7YHA

Crystal structure of IMP-1 MBL in complex with (3-(4-(p-tolyl)-1H-1,2,3-triazol-1-yl)benzyl)phosphonic acid

Summary for 7YHA

Entry DOI	10.2210/pdb7yha/pdb
Descriptor	Beta-lactamase class B IMP-1, ZINC ION, [3-[4-(4-methylphenyl)-1,2,3-triazol-1-yl]phenyl]methylphosphonic acid, ... (4 entities in total)
Functional Keywords	metallo-beta-lactamase imp-1, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Pseudomonas aeruginosa
Total number of polymer chains	4
Total formula weight	99980.13
Authors	Li, G.-B.,Yan, Y.-H. (deposition date: 2022-07-13, release date: 2023-06-07, Last modification date: 2023-11-29)
Primary citation	Yan, Y.H.,Ding, H.S.,Zhu, K.R.,Mu, B.S.,Zheng, Y.,Huang, M.Y.,Zhou, C.,Li, W.F.,Wang, Z.,Wu, Y.,Li, G.B. Metal binding pharmacophore click-derived discovery of new broad-spectrum metallo-beta-lactamase inhibitors. Eur.J.Med.Chem., 257:115473-115473, 2023 Cited by PubMed: 37209449 DOI: 10.1016/j.ejmech.2023.115473 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.135 Å)

Structure validation