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6QQG	High pressure structure of bovine insulin (60 MPa) Descriptor: Insulin Authors: Kurpiewska, K, Milaczewska, A, Lewinski, K. Deposit date: 2019-02-18 Release date: 2019-03-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.149 Å) Cite: Insulin conformational changes under high pressure in structural studies and molecular dynamics simulations J.Mol.Struct., 2020
6QRH	High pressure structure of bovine insulin (100 MPa) Descriptor: Insulin Authors: Kurpiewska, K, Milaczewska, A, Lewinski, K. Deposit date: 2019-02-19 Release date: 2019-02-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.152 Å) Cite: Insulin conformational changes under high pressure in structural studies and molecular dynamics simulations J.Mol.Struct., 2020
6QRK	High pressure structure of bovine insulin (200 MPa) Descriptor: Insulin Authors: Kurpiewska, K, Milaczewska, A, Lewinski, K. Deposit date: 2019-02-19 Release date: 2019-03-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.102 Å) Cite: Insulin conformational changes under high pressure in structural studies and molecular dynamics simulations J.Mol.Struct., 2020
6RVA	STRUCTURE OF [ASP58]-IGF-I ANALOGUE Descriptor: Insulin-like growth factor I Authors: Jiracek, J, Zakova, L, Socha, O. Deposit date: 2019-05-31 Release date: 2019-10-02 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses. J.Biol.Chem., 294, 2019
6S34	Zinc free, dimeric human insulin determined to 1.35 Angstrom resolution Descriptor: 1,2-ETHANEDIOL, Insulin A chain, Insulin B chain Authors: Johansson, E. Deposit date: 2019-06-24 Release date: 2019-07-03 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Zinc free, dimeric human insulin determined to 1.35 Angstrom resolution Not Published
6S4I	Crystal structure of zinc free A14E, B25H, B29K(N(eps)-[2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl]), desB30 human insulin Descriptor: Insulin, NITRATE ION Authors: Johansson, E. Deposit date: 2019-06-28 Release date: 2020-07-15 Last modified: 2020-08-12 Method: X-RAY DIFFRACTION (1.511 Å) Cite: Molecular engineering of safe and efficacious oral basal insulin. Nat Commun, 11, 2020
6S4J	Crystal structure of zinc free A14E, B25H, B29K(N(eps)-[2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl]), desB27, desB30 human insulin Descriptor: IMIDAZOLE, Insulin, KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] Authors: Johansson, E. Deposit date: 2019-06-28 Release date: 2020-07-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Molecular engineering of safe and efficacious oral basal insulin. Nat Commun, 11, 2020
6SOF	human insulin receptor ectodomain bound by 4 insulin Descriptor: Insulin, Insulin receptor Authors: Gutmann, T, Schaefer, I.B, Poojari, C.S, Vattulainen, I, Strauss, M, Coskun, U. Deposit date: 2019-08-29 Release date: 2019-11-13 Last modified: 2020-05-27 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain. J.Cell Biol., 219, 2020
6TC2	Monoclinic human insulin in complex with p-coumaric acid Descriptor: 4'-HYDROXYCINNAMIC ACID, Insulin, PHOSPHATE ION, ... Authors: Triandafillidis, D.-P, Parthenios, N, Spiliopoulou, M, Valmas, A, Kosinas, C, Gozzo, F, Reinle-Schmitt, M, Beckers, D, Degen, T, Pop, M, Fitch, A, Wollenhaupt, J, Weiss, M.S, Karavassili, F, Margiolaki, I. Deposit date: 2019-11-04 Release date: 2020-11-11 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.36 Å) Cite: Insulin polymorphism induced by two polyphenols: new crystal forms and advances in macromolecular powder diffraction. Acta Crystallogr D Struct Biol, 76, 2020
6TYH	Four-Disulfide Insulin Analog A22/B22 Descriptor: ACETONE, CHLORIDE ION, GLYCEROL, ... Authors: Blakely, A.D, Xiong, X. Deposit date: 2019-08-08 Release date: 2019-11-13 Last modified: 2020-03-11 Method: X-RAY DIFFRACTION (1.600019 Å) Cite: Novel four-disulfide insulin analog with high aggregation stability and potency. Chem Sci, 11, 2020
6U46	Solution Structure of a Heat-Resistant Long-Acting Insulin Analog Descriptor: Insulin Authors: Yang, Y, Weiss, M.A. Deposit date: 2019-08-23 Release date: 2020-08-26 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Solution Structure of a Heat-Resistant Long-Acting Insulin Analog To Be Published
6UM2	Structure of M-6-P/IGFII Receptor and IGFII complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cation-independent mannose-6-phosphate receptor, Insulin-like growth factor II Authors: Wang, R, Qi, X, Li, X. Deposit date: 2019-10-08 Release date: 2020-02-26 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (4.32 Å) Cite: Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments Sci Adv, 6, 2020
6VEP	Human insulin in complex with the human insulin microreceptor in turn in complex with Fv 83-7 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Lawrence, M.C, Menting, J.G.T. Deposit date: 2020-01-02 Release date: 2020-06-03 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A structurally minimized yet fully active insulin based on cone-snail venom insulin principles. Nat.Struct.Mol.Biol., 27, 2020
6VWG	Head region of the open conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II. Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor II, Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain Authors: Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I. Deposit date: 2020-02-19 Release date: 2020-05-13 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (3.21 Å) Cite: How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor. Structure, 28, 2020
6VWI	Head region of the closed conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II. Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor II, Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain Authors: Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I. Deposit date: 2020-02-19 Release date: 2020-05-13 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor. Structure, 28, 2020
6X4X	B24Y DKP insulin Descriptor: Insulin, Insulin chain A Authors: Weiss, M.A, Yang, Y. Deposit date: 2020-05-24 Release date: 2020-08-05 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Evolution of insulin at the edge of foldability and its medical implications. Proc.Natl.Acad.Sci.USA, 117, 2020
6Z7W	Human insulin in complex with the analytical antibody HUI-018 Fab Descriptor: HUI-018 Fab Heavy Chain, Insulin, MAb 6H10 light chain Authors: Johansson, E. Deposit date: 2020-06-02 Release date: 2020-12-30 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.42 Å) Cite: Insulin binding to the analytical antibody sandwich pair OXI-005 and HUI-018: Epitope mapping and binding properties. Protein Sci., 30, 2021
6Z7Y	Human insulin in complex with the analytical antibody OXI-005 Fab Descriptor: Insulin, OXI-005 Fab Heavy chain, OXI-005 Fab Light chain Authors: Johansson, E. Deposit date: 2020-06-02 Release date: 2020-12-30 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Insulin binding to the analytical antibody sandwich pair OXI-005 and HUI-018: Epitope mapping and binding properties. Protein Sci., 30, 2021
6Z7Z	Porcine insulin in complex with the analytical antibody OXI-005 Fab Descriptor: Insulin, MAGNESIUM ION, OXI-005 Fab Heavy chain, ... Authors: Johansson, E. Deposit date: 2020-06-02 Release date: 2020-12-30 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Insulin binding to the analytical antibody sandwich pair OXI-005 and HUI-018: Epitope mapping and binding properties. Protein Sci., 30, 2021
6ZHB	3D electron diffraction structure of bovine insulin Descriptor: Insulin, ZINC ION Authors: Blum, T, Housset, D, Clabbers, M.T.B, van Genderen, E, Bacia-Verloop, M, Zander, U, McCarthy, A.A, Schoehn, G, Ling, W.L, Abrahams, J.P. Deposit date: 2020-06-22 Release date: 2021-01-27 Last modified: 2024-01-24 Method: ELECTRON CRYSTALLOGRAPHY (3.25 Å) Cite: Statistically correcting dynamical electron scattering improves the refinement of protein nanocrystals, including charge refinement of coordinated metals. Acta Crystallogr D Struct Biol, 77, 2021
6ZI8	X-ray diffraction structure of bovine insulin at 2.3 A resolution Descriptor: CHLORIDE ION, Insulin, ZINC ION Authors: Housset, D, Ling, W.L, Bacia-Verloop, M, Zander, U, McCarthy, A.A, Schoehn, G. Deposit date: 2020-06-25 Release date: 2021-01-20 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Statistically correcting dynamical electron scattering improves the refinement of protein nanocrystals, including charge refinement of coordinated metals. Acta Crystallogr D Struct Biol, 77, 2021
7AC4	Structure of insulin collected by rotation serial crystallography on a COC membrane at a synchrotron source Descriptor: Insulin, R-1,2-PROPANEDIOL, SODIUM ION Authors: Martiel, I, Padeste, C, Karpik, A, Huang, C.Y, Vera, L, Wang, M, Marsh, M. Deposit date: 2020-09-09 Release date: 2021-09-01 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.46 Å) Cite: Versatile microporous polymer-based supports for serial macromolecular crystallography. Acta Crystallogr D Struct Biol, 77, 2021
7BW7	Cryo-EM Structure for the Ectodomain of the Full-length Human Insulin Receptor in Complex with 1 Insulin. Descriptor: Insulin fusion, Insulin receptor Authors: Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T. Deposit date: 2020-04-13 Release date: 2021-04-14 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor To Be Published
7BW8	Cryo-EM Structure for the Insulin Binding Region in the Ectodomain of the Full-length Human Insulin Receptor in Complex with 1 Insulin Descriptor: Insulin fusion, Insulin receptor Authors: Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T. Deposit date: 2020-04-14 Release date: 2021-04-14 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor To Be Published
7BWA	Cryo-EM Structure for the Ectodomain of the Full-length Human Insulin Receptor in Complex with 2 Insulin Descriptor: Insulin fusion, Insulin receptor Authors: Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T. Deposit date: 2020-04-14 Release date: 2021-04-14 Method: ELECTRON MICROSCOPY (4.9 Å) Cite: Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor To Be Published

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