5XXW
 
 | | GDP-microtubule complexed with KIF5C in ATP state | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Morikawa, M, Shigematsu, H, Nitta, R, Hirokawa, N. | | Deposit date: | 2017-07-05 | | Release date: | 2018-10-10 | | Last modified: | 2019-11-06 | | Method: | ELECTRON MICROSCOPY (6 Å) | | Cite: | Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport
J. Cell Biol., 217, 2018
|
|
5XXV
 | | GDP-microtubule complexed with KIF5C in AMPPNP state | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Morikawa, M, Shigematsu, H, Nitta, R, Hirokawa, N. | | Deposit date: | 2017-07-05 | | Release date: | 2018-10-10 | | Last modified: | 2019-11-06 | | Method: | ELECTRON MICROSCOPY (6.46 Å) | | Cite: | Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport
J. Cell Biol., 217, 2018
|
|
5YL2
 | | Crystal structure of T2R-TTL-Y28 complex | | Descriptor: | (E)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)-3-(4-methoxy-3-oxidanyl-phenyl)prop-2-en-1-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | Authors: | Yang, J.H, Yang, T, Wen, J.L, Chen, L.J. | | Deposit date: | 2017-10-16 | | Release date: | 2018-04-18 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.
J. Biol. Chem., 2018
|
|
7SJ9
 | | 13pf E254A microtubule from recombinant human tubulin decorated with EB3 | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Microtubule-associated protein RP/EB family member 3, ... | | Authors: | LaFrance, B.J, Greber, B.J, Zhang, R, McCollum, C, Nogales, E. | | Deposit date: | 2021-10-16 | | Release date: | 2022-01-19 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structural transitions in the GTP cap visualized by cryo-electron microscopy of catalytically inactive microtubules.
Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7SJ8
 | | 13pf wildtype microtubule from recombinant human tubulin decorated with kinesin | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | LaFrance, B.J, Greber, B.J, Zhang, R, McCollum, C, Nogales, E. | | Deposit date: | 2021-10-16 | | Release date: | 2022-01-19 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural transitions in the GTP cap visualized by cryo-electron microscopy of catalytically inactive microtubules.
Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7SJA
 | | Undecorated 13pf E254N microtubule from recombinant human tubulin | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Tubulin alpha-1B chain, ... | | Authors: | LaFrance, B.J, Greber, B.J, Zhang, R, McCollum, C, Nogales, E. | | Deposit date: | 2021-10-16 | | Release date: | 2022-01-19 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structural transitions in the GTP cap visualized by cryo-electron microscopy of catalytically inactive microtubules.
Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7SJ7
 | | Undecorated 13pf wildtype microtubule from recombinant human tubulin | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | LaFrance, B.J, Greber, B.J, Zhang, R, McCollum, C, Nogales, E. | | Deposit date: | 2021-10-16 | | Release date: | 2022-01-19 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structural transitions in the GTP cap visualized by cryo-electron microscopy of catalytically inactive microtubules.
Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
5YLS
 | | Crystal structure of T2R-TTL-Y50 complex | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, E-3-(3-azanyl-4-methoxy-phenyl)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)prop-2-en-1-one, ... | | Authors: | Yang, J.H, Chen, L.J. | | Deposit date: | 2017-10-18 | | Release date: | 2018-04-11 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.
J. Biol. Chem., 293, 2018
|
|
5YL4
 | | CRYSTAL STRUCTURE OF T2R-TTL-8WR COMPLEX | | Descriptor: | (3Z,6Z)-3-[(4-tert-butyl-1H-imidazol-5-yl)methylidene]-6-[[3-(phenylcarbonyl)phenyl]methylidene]piperazine-2,5-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | Authors: | Fu, Z.Y, Li, W.B, Chu, Y.Y, Hou, Y.W, Ji, C.P. | | Deposit date: | 2017-10-17 | | Release date: | 2017-11-15 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.64 Å) | | Cite: | Design, synthesis and biological activity evaluation of plinabulin derivatives based on co-crystal structure
To Be Published
|
|
5YLJ
 | | Crystal structure of T2R-TTL-Millepachine complex | | Descriptor: | (E)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | Authors: | Yang, J.H, Chen, L.J. | | Deposit date: | 2017-10-17 | | Release date: | 2018-04-11 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.
J. Biol. Chem., 293, 2018
|
|
7SGS
 | | Cryo-EM structure of full-length MAP7 bound to the microtubule | | Descriptor: | Ensconsin, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Ferro, L.S, Fang, Q, Eshun-Wilson, L, Fernandes, J, Jack, A, Farrell, D.P, Golcuk, M, Huijben, T, Costa, K, Gur, M, DiMaio, F, Nogales, E, Yildiz, A. | | Deposit date: | 2021-10-07 | | Release date: | 2022-05-18 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural and functional insight into regulation of kinesin-1 by microtubule-associated protein MAP7.
Science, 375, 2022
|
|
7RX0
 | | Complex of AMPPNP-Kif7 and Gli2 Zinc-Finger domain bound to microtubules | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF7, MAGNESIUM ION, ... | | Authors: | Mani, N, Wilson-Kubalek, E.M, Haque, F, Freniere, C, Milligan, R.A, Subramanian, R. | | Deposit date: | 2021-08-20 | | Release date: | 2022-06-15 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.89 Å) | | Cite: | Cytoskeletal regulation of a transcription factor by DNA mimicry via coiled-coil interactions.
Nat.Cell Biol., 24, 2022
|
|
5YZ3
 | | Crystal structure of T2R-TTL-28 complex | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Yu, Y, Chen, Q. | | Deposit date: | 2017-12-12 | | Release date: | 2018-10-24 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.545 Å) | | Cite: | A Novel Microtubule Inhibitor Overcomes Multidrug Resistance in Tumors.
Cancer Res., 78, 2018
|
|
5Z4U
 | | Crystal Structure of T2R-TTL complex with 7a3 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(4-ethoxyphenyl)-1-methyl-3-(3,4,5-trimethoxyphenyl)-1H-pyrazole, CALCIUM ION, ... | | Authors: | Lai, Q, Wang, Y, Yang, J, Yao, Y. | | Deposit date: | 2018-01-14 | | Release date: | 2019-01-23 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.18 Å) | | Cite: | Crystal Structure of T2R-TTL complex with 7a3
To Be Published
|
|
5Z4P
 | | Crystal structure of tubulin-stathmin-TTL-Compound TCA complex | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6,7,8-trimethoxy-1-(4-methoxyphenyl)-4,5-dihydro-2~{H}-benzo[e]indazole, CALCIUM ION, ... | | Authors: | Zhang, H, Luo, C. | | Deposit date: | 2018-01-12 | | Release date: | 2019-01-16 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Discovery and Design of novel Tubulin inhibitors
To Be Published
|
|
5ZUE
 | | GTP-bound, double-stranded, curved FtsZ protofilament structure | | Descriptor: | Cell division protein FtsZ, GUANOSINE-5'-TRIPHOSPHATE | | Authors: | Guan, F, Yu, J, Yu, J, Liu, Y, Li, Y, Feng, X.H, Huang, K.C, Chang, Z, Ye, S. | | Deposit date: | 2018-05-07 | | Release date: | 2018-07-04 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Lateral interactions between protofilaments of the bacterial tubulin homolog FtsZ are essential for cell division
Elife, 7, 2018
|
|
6U0H
 | | Tubulin lattice of the ciliary doublet microtubule from Tetrahymena thermophila | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Ichikawa, M, Khalifa, A.A.Z, Vargas, J, Basu, K, Bui, K.H. | | Deposit date: | 2019-08-14 | | Release date: | 2019-09-25 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Tubulin lattice in cilia is in a stressed form regulated by microtubule inner proteins.
Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6U0U
 | | Protofilament Ribbon Flagellar Proteins Rib43a-L | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Ichikawa, M, Khalifa, A.A.Z, Vargas, J, Basu, K, Bui, K.H. | | Deposit date: | 2019-08-14 | | Release date: | 2019-09-25 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.16 Å) | | Cite: | Tubulin lattice in cilia is in a stressed form regulated by microtubule inner proteins.
Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6QQN
 | | Tubulin-TH588 complex | | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | Authors: | Patterson, J.C, Joughin, B.A, Prota, A.E, Muehlethaler, T, Jonas, O.H, Whitman, M.A, Varmeh, S, Chen, S, Balk, S.P, Steinmetz, M.O, Lauffenburger, D.A, Yaffe, M.B. | | Deposit date: | 2019-02-18 | | Release date: | 2019-07-24 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.301 Å) | | Cite: | VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells.
Cell Syst, 9, 2019
|
|
6QUY
 | | NgCKK (N.Gruberi CKK) decorated 13pf taxol-GDP microtubule | | Descriptor: | CKK domain protein, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Atherton, J.M, Luo, Y, Xiang, S, Yang, C, Jiang, K, Stangier, M, Vemu, A, Cook, A, Wang, S, Roll-Mecak, A, Steinmetz, M.O, Akhmanova, A, Baldus, M, Moores, C.A. | | Deposit date: | 2019-02-28 | | Release date: | 2019-11-27 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structural determinants of microtubule minus end preference in CAMSAP CKK domains.
Nat Commun, 10, 2019
|
|
6UNX
 | | Structure of E. coli FtsZ(L178E)-GTP complex | | Descriptor: | Cell division protein FtsZ, GUANOSINE-5'-TRIPHOSPHATE | | Authors: | Schumacher, M.A. | | Deposit date: | 2019-10-13 | | Release date: | 2020-02-05 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | High-resolution crystal structures of Escherichia coli FtsZ bound to GDP and GTP.
Acta Crystallogr.,Sect.F, 76, 2020
|
|
6QVE
 | | NgCKK (Naegleria Gruberi CKK) decorated 14pf taxol-GDP microtubule | | Descriptor: | Beta1-tubulin, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Atherton, J.M, Luo, Y, Xiang, S, Yang, C, Jiang, K, Stangier, M, Vemu, A, Cook, A, Wang, S, Roll-Mecak, A, Steinmetz, M.O, Akhmanova, A, Baldus, M, Moores, C.A. | | Deposit date: | 2019-03-01 | | Release date: | 2019-11-27 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural determinants of microtubule minus end preference in CAMSAP CKK domains.
Nat Commun, 10, 2019
|
|
6QTN
 | | Tubulin-cyclostreptin complex | | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | Authors: | Balaguer, F.d.A, Muehlethaler, T, Estevez-Gallego, J, Calvo, E, Gimenez-Abian, J.F, Risinger, A.L, Sorensen, E.J, Vanderwal, C.D, Altmann, K.-H, Mooberry, S.L, Steinmetz, M.O, Oliva, M.A, Prota, A.E, Diaz, J.F. | | Deposit date: | 2019-02-25 | | Release date: | 2019-04-03 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands.
Int J Mol Sci, 20, 2019
|
|
6QUS
 | | HsCKK (human CAMSAP1) decorated 13pf taxol-GDP microtubule | | Descriptor: | Calmodulin-regulated spectrin-associated protein 1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Atherton, J.M, Luo, Y, Xiang, S, Yang, C, Jiang, K, Stangier, M, Vemu, A, Cook, A, Wang, S, Roll-Mecak, A, Steinmetz, M.O, Akhmanova, A, Baldus, M, Moores, C.A. | | Deposit date: | 2019-02-28 | | Release date: | 2019-11-27 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural determinants of microtubule minus end preference in CAMSAP CKK domains.
Nat Commun, 10, 2019
|
|
6REV
 | |
