8SC2
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8SC6
| Human OCT1 bound to thiamine in inward-open conformation | Descriptor: | 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, Solute carrier family 22 member 1 | Authors: | Zeng, Y.C, Sobti, M, Stewart, A.G. | Deposit date: | 2023-04-04 | Release date: | 2023-10-18 | Last modified: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | Structural basis of promiscuous substrate transport by Organic Cation Transporter 1. Nat Commun, 14, 2023
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8SC3
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8OMU
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8G92
| Structure of inhibitor 16d-bound SPNS2 | Descriptor: | 3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine, Sphingosine-1-phosphate transporter SPNS2 | Authors: | Chen, H, Li, X. | Deposit date: | 2023-02-21 | Release date: | 2023-05-24 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate. Cell, 186, 2023
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8FVZ
| PiPT Y150A | Descriptor: | CITRATE ANION, PHOSPHATE ION, Phosphate transporter | Authors: | Gupta, M, Finer-Moore, J, Stroud, R.M. | Deposit date: | 2023-01-20 | Release date: | 2024-01-03 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Roles of PiPT residues in phosphate binding and transport tested by mutagenesis To be published
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8BVT
| Cryo-EM structure of rat SLC22A6 bound to probenecid | Descriptor: | 4-(dipropylsulfamoyl)benzoic acid, Solute carrier family 22 member 6, Synthetic nanobody (Sybody) | Authors: | Parker, J.L, Kato, T, Newstead, S. | Deposit date: | 2022-12-06 | Release date: | 2023-07-19 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.94 Å) | Cite: | Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1. Nat.Struct.Mol.Biol., 30, 2023
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8BW7
| Cryo-EM structure of rat SLC22A6 bound to alpha-ketoglutaric acid | Descriptor: | 2-OXOGLUTARIC ACID, CHLORIDE ION, Solute carrier family 22 member 6, ... | Authors: | Parker, J.L, Kato, T, Newstead, S. | Deposit date: | 2022-12-06 | Release date: | 2023-07-19 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.53 Å) | Cite: | Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1. Nat.Struct.Mol.Biol., 30, 2023
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8BVS
| Cryo-EM structure of rat SLC22A6 bound to tenofovir | Descriptor: | CHLORIDE ION, Solute carrier family 22 member 6, Synthetic nanobody (Sybody), ... | Authors: | Parker, J.L, Kato, T, Newstead, S. | Deposit date: | 2022-12-05 | Release date: | 2023-07-19 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.61 Å) | Cite: | Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1. Nat.Struct.Mol.Biol., 30, 2023
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8BVR
| Cryo-EM structure of rat SLC22A6 in the apo state | Descriptor: | PHOSPHATE ION, Solute carrier family 22 member 6, Synthetic nanobody (Sybody) | Authors: | Parker, J.L, Kato, T, Newstead, S. | Deposit date: | 2022-12-05 | Release date: | 2023-07-19 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1. Nat.Struct.Mol.Biol., 30, 2023
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8EX7
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8EX8
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8EX4
| Human S1P transporter Spns2 in an inward-facing open conformation (state 1) | Descriptor: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Sphingosine-1-phosphate transporter SPNS2 | Authors: | Ahmed, S, Zhao, H, Dai, Y, Lee, C.H. | Deposit date: | 2022-10-24 | Release date: | 2023-05-31 | Last modified: | 2023-06-28 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate. Cell, 186, 2023
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8EX5
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8EX6
| Human S1P transporter Spns2 in an inward-facing open conformation (state 1*) | Descriptor: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Sphingosine-1-phosphate transporter SPNS2 | Authors: | Ahmed, S, Zhao, H, Dai, Y, Lee, C.H. | Deposit date: | 2022-10-24 | Release date: | 2023-05-31 | Last modified: | 2023-06-28 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate. Cell, 186, 2023
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8ET8
| Cryo-EM structure of the organic cation transporter 1 in complex with verapamil | Descriptor: | (2S)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, OCT1 | Authors: | Suo, Y, Wright, N.J, Lee, S.-Y. | Deposit date: | 2022-10-16 | Release date: | 2023-05-31 | Last modified: | 2023-08-02 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2. Nat.Struct.Mol.Biol., 30, 2023
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8ET7
| Cryo-EM structure of the organic cation transporter 1 in complex with diphenhydramine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE, OCT1 | Authors: | Suo, Y, Wright, N.J, Lee, S.-Y. | Deposit date: | 2022-10-16 | Release date: | 2023-05-31 | Last modified: | 2023-08-02 | Method: | ELECTRON MICROSCOPY (3.77 Å) | Cite: | Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2. Nat.Struct.Mol.Biol., 30, 2023
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8ET9
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8ET6
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7YUF
| apo human SPNS2 | Descriptor: | NbFab H-chain, NbFab L-chain, Sphingosine-1-phosphate transporter SPNS2, ... | Authors: | He, Y, Duan, Y. | Deposit date: | 2022-08-17 | Release date: | 2023-09-06 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | Structural basis of Sphingosine-1-phosphate transport via human SPNS2. Cell Res., 34, 2024
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7YUD
| FTY720p-bound human SPNS2 | Descriptor: | (2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol, NbFab L-chain, NbFab-H-chain, ... | Authors: | He, Y, Duan, Y. | Deposit date: | 2022-08-17 | Release date: | 2023-09-06 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structural basis of Sphingosine-1-phosphate transport via human SPNS2. Cell Res., 34, 2024
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7YUB
| S1P-bound human SPNS2 | Descriptor: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, NbFab-H-chain, NbFab-L-chain, ... | Authors: | He, Y, Duan, Y. | Deposit date: | 2022-08-17 | Release date: | 2023-09-06 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | Structural basis of Sphingosine-1-phosphate transport via human SPNS2. Cell Res., 34, 2024
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7ZH0
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7ZH6
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7ZHA
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