PDB: 729 resultsInfo pagesStatus searchChemie searchBIRD

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4ICZ	HER2 1221/1222 phosphorylation regulated by PTPN9 Descriptor: HER2, Tyrosine-protein phosphatase non-receptor type 9 Authors: Xu, Y.F, Wang, H.M, Liu, C.H, Yu, X, Sun, J.P. Deposit date: 2012-12-11 Release date: 2013-12-11 Method: X-RAY DIFFRACTION (1.9 Å) Cite: HER2 1221/1222 phosphorylation regulated by PTPN9 To be Published
4J51	Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04 Descriptor: 3-[(3-chlorophenyl)ethynyl]-2-{4-[2-(cyclopropylamino)-2-oxoethoxy]phenyl}-6-hydroxy-1-benzofuran-5-carboxylic acid, Tyrosine-protein phosphatase non-receptor type 22 Authors: Liu, D, He, Y, Zhang, Z.-Y. Deposit date: 2013-02-07 Release date: 2013-07-24 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: A Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune Diseases. J.Med.Chem., 56, 2013
4NND	Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites Descriptor: Receptor tyrosine-protein kinase erbB-2, Tyrosine-protein phosphatase non-receptor type 18 Authors: Wang, H, Yang, F, Yang, D, Du, Y. Deposit date: 2013-11-17 Release date: 2014-11-19 Method: X-RAY DIFFRACTION (2.502 Å) Cite: Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites To be Published
4QBE	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop Descriptor: Tyrosine-protein phosphatase non-receptor type 1 Authors: Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X. Deposit date: 2014-05-08 Release date: 2014-12-24 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.292 Å) Cite: The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57C, 2014
4QBW	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 Authors: Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X, Sun, J.P. Deposit date: 2014-05-08 Release date: 2015-02-11 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.912 Å) Cite: The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57, 2014
4PVG	Crystal structure of protein tyrosine phosphatase Shp2 catalytic domain complex with small molecular compound L88N79 Descriptor: 2-[3-({4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutanoyl}amino)phenyl]-6-hydroxy-3-iodo-1-methyl-1H-indole-5-carboxylic acid, Tyrosine-protein phosphatase non-receptor type 11 Authors: Zhang, Z.-Y, Zeng, L, Liu, D, Yu, Z. Deposit date: 2014-03-17 Release date: 2015-04-15 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of protein tyrosine Shp2 catalytic domain complex with compound L88N79 To be Published
4QAP	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 Authors: Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X, Sun, J.P. Deposit date: 2014-05-05 Release date: 2015-02-11 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.903 Å) Cite: The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57, 2014
4QAH	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 Authors: Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Bi, W.X. Deposit date: 2014-05-05 Release date: 2014-12-24 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.403 Å) Cite: The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57C, 2014
4QUM	Crystal structure of PTPN3 (PTPH1) in complex with a dually phosphorylated MAPK12 peptide Descriptor: Mitogen-activated protein kinase 12, Tyrosine-protein phosphatase non-receptor type 3 Authors: Chen, K.E, Meng, T.C, Wang, A.H.J. Deposit date: 2014-07-10 Release date: 2014-12-10 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.516 Å) Cite: Reciprocal allosteric regulation of p38 gamma and PTPN3 involves a PDZ domain-modulated complex formation. Sci.Signal., 7, 2014
4QUN	Crystal structure of the PTPN3 (PTPH1) catalytic domain C842S mutant Descriptor: GLYCEROL, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 3 Authors: Chen, K.E, Meng, T.C, Wang, A.H.J. Deposit date: 2014-07-11 Release date: 2014-12-10 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Reciprocal allosteric regulation of p38 gamma and PTPN3 involves a PDZ domain-modulated complex formation. Sci.Signal., 7, 2014
4RI4	Crystal structure of PTPN3 (PTPH1) Y676I mutant in complex with vanadate Descriptor: Tyrosine-protein phosphatase non-receptor type 3, VANADATE ION Authors: Chen, K.-E, Meng, T.C, Wang, A.H.-J. Deposit date: 2014-10-05 Release date: 2015-03-11 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.596 Å) Cite: Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4RI5	Crystal structure of PTPN3 (PTPH1) D811E mutant in complex with metavanadate Descriptor: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 3, oxido(dioxo)vanadium Authors: Chen, K.-E, Meng, T.C, Wang, A.H.-J. Deposit date: 2014-10-05 Release date: 2015-03-11 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.26 Å) Cite: Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4RDD	Co-crystal structure of SHP2 in complex with a Cefsulodin derivative Descriptor: 1-({(2R)-4-carboxy-2-[(R)-carboxy{[(2R)-2-phenyl-2-sulfoacetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium, Tyrosine-protein phosphatase non-receptor type 11 Authors: Zhang, Z.Y, Yu, Z.H, He, R, Zhang, R.Y. Deposit date: 2014-09-18 Release date: 2015-07-01 Last modified: 2015-12-16 Method: X-RAY DIFFRACTION (1.601 Å) Cite: Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors. ACS Med Chem Lett, 6, 2015
4RH5	Crystal structure of PTPN3 (PTPH1) in complex with Eps15 pTyr849 peptide Descriptor: Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3 Authors: Chen, K.-E, Meng, T.C, Wang, A.H.-J. Deposit date: 2014-10-01 Release date: 2015-03-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
5J8R	Crystal Structure of the Catalytic Domain of Human Protein Tyrosine Phosphatase non-receptor Type 12 - K61R mutant Descriptor: Tyrosine-protein phosphatase non-receptor type 12 Authors: Li, H, Yang, F, Xu, Y.F, Wang, W.J, Xiao, P, Yu, X, Sun, J.P. Deposit date: 2016-04-08 Release date: 2016-04-27 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.043 Å) Cite: Crystal structure and substrate specificity of PTPN12. Cell Rep, 15, 2016
5KA8	Protein Tyrosine Phosphatase 1B L192A mutant, open state Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, Tyrosine-protein phosphatase non-receptor type 1 Authors: Choy, M.S, Peti, W, Page, R. Deposit date: 2016-06-01 Release date: 2017-03-01 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.971 Å) Cite: Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
5KA9	Protein Tyrosine Phosphatase 1B L192A mutant in complex with TCS401, open state Descriptor: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... Authors: Choy, M.S, Peti, W, Page, R. Deposit date: 2016-06-01 Release date: 2017-03-01 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
5K9W	Protein Tyrosine Phosphatase 1B (1-301) in complex with TCS401, closed state Descriptor: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... Authors: Choy, M.S, Peti, W, Page, R. Deposit date: 2016-06-01 Release date: 2017-03-01 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
5KA7	Protein Tyrosine Phosphatase 1B T178A mutant in complex with TCS401, closed state Descriptor: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... Authors: Choy, M.S, Peti, W, Page, R. Deposit date: 2016-06-01 Release date: 2017-03-08 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.061 Å) Cite: Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
5KA0	Protein Tyrosine Phosphatase 1B Delta helix 7, open state Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ... Authors: Choy, M.S, Peti, W, Page, R. Deposit date: 2016-06-01 Release date: 2017-03-01 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.991 Å) Cite: Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
5KAD	Protein Tyrosine Phosphatase 1B N193A mutant in complex with TCS401, closed state Descriptor: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... Authors: Choy, M.S, Peti, W, Page, R. Deposit date: 2016-06-01 Release date: 2017-03-01 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
5K9V	Protein Tyrosine Phosphatase 1B (1-301), open state Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ... Authors: Choy, M.S, Peti, W, Page, R. Deposit date: 2016-06-01 Release date: 2017-03-01 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.898 Å) Cite: Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
5KAA	Protein Tyrosine Phosphatase 1B Delta helix 7, P185G mutant, open state Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ... Authors: Choy, M.S, Machado, L.E.S.F, Peti, W, Page, R. Deposit date: 2016-06-01 Release date: 2017-03-08 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.968 Å) Cite: Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
5KA4	Protein Tyrosine Phosphatase 1B T178A mutant, open state Descriptor: Tyrosine-protein phosphatase non-receptor type 1 Authors: Choy, M.S, Peti, W, Page, R. Deposit date: 2016-06-01 Release date: 2017-03-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.185 Å) Cite: Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017
5KAB	Protein Tyrosine Phosphatase 1B Delta helix 7, P185G mutant in complex with TCS401, open state Descriptor: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... Authors: Choy, M.S, Machado, L.E.S.F, Peti, W, Page, R. Deposit date: 2016-06-01 Release date: 2017-03-08 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.968 Å) Cite: Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Mol. Cell, 65, 2017

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