PDB: 2407 resultsInfo pagesStatus searchChemie searchBIRD

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6PG8	WDR5delta23 bound to (2-(3-phenylpropyl)-1H-imidazol-4-yl)methanol Descriptor: CHLORIDE ION, SULFATE ION, WD repeat-containing protein 5, ... Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG4	WDR5delta32 bound to (2-methyl-1H-imidazol-4-yl)methanol Descriptor: (2-methyl-1H-imidazol-4-yl)methanol, SULFATE ION, WD repeat-containing protein 5 Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG9	WDR5delta23 bound to N-(4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)benzamide Descriptor: N-{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]butyl}benzamide, WD repeat-containing protein 5 Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PGA	WDR5delta32 bound to methyl (4-(4-(hydroxymethyl)-1H-imidazol-2-yl)butyl)carbamate Descriptor: SULFATE ION, WD repeat-containing protein 5, methyl {4-[5-(hydroxymethyl)-1H-imidazol-2-yl]butyl}carbamate Authors: Dennis, M.L, Peat, T.S. Deposit date: 2019-06-24 Release date: 2019-12-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6QTS	Crystal structure of a mutant Arabidopsis WD40 domain in complex with a photoreceptor Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ... Authors: Hothorn, M, Lau, K. Deposit date: 2019-02-25 Release date: 2019-07-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.11 Å) Cite: Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTR	Crystal structure of a mutant Arabidopsis WD40 domain in complex with a transcription factor Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ... Authors: Hothorn, M, Lau, K. Deposit date: 2019-02-25 Release date: 2019-07-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.37 Å) Cite: Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTT	Crystal structure of an Arabidopsis WD40 domain in complex with a transcription factor homolog Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, MALONATE ION, ... Authors: Hothorn, M, Lau, K. Deposit date: 2019-02-25 Release date: 2019-07-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.51 Å) Cite: Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTQ	Crystal structure of an Arabidopsis WD40 domain in complex with photoreceptor Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ... Authors: Hothorn, M, Lau, K. Deposit date: 2019-02-25 Release date: 2019-07-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTX	Crystal structure of an Arabidopsis WD40 domain in complex with a flowering transcription factor homolog Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ... Authors: Hothorn, M, Lau, K. Deposit date: 2019-02-25 Release date: 2019-07-10 Last modified: 2019-10-02 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTV	Crystal structure of an Arabidopsis WD40 domain in complex with an atypical bHLH transcription factor Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, MALONATE ION, ... Authors: Hothorn, M, Lau, K. Deposit date: 2019-02-25 Release date: 2019-07-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.31 Å) Cite: Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
7MT1	Crystal structure of Human Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1) Descriptor: GLYCEROL, Platelet-activating factor acetylhydrolase IB subunit beta, UNKNOWN ATOM OR ION Authors: Hutchinson, A, Seitova, A, Dong, A, Loppnau, P, Edwards, A.M, Arrowsmith, C.H, Halabelian, L, Structural Genomics Consortium (SGC) Deposit date: 2021-05-12 Release date: 2021-06-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Crystal structure of Human Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1) To Be Published
6QTO	Crystal structure of an Arabidopsis WD40 domain in complex with a transcription factor Descriptor: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ... Authors: Hothorn, M, Lau, K. Deposit date: 2019-02-25 Release date: 2019-07-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.27 Å) Cite: Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTW	Crystal structure of an Arabidopsis WD40 domain in complex with a blue light photoreceptor Descriptor: Cryptochrome-1, E3 ubiquitin-protein ligase COP1, GLYCEROL, ... Authors: Hothorn, M, Lau, K. Deposit date: 2019-02-25 Release date: 2019-07-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.39 Å) Cite: Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTU	Crystal structure of Arabidopsis WD40 domain in complex with a BBX transcription factor Descriptor: B-box zinc finger protein 24, E3 ubiquitin-protein ligase COP1, GLYCEROL, ... Authors: Hothorn, M, Lau, K. Deposit date: 2019-02-25 Release date: 2019-07-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6R60	asymmetric antiparallel assembly of two 5-bladed beta-propeller fragments Descriptor: WD-40 repeat protein Authors: Afanasieva, E, Lupas, A.N, Hartmann, M.D. Deposit date: 2019-03-26 Release date: 2019-11-13 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural diversity of oligomeric beta-propellers with different numbers of identical blades. Elife, 8, 2019
6R5Z	9-bladed beta-propeller formed by three 3-bladed fragments Descriptor: 9-bladed beta-propeller formed by three 3-bladed fragments Authors: Martin, J, Lupas, A.N, Hartmann, M.D. Deposit date: 2019-03-26 Release date: 2019-11-13 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural diversity of oligomeric beta-propellers with different numbers of identical blades. Elife, 8, 2019
6R5X	8-bladed beta-propeller formed by four 2-bladed fragments Descriptor: WD-40 repeat protein Authors: Martin, J, Lupas, A.N, Hartmann, M.D. Deposit date: 2019-03-25 Release date: 2019-11-13 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural diversity of oligomeric beta-propellers with different numbers of identical blades. Elife, 8, 2019
7MSB	Structure of EED bound to EEDi-4259 Descriptor: (9aM,12aS)-12-{[(5-fluoro-1-benzofuran-4-yl)methyl]amino}-7-(trifluoromethyl)-4,5-dihydro-3H-2,4,11,12a-tetraazabenzo[4,5]cycloocta[1,2,3-cd]inden-3-one, Polycomb protein EED Authors: Petrunak, E, Stuckey, J. Deposit date: 2021-05-11 Release date: 2021-10-20 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression. J.Med.Chem., 64, 2021
7MSD	Structure of EED bound to EEDi-6068 Descriptor: (9aP,12aR)-4-(2,2-difluoropropyl)-12-{[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]amino}-7-(trifluoromethyl)-4,5-dihydro-3H-2,4,8,11,12a-pentaazabenzo[4,5]cycloocta[1,2,3-cd]inden-3-one, FORMIC ACID, Polycomb protein EED Authors: Petrunak, E, Stuckey, J. Deposit date: 2021-05-11 Release date: 2021-10-20 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression. J.Med.Chem., 64, 2021
6R5Y	8-bladed beta-propeller formed by two 4-bladed fragments Descriptor: WD-40 repeat protein, ZINC ION Authors: Martin, J, Lupas, A.N, Hartmann, M.D. Deposit date: 2019-03-25 Release date: 2019-11-13 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structural diversity of oligomeric beta-propellers with different numbers of identical blades. Elife, 8, 2019
6YVI	EED in complex with a cyano-benzofuran Descriptor: 5-fluoranyl-4-[[[8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl]amino]methyl]-2,3-dihydro-1-benzofuran-7-carbonitrile, CALCIUM ION, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... Authors: Read, J.A. Deposit date: 2020-04-28 Release date: 2021-05-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase. Bioorg.Med.Chem.Lett., 39, 2021
6YVJ	EED in complex with a triazolopyrimidine Descriptor: GLYCEROL, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, N-[(5-fluoranyl-2,3-dihydro-1-benzofuran-4-yl)methyl]-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... Authors: Read, J.A. Deposit date: 2020-04-28 Release date: 2021-05-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase. Bioorg.Med.Chem.Lett., 39, 2021
7AXU	Structure of WDR5:CS-VIP8 cocrystal after illumination in situ Descriptor: WD repeat-containing protein 5 Authors: Werel, L, Essen, L.-O. Deposit date: 2020-11-10 Release date: 2021-11-24 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8, 2022
7AXQ	Structure of the cryo-trapped WDR5:CS-VIP8 cocrystal after illumination at 405 nm and 180 K Descriptor: CS-VIP8, WD repeat-containing protein 5 Authors: Werel, L, Essen, L.-O. Deposit date: 2020-11-10 Release date: 2021-12-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.562 Å) Cite: Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8, 2022
7AXX	Structure of WDR5:CS-VIP8 crystal after illumination at 405 nm and room temperature Descriptor: (ALQ)(4FO)R(ABA)(DPN)(EDN)(S7Z), WD repeat-containing protein 5 Authors: Werel, L, Essen, L.-O. Deposit date: 2020-11-10 Release date: 2021-12-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8, 2022

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