6CE9
| Insulin Receptor ectodomain in complex with two insulin molecules | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. | Deposit date: | 2018-02-11 | Release date: | 2018-03-14 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis. Nature, 556, 2018
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6CEB
| Insulin Receptor ectodomain in complex with two insulin molecules - C1 symmetry | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. | Deposit date: | 2018-02-11 | Release date: | 2018-03-14 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis. Nature, 556, 2018
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6CK2
| Insulin analog containing a YB26W mutation | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | Authors: | Rege, N.K, Yee, V.C, Weiss, M.A. | Deposit date: | 2018-02-27 | Release date: | 2018-06-13 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structure-based stabilization of insulin as a therapeutic protein assembly via enhanced aromatic-aromatic interactions. J. Biol. Chem., 293, 2018
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6FEY
| Crystal structure of Drosophila neural ectodermal development factor Imp-L2 with Drosophila DILP5 insulin | Descriptor: | Neural/ectodermal development factor IMP-L2, Probable insulin-like peptide 5 | Authors: | Brzozowski, A.M, Kulahin, N, Kristensen, O, Schluckebier, G, Meyts, P.D. | Deposit date: | 2018-01-03 | Release date: | 2018-09-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.48 Å) | Cite: | Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones. Nat Commun, 9, 2018
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6FF3
| Crystal structure of Drosophila neural ectodermal development factor Imp-L1 with Human IGF-I | Descriptor: | Insulin-like growth factor I, Neural/ectodermal development factor IMP-L2 | Authors: | Brzozowski, A.M, Kulahin, N, Kristensen, O, Schluckebier, G, Meyts, P.D, Viola, C.M. | Deposit date: | 2018-01-03 | Release date: | 2018-09-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones. Nat Commun, 9, 2018
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6GNQ
| Monoclinic crystalline form of human insulin, complexed with meta-cresol | Descriptor: | 1,2-ETHANEDIOL, Insulin, M-CRESOL, ... | Authors: | Margiolaki, I, Karavassili, F, Valmas, A, Dimarogona, M, Giannopoulou, A.E, Fili, S, Schluckebier, G, Norrman, M, Beckers, D, Fitch, A.N. | Deposit date: | 2018-05-31 | Release date: | 2019-06-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Monoclinic crystalline form of human insulin, complexed with meta-cresol To Be Published
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6GV0
| Insulin glulisine | Descriptor: | FORMIC ACID, Insulin, ZINC ION | Authors: | Chayen, N.E, Helliwell, J.R, Solomon-Gamsu, H.V, Govada, L, Morgan, M, Gillis, R.B, Adams, G. | Deposit date: | 2018-06-20 | Release date: | 2019-07-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.26 Å) | Cite: | Analysis of insulin glulisine at the molecular level by X-ray crystallography and biophysical techniques. Sci Rep, 11, 2021
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6H3M
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6HN5
| Leucine-zippered human insulin receptor ectodomain with single bound insulin - "upper" membrane-distal part | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, ... | Authors: | Weis, F, Menting, J.G, Margetts, M.B, Chan, S.J, Xu, Y, Tennagels, N, Wohlfart, P, Langer, T, Mueller, C.W, Dreyer, M.K, Lawrence, M.C. | Deposit date: | 2018-09-14 | Release date: | 2018-11-21 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The signalling conformation of the insulin receptor ectodomain. Nat Commun, 9, 2018
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6INS
| X-RAY ANALYSIS OF THE SINGLE CHAIN B29-A1 PEPTIDE-LINKED INSULIN MOLECULE. A COMPLETELY INACTIVE ANALOGUE | Descriptor: | INSULIN, ZINC ION | Authors: | Derewenda, U, Derewenda, Z, Dodson, E.J, Dodson, G.G, Bing, X, Markussen, J. | Deposit date: | 1992-11-25 | Release date: | 1994-01-31 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | X-ray analysis of the single chain B29-A1 peptide-linked insulin molecule. A completely inactive analogue. J.Mol.Biol., 220, 1991
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6JK8
| Cryo-EM structure of the full-length human IGF-1R in complex with insulin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, ... | Authors: | Zhang, X, Yu, D, Wang, T. | Deposit date: | 2019-02-27 | Release date: | 2020-03-04 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Visualization of Ligand-Bound Ectodomain Assembly in the Full-Length Human IGF-1 Receptor by Cryo-EM Single-Particle Analysis. Structure, 28, 2020
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6JR3
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6K59
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6KH8
| Solution structure of Zn free Bovine Pancreatic Insulin in 20% acetic acid-d4 (pH 1.9) | Descriptor: | Insulin A Chain, Insulin B chain | Authors: | Bhunia, A, Ratha, B.N, Kar, R.K, Brender, J.R. | Deposit date: | 2019-07-14 | Release date: | 2020-10-07 | Last modified: | 2020-11-18 | Method: | SOLUTION NMR | Cite: | High-resolution structure of a partially folded insulin aggregation intermediate. Proteins, 88, 2020
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6KH9
| Solution structure of bovine insulin amyloid intermediate-1 | Descriptor: | Insulin A chain, Insulin B chain | Authors: | Ratha, B.N, Kar, R.K, Brender, J.B, Bhunia, A. | Deposit date: | 2019-07-14 | Release date: | 2020-08-12 | Last modified: | 2020-11-18 | Method: | SOLUTION NMR | Cite: | High-resolution structure of a partially folded insulin aggregation intermediate. Proteins, 88, 2020
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6KHA
| Solution structure of bovine insulin amyloid intermediate-2 | Descriptor: | Insulin A chain, Insulin B chain | Authors: | Ratha, B.N, Kar, R.K, Brender, J.B, Bhunia, A. | Deposit date: | 2019-07-14 | Release date: | 2020-08-12 | Last modified: | 2020-11-18 | Method: | SOLUTION NMR | Cite: | High-resolution structure of a partially folded insulin aggregation intermediate. Proteins, 88, 2020
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6NWV
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6O17
| Recombinant Human Insulin | Descriptor: | Insulin chain A, Insulin chain B | Authors: | Reyes-Grajeda, J.P. | Deposit date: | 2019-02-18 | Release date: | 2020-02-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Human WT insulin To Be Published
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6OR0
| Crystal structure of Insulin from Non-merohedrally twinned crystals | Descriptor: | Insulin chain A, Insulin chain B | Authors: | Sevvana, M, Ruf, M, Uson, I, Sheldrick, G.M, Herbst-Irmer, R. | Deposit date: | 2019-04-29 | Release date: | 2019-12-11 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Non-merohedral twinning: from minerals to proteins. Acta Crystallogr D Struct Biol, 75, 2019
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6P4Z
| Structure of gadolinium-caged cobalt (III) insulin hexamer | Descriptor: | CHLORIDE ION, COBALT (II) ION, GADOLINIUM ATOM, ... | Authors: | Tran, T.H, Taylor, S.K, Stojanovic, M.N, Tong, L. | Deposit date: | 2019-05-29 | Release date: | 2019-06-12 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Insulin Hexamer-Caged Gadolinium Ion as MRI Contrast-o-phore ChemBioChem, 24, 2018
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6PXV
| Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the extracellular region. | Descriptor: | Insulin, Insulin receptor | Authors: | Uchikawa, E, Choi, E, Shang, G.J, Yu, H.T, Bai, X.C. | Deposit date: | 2019-07-27 | Release date: | 2019-09-04 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex. Elife, 8, 2019
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6PXW
| Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the top part of the receptor complex. | Descriptor: | Insulin, Insulin receptor | Authors: | Uchikawa, E, Choi, E, Shang, G.J, Yu, H.T, Bai, X.C. | Deposit date: | 2019-07-28 | Release date: | 2019-09-04 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex. Elife, 8, 2019
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6PYH
| Cryo-EM structure of full-length IGF1R-IGF1 complex. Only the extracellular region of the complex is resolved. | Descriptor: | Insulin-like growth factor 1 receptor, Insulin-like growth factor I | Authors: | Li, J, Choi, E, Yu, H.T, Bai, X.C. | Deposit date: | 2019-07-29 | Release date: | 2019-10-23 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural basis of the activation of type 1 insulin-like growth factor receptor. Nat Commun, 10, 2019
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6Q8Q
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6QQ7
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