7PMK
| S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I) | Descriptor: | Cell division control protein 45,Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA helicase, ... | Authors: | Jenkyn-Bedford, M, Yeeles, J.T.P, Deegan, T.D. | Deposit date: | 2021-09-02 | Release date: | 2021-11-10 | Last modified: | 2022-02-02 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | A conserved mechanism for regulating replisome disassembly in eukaryotes. Nature, 600, 2021
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7PLO
| H. sapiens replisome-CUL2/LRR1 complex | Descriptor: | Cell division control protein 45 homolog, Claspin, Cullin-2, ... | Authors: | Jones, M.J, Yeeles, J.T.P, Deegan, T.D, Jenkyn-Bedford, M. | Deposit date: | 2021-09-01 | Release date: | 2021-11-10 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | A conserved mechanism for regulating replisome disassembly in eukaryotes. Nature, 600, 2021
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7PMN
| S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II) | Descriptor: | Cell division control protein 45,Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha-binding protein, ... | Authors: | Jenkyn-Bedford, M, Yeeles, J.T.P, Deegan, T.D. | Deposit date: | 2021-09-02 | Release date: | 2021-11-10 | Last modified: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | A conserved mechanism for regulating replisome disassembly in eukaryotes. Nature, 600, 2021
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7R3X
| The crystal structure of the L439V variant of Pol2CORE in complex with DNA and an incoming nucleotide | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ACETATE ION, CALCIUM ION, ... | Authors: | Barbari, S.R, Beach, A.K, Markgren, J.G, Parkash, V, Johansson, E, Shcherbakova, P.V. | Deposit date: | 2022-02-08 | Release date: | 2022-07-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ε variants at low dNTP levels. Nucleic Acids Res., 50, 2022
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7R3Y
| The crystal structure of the V426L variant of Pol2CORE in complex with DNA and an incoming nucleotide | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA Primer, ... | Authors: | Barbari, S.R, Beach, A.K, Markgren, J.G, Parkash, V, Johansson, E, Shcherbakova, P.V. | Deposit date: | 2022-02-08 | Release date: | 2022-07-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ε variants at low dNTP levels. Nucleic Acids Res., 50, 2022
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7QHS
| S. cerevisiae CMGE nucleating origin DNA melting | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, ... | Authors: | Lewis, J.S, Sousa, J.S, Costa, A. | Deposit date: | 2021-12-14 | Release date: | 2022-06-15 | Last modified: | 2022-07-06 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Mechanism of replication origin melting nucleated by CMG helicase assembly. Nature, 606, 2022
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8D0B
| Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template | Descriptor: | CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ... | Authors: | He, Q, Lin, X, Chavez, B.L, Agrawal, S, Lusk, B.L, Lim, C. | Deposit date: | 2022-05-26 | Release date: | 2022-06-22 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | Structures of the human CST-Pol alpha-primase complex bound to telomere templates. Nature, 608, 2022
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8D0K
| Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template - PRIM2C advanced PIC | Descriptor: | CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ... | Authors: | He, Q, Lin, X, Chavez, B.L, Agrawal, S, Lusk, B.L, Lim, C. | Deposit date: | 2022-05-26 | Release date: | 2022-06-22 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (4.27 Å) | Cite: | Structures of the human CST-Pol alpha-primase complex bound to telomere templates. Nature, 608, 2022
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8D96
| Human DNA polymerase alpha/primase elongation complex I bound to primer/template | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*AP*AP*TP*GP*GP*TP*CP*GP*TP*GP*CP*CP*GP*CP*CP*AP*AP*TP*AP*A)-3'), DNA polymerase alpha catalytic subunit, ... | Authors: | He, Q, Baranovskiy, A, Lim, C, Tahirov, T. | Deposit date: | 2022-06-09 | Release date: | 2023-04-19 | Last modified: | 2023-05-31 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Structures of human primosome elongation complexes. Nat.Struct.Mol.Biol., 30, 2023
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8D9D
| Human DNA polymerase-alpha/primase elongation complex II bound to primer/template | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*GP*GP*TP*CP*GP*TP*GP*CP*CP*GP*CP*CP*AP*AP*TP*AP*A)-3'), DNA polymerase alpha catalytic subunit, ... | Authors: | He, Q, Baranovskiy, A, Lim, C, Tahirov, T. | Deposit date: | 2022-06-09 | Release date: | 2023-04-19 | Last modified: | 2023-05-31 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Structures of human primosome elongation complexes. Nat.Struct.Mol.Biol., 30, 2023
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8G9L
| DNA initiation subcomplex of Xenopus laevis DNA polymerase alpha-primase | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA primase large subunit, ... | Authors: | Mullins, E.A, Durie, C.L, Ohi, M.D, Chazin, W.J, Eichman, B.F. | Deposit date: | 2023-02-21 | Release date: | 2023-04-12 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase. Nat.Struct.Mol.Biol., 2024
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8G9F
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8G99
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8G9N
| Partial DNA elongation subcomplex of Xenopus laevis DNA polymerase alpha-primase | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA template, ... | Authors: | Mullins, E.A, Durie, C.L, Ohi, M.D, Chazin, W.J, Eichman, B.F. | Deposit date: | 2023-02-21 | Release date: | 2023-04-12 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase. Nat.Struct.Mol.Biol., 2024
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8G9O
| Complete DNA elongation subcomplex of Xenopus laevis DNA polymerase alpha-primase | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA primase large subunit, ... | Authors: | Mullins, E.A, Durie, C.L, Ohi, M.D, Chazin, W.J, Eichman, B.F. | Deposit date: | 2023-02-21 | Release date: | 2023-04-12 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase. Nat.Struct.Mol.Biol., 2024
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8FOJ
| Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the post RNA handoff state | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | Deposit date: | 2022-12-30 | Release date: | 2023-05-31 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
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8FOK
| Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the DNA elongation state | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | Deposit date: | 2022-12-30 | Release date: | 2023-05-31 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.56 Å) | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
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8FOC
| Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase in Apo state conformation I | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | Deposit date: | 2022-12-30 | Release date: | 2023-05-31 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
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8FOH
| Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the RNA synthesis state | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | Deposit date: | 2022-12-30 | Release date: | 2023-05-31 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
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8FOE
| Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex bound to a template DNA | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | Deposit date: | 2022-12-30 | Release date: | 2023-05-31 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (5.6 Å) | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
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8FOD
| Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in Apo state conformation II | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | Deposit date: | 2022-12-30 | Release date: | 2023-05-31 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
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3IAY
| Ternary complex of DNA polymerase delta | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*TP*CP*CP*TP*CP*CP*CP*CP*TP*AP*(DOC))-3', 5'-D(*TP*AP*AP*GP*GP*TP*AP*GP*GP*GP*GP*AP*GP*GP*AP*T)-3', ... | Authors: | Swan, M.K, Aggarwal, A.K. | Deposit date: | 2009-07-15 | Release date: | 2009-09-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase delta Nat.Struct.Mol.Biol., 16, 2009
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8OJB
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8OJ6
| HSV-1 DNA polymerase-processivity factor complex in pre-translocation state | Descriptor: | DNA (22-MER), DNA (48-MER), DNA polymerase catalytic subunit, ... | Authors: | Gustavsson, E, Grunewald, K, Elias, P, Hallberg, B.M. | Deposit date: | 2023-03-24 | Release date: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (2.41 Å) | Cite: | Dynamics of the Herpes simplex virus DNA polymerase holoenzyme during DNA synthesis and proof-reading revealed by Cryo-EM To Be Published
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8OJC
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