6QQN

Tubulin-TH588 complex

Summary for 6QQN

Entry DOI	10.2210/pdb6qqn/pdb
Descriptor	Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, N~4~-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine, ... (13 entities in total)
Functional Keywords	cell cycle, tubulin fold, cytoskeleton, microtubule
Biological source	Rattus norvegicus (Norway rat) More
Total number of polymer chains	6
Total formula weight	264903.60
Authors	Patterson, J.C.,Joughin, B.A.,Prota, A.E.,Muehlethaler, T.,Jonas, O.H.,Whitman, M.A.,Varmeh, S.,Chen, S.,Balk, S.P.,Steinmetz, M.O.,Lauffenburger, D.A.,Yaffe, M.B. (deposition date: 2019-02-18, release date: 2019-07-24, Last modification date: 2024-01-24)
Primary citation	Patterson, J.C.,Joughin, B.A.,Prota, A.E.,Muhlethaler, T.,Jonas, O.H.,Whitman, M.A.,Varmeh, S.,Chen, S.,Balk, S.P.,Steinmetz, M.O.,Lauffenburger, D.A.,Yaffe, M.B. VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells. Cell Syst, 9:74-92.e8, 2019 Cited by PubMed: 31302152 DOI: 10.1016/j.cels.2019.05.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.301 Å)

Structure validation