PDB: 621 resultsInfo pagesStatus searchChemie searchBIRD

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5YPM	Crystal structure of NDM-1 bound to hydrolyzed meropenem representing an EI1 complex Descriptor: (2S,3R)-2-[(2S,3R)-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfan yl-3-methyl-2,3-dihydro-1H-pyrrole-5-carboxylic acid, Metallo-beta-lactamase NDM-1, SULFATE ION, ... Authors: Feng, H, Wang, D, Liu, W. Deposit date: 2017-11-02 Release date: 2018-02-21 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.15 Å) Cite: The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis. Nat Commun, 8, 2017
1L9Y	FEZ-1-Y228A, A Mutant of the Metallo-beta-lactamase from Legionella gormanii Descriptor: CHLORIDE ION, FEZ-1 b-lactamase, GLYCEROL, ... Authors: Garcia-Saez, I, Mercuri, P.S, Galleni, M, Dideberg, O. Deposit date: 2002-03-27 Release date: 2003-07-01 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Three-dimensional Structure of FEZ-1, a Monomeric Subclass B3 Metallo-beta-lactamase from Fluoribacter gormanii, in Native Form and in Complex with -Captopril J.Mol.Biol., 325, 2003
1MQO	Metallo-beta-lactamase BcII Cd substituted from Bacillus cereus at 1.35 angstroms resolution Descriptor: Beta-lactamase II, CADMIUM ION, CITRIC ACID Authors: Garcia-Saez, I, Chantalat, L, Dideberg, O. Deposit date: 2002-09-17 Release date: 2004-05-18 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.35 Å) Cite: High resolution structure of the Cd substituted BcII from Bacillus cereus To be Published
1KO2	VIM-2, a Zn-beta-lactamase from Pseudomonas aeruginosa with an oxidized Cys (cysteinesulfonic) Descriptor: ACETATE ION, VIM-2 metallo-beta-lactamase, ZINC ION Authors: Garcia-Saez, I, Docquier, J.-D, Rossolini, G.M, Dideberg, O. Deposit date: 2001-12-20 Release date: 2003-09-02 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The three-dimensional structure of VIM-2, a Zn-beta-lactamase from Pseudomonas aeruginosa in its reduced and oxidised form J.Mol.Biol., 375, 2008
1M2X	Crystal Structure of the metallo-beta-lactamase BlaB of Chryseobacterium meningosepticum in complex with the inhibitor D-captopril Descriptor: 1-(3-MERCAPTO-2-METHYL-PROPIONYL)-PYRROLIDINE-2-CARBOXYLIC ACID, GLYCEROL, SODIUM ION, ... Authors: Garcia-Saez, I, Dideberg, O. Deposit date: 2002-06-26 Release date: 2003-07-29 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.5 Å) Cite: The 1.5 A structure of Chryseobacterium meningosepticum Zn-beta-lactamase in complex with the inhibitor, D-captopril J.Biol.Chem., 278, 2003
1KO3	VIM-2, a Zn-beta-lactamase from Pseudomonas aeruginosa with Cys221 reduced Descriptor: ACETATE ION, CHLORIDE ION, HYDROXIDE ION, ... Authors: Garcia-Saez, I, Docquier, J.-D, Rossolini, G.M, Dideberg, O. Deposit date: 2001-12-20 Release date: 2003-09-02 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.91 Å) Cite: The three-dimensional structure of VIM-2, a Zn-beta-lactamase from Pseudomonas aeruginosa in its reduced and oxidised form J.Mol.Biol., 375, 2008
1JT1	FEZ-1 metallo-beta-lactamase from Legionella gormanii modelled with D-captopril Descriptor: 1-(3-MERCAPTO-2-METHYL-PROPIONYL)-PYRROLIDINE-2-CARBOXYLIC ACID, CHLORIDE ION, FEZ-1, ... Authors: Garcia-Saez, I, Mercuri, P.S, Kahn, R, Papamicael, C, Frere, J.M, Galleni, M, Dideberg, O. Deposit date: 2001-08-20 Release date: 2003-01-21 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Three-dimensional Structure of FEZ-1, a Monomeric Subclass B3 Metallo-[beta]-lactamase from Fluoribacter gormanii, in Native Form and in Complex with -Captopril J.MOL.BIOL., 325, 2003
5FQA	Crystal Structure of Bacillus cereus Metallo-Beta-Lactamase II Descriptor: 1,2-ETHANEDIOL, BETA-LACTAMASE 2, FE (III) ION, ... Authors: Cahill, S.T, Brem, J, McDonough, M.A, Schofield, C.J. Deposit date: 2015-12-08 Release date: 2016-08-10 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Use of ferrous iron by metallo-beta-lactamases. J. Inorg. Biochem., 163, 2016
4NQ4	Bacillus cereus Zn-dependent metallo-beta-lactamase at pH 7 Descriptor: Beta-lactamase 2, POTASSIUM ION, ZINC ION Authors: Gonzalez, J.M, Gonzalez, M.M, Vila, A.J. Deposit date: 2013-11-23 Release date: 2014-11-26 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Inhibition of metallo-lactamases with bicyclic compounds TO BE PUBLISHED
7XHX	Crystal structure of metallo-beta-lactamase IMP-6 Descriptor: Beta-lactamase, ZINC ION Authors: Yamamoto, K, Tanaka, H, Kurisu, G, Nakano, R, Yano, H, Sakai, H. Deposit date: 2022-04-11 Release date: 2023-02-15 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural insights into the substrate specificity of IMP-6 and IMP-1 metallo-beta-lactamases. J.Biochem., 173, 2022
7XHW	Crystal structure of metallo-beta-lactamase IMP-1 Descriptor: Beta-lactamase, ZINC ION Authors: Yamamoto, K, Tanaka, H, Kurisu, G, Nakano, R, Yano, H, Sakai, H. Deposit date: 2022-04-11 Release date: 2023-02-15 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Structural insights into the substrate specificity of IMP-6 and IMP-1 metallo-beta-lactamases. J.Biochem., 173, 2022
3KNS	Bacillus cereus metallo-beta-lactamase Cys221Asp mutant, 20 mM Zn(II) Descriptor: ACETIC ACID, Beta-lactamase 2, GLYCEROL, ... Authors: Medrano Martin, F.J, Gonzalez, J.M, Vila, A.J. Deposit date: 2009-11-12 Release date: 2010-11-24 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Metallo-beta-lactamases withstand low Zn(II) conditions by tuning metal-ligand interactions. Nat.Chem.Biol., 8, 2012
5HH4	Crystal structure of metallo-beta-lactamase IMP-1 in complex with a phosphonate-based inhibitor Descriptor: 1,2-ETHANEDIOL, 6-(phosphonomethyl)pyridine-2-carboxylic acid, Beta-lactamase IMP-1, ... Authors: Hinchliffe, P, Spencer, J. Deposit date: 2016-01-09 Release date: 2017-01-18 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural and Kinetic Studies of the Potent Inhibition of Metallo-beta-lactamases by 6-Phosphonomethylpyridine-2-carboxylates. Biochemistry, 57, 2018
3LVZ	New refinement of the crystal structure of BJP-1, a subclass B3 metallo-beta-lactamase of Bradyrhizobium japonicum Descriptor: Blr6230 protein, ZINC ION Authors: Docquier, J.D, Benvenuti, M, Calderone, V, Stoczko, M, Rossolini, G.M, Mangani, S. Deposit date: 2010-02-23 Release date: 2011-01-12 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: High-resolution crystal structure of the subclass B3 metallo-beta-lactamase BJP-1: rational basis for substrate specificity and interaction with sulfonamides. Antimicrob.Agents Chemother., 54, 2010
5HIQ	Crystal Structure of PQS Response Protein PqsE in Complex with 2-(1H-pyrrol-1-yl)benzoic acid Descriptor: 2-pyrrol-1-ylbenzoic acid, FE (III) ION, PqsE Authors: Witzgall, F, Blankenfeldt, W. Deposit date: 2016-01-12 Release date: 2016-04-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa Virulence by Discovery of Small Tool Compounds. Acs Chem.Biol., 11, 2016
7Y7U	Dimeric structure of a Quorum-Quenching metallo-hydrolase, LrsL Descriptor: MBL fold metallo-hydrolase, ZINC ION Authors: Momin, A.A, Arold, S.T. Deposit date: 2022-06-22 Release date: 2022-08-31 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.89 Å) Cite: The exceptionally efficient quorum quenching enzyme LrsL suppresses Pseudomonas aeruginosa biofilm production. Front Microbiol, 13, 2022
7YHD	Crystal structure of VIM-2 MBL in complex with 3-(4-(4-(2-aminoethoxy)phenyl)-1H-1,2,3-triazol-1-yl)phthalic acid Descriptor: 3-[4-[4-(2-azanylethoxy)phenyl]-1,2,3-triazol-1-yl]phthalic acid, Beta-lactamase class B VIM-2, ZINC ION Authors: Li, G.-B, Yan, Y.-H. Deposit date: 2022-07-13 Release date: 2023-06-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.696 Å) Cite: Metal binding pharmacophore click-derived discovery of new broad-spectrum metallo-beta-lactamase inhibitors. Eur.J.Med.Chem., 257, 2023
7YHB	Crystal structure of VIM-2 MBL in complex with (2-(4-phenyl-1H-1,2,3-triazol-1-yl)benzyl)phosphonic acid Descriptor: Beta-lactamase class B VIM-2, ZINC ION, [2-(4-phenyl-1,2,3-triazol-1-yl)phenyl]methylphosphonic acid Authors: Li, G.-B, Yan, Y.-H. Deposit date: 2022-07-13 Release date: 2023-06-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.43 Å) Cite: Metal binding pharmacophore click-derived discovery of new broad-spectrum metallo-beta-lactamase inhibitors. Eur.J.Med.Chem., 257, 2023
7YH9	Crystal structure of IMP-1 MBL in complex with 3-(4-benzyl-1H-1,2,3-triazol-1-yl)phthalic acid Descriptor: 3-[4-(phenylmethyl)-1,2,3-triazol-1-yl]phthalic acid, Beta-lactamase class B IMP-1, ZINC ION Authors: Li, G.-B, Yan, Y.-H. Deposit date: 2022-07-13 Release date: 2023-06-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Metal binding pharmacophore click-derived discovery of new broad-spectrum metallo-beta-lactamase inhibitors. Eur.J.Med.Chem., 257, 2023
7YHC	Crystal structure of VIM-2 MBL in complex with 3-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)phthalic acid Descriptor: 3-[4-(3-aminophenyl)-1,2,3-triazol-1-yl]phthalic acid, Beta-lactamase class B VIM-2, ZINC ION Authors: Li, G.-B, Yan, Y.-H. Deposit date: 2022-07-13 Release date: 2023-06-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.153 Å) Cite: Metal binding pharmacophore click-derived discovery of new broad-spectrum metallo-beta-lactamase inhibitors. Eur.J.Med.Chem., 257, 2023
7YHA	Crystal structure of IMP-1 MBL in complex with (3-(4-(p-tolyl)-1H-1,2,3-triazol-1-yl)benzyl)phosphonic acid Descriptor: Beta-lactamase class B IMP-1, ZINC ION, [3-[4-(4-methylphenyl)-1,2,3-triazol-1-yl]phenyl]methylphosphonic acid Authors: Li, G.-B, Yan, Y.-H. Deposit date: 2022-07-13 Release date: 2023-06-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.135 Å) Cite: Metal binding pharmacophore click-derived discovery of new broad-spectrum metallo-beta-lactamase inhibitors. Eur.J.Med.Chem., 257, 2023
5HH5	Crystal structure of B3 metallo-beta-lactamase L1 complexed with a phosphonate-based inhibitor Descriptor: 6-(phosphonomethyl)pyridine-2-carboxylic acid, GLYCEROL, Metallo-beta-lactamase L1, ... Authors: Hinchliffe, P, Spencer, J. Deposit date: 2016-01-09 Release date: 2017-01-18 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural and Kinetic Studies of the Potent Inhibition of Metallo-beta-lactamases by 6-Phosphonomethylpyridine-2-carboxylates. Biochemistry, 57, 2018
3L6N	Crystal structure of metallo-beta-lactamase IND-7 Descriptor: SULFATE ION, ZINC ION, metallo-beta-lactamase Authors: Yamaguchi, Y, Kurosaki, H, Yamagata, Y. Deposit date: 2009-12-23 Release date: 2010-04-14 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structure of metallo-beta-lactamase IND-7 from a Chryseobacterium indologenes clinical isolate at 1.65-A resolution J.Biochem., 147, 2010
5IQK	Rm3 metallo-beta-lactamase Descriptor: ZINC ION, beta-lactamase Rm3 Authors: Salimraj, R, Spencer, J. Deposit date: 2016-03-10 Release date: 2016-03-23 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural and Biochemical Characterization of Rm3, a Subclass B3 Metallo-beta-Lactamase Identified from a Functional Metagenomic Study. Antimicrob.Agents Chemother., 60, 2016
5HH6	Crystal structure of B3 metallo-beta-lactamase L1 in complex with a phosphonate-based inhibitor Descriptor: 6-[(~{S})-oxidanyl(phosphono)methyl]pyridine-2-carboxylic acid, Metallo-beta-lactamase L1, SULFATE ION, ... Authors: Hinchliffe, P, Spencer, J. Deposit date: 2016-01-09 Release date: 2017-01-18 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural and Kinetic Studies of the Potent Inhibition of Metallo-beta-lactamases by 6-Phosphonomethylpyridine-2-carboxylates. Biochemistry, 57, 2018

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