PDB: 729 resultsInfo pagesStatus searchChemie searchBIRD

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3QCL	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 2-[(3,4-dichlorobenzyl)sulfanyl]-4-(4-hydroxybut-1-yn-1-yl)benzoic acid Descriptor: 2-[(3,4-dichlorobenzyl)sulfanyl]-4-(4-hydroxybut-1-yn-1-yl)benzoic acid, Receptor-type tyrosine-protein phosphatase gamma Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCK	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 2-[(3,4-dichlorobenzyl)sulfanyl]benzoic acid Descriptor: 2-[(3,4-dichlorobenzyl)sulfanyl]benzoic acid, Receptor-type tyrosine-protein phosphatase gamma Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCI	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with N-[(3-aminophenyl)sulfonyl]-3-[(3,4-dichlorobenzyl)sulfanyl]thiophene-2-carboxamide Descriptor: N-[(3-aminophenyl)sulfonyl]-3-[(3,4-dichlorobenzyl)sulfanyl]thiophene-2-carboxamide, Receptor-type tyrosine-protein phosphatase gamma Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.27 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCD	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with vanadate, trigonal crystal form Descriptor: ACETIC ACID, Receptor-type tyrosine-protein phosphatase gamma, VANADATE ION Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCJ	Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 5-[({3-[(3,4-dichlorobenzyl)sulfanyl]thiophen-2-yl}carbonyl)sulfamoyl]-2-methoxybenzoic acid Descriptor: 5-[({3-[(3,4-dichlorobenzyl)sulfanyl]thiophen-2-yl}carbonyl)sulfamoyl]-2-methoxybenzoic acid, Receptor-type tyrosine-protein phosphatase gamma Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCB	Human receptor protein tyrosine phosphatase gamma, domain 1, apo Descriptor: Receptor-type tyrosine-protein phosphatase gamma, SULFATE ION Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QCN	Human receptor protein tyrosine phosphatase gamma, domain 1, trigonal crystal form Descriptor: Receptor-type tyrosine-protein phosphatase gamma Authors: Sheriff, S. Deposit date: 2011-01-16 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54, 2011
3QKQ	Protein Tyrosine Phosphatase 1B - W179F mutant bound with vanadate Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, ... Authors: Brandao, T.A.S, Johnson, S.J, Hengge, A.C. Deposit date: 2011-02-01 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B. Arch.Biochem.Biophys., 525, 2012
3QKP	Protein Tyrosine Phosphatase 1B - Apo W179F mutant with open WPD-loop Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1 Authors: Brandao, T.A.S, Johnson, S.J, Hengge, A.C. Deposit date: 2011-02-01 Release date: 2012-08-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B. Arch.Biochem.Biophys., 525, 2012
2YDU	Crystal structure of YopH in complex with 3-(1,1-dioxido-3- oxoisothiazolidin-5-yl)benzaldeyde Descriptor: 3-[(2S)-1,1-DIOXIDO-4-OXOTETRAHYDROTHIOPHEN-2-YL]BENZALDEHYDE, OUTER PROTEIN H PHOSPHATASE Authors: Lountos, G.T, Kim, S.E, Bahta, M, Ulrich, R.G, Waugh, D.S, Burke, T.R. Deposit date: 2011-03-24 Release date: 2011-11-02 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Isothiazolidinone (Izd) as a Phosphoryl Mimetic in Inhibitors of the Yersinia Pestis Protein Tyrosine Phosphatase Yoph. Acta Crystallogr.,Sect.D, 67, 2011
3RO1	Crystal structure of the complex of the archaeal sulfolobus PTP-fold phosphatase with terpyridine platinum(II) Descriptor: 2,2':6',2''-TERPYRIDINE PLATINUM(II) Chloride, protein tyrosine phosphatase Authors: Lo, Y.-C, Wang, A.H.-J. Deposit date: 2011-04-25 Release date: 2011-10-05 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Terpyridine platinum(II) complexes inhibit cysteine proteases by binding to active-site cysteine. J.Biomol.Struct.Dyn., 29, 2011
3S3H	Crystal structure of the catalytic domain of PTP10D from Drosophila melanogaster with a phosphopeptide substrate GP4 Descriptor: 1,4-BUTANEDIOL, 1-BUTANOL, Tyrosine-protein phosphatase 10D, ... Authors: Madan, L.L, Gopal, B. Deposit date: 2011-05-18 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D Biochemistry, 50, 2011
3S3F	Crystal Structure of the catalytic domain of PTP10D from Drosophila melanogaster with a small molecule inhibitor Vanadate Descriptor: 1,4-BUTANEDIOL, 1-BUTANOL, ISOPROPYL ALCOHOL, ... Authors: Madan, L.L, Gopal, B. Deposit date: 2011-05-18 Release date: 2011-11-02 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D Biochemistry, 50, 2011
3S3K	Crystal structure of the catalytic domain of PTP10D from Drosophila melanogaster with a small molecular inhibitor para-NitroCatechol Sulphate Descriptor: N,4-DIHYDROXY-N-OXO-3-(SULFOOXY)BENZENAMINIUM, Tyrosine-protein phosphatase 10D Authors: Madan, L.L, Gopal, B. Deposit date: 2011-05-18 Release date: 2011-11-02 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D Biochemistry, 50, 2011
3S3E	Crystal structure of the catalytic domain of PTP10D from Drosophila melanogaster Descriptor: 1,4-BUTANEDIOL, 1-BUTANOL, ISOPROPYL ALCOHOL, ... Authors: Madan, L.L, Gopal, B. Deposit date: 2011-05-18 Release date: 2011-11-02 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D Biochemistry, 50, 2011
3S4O	Protein Tyrosine Phosphatase (putative) from Leishmania major Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Protein tyrosine phosphatase-like protein, THIOSULFATE Authors: Merritt, E.A, Arakaki, T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP), Structural Genomics of Pathogenic Protozoa Consortium (SGPP) Deposit date: 2011-05-19 Release date: 2011-06-15 Last modified: 2017-11-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Protein Tyrosine Phosphatase from Leishmania major To be Published
3SME	Structure of PTP1B inactivated by H2O2/bicarbonate Descriptor: MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 Authors: Tanner, J.J, Singh, H. Deposit date: 2011-06-27 Release date: 2011-10-19 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The Biological Buffer Bicarbonate/CO(2) Potentiates H(2)O(2)-Mediated Inactivation of Protein Tyrosine Phosphatases. J.Am.Chem.Soc., 133, 2011
3SR9	Crystal structure of mouse PTPsigma Descriptor: Receptor-type tyrosine-protein phosphatase S Authors: Wang, J, Hou, L, Li, J, Ding, J. Deposit date: 2011-07-07 Release date: 2012-05-30 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural insights into the homology and differences between mouse protein tyrosine phosphatase-sigma and human protein tyrosine phosphatase-sigma Acta Biochim.Biophys.Sin., 43, 2011
3ZV2	Human protein-tyrosine phosphatase 1b C215A, S216A mutant Descriptor: Tyrosine-protein phosphatase non-receptor type 1 Authors: Barford, D, Salmeen, A, Tonks, N.K. Deposit date: 2011-07-22 Release date: 2011-08-31 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Conformation-sensing antibodies stabilize the oxidized form of PTP1B and inhibit its phosphatase activity. Cell, 147, 2011
3U96	Crystal Structure of YopHQ357F(Catalytic Domain, Residues 163-468) in complex with pNCS Descriptor: N,4-DIHYDROXY-N-OXO-3-(SULFOOXY)BENZENAMINIUM, SULFATE ION, Tyrosine-protein phosphatase yopH Authors: Ho, M.C, Ke, S. Deposit date: 2011-10-17 Release date: 2012-08-29 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Investigation of catalytic loop structure, dynamics, and function relationship of Yersinia protein tyrosine phosphatase by temperature-jump relaxation spectroscopy and X-ray structural determination. J.Phys.Chem.B, 116, 2012
4DGP	The wild-type Src homology 2 (SH2)-domain containing protein tyrosine phosphatase-2 (SHP2) Descriptor: Tyrosine-protein phosphatase non-receptor type 11 Authors: Yu, Z.H, Xu, J, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L.N, Liu, S.J, Zhang, Z.Y. Deposit date: 2012-01-26 Release date: 2013-03-06 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations. J.Biol.Chem., 288, 2013
4DGX	LEOPARD Syndrome-Associated SHP2/Y279C mutant Descriptor: Tyrosine-protein phosphatase non-receptor type 11 Authors: Yu, Z.H, Xu, J, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L.N, Liu, S.J, Zhang, Z.Y. Deposit date: 2012-01-27 Release date: 2013-03-06 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations. J.Biol.Chem., 288, 2013
4AZ1	Crystal structure of the Trypanosoma cruzi protein tyrosine phosphatase TcPTP1, a potential therapeutic target for Chagas' disease Descriptor: 1,2-ETHANEDIOL, FORMIC ACID, TYROSINE SPECIFIC PROTEIN PHOSPHATASE Authors: Lountos, G.T, Tropea, J.E, Waugh, D.S. Deposit date: 2012-06-22 Release date: 2012-11-21 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.181 Å) Cite: Structure of the Trypanosoma Cruzi Protein Tyrosine Phosphatase Tcptp1, a Potential Therapeutic Target for Chagas' Disease. Mol.Biochem.Parasitol., 187, 2012
4GE6	Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 7 Descriptor: N-(4-bromo-3-methylbenzoyl)-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithyl-3-{[(4-hydroxy-3-methoxyphenyl)acetyl]amino}-D-alaninamide, Tyrosine-protein phosphatase non-receptor type 9 Authors: Zhang, Z.-Y, Liu, S, Zhang, S. Deposit date: 2012-08-01 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes. J.Am.Chem.Soc., 134, 2012
4GE2	Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 3 Descriptor: N-acetyl-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithinamide, Tyrosine-protein phosphatase non-receptor type 9 Authors: Zhang, Z.-Y, Liu, S, Zhang, S. Deposit date: 2012-08-01 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes. J.Am.Chem.Soc., 134, 2012

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