Deposit date: 2019-03-31 Release date: 2019-05-08 Last modified: 2019-11-06 Method: ELECTRON MICROSCOPY (5.1 Å) Cite: Cryo-EM reveals the asymmetric assembly of squid hemocyanin. Iucrj, 6, 2019

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