1AZG
| NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE KINASE COMPLEXED WITH THE SYNTHETIC PEPTIDE P2L CORRESPONDING TO RESIDUES 91-104 OF THE P85 SUBUNIT OF PI3-KINASE, MINIMIZED AVERAGE (PROBMAP) STRUCTURE | Descriptor: | FYN, PRO-PRO-ARG-PRO-LEU-PRO-VAL-ALA-PRO-GLY-SER-SER-LYS-THR | Authors: | Renzoni, D.A, Pugh, D.J.R, Siligardi, G, Das, P, Morton, C.J, Rossi, C, Waterfield, M.D, Campbell, I.D, Ladbury, J.E. | Deposit date: | 1997-11-18 | Release date: | 1998-02-25 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase. Biochemistry, 35, 1996
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1AZE
| NMR STRUCTURE OF THE COMPLEX BETWEEN THE C32S-Y7V MUTANT OF THE NSH3 DOMAIN OF GRB2 WITH A PEPTIDE FROM SOS, 10 STRUCTURES | Descriptor: | GRB2, SOS | Authors: | Vidal, M, Gincel, E, Goudreau, N, Cornille, F, Parker, F, Duchesne, M, Tocque, B, Garbay, C, Roques, B.P. | Deposit date: | 1997-11-17 | Release date: | 1999-05-18 | Last modified: | 2021-11-03 | Method: | SOLUTION NMR | Cite: | Molecular and cellular analysis of Grb2 SH3 domain mutants: interaction with Sos and dynamin. J.Mol.Biol., 290, 1999
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1AWO
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1AOJ
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1BU1
| SRC FAMILY KINASE HCK SH3 DOMAIN | Descriptor: | PROTEIN (HEMOPOIETIC CELL KINASE) | Authors: | Arold, S, Franken, P, Dumas, C. | Deposit date: | 1998-09-09 | Release date: | 1998-11-11 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef. Biochemistry, 37, 1998
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1BK2
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1CSK
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1CKB
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1CKA
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5QU6
| Crystal Structure of swapped human Nck SH3.1 domain, 1.8A, triclinic | Descriptor: | Cytoplasmic protein NCK1 | Authors: | Rudolph, M.G. | Deposit date: | 2019-12-13 | Release date: | 2020-02-12 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.816 Å) | Cite: | Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain. J.Biol.Chem., 295, 2020
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5QU8
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5QU3
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5QUA
| Crystal Structure of swapped human Nck SH3.1 domain, 1.5A, C2221 | Descriptor: | Cytoplasmic protein NCK1 | Authors: | Rudolph, M.G. | Deposit date: | 2019-12-13 | Release date: | 2020-02-12 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain. J.Biol.Chem., 295, 2020
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5QU1
| Crystal Structure of the monomeric human Nck SH3.1 domain, triclinic, 1.08A | Descriptor: | Cytoplasmic protein NCK1, SULFATE ION | Authors: | Burger, D, Ruf, A, Benz, J, Schlatter, D, Rudolph, M.G. | Deposit date: | 2019-12-13 | Release date: | 2020-02-12 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain. J.Biol.Chem., 295, 2020
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5QU5
| Domain Swap in the first SH3 domain of human Nck1 | Descriptor: | Cytoplasmic protein NCK1 | Authors: | Burger, D, Ruf, A, Benz, J, Schlatter, D, Rudolph, M.G. | Deposit date: | 2019-12-13 | Release date: | 2020-02-12 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.11 Å) | Cite: | Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain. J.Biol.Chem., 295, 2020
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5QU2
| Crystal Structure of human Nck SH3.1 in complex with peptide PPPVPNPDY | Descriptor: | ACE-PRO-PRO-PRO-VAL-PRO-ASN-PRO-ASP-TYR-NH2, Cytoplasmic protein NCK1, SULFATE ION | Authors: | Rudolph, M.G. | Deposit date: | 2019-12-13 | Release date: | 2020-02-12 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.04 Å) | Cite: | Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain. J.Biol.Chem., 295, 2020
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5QU7
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5QU4
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1E6H
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1E6G
| A-SPECTRIN SH3 DOMAIN A11V, V23L, M25I, V53I, V58L MUTANT | Descriptor: | SPECTRIN ALPHA CHAIN, SULFATE ION | Authors: | Vega, M.C, Serrano, L. | Deposit date: | 2000-08-15 | Release date: | 2002-05-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Conformational Strain in the Hydrophobic Core and its Implications for Protein Folding and Design Nat.Struct.Biol., 9, 2002
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1GCQ
| CRYSTAL STRUCTURE OF VAV AND GRB2 SH3 DOMAINS | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, VAV PROTO-ONCOGENE | Authors: | Nishida, M, Nagata, K, Hachimori, Y, Ogura, K, Inagaki, F. | Deposit date: | 2000-08-08 | Release date: | 2001-08-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Novel recognition mode between Vav and Grb2 SH3 domains. EMBO J., 20, 2001
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1GFD
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1GBQ
| SOLUTION NMR STRUCTURE OF THE GRB2 N-TERMINAL SH3 DOMAIN COMPLEXED WITH A TEN-RESIDUE PEPTIDE DERIVED FROM SOS DIRECT REFINEMENT AGAINST NOES, J-COUPLINGS, AND 1H AND 13C CHEMICAL SHIFTS, MINIMIZED AVERAGE STRUCTURE | Descriptor: | GRB2, SOS-1 | Authors: | Wittekind, M, Mapelli, C, Lee, V, Goldfarb, V, Friedrichs, M.S, Meyers, C.A, Mueller, L. | Deposit date: | 1996-12-23 | Release date: | 1997-09-04 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Solution structure of the Grb2 N-terminal SH3 domain complexed with a ten-residue peptide derived from SOS: direct refinement against NOEs, J-couplings and 1H and 13C chemical shifts. J.Mol.Biol., 267, 1997
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1GFC
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1G2B
| ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN, CIRCULAR PERMUTANT, CUT AT N47-D48 | Descriptor: | SPECTRIN ALPHA CHAIN, SULFATE ION | Authors: | Berisio, R, Viguera, A.R, Serrano, L, Wilmanns, M. | Deposit date: | 2000-10-18 | Release date: | 2000-11-01 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | Atomic resolution structure of a mutant of the spectrin SH3 domain. Acta Crystallogr.,Sect.D, 57, 2001
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