PDB: 278 resultsInfo pagesStatus searchChemie searchBIRD

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2KHO	NMR-RDC / XRAY structure of E. coli HSP70 (DNAK) chaperone (1-605) complexed with ADP and substrate Descriptor: Heat shock protein 70 Authors: Zuiderweg, E.R.P, Bertelsen, E.B. Deposit date: 2009-04-10 Release date: 2009-05-12 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate. Proc.Natl.Acad.Sci.USA, 106, 2009
6NHK	Mortalin nucleotide binding domain in the ADP-bound state Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... Authors: Page, R.C, Moseng, M.A, Nix, J.C. Deposit date: 2018-12-23 Release date: 2019-04-17 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.777 Å) Cite: Biophysical Consequences of EVEN-PLUS Syndrome Mutations for the Function of Mortalin. J.Phys.Chem.B, 123, 2019
1BPR	NMR STRUCTURE OF THE SUBSTRATE BINDING DOMAIN OF DNAK, MINIMIZED AVERAGE STRUCTURE Descriptor: DNAK Authors: Wang, H, Kurochkin, A.V, Pang, Y, Hu, W, Flynn, G.C, Zuiderweg, E.R.P. Deposit date: 1998-08-11 Release date: 1999-03-02 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: NMR solution structure of the 21 kDa chaperone protein DnaK substrate binding domain: a preview of chaperone-protein interaction. Biochemistry, 37, 1998
6P2U	Structure of Mortalin-NBD with N6-propargyladenosine-5'-diphosphate Descriptor: 9-{5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-alpha-D-ribofuranosyl}-N-(prop-2-yn-1-yl)-9H-purin-6-amine, MAGNESIUM ION, PHOSPHATE ION, ... Authors: Moseng, M.A, Page, R.C. Deposit date: 2019-05-22 Release date: 2019-06-19 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: 2- and N6-functionalized adenosine-5'-diphosphate analogs for the inhibition of mortalin. Febs Lett., 593, 2019
1DKZ	THE SUBSTRATE BINDING DOMAIN OF DNAK IN COMPLEX WITH A SUBSTRATE PEPTIDE, DETERMINED FROM TYPE 1 NATIVE CRYSTALS Descriptor: SUBSTRATE BINDING DOMAIN OF DNAK, SUBSTRATE PEPTIDE (7 RESIDUES) Authors: Zhu, X, Zhao, X, Burkholder, W.F, Gragerov, A, Ogata, C.M, Gottesman, M.E, Hendrickson, W.A. Deposit date: 1996-06-03 Release date: 1996-12-07 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural analysis of substrate binding by the molecular chaperone DnaK. Science, 272, 1996
6PMT	Structure of Mortalin-NBD with adenosine-5'-monophosphate and thiodiphosphate Descriptor: ADENOSINE MONOPHOSPHATE, PHOSPHATE ION, Stress-70 protein, ... Authors: Moseng, M.A, Nix, J.C, Page, R.C. Deposit date: 2019-07-02 Release date: 2020-07-08 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of the mortalin nucleotide binding domain in complex with adenosine monophosphate to be published
5XI9	Solution structure for human HSP70 substrate binding domain Descriptor: Heat shock 70 kDa protein 1A Authors: Hoshikawa, M, Tochio, N, Tate, S. Deposit date: 2017-04-26 Release date: 2018-05-16 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication. Molecules, 23, 2018
5XIR	Solution structure for human HSP70 substrate binding domain L542Y mutant Descriptor: Heat shock 70 kDa protein 1A Authors: Hoshikawa, M, Tochio, N, Tate, S. Deposit date: 2017-04-27 Release date: 2018-05-16 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication. Molecules, 23, 2018
5TKY	Crystal structure of the co-translational Hsp70 chaperone Ssb in the ATP-bound, open conformation Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative uncharacterized protein Authors: Gumiero, A, Gese, G.V, Weyer, F.A, Lapouge, K, Sinning, I. Deposit date: 2016-10-10 Release date: 2016-11-16 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain. Nat Commun, 7, 2016
5UMB	Crystal structure of ATPase domain of Malaria GRP78 with ADP bound Descriptor: ADENOSINE-5'-DIPHOSPHATE, Chaperone DnaK, MAGNESIUM ION, ... Authors: Chen, Y, Antoshchenko, T, Pizarro, J.C, Song, J.H, Park, H. Deposit date: 2017-01-26 Release date: 2022-07-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Repurposing drugs to target the malaria parasite unfolding protein response. Sci Rep, 8, 2018
7PLK	Crystal structure bovine Hsc70(aa1-554)E213A/D214A in complex with nicotinic-acid-derivative Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-pyrrol-1-ylpyridine-3-carboxylic acid, GLYCEROL, ... Authors: Zehe, M, Grimm, C, Sotriffer, C. Deposit date: 2021-08-31 Release date: 2022-09-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.48781371 Å) Cite: Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct. Acs Chem.Biol., 2024
1U00	HscA substrate binding domain complexed with the IscU recognition peptide ELPPVKIHC Descriptor: Chaperone protein hscA, IscU recognition peptide Authors: Cupp-Vickery, J.R, Peterson, J.C, Ta, D.T, Vickery, L.E. Deposit date: 2004-07-12 Release date: 2004-10-05 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal Structure of the Molecular Chaperone HscA Substrate Binding Domain Complexed with the IscU Recognition Peptide ELPPVKIHC. J.Mol.Biol., 342, 2004
7RAX	ATP-binding state of the nucleotide-binding domain of Hsp70 DnaK mutant T199A Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK, GLYCEROL, ... Authors: Wang, W, Hendrickson, W.A. Deposit date: 2021-07-04 Release date: 2023-07-05 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.41 Å) Cite: Visualization of Hsp70-catalyzed ATP Hydrolysis To Be Published
1YUW	crystal structure of bovine hsc70(aa1-554)E213A/D214A mutant Descriptor: Heat shock cognate 71 kDa protein Authors: Jiang, J, Lafer, E.M, Prasad, K, Sousa, R. Deposit date: 2005-02-14 Release date: 2005-10-04 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural basis of interdomain communication in the Hsc70 chaperone Mol.Cell, 20, 2005
6S02	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain - ADP bound state Descriptor: ADENOSINE-5'-DIPHOSPHATE, Heat shock protein 70, MAGNESIUM ION Authors: Vakonakis, I, Day, J. Deposit date: 2019-06-13 Release date: 2019-10-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.87 Å) Cite: ThePlasmodium falciparumHsp70-x chaperone assists the heat stress response of the malaria parasite. Faseb J., 33, 2019
6RZQ	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain - ANP-PnP bound state Descriptor: GLYCEROL, Heat shock protein 70, MAGNESIUM ION, ... Authors: Vakonakis, I, Day, J. Deposit date: 2019-06-13 Release date: 2019-10-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.81 Å) Cite: ThePlasmodium falciparumHsp70-x chaperone assists the heat stress response of the malaria parasite. Faseb J., 33, 2019
6SR6	Crystal structure of the RAC core with a pseudo substrate bound to Ssz1 SBD Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative heat shock protein, ... Authors: Valentin Gese, G, Lapouge, K, Kopp, J, Sinning, I. Deposit date: 2019-09-05 Release date: 2020-03-25 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb. Nat Commun, 11, 2020
2BUP	T13G Mutant of the ATPASE fragment of Bovine HSC70 Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... Authors: Sousa, M.C, Mckay, D.B. Deposit date: 1998-09-08 Release date: 1998-09-16 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The hydroxyl of threonine 13 of the bovine 70-kDa heat shock cognate protein is essential for transducing the ATP-induced conformational change. Biochemistry, 37, 1998
2BPR	NMR STRUCTURE OF THE SUBSTRATE BINDING DOMAIN OF DNAK, 25 STRUCTURES Descriptor: DNAK Authors: Wang, H, Kurochkin, A.V, Pang, Y, Hu, W, Flynn, G.C, Zuiderweg, E.R.P. Deposit date: 1998-08-11 Release date: 1999-03-02 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: NMR solution structure of the 21 kDa chaperone protein DnaK substrate binding domain: a preview of chaperone-protein interaction. Biochemistry, 37, 1998
1QQO	E175S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, HYDROLASE (ACTING ON ACID ANHYDRIDES), ... Authors: Johnson, E.R, McKay, D.B. Deposit date: 1999-06-07 Release date: 1999-09-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Mapping the role of active site residues for transducing an ATP-induced conformational change in the bovine 70-kDa heat shock cognate protein. Biochemistry, 38, 1999
1QQM	D199S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, D199S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN, ... Authors: Johnson, E.R, Mckay, D.B. Deposit date: 1999-06-07 Release date: 1999-09-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Mapping the role of active site residues for transducing an ATP-induced conformational change in the bovine 70-kDa heat shock cognate protein. Biochemistry, 38, 1999
1QQN	D206S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, D206S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN, ... Authors: Johnson, E.R, McKay, D.B. Deposit date: 1999-06-07 Release date: 1999-09-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Mapping the role of active site residues for transducing an ATP-induced conformational change in the bovine 70-kDa heat shock cognate protein. Biochemistry, 38, 1999
3QFP	Crystal structure of yeast Hsp70 (Bip/Kar2) ATPase domain Descriptor: 78 kDa glucose-regulated protein homolog, PHOSPHATE ION Authors: Yan, M, Li, J.Z, Sha, B.D. Deposit date: 2011-01-22 Release date: 2011-06-29 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Structural analysis of the Sil1-Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor. Biochem.J., 438, 2011
3QNJ	Crystal structure of the substrate binding domain of E.coli DnaK in complex with the antimicrobial peptide oncocin Descriptor: Chaperone protein DnaK, SULFATE ION, antimicrobial peptide oncocin Authors: Zahn, M, Straeter, N. Deposit date: 2011-02-08 Release date: 2011-03-23 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Rational Design of Oncocin Derivatives with Superior Protease Stabilities and Antibacterial Activities Based on the High-Resolution Structure of the Oncocin-DnaK Complex. Chembiochem, 12, 2011
3QFU	Crystal structure of Yeast Hsp70 (Bip/kar2) complexed with ADP Descriptor: 78 kDa glucose-regulated protein homolog, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Yan, M, Li, J.Z, Sha, B.D. Deposit date: 2011-01-22 Release date: 2011-06-29 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural analysis of the Sil1-Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor. Biochem.J., 438, 2011

 

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