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6D8Z
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BU of 6d8z by Molmil
Crystal Structure of the C-terminal Guanine Nucleotide Exchange Factor Module of Human Trio
Descriptor: Triple functional domain protein
Authors:Bandekar, S, Tesmer, J.J.
Deposit date:2018-04-27
Release date:2019-02-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential.
Sci Signal, 12, 2019
6DLU
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BU of 6dlu by Molmil
Cryo-EM of the GMPPCP-bound human dynamin-1 polymer assembled on the membrane in the constricted state
Descriptor: Dynamin-1, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
Authors:Kong, L, Wang, H, Fang, S, Canagarajah, B, Kehr, A.D, Rice, W.J, Hinshaw, J.E.
Deposit date:2018-06-02
Release date:2018-08-01
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (3.75 Å)
Cite:Cryo-EM of the dynamin polymer assembled on lipid membrane.
Nature, 560, 2018
6DLV
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BU of 6dlv by Molmil
Cryo-EM of the GTP-bound human dynamin-1 polymer assembled on the membrane in the super constricted state
Descriptor: Dynamin-1
Authors:Kong, L, Wang, H, Fang, S, Canagarajah, B, Kehr, A.D, Rice, W.J, Hinshaw, J.E.
Deposit date:2018-06-02
Release date:2018-08-01
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (10.1 Å)
Cite:Cryo-EM of the dynamin polymer assembled on lipid membrane.
Nature, 560, 2018
1NTY
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BU of 1nty by Molmil
Crystal structure of the first DH/PH domain of Trio to 1.7 A
Descriptor: Triple functional domain protein
Authors:Skowronek, K.R, Zheng, Y, Nassar, N.
Deposit date:2003-01-30
Release date:2004-06-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids.
J.Biol.Chem., 279, 2004
6E31
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BU of 6e31 by Molmil
Crystal structure of RIAM in an autoinhibited configuration.
Descriptor: Rap1-interacting adapter molecule
Authors:Chang, Y.C, Su, W, Zhang, H, Huang, Q, Philips, M.R, Wu, J.
Deposit date:2018-07-12
Release date:2019-02-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular basis for autoinhibition of RIAM regulated by FAK in integrin activation.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
3HK0
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BU of 3hk0 by Molmil
Crystal Structure of the RA and PH Domains of Grb10
Descriptor: Growth factor receptor-bound protein 10, THIOCYANATE ION
Authors:Hubbard, S.R, Depetris, R.S, Wu, J.
Deposit date:2009-05-22
Release date:2009-08-04
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14.
Nat.Struct.Mol.Biol., 16, 2009
3HW2
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BU of 3hw2 by Molmil
Crystal structure of the SifA-SKIP(PH) complex
Descriptor: Pleckstrin homology domain-containing family M member 2, Protein sifA
Authors:Diacovich, L, Dumont, A, Lafitte, D, Soprano, E, Guilhon, A.-A, Bignon, C, Gorvel, J.-P, Bourne, Y, Meresse, S.
Deposit date:2009-06-17
Release date:2009-11-03
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Interaction between the SifA virulence factor and its host target skip is essential for salmonella pathogenesis
J.Biol.Chem., 284, 2009
4MT6
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BU of 4mt6 by Molmil
Crystal structure of closed inactive collybistin
Descriptor: Rho guanine nucleotide exchange factor 9
Authors:Schneeberger, D, Schindelin, H.
Deposit date:2013-09-19
Release date:2014-08-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (5.501 Å)
Cite:A conformational switch in collybistin determines the differentiation of inhibitory postsynapses.
Embo J., 33, 2014
4MT7
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BU of 4mt7 by Molmil
Crystal structure of collybistin I
Descriptor: Rho guanine nucleotide exchange factor 9
Authors:Schneeberger, D, Schindelin, H.
Deposit date:2013-09-19
Release date:2014-08-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:A conformational switch in collybistin determines the differentiation of inhibitory postsynapses.
Embo J., 33, 2014
4NSW
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BU of 4nsw by Molmil
Crystal structure of the BAR-PH domain of ACAP1
Descriptor: Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
Authors:Pang, X, Zhang, K, Ma, J, Zhou, Q, Sun, F.
Deposit date:2013-11-29
Release date:2014-10-15
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A PH Domain in ACAP1 Possesses Key Features of the BAR Domain in Promoting Membrane Curvature
Dev.Cell, 31, 2014
1QQG
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BU of 1qqg by Molmil
CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1
Descriptor: INSULIN RECEPTOR SUBSTRATE 1
Authors:Dhe-Paganon, S, Shoelson, S.E.
Deposit date:1999-06-04
Release date:1999-08-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1.
Proc.Natl.Acad.Sci.USA, 96, 1999
6FSF
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BU of 6fsf by Molmil
Crystal structure of the tandem PX-PH-domains of Bem3 from Saccharomyces cerevisiae
Descriptor: GTPase-activating protein BEM3
Authors:Ali, I, Eu, S, Koch, D, Bleimling, N, Goody, R.S, Mueller, M.P.
Deposit date:2018-02-19
Release date:2018-05-02
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the tandem PX-PH domains of Bem3 from Saccharomyces cerevisiae.
Acta Crystallogr F Struct Biol Commun, 74, 2018
3KSY
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BU of 3ksy by Molmil
Crystal structure of the Histone domain, DH-PH unit, and catalytic unit of the Ras activator Son of Sevenless (SOS)
Descriptor: Son of sevenless homolog 1
Authors:Gureasko, J, Kuchment, O, Kuriyan, J.
Deposit date:2009-11-24
Release date:2010-02-16
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.178 Å)
Cite:Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless.
Proc.Natl.Acad.Sci.USA, 107, 2010
1RJ2
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BU of 1rj2 by Molmil
Crystal structure of the DH/PH fragment of Dbs without bound GTPase
Descriptor: Guanine nucleotide exchange factor DBS [Fragment]
Authors:Worthylake, D.K, Rossman, K.L, Sondek, J.
Deposit date:2003-11-18
Release date:2004-06-29
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of the DH/PH fragment of Dbs without bound GTPase.
Structure, 12, 2004
3LJU
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BU of 3lju by Molmil
Crystal structure of full length centaurin alpha-1 bound with the head group of PIP3
Descriptor: (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, Arf-GAP with dual PH domain-containing protein 1, ZINC ION
Authors:Shen, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2010-01-26
Release date:2010-11-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.702 Å)
Cite:Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
Proc.Natl.Acad.Sci.USA, 107, 2010
3MDB
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BU of 3mdb by Molmil
Crystal structure of the ternary complex of full length centaurin alpha-1, KIF13B FHA domain, and IP4
Descriptor: (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, Arf-GAP with dual PH domain-containing protein 1, Kinesin-like protein KIF13B, ...
Authors:Shen, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2010-03-30
Release date:2010-08-04
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.952 Å)
Cite:Crystal structure of the ternary complex of full length centaurin alpha-1, KIF13B FHA domain, and IP4
to be published
3MPX
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BU of 3mpx by Molmil
Crystal structure of the DH and PH-1 domains of human FGD5
Descriptor: FYVE, RhoGEF and PH domain-containing protein 5, UNKNOWN ATOM OR ION
Authors:Shen, Y, Nedyalkova, L, Tong, Y, Tempel, W, Crombet, L, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2010-04-27
Release date:2010-06-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the DH and PH-1 domains of human FGD5
TO BE PUBLISHED
3A8Q
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BU of 3a8q by Molmil
Low-resolution crystal structure of the Tiam2 PHCCEx domain
Descriptor: T-lymphoma invasion and metastasis-inducing protein 2
Authors:Terawaki, S, Kitano, K, Mori, T, Zhai, Y, Higuchi, Y, Itoh, N, Watanabe, T, Kaibuchi, K, Hakoshima, T.
Deposit date:2009-10-07
Release date:2009-11-24
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module
Embo J., 29, 2010
3A8P
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BU of 3a8p by Molmil
Crystal structure of the Tiam2 PHCCEx domain
Descriptor: T-lymphoma invasion and metastasis-inducing protein 2
Authors:Terawaki, S, Kitano, K, Mori, T, Zhai, Y, Higuchi, Y, Itoh, N, Watanabe, T, Kaibuchi, K, Hakoshima, T.
Deposit date:2009-10-07
Release date:2009-11-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module
Embo J., 29, 2010
3A8N
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BU of 3a8n by Molmil
Crystal structure of the Tiam1 PHCCEx domain
Descriptor: T-lymphoma invasion and metastasis-inducing protein 1
Authors:Terawaki, S, Kitano, K, Mori, T, Zhai, Y, Higuchi, Y, Itoh, N, Watanabe, T, Kaibuchi, K, Hakoshima, T.
Deposit date:2009-10-07
Release date:2009-11-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module
Embo J., 29, 2010
3SNH
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BU of 3snh by Molmil
Crystal structure of nucleotide-free human dynamin1
Descriptor: Dynamin-1
Authors:Faelber, K, Daumke, O.
Deposit date:2011-06-29
Release date:2011-09-21
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Crystal structure of nucleotide-free dynamin.
Nature, 477, 2011
3TCA
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BU of 3tca by Molmil
Crystal structure of the Ras-associating and pleckstrin-homology domains of RIAM
Descriptor: Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Authors:Wu, J, Hubbard, S.R.
Deposit date:2011-08-08
Release date:2012-09-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector.
J.Cell Biol., 199, 2012
3CXB
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BU of 3cxb by Molmil
Crystal Structure of sifa and skip
Descriptor: Pleckstrin homology domain-containing family M member 2, Protein sifA
Authors:Huang, Z, Chai, J.
Deposit date:2008-04-24
Release date:2008-12-02
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation
Cell Host Microbe, 4, 2008
3FEH
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BU of 3feh by Molmil
Crystal structure of full length centaurin alpha-1
Descriptor: Centaurin-alpha-1, UNKNOWN ATOM OR ION, ZINC ION
Authors:Shen, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2008-11-29
Release date:2008-12-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin {alpha}1.
Proc.Natl.Acad.Sci.USA, 107, 2010
3FM8
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BU of 3fm8 by Molmil
Crystal structure of full length centaurin alpha-1 bound with the FHA domain of KIF13B (CAPRI target)
Descriptor: Centaurin-alpha-1, Kinesin-like protein KIF13B, SULFATE ION, ...
Authors:Shen, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2008-12-19
Release date:2009-08-25
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
Proc.Natl.Acad.Sci.USA, 107, 2010

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